Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 958 produtos de "Dano de DNA/Reparo de DNA"
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Edotecarin
CAS:<p>Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).</p>Fórmula:C29H28N4O11Pureza:98%Cor e Forma:SolidPeso molecular:608.55Karenitecin
CAS:<p>Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.</p>Fórmula:C25H28N2O4SiPureza:98%Cor e Forma:SolidPeso molecular:448.59ATR-IN-17
CAS:<p>ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).</p>Fórmula:C22H28N6O2SCor e Forma:SolidPeso molecular:440.56OSUAB-0284
CAS:<p>OSUAB-0284 is an inhibitor of bacterial topoisomerase. It exhibits significant activity against staphylococci, particularly methicillin-resistant Staphylococcus aureus (MRSA). The compound exerts its antibacterial effect by inhibiting bacterial topoisomerase and may be used in research on infections caused by drug-resistant bacteria, including MRSA.</p>Fórmula:C22H23FN6O6Cor e Forma:SolidPeso molecular:486.45ATM Inhibitor-4
<p>ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.</p>Fórmula:C26H29FN6O3Cor e Forma:SolidPeso molecular:492.55PARP-1/HDAC-IN-1
CAS:<p>PARP-1/HDAC-IN-1 is a PARP-1 and HDAC6 inhibitor with anticancer, antimigratory, and antiangiogenic activities and is used in tumor research.</p>Fórmula:C22H18N4O4Pureza:95.94%Cor e Forma:SolidPeso molecular:402.4KU 59403
CAS:<p>KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).</p>Fórmula:C29H32N4O4S2Pureza:99.10%Cor e Forma:SolidPeso molecular:564.72PPARγ agonist 2
<p>PPARγ agonist 2 is a highly effective compound that acts as a partial agonist for PPARγ.</p>Fórmula:C24H20O5Cor e Forma:SolidPeso molecular:388.41SPR719
CAS:<p>SPR719 is an inhibitor of gyrase B, has bactericidal activity.</p>Fórmula:C21H25FN6O3Pureza:98%Cor e Forma:SolidPeso molecular:428.46ATR-IN-14
CAS:<p>ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.</p>Fórmula:C20H20FN7OCor e Forma:SolidPeso molecular:393.42WSD0628
CAS:<p>WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].</p>Fórmula:C23H23F2N5O2Cor e Forma:SolidPeso molecular:439.46DNA-PK-IN-9
<p>DNA-PK-IN-9 (YK6) is a potent DNA-PK inhibitor with an IC50 of 10.47 nM, important in cancer research.</p>Fórmula:C21H21N5O2Cor e Forma:SolidPeso molecular:375.42Topoisomerase II inhibitor 18
CAS:<p>Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].</p>Fórmula:C20H21N3OSCor e Forma:SolidPeso molecular:351.47PPARγ agonist 17
CAS:<p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>Fórmula:C48H63NO7Cor e Forma:SolidPeso molecular:766.016Anti-NASH agent 2
CAS:<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Fórmula:C32H51N3O2Cor e Forma:SolidPeso molecular:509.766SP-C01
CAS:<p>SP-C01 is an orally active soluble epoxide hydrolase (sEH) inhibitor and a partial agonist of PPARγ. It can inhibit the phosphorylation of Ser273.</p>Fórmula:C22H22F4N2O5Cor e Forma:SolidPeso molecular:470.41Topoisomerase inhibitor 5
CAS:<p>Topoisomerase inhibitor 5 (compound 158) is an inhibitor of bacterial topoisomerase, with a minimum inhibitory concentration of 0.125 μg/mL, and exhibits anti-tuberculosis activity.</p>Fórmula:C24H25FN4O6Cor e Forma:SolidPeso molecular:484.477Topoisomerase I/II inhibitor 7
CAS:<p>Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.</p>Fórmula:C18H13ClN2O3Cor e Forma:SolidPeso molecular:340.76DNA-PK-IN-6
CAS:<p>DNA-PK-IN-6 inhibits DNA-PKcs, disrupting tumor DNA repair and triggering apoptosis; enhances radiotherapy and targets various tumors (WO2021197159A1).</p>Fórmula:C19H21N7OCor e Forma:SolidPeso molecular:363.42MC3138
CAS:<p>MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.</p>Fórmula:C25H25NO6Pureza:99.57%Cor e Forma:SolidPeso molecular:435.47
