Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2595 produtos de "Cromatina/Epigenética"
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aPKC-I
CAS:aPKC-I specifically inhibits PKCζ/i, blocks VEGF effects, and prevents IR-induced permeability in cells and live models.Fórmula:C15H17NO4SCor e Forma:SolidPeso molecular:307.36NAT2-IN-1
CAS:NAT2-IN-1 (APA) is a selective inhibitor of the drug metabolism enzyme N-acetyltransferase 2 (NAT2), capable of targeting and eliminating cells with slow NAT2Fórmula:C19H20N4O3Cor e Forma:SolidPeso molecular:352.39SC-10
CAS:SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.Fórmula:C17H22ClNO2SPureza:99.24% - 99.58%Cor e Forma:SolidPeso molecular:339.88HDAC6-IN-46
CAS:HDAC6-IN-46 (compound 12) is a selective inhibitor of histone deacetylase 6 (HDAC6), exhibiting an IC50 of 6.2 nM. It is utilized in research related to Alzheimer's disease.Fórmula:C26H21N3O4Cor e Forma:SolidPeso molecular:439.46Tinostamustine HCl
CAS:Tinostamustine (EDO-S101) is an alkylating HDACi fusion molecule, enhancing potency and overcoming drug resistance.Fórmula:C19H29Cl3N4O2Cor e Forma:SolidPeso molecular:451.82SPC-180002
CAS:SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Fórmula:C18H23NO4Pureza:98%Cor e Forma:SolidPeso molecular:317.38BI-9321
CAS:BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.Fórmula:C22H21FN4Pureza:98%Cor e Forma:SolidPeso molecular:360.43JNJ-9350
CAS:JNJ-9350: SMOX inhibitor (IC50 0.01 μM), PAO inhibitor (IC50 0.79 μM), for cancer research.Fórmula:C25H22N6OCor e Forma:SolidPeso molecular:422.48NSC 698600
CAS:NSC 698600 is a potent inhibitor of PCAF(p300/CBP-associated factor) with IC 50 of 6.51 μM that shows good inhibition activity of cancer cell proliferation [1].Fórmula:C14H12N2O2SCor e Forma:SolidPeso molecular:272.32SIRT6-IN-1
CAS:SIRT6-IN-1, a novel SIRT6 inhibitor, reduces glycemia and improves oral glucose tolerance in unfed wild-type mice.Fórmula:C19H14N4O5SCor e Forma:SolidPeso molecular:410.4MAT2A-IN-5
CAS:MAT2A-IN-5 inhibits MAT2A in tumors, curbing growth in gastric, colon, liver, and pancreatic cancers.Fórmula:C17H12ClF3N2OCor e Forma:SolidPeso molecular:352.74MicroRNA-21-IN-2
CAS:MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer.Fórmula:C17H15N3O3SPureza:99.45%Cor e Forma:SolidPeso molecular:341.38CAY10721
CAS:CAY10721 inhibits SIRT3 (39% at 200 μM), linked to OSCC and breast cancer; lowers OSCC growth, enhances radio/chemo sensitivity.Fórmula:C18H13N3O3SCor e Forma:SolidPeso molecular:351.38SIRT1-IN-2
CAS:SIRT1-IN-2 (compound 3h) is a potent and selective inhibitor of SIRT1 (silent information regulator 1) with an IC 50 of 1.6 μM [1].Fórmula:C13H15ClN2OCor e Forma:SolidPeso molecular:250.72CSV0C018875 Hydrochloride
CAS:CSV0C018875 Hydrochloride: Novel G9a inhibitor with low toxicity, effective in enzyme/cell assays, outperforms BIX-0129.Fórmula:C18H18Cl2N2OCor e Forma:SolidPeso molecular:349.255MC4343
MC4343, a potent dual inhibitor targeting both EZH2 and histone deacetylase, presents promising potential for cancer research applications.Fórmula:C36H41N5O4Cor e Forma:SolidPeso molecular:607.74TK4b
CAS:TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).Fórmula:C21H22N2O2Cor e Forma:SolidPeso molecular:334.41HDAC-IN-43
CAS:HDAC-IN-43: potent HDAC 1/3/6 inhibitor (IC50: 82 nM HDAC1, 45 nM HDAC3, 24 nM HDAC6); weak PI3K/mTOR (IC50: 3.6μM, 3.7μM); anti-proliferative.Fórmula:C22H28N6O4Cor e Forma:SolidPeso molecular:440.5SYK/JAK-IN-1
CAS:SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.Fórmula:C24H26N8O3Cor e Forma:SolidPeso molecular:474.52PRMT5-IN-2
CAS:PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.Fórmula:C17H16ClFN4O4Pureza:98%Cor e Forma:SolidPeso molecular:394.78
