ATM/ATR
Os inibidores de ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) têm como alvo quinases chave envolvidas na resposta ao dano ao DNA (DDR) que são ativadas em resposta a quebras de fita dupla de DNA e estresse de replicação. Esses inibidores perturbam a capacidade dessas quinases de detectar e reparar danos no DNA, o que pode levar a um aumento da instabilidade genômica e morte celular, particularmente em células cancerígenas que dependem de mecanismos robustos de reparo do DNA para sobreviver. Os inibidores de ATM/ATR são ferramentas cruciais na pesquisa e terapia do câncer, especialmente em combinação com agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma ampla gama de inibidores de ATM/ATR de alta qualidade para apoiar sua pesquisa em resposta ao dano ao DNA, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 78 produtos para "ATM/ATR".
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FEN1-IN-1
CAS:FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.Fórmula:C15H12N2O5SPureza:99.72% - 99.93%Cor e Forma:White SolidPeso molecular:332.331Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Fórmula:C23H26O7Pureza:99.13% - 99.92%Cor e Forma:Yellow SolidPeso molecular:414.4483Elimusertib hydrochloride
Elimusertib hydrochloride is a effective, orally available and selective ATR inhibitor with anti-tumorFórmula:C20H22ClN7OPureza:98.8% - 99.03%Cor e Forma:SolidPeso molecular:411.89Antitumor agent-28
CAS:Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.Fórmula:C25H32N6O4SCor e Forma:SolidPeso molecular:512.63ATM Inhibitor-6
CAS:ATM inhibitor-6 (A-193), a selective inhibitor of ATM kinase, is utilized in cancer research [1].Fórmula:C28H33FN6O2Peso molecular:504.60ATR kinase substrate peptide
ATRkinase substrate peptide (compound 45) is a potent and selective inhibitor of the ATR protein kinase, with a Ki of 6 nM. It inhibits ATR activity by competing with the ATP binding site of the ATR kinase, thereby blocking ATR-mediated signal transduction. This compound can be utilized to study the role of ATR kinase in the DNA damage response.Fórmula:C81H132N22O25Peso molecular:1812.9734CA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Fórmula:C34H46N2O6SCor e Forma:SolidPeso molecular:610.80Berzosertib
CAS:Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.Fórmula:C24H25N5O3SPureza:97.34% - >99.99%Cor e Forma:SolidPeso molecular:463.55Hexapeptide-11
CAS:Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.Fórmula:C36H48N6O7Pureza:98%Cor e Forma:SolidPeso molecular:676.8Abd110
CAS:Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].Fórmula:C41H42N8O7SCor e Forma:SolidPeso molecular:790.89ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value ofFórmula:C26H34N6O2Pureza:98%Cor e Forma:SolidPeso molecular:462.59ATM Inhibitor-9
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].Fórmula:C25H32N6O2Pureza:98%Cor e Forma:SolidPeso molecular:448.56Gartisertib-d8
CAS:Gartisertib-d8 (VX-803-d8) is the deuterated form of Gartisertib. Gartisertib (VX-803) acts as an orally active, selective ATP-competitive ATR inhibitor, with a Ki of less than 150 pM. It effectively inhibits ATR-driven phosphorylation of checkpoint kinase-1 (Chk1), with an IC50 value of 8 nM, and exhibits antitumor activity.Fórmula:C25H29F2N9O3Peso molecular:549.61ATR-IN-30
CAS:ATR-IN-30 is a specific ATR ligand utilized in the creation of ATR PROTACs, including PROTAC ATR degrader-2.Fórmula:C27H30N6O4Peso molecular:502.56ICT10336
ICT10336 is a hypoxia-reactive prodrug of the ATR inhibitor AZD6738. It specifically activates under hypoxic conditions in vitro, selectively releasing AZD6738. This action inhibits ATR activation at the T1989 and S428 phosphorylation sites, consequently disrupting HIF1a-mediated adaptation of hypoxic cancer cells and inducing cell death in both 2D and 3D cancer models. ICT10336 is also a metabolic substrate of CYPOR activity.Fórmula:C32H40N10O7SCor e Forma:SolidPeso molecular:708.28021GJ071 oxalate
CAS:GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.Fórmula:C20H29N3O7SPureza:99.93%Cor e Forma:White SolidPeso molecular:455.525ATR-IN-9
CAS:ATR-IN-9 from patent WO2020087170A1 is a potent ATR kinase inhibitor with an IC50 of 10 nM.Fórmula:C22H27N7O2Cor e Forma:SolidPeso molecular:421.505GJ103 sodium salt
CAS:GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Fórmula:C16H13N4NaO3SPureza:99.70% - 99.91%Cor e Forma:Orange SolidPeso molecular:364.354PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Cor e Forma:SolidPeso molecular:389.878KU-55933
CAS:KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.Fórmula:C21H17NO3S2Pureza:97.21% - >99.99%Cor e Forma:Yellow SolidPeso molecular:395.49
