Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 958 produtos de "Dano de DNA/Reparo de DNA"
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NC190 sodium
CAS:<p>NC190 inhibits topoisomerase II, halts FM3A cell growth (IC50: 0.019 μg/ml in 48h), and suppresses DNA synthesis by 90% at 0.1 μg/ml.</p>Fórmula:C23H22N4NaO5Pureza:98%Cor e Forma:SolidPeso molecular:457.442BMS-711939
CAS:<p>BMS-711939: Potent PPARα agonist, EC50=4 nM, shown effective and safe in preclinical trials.</p>Fórmula:C22H20ClFN2O6Cor e Forma:SolidPeso molecular:462.86NHC-triphosphate
CAS:<p>NHC-triphosphate is a weak alternative substrate for the viral polymerase and changes the mobility of the product in polyacrylamide electrophoresis gels.</p>Fórmula:C9H16N3O15P3Pureza:98%Cor e Forma:SolidPeso molecular:499.16Topoisomerase IIα-IN-2
CAS:<p>Topoisomerase IIα-IN-2 (compound 5) is a DNA-binding ligands and a potent inhibitor of the topoisomerase TopoIIα.</p>Fórmula:C22H20N4O5Cor e Forma:SolidPeso molecular:420.42Naveglitazar
CAS:<p>Naveglitazar (LY 519818, LY 9818), a PPAR modulator in phase II trials for type 2 diabetes.</p>Fórmula:C25H26O6Cor e Forma:SolidPeso molecular:422.47LY-510929
CAS:<p>LY-510929: PPAR agonist for hyperlipidemia, metabolic issues, type 2 diabetes.</p>Fórmula:C26H25NO5SPureza:98%Cor e Forma:SolidPeso molecular:463.55HWL-088
CAS:<p>HWL-088 is a potent free fatty acid receptor 1 (FFA1/GPR40) agonist. HWL-088 significantly improves glucose tolerance in normal and diabetic models.</p>Fórmula:C22H19FO4Cor e Forma:SolidPeso molecular:366.38CCT128930
CAS:<p>'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'</p>Fórmula:C18H20ClN5Pureza:99.07% - 99.18%Cor e Forma:SolidPeso molecular:341.84PluriSIn #2
CAS:<p>PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.</p>Fórmula:C11H8FN3O3Pureza:98% - 99.79%Cor e Forma:SolidPeso molecular:249.2HDAC-IN-5
CAS:<p>HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.</p>Fórmula:C26H24F3N5O2SPureza:98%Cor e Forma:SolidPeso molecular:527.56Ertiprotafib
CAS:<p>Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.</p>Fórmula:C31H27BrO3SPureza:98.70%Cor e Forma:SolidPeso molecular:559.51Sirt2-IN-1
CAS:<p>Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).</p>Fórmula:C28H27N7O2S2Pureza:99.57% - 99.84%Cor e Forma:SolidPeso molecular:557.69CAY10767
CAS:<p>CAY10767 is a PPARα agonist with an EC50 of 37 nM; over 2700x selective against PPARγ/δ.</p>Fórmula:C22H20FNO3Cor e Forma:SolidPeso molecular:365.4Guadecitabine sodium
CAS:<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Fórmula:C18H24N9NaO10PPureza:98%Cor e Forma:SolidPeso molecular:580.407Topoisomerase I inhibitor 7
CAS:<p>Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I.</p>Fórmula:C22H19N3O5Cor e Forma:SolidPeso molecular:405.4LG100754
CAS:<p>LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.</p>Fórmula:C26H36O3Cor e Forma:SolidPeso molecular:396.569-Hydroxyellipticine hydrochloride
CAS:<p>9-Hydroxyellipticine hydrochloride is an inhibitor of Topo II and RyR, exhibits antitumor and antileukemic activity, and inhibits carrageenan gum-induced edema.</p>Fórmula:C17H15ClN2OPureza:98%Cor e Forma:SolidPeso molecular:298.77Topoisomerase II inhibitor 16
CAS:<p>Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the</p>Fórmula:C19H12F4N6OPureza:98%Cor e Forma:SolidPeso molecular:416.33Topoisomerase IV inhibitor 1
CAS:<p>Compound 7d: Inhibits TOPO IV (IC50: 0.23 μM), DNA gyrase (IC50: 0.43 μM), antibacterial against S. aureus (MIC: 0.972 μM), E. coli (MIC: 0.608 μM).</p>Fórmula:C34H32FN7O6SPureza:98%Cor e Forma:SolidPeso molecular:685.72PB131
CAS:<p>PB131, a selective and brain-permeable HDAC6 inhibitor, exhibits high binding affinity (IC50: 1.8 nM) and potent anti-inflammatory activity, making it suitable</p>Fórmula:C16H16FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:301.32GW 9578
CAS:<p>GW 9578 is a PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.</p>Fórmula:C26H34F2N2O3SPureza:98%Cor e Forma:SolidPeso molecular:492.62Chiglitazar
CAS:<p>Chiglitazar is a PPAR α/γ/δ agonist and insulin sensitizer used in the treatment of type 2 diabetes mellitus , anti-inflammatory and anti-fibrotic.</p>Fórmula:C36H29FN2O4Cor e Forma:SolidPeso molecular:572.63HDAC-IN-58
CAS:<p>HDAC-IN-58, a selective HDAC6 inhibitor, exhibits potent inhibitory activity with an IC50 of 2.06 nM, rendering it suitable for research into chronic</p>Fórmula:C16H13ClF2N4O3SPureza:98%Cor e Forma:SolidPeso molecular:414.81Topoisomerase IV inhibitor 2
CAS:<p>Compound 5d, a potent TOPO IV inhibitor (IC50: 0.35 μM), also inhibits DNA gyrase (IC50: 0.55 μM) and has antibacterial activity.</p>Fórmula:C33H30FN7O6SPureza:98%Cor e Forma:SolidPeso molecular:671.7HDAC ligand-1
CAS:<p>HDAC ligand-1 is a synthetic precursor utilized in the production of PROTAC-based HDAC degraders [1].</p>Fórmula:C7H8N2OPureza:98%Cor e Forma:SolidPeso molecular:136.15ATR-IN-23
CAS:<p>ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces</p>Fórmula:C20H22N6O3S2Pureza:98%Cor e Forma:SolidPeso molecular:458.56BRD 9757
CAS:<p>BRD 9757 (N-Hydroxy-1-cyclopentene-1-carboxamide) is a selective inhibitor of HDAC6 (IC50 = 30 nM).</p>Fórmula:C6H9NO2Pureza:98.39% - 99.87%Cor e Forma:SolidPeso molecular:127.14NSC16168
CAS:<p>NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.</p>Fórmula:C17H15NO9S3Pureza:99.88%Cor e Forma:SolidPeso molecular:473.5Dehydroepiandrosterone sulfate
CAS:<p>Dehydroepiandrosterone sulfate (PB-005) influences the migration of neurons, arborization of dendrites, and formation of new synapses.</p>Fórmula:C19H28O5SPureza:97.18%Cor e Forma:SolidPeso molecular:368.49ISX-1
CAS:<p>ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.</p>Fórmula:C14H14N4O2SPureza:98.7%Cor e Forma:SolidPeso molecular:302.35Linotroban
CAS:<p>Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.</p>Fórmula:C14H15NO5S2Pureza:97.95% - >99.99%Cor e Forma:SolidPeso molecular:341.4Dazmegrel
CAS:<p>Dazmegrel (UK 38,485) is a thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy.</p>Fórmula:C16H17N3O2Pureza:98.81%Cor e Forma:SolidPeso molecular:283.33Vutiglabridin
CAS:<p>Vutiglabridin (HSG4112), a PON2 modulator, is more stable and aids weight loss than Glabridin. In phase 2 trials for obesity, shows promise for PD therapy.</p>Fórmula:C22H26O4Pureza:98.47% - 99.07%Cor e Forma:SolidPeso molecular:354.44Chloroquinoxaline sulfonamide
CAS:<p>Chloroquinoxaline sulfonamide (Chloroquinoxaline) is an organic micropollutant with antimicrobial activity.</p>Fórmula:C14H11ClN4O2SPureza:99.79% - 99.89%Cor e Forma:SolidPeso molecular:334.78DN-1289
<p>DN-1289: oral, BBB-penetrating, selectively inhibits DLK (IC50=17nM) & LZK (IC50=40nM), blocks p-c-Jun in mouse optic nerve crush.</p>Fórmula:C18H19F4N7O2Pureza:98.56%Cor e Forma:SolidPeso molecular:441.38SIRT5 inhibitor 1
CAS:<p>SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.</p>Fórmula:C31H39FN6O6S2Pureza:97.8%Cor e Forma:SolidPeso molecular:674.81Cedazuridine
CAS:<p>Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.</p>Fórmula:C9H14F2N2O5Pureza:99.66%Cor e Forma:SolidPeso molecular:268.21AGI-24512
CAS:<p>AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in</p>Fórmula:C24H24N4O2Pureza:98.55%Cor e Forma:SolidPeso molecular:400.47Procainamide
CAS:<p>Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.</p>Fórmula:C13H21N3OPureza:99.92% - 99.92%Cor e Forma:SolidPeso molecular:235.33L82
CAS:<p>L82: A selective, non-competitive DNA Lig1 inhibitor with anti-proliferative effects on breast cancer cells. IC50=12 μM.</p>Fórmula:C11H8ClN5O4Pureza:97.45% - 98.91%Cor e Forma:SolidPeso molecular:309.67BTB09089
CAS:<p>BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production</p>Fórmula:C14H12Cl2N4OS2Pureza:99.78%Cor e Forma:SoildPeso molecular:387.31SIRT6-IN-5
CAS:<p>SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.</p>Fórmula:C19H14N2O6Pureza:98.77%Cor e Forma:SolidPeso molecular:366.32HDAC8-IN-20a
CAS:<p>HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM.</p>Fórmula:C15H15NO4Pureza:98.24% - 99.22%Cor e Forma:SolidPeso molecular:273.28Suksdorfin
CAS:<p>Suksdorfin has hypoglycemic effects and activates PPARγ, which promotes insulin-dependent glucose uptake by adipocytes and can be used to study obesity .</p>Fórmula:C21H24O7Pureza:98.54%Cor e Forma:SolidPeso molecular:388.41Bobcat339 hydrochloride
CAS:<p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>Fórmula:C16H13Cl2N3OPureza:99.22%Cor e Forma:SolidPeso molecular:334.2Alalevonadifloxacin
CAS:<p>Alalevonadifloxacin is a DNA gyrase and DNA topoisomerase inhibitor and a novel antibacterial compound of the quinolone class targeting MRSa.</p>Fórmula:C23H30FN3O8SPureza:99.75% - 99.82%Cor e Forma:SoildPeso molecular:527.56Pegamotecan
CAS:<p>Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell</p>Fórmula:C52H48N6O14Pureza:96.40% - 97.83%Cor e Forma:SolidPeso molecular:980.984Miriplatin hydrate
CAS:Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).Fórmula:C34H70N2O5PtPureza:99.6%Cor e Forma:SolidPeso molecular:782.01BRD6688
CAS:<p>BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes</p>Fórmula:C16H18N4OPureza:97.53%Cor e Forma:SolidPeso molecular:282.34PARP10-IN-2
CAS:<p>PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and</p>Fórmula:C14H10N2O2Pureza:99.27%Cor e Forma:SolidPeso molecular:238.24Tenifatecan
CAS:<p>Tenifatecan (SN2310) is a highly lipophilic preparation of 7-ethyl-10-hydroxycamptothecin (SN) with potential antitumor activity.</p>Fórmula:C55H72N2O9Pureza:99.58% - 99.82%Cor e Forma:SolidPeso molecular:905.17SS-208
CAS:<p>SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.</p>Fórmula:C13H11Cl2N3O4Pureza:99.69%Cor e Forma:SolidPeso molecular:344.15(R)-(-)-Rolipram
CAS:<p>(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.</p>Fórmula:C16H21NO3Pureza:99.54%Cor e Forma:SolidPeso molecular:275.34Givinostat hydrochloride
CAS:<p>Givinostat HCl (ITF2357 HCl) inhibits HDAC1/3 (IC50: 198/157 nM) with anti-inflammatory, anti-angiogenic, and antineoplastic properties.</p>Fórmula:C24H28ClN3O4Pureza:99.39%Cor e Forma:SolidPeso molecular:457.95EB-47
CAS:<p>EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).</p>Fórmula:C24H27N9O6Pureza:99.81%Cor e Forma:SolidPeso molecular:537.53CEP-9722
CAS:<p>CEP-9722 is a PARP-1 and PARP-2 inhibitor with anticancer activity and is used in the study of ovarian cancer.</p>Fórmula:C24H26N4O3Pureza:98.38% - 98.56%Cor e Forma:SolidPeso molecular:418.49ACY-957
CAS:<p>ACY-957: Oral HDAC1/2 inhibitor (IC50: HDAC1=7nM, HDAC2=18nM, HDAC3=1300nM); inactive on HDAC4/5/6/7/8/9.</p>Fórmula:C24H23N5OSPureza:99.79%Cor e Forma:SolidPeso molecular:429.54OUL232
CAS:<p>OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.</p>Fórmula:C10H10N4O2SPureza:99.04%Cor e Forma:SolidPeso molecular:250.28ACY-1083
CAS:<p>ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.</p>Fórmula:C17H18F2N4O2Pureza:99.19% - 99.43%Cor e Forma:SolidPeso molecular:348.35BRD4097
CAS:<p>BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve</p>Fórmula:C16H17N3O2Pureza:99.75%Cor e Forma:SolidPeso molecular:283.33BRD2492
CAS:<p>BRD2492 is an HDAC1 and HDAC2 inhibitor with antiproliferative activity, inhibits HDAC1/2 and induces apoptosis.</p>Fórmula:C20H18N4O2Pureza:99.56%Cor e Forma:SolidPeso molecular:346.38KRP-101
CAS:<p>KRP-101, a PPARɑ agonist, is used potentially for the treatment of diabetes and hyperlipidaemia.</p>Fórmula:C26H26FNO5Cor e Forma:SolidPeso molecular:451.49PPARγ agonist 7
CAS:<p>PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ).</p>Fórmula:C20H30O6Cor e Forma:SolidPeso molecular:366.45K-756
CAS:<p>K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).</p>Fórmula:C24H27N5O3Pureza:99.81%Cor e Forma:SolidPeso molecular:433.5L-783483
CAS:<p>L-783483 is an agonist of PPAR.</p>Fórmula:C22H21ClF3NO4SPureza:98%Cor e Forma:SolidPeso molecular:487.92ATR-IN-21
CAS:<p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>Fórmula:C23H27N7OPureza:98%Cor e Forma:SolidPeso molecular:417.51HDAC8-IN-4
CAS:<p>HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].</p>Fórmula:C17H14N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:342.44Duocarmycin analog-2
CAS:<p>Duocarmycin analog-2 is a potent DNA alkylating agent that exhibits antitumor effects and can be used in the synthesis of immunocouplers.</p>Fórmula:C29H23ClN4O3Cor e Forma:SolidPeso molecular:510.97GNE-8505
CAS:<p>GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).</p>Fórmula:C21H24F3N5OCor e Forma:SolidPeso molecular:419.44CM-579 trihydrochloride (1846570-40-8 free base)
<p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>Fórmula:C29H43Cl3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:602.04LCB-2853
CAS:<p>LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.</p>Fórmula:C21H24ClNO4SPureza:97.15%Cor e Forma:SolidPeso molecular:421.94ARN-21934
CAS:<p>ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.</p>Fórmula:C21H24N6Pureza:99.8%Cor e Forma:SolidPeso molecular:360.46XY-4
CAS:<p>XY-4, a derivative of 1-palmitoyl lysophosphatidic acid (1-palmitoyl LPA094) and an agonist of peroxisome proliferator-activated receptor γ (PPARγ), effectively</p>Fórmula:C19H37F2O6PCor e Forma:SolidPeso molecular:430.46Bocodepsin hydrochloride
CAS:<p>Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration.</p>Fórmula:C26H40ClN5O6S2Pureza:98%Cor e Forma:SolidPeso molecular:618.21TP0480066
CAS:<p>TP0480066 inhibits topoisomerase II, DNA gyrase (IC50=1.1nM), topo IV (IC50=62.89nM), effective against drug-resistant bacteria and N. gonorrhoeae.</p>Fórmula:C18H14FN3O5Cor e Forma:SolidPeso molecular:371.32Topoisomerase IIα-IN-8
CAS:<p>Topoisomerase IIα-IN-8 (compound 15) serves as a modest inhibitor of human DNA topoisomerase IIα (htIIα), exhibiting an inhibitory concentration (IC50) of 462 ± 38.0 μM [1].</p>Fórmula:C15H15FN6OCor e Forma:SolidPeso molecular:314.324ATR-IN-13
CAS:<p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>Fórmula:C24H24FN9OCor e Forma:SolidPeso molecular:473.51GSK-3484862
CAS:<p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>Fórmula:C19H19N5OSPureza:99.87% - 99.963%Cor e Forma:SolidPeso molecular:365.45Peliglitazar
CAS:<p>Peliglitazar is a activator of α/γ peroxisome proliferator-activated receptor.</p>Fórmula:C30H30N2O7Cor e Forma:SolidPeso molecular:530.57SR 2595
CAS:<p>SR2595 is an inverse agonist of nuclear receptor PPARγ with an IC 50 of 30 nM [1].</p>Fórmula:C37H38N2O3Cor e Forma:SolidPeso molecular:558.71BMS-250749
CAS:<p>BMS-250749 is a fluoroglycosylated fluoroindolocarbazole, it has antitumor activity.</p>Fórmula:C26H18F3N3O6Pureza:98%Cor e Forma:SolidPeso molecular:525.43HDAC6-IN-21
CAS:<p>HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histone deacetylase 6 (HDAC6) [1].</p>Fórmula:C14H13F2N5O2Pureza:98%Cor e Forma:SolidPeso molecular:321.28DS-6930
CAS:<p>DS-6930 is an potent and selective PPAR γ Agonists with EC50 of 41 nM.</p>Fórmula:C23H21N3O4Cor e Forma:SolidPeso molecular:403.43CM-675
CAS:<p>CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to</p>Fórmula:C31H32N6O3Pureza:99.82%Cor e Forma:SolidPeso molecular:536.62SIRT6-IN-3
CAS:<p>SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts</p>Fórmula:C21H30Br3ClN6SPureza:98%Cor e Forma:SolidPeso molecular:673.73Makaluvamine A
CAS:<p>Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors.</p>Fórmula:C11H11N3OCor e Forma:SolidPeso molecular:201.22Tankyrase-IN-5
CAS:<p>Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitory</p>Fórmula:C17H18N2O2Pureza:98%Cor e Forma:SolidPeso molecular:282.34SU-11752
CAS:<p>SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.</p>Fórmula:C26H27N3O5SCor e Forma:SolidPeso molecular:493.57Pparδ agonist 1
CAS:<p>Pparδ agonist 1 is an agonist of PPAR-δ(EC50 of 5.06 nM).</p>Fórmula:C26H27NO5Pureza:98%Cor e Forma:SolidPeso molecular:433.5U-46619
CAS:<p>U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (</p>Fórmula:C21H34O4Pureza:98%Cor e Forma:SolidPeso molecular:350.49ATR-IN-20
<p>ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.</p>Fórmula:C29H31N5O4SCor e Forma:SolidPeso molecular:545.65CAY10410
CAS:<p>CAY10410 is a PGD2/PGJ2 analog, modified for enhanced PPARγ activity and metabolic stability, non-toxic to SH-SY5Y cells at ≤25μM.</p>Fórmula:C20H30O3Cor e Forma:SolidPeso molecular:318.45LMP744 hydrochloride
CAS:<p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>Fórmula:C24H25ClN2O7Pureza:99.59% - 99.85%Cor e Forma:SolidPeso molecular:488.92AZ 5704
CAS:<p>ATM kinase inhibitor with 0.6 nM IC50, >600-fold selective, enhances irinotecan effects, oral use.</p>Fórmula:C23H23FN6O2Cor e Forma:SolidPeso molecular:434.479A1P9
CAS:<p>9A1P9, a multi-tail ionizable cationic phospholipid, facilitates membrane destabilization and is applicable for CRISPR-Cas9 gene editing in mice [1].</p>Fórmula:C27H58NO4PCor e Forma:SolidPeso molecular:491.73BO 2367
CAS:<p>BO 2367, a topoisomerase inhibitor, is used to suppress the growth of tumor .</p>Fórmula:C21H22ClF2N3O3Cor e Forma:SolidPeso molecular:437.87ATR-IN-22
CAS:<p>ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and</p>Fórmula:C25H31N7OPureza:98%Cor e Forma:SolidPeso molecular:445.56ATR-IN-5
CAS:<p>ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.</p>Fórmula:C27H32F3N9OCor e Forma:SolidPeso molecular:555.6Topoisomerase I inhibitor 9
CAS:<p>Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value</p>Fórmula:C23H15Br2FN2Pureza:98%Cor e Forma:SolidPeso molecular:498.19Topoisomerase inhibitor 2
CAS:<p>Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].</p>Fórmula:C23H23N5O4Pureza:98%Cor e Forma:SolidPeso molecular:433.46
