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Dano de DNA/Reparo de DNA

Dano de DNA/Reparo de DNA

Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.

Subcategorias de "Dano de DNA/Reparo de DNA"

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Foram encontrados 1006 produtos de "Dano de DNA/Reparo de DNA"

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  • MSN8C
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    MSN8C

    CAS:
    MSN8C, a mansonone E analog, acts as a novel catalytic inhibitor of human DNA topoisomerase II, inducing apoptosis in cancer cells and exhibiting considerable
    Fórmula:C13H10O3
    Cor e Forma:Solid
    Peso molecular:214.22

    Ref: TM-T81745

  • ATR-IN-18
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    ATR-IN-18

    CAS:
    ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.
    Fórmula:C19H22F3N7O5S
    Cor e Forma:Solid
    Peso molecular:517.48

    Ref: TM-T63604

  • (S)-Ceralasertib
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    (S)-Ceralasertib

    CAS:
    (S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.
    Fórmula:C20H24N6O2S
    Cor e Forma:Solid
    Peso molecular:412.51

    Ref: TM-T12795

  • Pparδ agonist 1
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    Pparδ agonist 1

    CAS:
    Pparδ agonist 1 is an agonist of PPAR-δ(EC50 of 5.06 nM).
    Fórmula:C26H27NO5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:433.5

    Ref: TM-T12528

  • 8(S)-HETE
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    8(S)-HETE

    CAS:
    8(S)-HETE activates mouse keratinocyte PKC (IC50: 100 μM) and PPARα (>0.3 μM); identified by chiral HPLC in murine skin.
    Fórmula:C20H32O3
    Cor e Forma:Solid
    Peso molecular:320.47

    Ref: TM-T37158

  • 1,1'-(Azodicarbonyl)dipiperidine
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    1,1'-(Azodicarbonyl)dipiperidine

    CAS:
    1,1'-(Azodicarbonyl)dipiperidine (ADDP) serves as a widely employed reagent in the Mitsunobu reaction, facilitating the condensation between an alcohol and an acidic compound. Moreover, ADDP has found application in synthesizing agonists for the G protein-coupled receptor 120 (GPR120) with potential antidiabetic effects as well as in the creation of triple agonists for peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ.
    Fórmula:C12H20N4O2
    Cor e Forma:Solid
    Peso molecular:252.318

    Ref: TM-T85028

  • 8-Chloroadenosine-5'-triphosphate sodium
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    8-Chloroadenosine-5'-triphosphate sodium

    CAS:
    8-Chloroadenosine-5’-triphosphate (8-chloro ATP), a potent metabolite of the anticancer agent 8-chloro cyclic AMP (cAMP) and a nucleotide derivative, is
    Fórmula:C10H11ClN5O13P3·4Na
    Cor e Forma:Solid
    Peso molecular:629.55

    Ref: TM-T83786

  • L-783483
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    L-783483

    CAS:
    L-783483 is an agonist of PPAR.
    Fórmula:C22H21ClF3NO4S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:487.92

    Ref: TM-T27784

  • Anticancer agent 216
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    Anticancer agent 216

    CAS:
    Anticanceragent 216 (34A) is a camptothecin compound with IC50 values of 9.6 nM for MCF-7 cells and 11.6 nM for MDA-MB-231 cells.
    Fórmula:C23H21N3O6
    Cor e Forma:Solid
    Peso molecular:435.43

    Ref: TM-T88220

  • PPAR agonist 1
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    PPAR agonist 1

    CAS:
    PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.
    Fórmula:C20H25NO6S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:407.48

    Ref: TM-T10506

  • PPARγ agonist 8
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    PPARγ agonist 8

    CAS:
    PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferator
    Fórmula:C19H12F4O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:380.36

    Ref: TM-T79182

  • Darglitazone
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    Darglitazone

    CAS:
    Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions.
    Fórmula:C23H20N2O4S
    Pureza:99.76%
    Cor e Forma:Solid
    Peso molecular:420.48

    Ref: TM-T22708

  • GSK-3484862
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    GSK-3484862

    CAS:
    Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.
    Fórmula:C19H19N5OS
    Pureza:99.87% - 99.963%
    Cor e Forma:Solid
    Peso molecular:365.45

    Ref: TM-T11469

  • LCB-2853
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    LCB-2853

    CAS:
    LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.
    Fórmula:C21H24ClNO4S
    Pureza:97.15%
    Cor e Forma:Solid
    Peso molecular:421.94

    Ref: TM-T11825

  • Ambamustine
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    Ambamustine

    CAS:
    Ambamustine (PTT 119): a tripeptide nitrogen mustard, DNA inhibitor/alkylator with antitumor properties, researched for various disorders.
    Fórmula:C29H39Cl2FN4O4S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:629.61

    Ref: TM-T25073

  • ARN-21934
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    ARN-21934

    CAS:
    ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.
    Fórmula:C21H24N6
    Pureza:99.8%
    Cor e Forma:Solid
    Peso molecular:360.46

    Ref: TM-T36968

  • GNE-8505
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    GNE-8505

    CAS:
    GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
    Fórmula:C21H24F3N5O
    Cor e Forma:Solid
    Peso molecular:419.44

    Ref: TM-T11440

  • SR 2595
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    SR 2595

    CAS:
    <p>SR2595 is an inverse agonist of nuclear receptor PPARγ with an IC 50 of 30 nM [1].</p>
    Fórmula:C37H38N2O3
    Cor e Forma:Solid
    Peso molecular:558.71

    Ref: TM-T22154

  • Zabofloxacin
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    Zabofloxacin

    CAS:
    Zabofloxacin inhibits bacterial topoisomerases II/IV, effectively targeting gram-positive pathogens like S. aureus and S. pneumoniae.
    Fórmula:C19H20FN5O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:401.39

    Ref: TM-T13406

  • Oxamflatin
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    Oxamflatin

    CAS:
    Oxamflatin (Metacept-3) is a selective histone deacetylase (HDAC) inhibitor with an alkyne group capable of azide-alkyne cycloaddition reactions (CuAAc).
    Fórmula:C17H14N2O4S
    Pureza:98.25%
    Cor e Forma:Solid
    Peso molecular:342.37

    Ref: TM-T16415