Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 958 produtos de "Dano de DNA/Reparo de DNA"
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CUDA disodium
<p>CUDA disodium is an effective, soluble epoxide hydrolase (sEH) inhibitor, with IC50 values of 11.1 nM for murine sEH and 112 nM for human sEH. It selectively enhances the activity of peroxisome proliferator-activated receptor PPARalpha. CUDA disodium may be valuable for cardiovascular disease research.</p>Cor e Forma:Odour SolidSIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Fórmula:C22H24N2O9SCor e Forma:SolidPeso molecular:492.5HDAC-IN-76
HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.Fórmula:C27H26N4O4Cor e Forma:SolidPeso molecular:470.52(iso)-BRD20322
CAS:<p>(iso)-BRD20322 is an isomer of BRD20322, a novel potent inhibitor of spCas9，disrupts the binding of spCas9 to DNA and reduces non-specific DNA editing events.</p>Fórmula:C27H31N3O2Pureza:99.60% - 99.60%Cor e Forma:SoildPeso molecular:429.55CHDI 00484077
CAS:<p>CHDI 00484077 is a highly selective, central nervous system (CNS) permeable Class IIa HDAC inhibitor, and can be used to study Huntington's disease.</p>Fórmula:C18H21F3N4O2Pureza:99.26%Cor e Forma:SolidPeso molecular:382.38HDAC1/6-IN-2
<p>HDAC1/6-IN-2 (I-c4), a dual inhibitor of HDAC1 and HDAC6, exhibits potent activity with IC50 values of 3.1 nM for HDAC1 and 2.95 nM for HDAC6. This compound demonstrates notable antitumor activity.</p>Fórmula:C22H17FN4O3Cor e Forma:SolidPeso molecular:404.39ACT-387042
CAS:<p>ACT-387042 is a Bacterial Topoisomerase Inhibitor, it has broad-spectrum activity against Gram-positive and Gram-negative bacteria.</p>Fórmula:C23H26FN5O4SCor e Forma:SolidPeso molecular:487.55Gemfibrozil 1-O-β-glucuronide
CAS:<p>Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil , is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.</p>Fórmula:C21H30O9Pureza:98%Cor e Forma:SolidPeso molecular:426.46Z26395438
CAS:<p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>Fórmula:C17H15FN2OPureza:99.63%Cor e Forma:SolidPeso molecular:282.31Ketopioglitazone
CAS:<p>Ketopioglitazone is an active metabolite of pioglitazone.</p>Fórmula:C19H18N2O4SCor e Forma:SolidPeso molecular:370.42(±)4(5)-DiHDPA lactone
CAS:<p>(±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET , which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5</p>Fórmula:C22H32O3Cor e Forma:SolidPeso molecular:344.495Elomotecan hydrochloride
CAS:<p>Elomotecan hydrochloride (BN 80927), a potent hCPT analog, inhibits topoisomerases I/II, outperforming other anticancer drugs.</p>Fórmula:C29H33Cl2N3O4Cor e Forma:SolidPeso molecular:558.5Berzosertib
CAS:<p>Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C24H25N5O3SPureza:97.34% - >99.99%Cor e Forma:SolidPeso molecular:463.55Saroglitazar Magnesium
CAS:<p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>Fórmula:C50H56MgN2O8S2Pureza:98.1%Cor e Forma:SolidPeso molecular:901.431-Methyladenosine-d3
<p>1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium-labeled 1-Methyladenosine. This compound is a modification of RNA that serves as a biomarker for tumors, with elevated levels in the body linked to cancer development. Upon methylation, 1-Methyladenosine upregulates the expression of PPARδ, regulates cholesterol metabolism, and activates the Hedgehog signaling pathway, thereby driving the onset of liver tumors.</p>Cor e Forma:Odour SolidTopoisomerases/ribosomes-IN-1
<p>Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).</p>Fórmula:C53H83FN6O15Cor e Forma:SolidPeso molecular:1063.26ARN24139
<p>ARN24139: a topoisomerase II poison; IC50=7.3μM. Inhibits DU145, HeLa, A549 cell growth; IC50s=4.7, 3.8, 3.1μM.</p>Cor e Forma:Solid15-deoxy-Δ-12,14-Prostaglandin J2
CAS:<p>15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.</p>Fórmula:C20H28O3Pureza:98%Cor e Forma:Neat OilPeso molecular:316.43GJ071 oxalate
CAS:<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Fórmula:C20H29N3O7SPureza:99.97%Cor e Forma:SolidPeso molecular:455.53Leriglitazone
CAS:<p>Leriglitazone, pioglitazone's metabolite, is a PPARγ agonist (Ki:1.2μM, EC50:680nM), enhancing transcription and stabilizing AF-2.</p>Fórmula:C19H20N2O4SPureza:98%Cor e Forma:SolidPeso molecular:372.44
