Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 958 produtos de "Dano de DNA/Reparo de DNA"
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(1S,2R,7S)-Sitafloxacin
CAS:<p>(1S,2R,7S)-Sitafloxacin (DU-6856) is an enantiomer of Sitafloxacin and functions as a topoisomerase inhibitor. As an antibiotic, it demonstrates inhibitory activity against Escherichia coli DNA gyrase (IC50 0.18 μg/mL) and Staphylococcus aureus topoisomerase IV. (1S,2R,7S)-Sitafloxacin exhibits antibacterial properties and is utilized in the study of various bacterial infections.</p>Fórmula:C19H18ClF2N3O3Cor e Forma:SolidPeso molecular:409.81PARP1-IN-30
CAS:<p>PARP1-IN-30 is a specific and effective PARP1 inhibitor with cytotoxic properties. It precisely inhibits PARP1 in tumor cells lacking breast cancer 1 protein (BRCA1) or BRCA2. PARP1-IN-30 holds potential for use in cancer research.</p>Fórmula:C14H12ClNO4SCor e Forma:SolidPeso molecular:325.77PPARγ modulator-2
CAS:<p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>Fórmula:C26H21NO7S3SeCor e Forma:SolidPeso molecular:634.6ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Fórmula:C26H31N7O3Cor e Forma:SolidPeso molecular:489.57TERT activator-2
CAS:<p>TERT activator-2 (Compound 1030) is an activator of telomerase reverse transcriptase (TERT), which enhances the expression levels of TERT within cells. TERT activator-2 is applicable to research related to cellular lifespan and telomere functions.</p>Fórmula:C21H22N2O2Cor e Forma:SolidPeso molecular:334.412DNA crosslinker 2 dihydrochloride
CAS:<p>Potent DNA crosslinker 2 binds minor groove, increases Tm by 1.2°C, and inhibits NCI-H460, A2780, MCF-7 cancer cells.</p>Fórmula:C15H22Cl2N8OCor e Forma:SolidPeso molecular:401.29TH1338
CAS:<p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>Fórmula:C22H21N3O4Pureza:98.77%Cor e Forma:SolidPeso molecular:391.42DNA crosslinker 3 dihydrochloride
CAS:<p>Compound 1: a DNA minor groove binder with 1.4°C ΔTm; useful in cancer research.</p>Fórmula:C15H22Cl2N8OCor e Forma:SolidPeso molecular:401.29DNA crosslinker 1 dihydrochloride
CAS:<p>DNA Crosslinker 1 binds DNA minor groove with 1.1°C affinity increase; used in cancer research.</p>Fórmula:C15H22Cl2N8OCor e Forma:SolidPeso molecular:401.29ATM Inhibitor-11
CAS:<p>ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.</p>Fórmula:C27H33FN6O2Cor e Forma:SolidPeso molecular:492.59Atiratecan
CAS:<p>Atiratecan (TP300), a CH0793076-based camptothecin prodrug, combats BCRP+/- tumors; doesn't affect AChE.</p>Fórmula:C31H34N6O6Pureza:98%Cor e Forma:SolidPeso molecular:586.64DNA-PK-IN-2
CAS:<p>DNA-PK-IN-2 is an inhibitor of the DNA-PK enzyme complex, useful in cancer research.</p>Fórmula:C20H23N5O3Cor e Forma:SolidPeso molecular:381.43KSQ-4279 (gentisate)
CAS:<p>KSQ-4279 (gentisate) (Compound Formula I) serves as an effective inhibitor of USP1 and a selective inhibitor of PARP1. This compound shows promise for use in cancer research.</p>Fórmula:C34H31F3N8O5Cor e Forma:SolidPeso molecular:688.66DNA-PK-IN-15
CAS:<p>DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.</p>Fórmula:C23H23N9OCor e Forma:SolidPeso molecular:441.49HDAC6-IN-51
CAS:HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.Fórmula:C24H24ClN5O3Cor e Forma:SolidPeso molecular:465.93Cas9-IN-1
<p>Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM. Cas9-IN-1 acts by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.</p>Fórmula:C17H11Cl2F3N2O3SCor e Forma:SolidPeso molecular:451.25TDI-015051
CAS:<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Fórmula:C22H22FN5O4SCor e Forma:SolidPeso molecular:471.505ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Fórmula:C25H29FN6O3Cor e Forma:SolidPeso molecular:480.53Topoisomerase II inhibitor 6
<p>Topoisomerase II inhibitor 6, a potent tryptanthrin derivative, blocks G2 phase in CCRF-CEM cells, induces DNA breaks, and may be used for cancer research.</p>Fórmula:C19H18N4O2Cor e Forma:SolidPeso molecular:334.37DLK-IN-1
CAS:DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.Fórmula:C20H24F3N5O2Cor e Forma:SolidPeso molecular:423.43
