Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2435 produtos de "Cromatina/Epigenética"
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Momelotinib
CAS:Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Fórmula:C23H22N6O2Pureza:97.07% - 99.56%Cor e Forma:SolidPeso molecular:414.46MS436
CAS:MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.Fórmula:C18H17N5O3SPureza:97.95% - 98.92%Cor e Forma:SolidPeso molecular:383.42SNS-314 Mesylate
CAS:SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Fórmula:C18H15ClN6OS2·CH4O3SPureza:99.44% - 99.92%Cor e Forma:SolidPeso molecular:527.04BAY-598
CAS:BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over SMYD3, SUV420H1, and SUV420H2. Cost-effective and quality-assured.Fórmula:C22H20Cl2F2N6O3Pureza:99.18% - 99.78%Cor e Forma:SolidPeso molecular:525.342',3',5'-triacetyl-5-Azacytidine
CAS:2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.Fórmula:C14H18N4O8Pureza:98.34%Cor e Forma:SolidPeso molecular:370.31GSK046
CAS:GSK046 (iBET-BD2), potent oral BET BD2 inhibitor; IC50: BRD2 (264 nM), BRD3 (98 nM), BRD4 (49 nM), BRDT (214 nM); immunomodulatory.Fórmula:C23H27FN2O4Pureza:99.97%Cor e Forma:SolidPeso molecular:414.47RO495
CAS:<p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>Fórmula:C17H14Cl2N6OPureza:97.94%Cor e Forma:SolidPeso molecular:389.24GSK6853
CAS:GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.Fórmula:C22H27N5O3Pureza:98.71% - 99.21%Cor e Forma:SolidPeso molecular:409.48(Z)-LFM-A13
CAS:(Z)-LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.Fórmula:C11H8Br2N2O2Pureza:99.88%Cor e Forma:SolidPeso molecular:360Niraparib
CAS:Niraparib (MK-4827) inhibits PARP1/PARP2 (IC50: 3.8/2.1 nM), effective on BRCA mutant cancers, 330x less effective on PARP3, V-PARP, Tank1.Fórmula:C19H20N4OPureza:98% - 99.91%Cor e Forma:SolidPeso molecular:320.39AKBA
CAS:<p>AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.</p>Fórmula:C32H48O5Pureza:97.85% - 99.77%Cor e Forma:SolidPeso molecular:512.72MN-64
CAS:<p>MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.</p>Fórmula:C18H16O2Pureza:99.5% - 99.93%Cor e Forma:SolidPeso molecular:264.32SGC0946
CAS:<p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>Fórmula:C28H40BrN7O4Pureza:98% - 99.82%Cor e Forma:SolidPeso molecular:618.57SMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Fórmula:C13H13NO3SPureza:99.99%Cor e Forma:SolidPeso molecular:263.31OF-1
CAS:OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.Fórmula:C17H18BrN3O4SPureza:98.55% - ≥95%Cor e Forma:SolidPeso molecular:440.31AT9283
CAS:<p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Cor e Forma:SolidPeso molecular:381.43SETDB1-TTD-IN-1
CAS:SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.Fórmula:C28H31N5O2Pureza:98.26% - 99.96%Cor e Forma:SolidPeso molecular:469.58JMJD7-IN-1
CAS:<p>JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM.</p>Fórmula:C16H8Cl2N2O4Pureza:99.66%Cor e Forma:SolidPeso molecular:363.15PF-9366
CAS:PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).Fórmula:C20H19ClN4Pureza:97.28% - 99.88%Cor e Forma:SolidPeso molecular:350.84AG-270
CAS:<p>AG-270 is an allosteric and orally active inhibitor of MAT2A.</p>Fórmula:C30H27N5O2Pureza:98.28% - 98.87%Cor e Forma:SolidPeso molecular:489.57
