Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(421 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 958 produtos de "Dano de DNA/Reparo de DNA"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
ITF3756
CAS:<p>ITF3756 is a selective HDAC6 inhibitor.</p>Fórmula:C13H11N5O2SPureza:97.74%Cor e Forma:SolidPeso molecular:301.32ATR-IN-10
CAS:<p>ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).</p>Fórmula:C27H24N4OCor e Forma:SolidPeso molecular:420.51Hepsulfam
CAS:<p>Hepsulfam is an anticancer agent. It also displays excellent antileukemic activity (a median IC50: 0.91 μg/mL in a panel of different tumors).</p>Fórmula:C7H18N2O6S2Cor e Forma:SolidPeso molecular:290.36CM-579
CAS:<p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>Fórmula:C29H40N4O3Pureza:99.23%Cor e Forma:SolidPeso molecular:492.65C-333H
CAS:<p>C-333H is a new PPARalpha/gamma dual agonist.</p>Fórmula:C28H26N2O6Pureza:98%Cor e Forma:SolidPeso molecular:486.52F-14512
CAS:<p>F-14512, a DNA topoisomerase II inhibitor, is used potentially for the treatment of acute myeloid leukemia.</p>Fórmula:C33H47N5O8Cor e Forma:SolidPeso molecular:641.76MHY908
CAS:<p>MHY908, a novel inhibitor of melanogenesis, potently inhibits mushroom tyrosinase activity in a dose-dependent manner.</p>Fórmula:C17H14ClNO3SPureza:98%Cor e Forma:SolidPeso molecular:347.82S26948
CAS:<p>S26948 is a PPARγ agonist.</p>Fórmula:C28H25NO7SPureza:98%Cor e Forma:SolidPeso molecular:519.57Topoisomerase IIα-IN-1
CAS:<p>Topoisomerase IIα-IN-1 (compound 2) is a DNA-binding ligands and a potent inhibitor of TopoIIα, a topoisomerase.</p>Fórmula:C22H20N4O5Cor e Forma:SolidPeso molecular:420.42KRP-297
CAS:<p>KRP297 is a PPAR agonist potentially for the treatment of type 2 diabetes and dyslipidemia.</p>Fórmula:C20H17F3N2O4SCor e Forma:SolidPeso molecular:438.42MPT0G211
CAS:<p>MPT0G211: oral HDAC6 inhibitor with IC50=0.291 nM, 1000x selectivity, neuroprotective, anti-metastatic, crosses blood-brain barrier for Alzheimer's.</p>Fórmula:C17H15N3O2Pureza:98% - 99.88%Cor e Forma:SolidPeso molecular:293.32ST247
CAS:<p>ST247: Potent PPARβ/δ inverse agonist, blocks CCL2 expression and agonist-driven PPARβ/δ transcription, promotes co-repressor interaction.</p>Fórmula:C19H26N2O5S2Cor e Forma:SolidPeso molecular:426.55SW155246
CAS:<p>SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).</p>Fórmula:C16H11ClN2O5SPureza:98.99%Cor e Forma:SolidPeso molecular:378.79XR 5944
CAS:<p>XR 5944 is an effective DNA binder that stabilizes topoisomerase-dependent cleavage and has shown superior efficacy in a variety of mouse and human tumor models</p>Fórmula:C34H34N8O2Pureza:98.29% - 98.66%Cor e Forma:SolidPeso molecular:586.69Huanglongmycin N
CAS:<p>Huanglongmycin N acts as a DNA topoisomerase I inhibitor, demonstrating an EC50 value of 14 μM.</p>Fórmula:C19H16O5Cor e Forma:SolidPeso molecular:324.33DNA-PK-IN-1
CAS:<p>DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.</p>Fórmula:C23H26N8O2Cor e Forma:SolidPeso molecular:446.5Eicosatetraynoic acid
CAS:<p>ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).</p>Fórmula:C20H24O2Pureza:98%Cor e Forma:SolidPeso molecular:296.4DNA-PK-IN-3
CAS:<p>DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.</p>Fórmula:C19H19N9OCor e Forma:SolidPeso molecular:389.41TFMB-(S)-2-HG
CAS:<p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>Fórmula:C13H11F3O4Pureza:98.07%Cor e Forma:SolidPeso molecular:288.22DC_501
CAS:<p>DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.</p>Fórmula:C25H23Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:452.38(S)-Gyramide A
CAS:<p>(S)-Gyramide A is a bacterial DNA gyrase inhibitor that acts by exhibiting antimicrobial activity and inhibiting bacterial cell division.</p>Fórmula:C21H27FN2O3SPureza:98%Cor e Forma:SolidPeso molecular:406.515-Aza-4'-thio-2'-deoxycytidine
CAS:<p>5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].</p>Fórmula:C8H12N4O3SCor e Forma:SolidPeso molecular:244.27Topoisomerase II inhibitor 4
CAS:<p>Compound E17, a topoisomerase II inhibitor, halts cell cycle at G2/M, possesses anticancer properties and cytotoxic effects.</p>Fórmula:C25H25N5O4Cor e Forma:SolidPeso molecular:459.5Lexitropsin
CAS:<p>Lexitropsin is a novel anticancer drug.</p>Fórmula:C20H29N5O4Cor e Forma:SolidPeso molecular:403.48ATR-IN-16
CAS:<p>ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.</p>Fórmula:C19H25N7OCor e Forma:SolidPeso molecular:367.45Piroxantrone
CAS:<p>Piroxantrone (CI942; PD111815) is an anthrapyrazole antibiotic that disrupts DNA replication and repair, with limited cardiotoxicity and antineoplastic range.</p>Fórmula:C21H25N5O4Cor e Forma:SolidPeso molecular:411.45Procarbazine free base
CAS:<p>Procarbazine: chemo drug for Hodgkin's, brain cancer; liver-activated; MAO inhibitor.</p>Fórmula:C12H19N3OPureza:98%Cor e Forma:SolidPeso molecular:221.3MLR24
CAS:<p>MLR24 is a selective modulator of PPARγ that acts by displaying robust anti-diabetic activity.</p>Fórmula:C28H24F3NO6Pureza:98%Cor e Forma:SolidPeso molecular:527.49CAY10744
CAS:<p>CAY10744, a topoisomerase II-α inhibitor (78.9% at 20 μM), blocks cancer cell proliferation with varying IC50s and induces apoptosis in T47D cells.</p>Fórmula:C24H16ClNO2Cor e Forma:SolidPeso molecular:385.84Anticancer agent 75
CAS:<p>Anticancer agent 75: potent, selective, less toxic to kidneys than Doxorubicin by 35x, with antiplasmodial properties.</p>Fórmula:C22H24N2OCor e Forma:SolidPeso molecular:332.44Givinostat hydrochloride monohydrate
CAS:<p>Givinostat hydrochloride monohydrate (ITF2357) is an HDAC inhibitor.</p>Fórmula:C24H27N3O4·HCl·H2OPureza:97.97% - 99.51%Cor e Forma:SolidPeso molecular:475.97ZINC08438472
CAS:<p>ZINC08438472 is a selective peroxisome proliferator-activated receptors-α agonist.</p>Fórmula:C25H25NO8SPureza:98%Cor e Forma:SolidPeso molecular:499.53Topoisomerase I inhibitor 4
CAS:<p>Topoisomerase I inhibitor 4 targets cancer cells like HepG2, A549, MCF-7, HeLa with low IC50, promising for research.</p>Fórmula:C23H19FN4OCor e Forma:SolidPeso molecular:386.42WEHI-150
CAS:<p>WEHI-150, a mitoxantrone analog, cross-links DNA, targets methylated CpG, halts transcription, and avoids guanine N-2 interaction.</p>Fórmula:C22H30N6O4Cor e Forma:SolidPeso molecular:442.51Exatecan mesylate dihydrate
CAS:<p>Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].</p>Fórmula:C25H30FN3O9SPureza:98%Cor e Forma:SolidPeso molecular:567.58ZINC17167211
CAS:<p>ZINC17167211 is a selective peroxisome proliferator-activated receptors-α agonist.</p>Fórmula:C24H17FN2O6SPureza:98%Cor e Forma:SolidPeso molecular:480.46Ceralasertib formate
CAS:<p>Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.</p>Fórmula:C21H26N6O4SCor e Forma:SolidPeso molecular:458.54CAY10514
CAS:<p>CAY10514 is an aromatic analog of 8(S)-HETE. It acts as a dual agonist of PPARα and PPARγ with EC50 values of 0.173 and 0.642 μM, respectively.</p>Fórmula:C20H28O4Cor e Forma:SolidPeso molecular:332.43Ranimustine
CAS:<p>Ranimustine (MCNU) can be used for polycythemia vera and chronic myelogenous leukemia research, which is a nitrosourea alkylating agent [1] [3] [4].</p>Fórmula:C10H18ClN3O7Cor e Forma:SolidPeso molecular:327.72AA-CW236
CAS:<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Fórmula:C17H16ClF3N4O2Cor e Forma:SolidPeso molecular:400.78PPARδ agonist 8
CAS:<p>Pparδ agonist 8 is a potent agonist of Pparδ. Pparδ agonist 8 has potential for the study of nonalcoholic fatty liver disease (NAFLD).</p>Fórmula:C25H29NO5Cor e Forma:SolidPeso molecular:423.5DRF 2519
CAS:<p>DRF 2519 is an activator of PPAR-alpha and PPAR-gamma.</p>Fórmula:C20H18N2O5SCor e Forma:SolidPeso molecular:398.43CLX 0921
CAS:<p>CLX 0921, a PPAR gamma agonist, is used potentially for the treatment of type 2 diabetes.</p>Fórmula:C28H25NO7SPureza:98%Cor e Forma:SolidPeso molecular:519.57ARTD10/PARP10-IN-1
CAS:<p>ARTD10/PARP10-IN-1 is a PARP inhibitor that inhibits ARTD8/PARP14 and has anticancer and antitumour activity for the study of prostate cancer.</p>Fórmula:C12H12N2O4Pureza:99.14%Cor e Forma:SolidPeso molecular:248.23Gartisertib
CAS:<p>Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.</p>Fórmula:C25H29F2N9O3Pureza:99.52%Cor e Forma:SolidPeso molecular:541.55NSC-311068
CAS:<p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>Fórmula:C10H6N4O4SCor e Forma:SolidPeso molecular:278.24Daniquidone
CAS:<p>Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasms</p>Fórmula:C15H11N3OPureza:98.39% - 99.52%Cor e Forma:SolidPeso molecular:249.27ICRF-196
CAS:<p>ICRF-196 is a Topoisomerase II Inhibitor and antineoplastic agent.</p>Fórmula:C12H18N4O4Cor e Forma:SolidPeso molecular:282.313-Oxo-9E,11E-octadecadienoic acid
CAS:<p>13-Oxo-9E,11E-octadecadienoic acid from tomato juice, an isomer of 9-oxo-ODA, activates PPARα and lowers triglycerides in diabetic mice.</p>Fórmula:C18H30O3Pureza:98%Cor e Forma:SolidPeso molecular:294.43Tetrahydrouridine
CAS:<p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>Fórmula:C9H16N2O6Pureza:98%Cor e Forma:SolidPeso molecular:248.23DC_517
CAS:<p>DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).</p>Fórmula:C33H35N3O2Cor e Forma:SolidPeso molecular:505.65Seladelpar Lysine dihydrate
CAS:<p>Seladelpar lysine, a selective PPAR-δ agonist, is used for the therapy of Homozygous Familial Hypercholesterolemia (HoFH).</p>Fórmula:C27H41F3N2O9SPureza:98%Cor e Forma:SolidPeso molecular:626.68BNS-22
CAS:<p>BNS-22 is a DNA topoisomerase II (Topo II) inhibitor, induces mitotic abnormalities and exhibits antiproliferative activity against human cancer cells.</p>Fórmula:C24H25NO5Pureza:99.62%Cor e Forma:SolidPeso molecular:407.46AM-3102
CAS:<p>AM-3102: An OEA analog; boosts PPARα, delays eating, resists hydrolysis, mimics OEA potency, and weakly binds CB1/CB2.</p>Fórmula:C21H41NO2Cor e Forma:SolidPeso molecular:339.56DNA-PK-IN-4
CAS:<p>DNA-PK-IN-4, an imidazolinone, targets DNA-PKcs to hinder tumor DNA repair and induce apoptosis, showing cancer research potential.</p>Fórmula:C20H24N6O3Cor e Forma:SolidPeso molecular:396.44G3335
CAS:<p>H-Trp-Glu-OH: Selective, reversible PPARγ modulator; cell-permeable; Kd ~8μM; potential diabetes lead.</p>Fórmula:C16H19N3O5Cor e Forma:SolidPeso molecular:333.34SKLB-197
CAS:<p>SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.</p>Fórmula:C25H24N6OCor e Forma:SolidPeso molecular:424.5ATR-IN-15
CAS:<p>ATR-IN-15, an ATR kinase inhibitor, has an IC50 of 8 nM and also targets LoVo cells, DNA-PK, and PI3K with higher IC50 values.</p>Fórmula:C19H22N8OCor e Forma:SolidPeso molecular:378.43PPARγ agonist 6
CAS:<p>PPARγ agonist 6 (Compound 12) is a potent agonist of selective PPARγ. PPARγ agonist 6 has potential for cancer disease research.</p>Fórmula:C27H26N2O4Cor e Forma:SolidPeso molecular:442.51PPARγ agonist 5
CAS:<p>PPARγ agonist 5 is a selective and potent PPARγ agonist that has shown research potential for cancer disease.</p>Fórmula:C33H31N5OCor e Forma:SolidPeso molecular:513.63CP-67804
CAS:<p>CP 67804 enhances topoisomerase II-mediated DNA cleaving.</p>Fórmula:C18H13F2NO4Cor e Forma:SolidPeso molecular:345.3DNA-PK-IN-7
CAS:<p>DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).</p>Fórmula:C19H21N9O2Cor e Forma:SolidPeso molecular:407.43Saroglitazar
CAS:<p>Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.</p>Fórmula:C25H29NO4SPureza:98.51%Cor e Forma:SolidPeso molecular:439.5717(S)-HDHA
CAS:<p>17(S)-HDHA: A DHA derivative in human blood/cells and mouse brain; leads to 17(S)-resolvins; inhibits IL-1β and leukocyte trafficking.</p>Fórmula:C22H32O3Cor e Forma:SolidPeso molecular:344.49ARH-049020
CAS:<p>ARH-049020, a peroxisome proliferator-activated receptor (PPAR) agonist, is used potentially for the treatment of insulin resistance and type 2 diabetes.</p>Fórmula:C24H31NO6Pureza:97.19% - 99.82%Cor e Forma:SolidPeso molecular:429.51Daltroban
CAS:<p>Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist.</p>Fórmula:C16H16ClNO4SPureza:99.74%Cor e Forma:SolidPeso molecular:353.82DNMT3A-IN-1
CAS:<p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>Fórmula:C30H38N6O4Cor e Forma:SolidPeso molecular:546.66NCI172112
CAS:<p>NCI172112 is is used to develop antitumor agents effective against CNS tumors.</p>Fórmula:C14H23Cl2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:336.26MD001
CAS:<p>MD001 is a PPARα/γ agonist, binds at Kds 9.55/0.14 μM, boosts transcription, and regulates glucose, lipid levels in diabetic mice.</p>Fórmula:C25H18O5Cor e Forma:SolidPeso molecular:398.41DB-959 (salt)
CAS:<p>DB-959, a PPAR agonist, is used potentially for the treatment of Alzheimer's disease.</p>Fórmula:C25H27NNaO5Cor e Forma:SolidPeso molecular:444.483XR-5000
CAS:<p>XR-5000 is a DNA topoisomerase I and II inhibitor.</p>Fórmula:C18H19N3OPureza:98%Cor e Forma:SolidPeso molecular:293.36Topoisomerase II inhibitor 8
CAS:<p>Compound 22 is a potent topoisomerase II inhibitor (IC50=0.52μM), with strong anti-proliferative effects, arresting cells at G2/M.</p>Fórmula:C14H8N4O3SCor e Forma:SolidPeso molecular:312.36-Methyl-5-azacytidine
CAS:<p>6-Methyl-5-azacytidine is a potent DNMT inhibitor.</p>Fórmula:C9H14N4O5Pureza:98%Cor e Forma:SolidPeso molecular:258.23TZD18
CAS:<p>TZD18, a novel PPAR alpha/gamma dual agonist, inhibits cell growth and induces apoptosis in human glioblastoma T98G cells.</p>Fórmula:C27H27NO5SCor e Forma:SolidPeso molecular:477.57CP-67015
CAS:<p>CP 67015 has an inhibitory effect on the function of topoisomerase, and is a direct mutagen in mammalian cells, which has effects on gene and chromosome levels.</p>Fórmula:C17H12F2N2O3Cor e Forma:SolidPeso molecular:330.29NS-220
CAS:<p>NS-220 selectively activates PPAR-alpha, reducing triglycerides and glucose in KK-Ay mice, also altering lipoproteins.</p>Fórmula:C21H27NO5Pureza:98%Cor e Forma:SolidPeso molecular:373.44Dihydro-5-azacytidine acetate
CAS:<p>Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1</p>Fórmula:C10H18N4O7Pureza:98%Cor e Forma:SolidPeso molecular:306.27NU-7163
CAS:<p>NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.</p>Fórmula:C18H17NO3Pureza:98%Cor e Forma:SolidPeso molecular:295.33GW409544
CAS:<p>GW409544 is an agonist of PPAR-alpha and PPAR-gamma.</p>Fórmula:C31H30N2O5Pureza:98%Cor e Forma:SolidPeso molecular:510.58L-796449
CAS:<p>L-796449 is an agonist of PPAR-gamma.</p>Fórmula:C28H27ClO4SPureza:98%Cor e Forma:SolidPeso molecular:495.03Cas9-IN-2
CAS:<p>Cas9-IN-2, an apo-Cas9 binder, inhibits Cas9 (IC50=246 μM), blocking Cas9:gRNA formation, regulating Cas9 function.</p>Fórmula:C21H27N5O4S2Cor e Forma:SolidPeso molecular:477.6PR-104
CAS:<p>PR-104: hypoxia-activated DNA cross-linker, pre-prodrug for nitrogen mustard, converts to PR-104A in tumors.</p>Fórmula:C14H20BrN4O12PSCor e Forma:SolidPeso molecular:579.27RG-12525
CAS:<p>RG-12525（NID 525） is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of</p>Fórmula:C25H21N5O2Pureza:95.49%Cor e Forma:SolidPeso molecular:423.47Sabarubicin
CAS:<p>Sabarubicin: a doxorubicin analogue with potent antitumor effects; superior in DNA fragmentation and topoisomerase II poisoning.</p>Fórmula:C32H37NO13Cor e Forma:SolidPeso molecular:643.64Topoisomerase I inhibitor 6
CAS:<p>Topoisomerase I inhibitor 6 traps DNA-Top1 complex, shows low non-cancer cell cytotoxicity, and has research value.</p>Fórmula:C23H21N7OCor e Forma:SolidPeso molecular:411.46LT175
CAS:<p>LT175 is a dual PPARα/γ partial agonist, insulin sensitizer, orally active, with lower adipogeny (EC50: hPPARα 0.22μm, mPPARα 0.26μm, hPPARγ 0.48μm).</p>Fórmula:C21H18O3Cor e Forma:SolidPeso molecular:318.37Romazarit
CAS:<p>Romazarit, a propionic acid derivative, is used as a PPARα agonist and acts as an antirheumatic drug.</p>Fórmula:C15H16ClNO4Pureza:98%Cor e Forma:SolidPeso molecular:309.74Pparδ agonist 7
CAS:<p>Pparδ agonist 7 is a potent agonist of Pparδ.</p>Fórmula:C25H25NO5Cor e Forma:SolidPeso molecular:419.47Resminostat
CAS:<p>Resminostat (4SC-201) is an orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity.</p>Fórmula:C16H19N3O4SPureza:99.46%Cor e Forma:SolidPeso molecular:349.4KDT 501 potassium
CAS:<p>KDT 501, a PPAR agonist and G protein-coupled receptor (GPR) 120 agonist, is used potentially for the treatment of type 2 diabetes.</p>Fórmula:C21H34KO5Pureza:98%Cor e Forma:SolidPeso molecular:405.596PPARγ agonist 4
CAS:<p>PPARγ agonist 4 (Compound 18b), a potent and selective PPARγ agonist, demonstrates antitumor efficacy only when used in conjunction with Imatinib.</p>Fórmula:C24H22FN3OCor e Forma:SolidPeso molecular:387.45DSO-5a
CAS:<p>DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation.</p>Fórmula:C23H24N2O7Pureza:98%Cor e Forma:SolidPeso molecular:440.45DB-959 (free base)
CAS:<p>DB-959 is a potential agonist of PPAR.</p>Fórmula:C25H27NO5Cor e Forma:SolidPeso molecular:421.493,6-Diamino-9(10H)-acridone
CAS:<p>3,6-Diamino-9(10H)-acridone is an inhibitor of topoisomerase [1].</p>Fórmula:C13H11N3OCor e Forma:SolidPeso molecular:225.25Mitobronitol
CAS:<p>Mitobronitol, a brominated mannitol analog, is an alkylating anticancer drug that aids in reducing allogeneic bone marrow transplant risks.</p>Fórmula:C6H12Br2O4Cor e Forma:SolidPeso molecular:307.97PPARα/δ agonist 1
CAS:<p>PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist with EC50 values of 7.0 nM for PPARα and 8.4 nM for PPARδ.</p>Fórmula:C22H22F3N3O5Cor e Forma:SolidPeso molecular:465.42NK314
CAS:<p>NK314, a benzo[c]phenanthridine, inhibits topoisomerase II causing DNA breaks within 1h, even without proteinase K digestion.</p>Fórmula:C22H20ClNO4Cor e Forma:SolidPeso molecular:397.85DNA-PK-IN-5
CAS:<p>DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.</p>Fórmula:C21H22N8O2Cor e Forma:SolidPeso molecular:418.45Mipicoledine
CAS:<p>DM-CHOC-PEN is a DNA alkylation agent that may be used to treat brain cancer.</p>Fórmula:C35H48Cl5NO4Cor e Forma:SolidPeso molecular:724.02NC190 sodium
CAS:<p>NC190 inhibits topoisomerase II, halts FM3A cell growth (IC50: 0.019 μg/ml in 48h), and suppresses DNA synthesis by 90% at 0.1 μg/ml.</p>Fórmula:C23H22N4NaO5Pureza:98%Cor e Forma:SolidPeso molecular:457.442BMS-711939
CAS:<p>BMS-711939: Potent PPARα agonist, EC50=4 nM, shown effective and safe in preclinical trials.</p>Fórmula:C22H20ClFN2O6Cor e Forma:SolidPeso molecular:462.86NHC-triphosphate
CAS:<p>NHC-triphosphate is a weak alternative substrate for the viral polymerase and changes the mobility of the product in polyacrylamide electrophoresis gels.</p>Fórmula:C9H16N3O15P3Pureza:98%Cor e Forma:SolidPeso molecular:499.16Topoisomerase IIα-IN-2
CAS:<p>Topoisomerase IIα-IN-2 (compound 5) is a DNA-binding ligands and a potent inhibitor of the topoisomerase TopoIIα.</p>Fórmula:C22H20N4O5Cor e Forma:SolidPeso molecular:420.42Naveglitazar
CAS:<p>Naveglitazar (LY 519818, LY 9818), a PPAR modulator in phase II trials for type 2 diabetes.</p>Fórmula:C25H26O6Cor e Forma:SolidPeso molecular:422.47LY-510929
CAS:<p>LY-510929: PPAR agonist for hyperlipidemia, metabolic issues, type 2 diabetes.</p>Fórmula:C26H25NO5SPureza:98%Cor e Forma:SolidPeso molecular:463.55HWL-088
CAS:<p>HWL-088 is a potent free fatty acid receptor 1 (FFA1/GPR40) agonist. HWL-088 significantly improves glucose tolerance in normal and diabetic models.</p>Fórmula:C22H19FO4Cor e Forma:SolidPeso molecular:366.38CCT128930
CAS:<p>'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'</p>Fórmula:C18H20ClN5Pureza:99.07% - 99.18%Cor e Forma:SolidPeso molecular:341.84PluriSIn #2
CAS:<p>PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.</p>Fórmula:C11H8FN3O3Pureza:98% - 99.79%Cor e Forma:SolidPeso molecular:249.2HDAC-IN-5
CAS:<p>HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.</p>Fórmula:C26H24F3N5O2SPureza:98%Cor e Forma:SolidPeso molecular:527.56Ertiprotafib
CAS:<p>Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.</p>Fórmula:C31H27BrO3SPureza:98.70%Cor e Forma:SolidPeso molecular:559.51Sirt2-IN-1
CAS:<p>Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).</p>Fórmula:C28H27N7O2S2Pureza:99.57% - 99.84%Cor e Forma:SolidPeso molecular:557.69CAY10767
CAS:<p>CAY10767 is a PPARα agonist with an EC50 of 37 nM; over 2700x selective against PPARγ/δ.</p>Fórmula:C22H20FNO3Cor e Forma:SolidPeso molecular:365.4Guadecitabine sodium
CAS:<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Fórmula:C18H24N9NaO10PPureza:98%Cor e Forma:SolidPeso molecular:580.407Topoisomerase I inhibitor 7
CAS:<p>Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I.</p>Fórmula:C22H19N3O5Cor e Forma:SolidPeso molecular:405.4LG100754
CAS:<p>LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.</p>Fórmula:C26H36O3Cor e Forma:SolidPeso molecular:396.569-Hydroxyellipticine hydrochloride
CAS:<p>9-Hydroxyellipticine hydrochloride is an inhibitor of Topo II and RyR, exhibits antitumor and antileukemic activity, and inhibits carrageenan gum-induced edema.</p>Fórmula:C17H15ClN2OPureza:98%Cor e Forma:SolidPeso molecular:298.77Topoisomerase II inhibitor 16
CAS:<p>Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the</p>Fórmula:C19H12F4N6OPureza:98%Cor e Forma:SolidPeso molecular:416.33Topoisomerase IV inhibitor 1
CAS:<p>Compound 7d: Inhibits TOPO IV (IC50: 0.23 μM), DNA gyrase (IC50: 0.43 μM), antibacterial against S. aureus (MIC: 0.972 μM), E. coli (MIC: 0.608 μM).</p>Fórmula:C34H32FN7O6SPureza:98%Cor e Forma:SolidPeso molecular:685.72PB131
CAS:<p>PB131, a selective and brain-permeable HDAC6 inhibitor, exhibits high binding affinity (IC50: 1.8 nM) and potent anti-inflammatory activity, making it suitable</p>Fórmula:C16H16FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:301.32GW 9578
CAS:<p>GW 9578 is a PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.</p>Fórmula:C26H34F2N2O3SPureza:98%Cor e Forma:SolidPeso molecular:492.62Chiglitazar
CAS:<p>Chiglitazar is a PPAR α/γ/δ agonist and insulin sensitizer used in the treatment of type 2 diabetes mellitus , anti-inflammatory and anti-fibrotic.</p>Fórmula:C36H29FN2O4Cor e Forma:SolidPeso molecular:572.63HDAC-IN-58
CAS:<p>HDAC-IN-58, a selective HDAC6 inhibitor, exhibits potent inhibitory activity with an IC50 of 2.06 nM, rendering it suitable for research into chronic</p>Fórmula:C16H13ClF2N4O3SPureza:98%Cor e Forma:SolidPeso molecular:414.81Topoisomerase IV inhibitor 2
CAS:<p>Compound 5d, a potent TOPO IV inhibitor (IC50: 0.35 μM), also inhibits DNA gyrase (IC50: 0.55 μM) and has antibacterial activity.</p>Fórmula:C33H30FN7O6SPureza:98%Cor e Forma:SolidPeso molecular:671.7HDAC ligand-1
CAS:<p>HDAC ligand-1 is a synthetic precursor utilized in the production of PROTAC-based HDAC degraders [1].</p>Fórmula:C7H8N2OPureza:98%Cor e Forma:SolidPeso molecular:136.15ATR-IN-23
CAS:<p>ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces</p>Fórmula:C20H22N6O3S2Pureza:98%Cor e Forma:SolidPeso molecular:458.56BRD 9757
CAS:<p>BRD 9757 (N-Hydroxy-1-cyclopentene-1-carboxamide) is a selective inhibitor of HDAC6 (IC50 = 30 nM).</p>Fórmula:C6H9NO2Pureza:98.39% - 99.87%Cor e Forma:SolidPeso molecular:127.14NSC16168
CAS:<p>NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.</p>Fórmula:C17H15NO9S3Pureza:99.88%Cor e Forma:SolidPeso molecular:473.5Dehydroepiandrosterone sulfate
CAS:<p>Dehydroepiandrosterone sulfate (PB-005) influences the migration of neurons, arborization of dendrites, and formation of new synapses.</p>Fórmula:C19H28O5SPureza:97.18%Cor e Forma:SolidPeso molecular:368.49ISX-1
CAS:<p>ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.</p>Fórmula:C14H14N4O2SPureza:98.7%Cor e Forma:SolidPeso molecular:302.35Linotroban
CAS:<p>Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.</p>Fórmula:C14H15NO5S2Pureza:97.95% - >99.99%Cor e Forma:SolidPeso molecular:341.4Dazmegrel
CAS:<p>Dazmegrel (UK 38,485) is a thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy.</p>Fórmula:C16H17N3O2Pureza:98.81%Cor e Forma:SolidPeso molecular:283.33Vutiglabridin
CAS:<p>Vutiglabridin (HSG4112), a PON2 modulator, is more stable and aids weight loss than Glabridin. In phase 2 trials for obesity, shows promise for PD therapy.</p>Fórmula:C22H26O4Pureza:98.47% - 99.07%Cor e Forma:SolidPeso molecular:354.44Chloroquinoxaline sulfonamide
CAS:<p>Chloroquinoxaline sulfonamide (Chloroquinoxaline) is an organic micropollutant with antimicrobial activity.</p>Fórmula:C14H11ClN4O2SPureza:99.79% - 99.89%Cor e Forma:SolidPeso molecular:334.78DN-1289
<p>DN-1289: oral, BBB-penetrating, selectively inhibits DLK (IC50=17nM) & LZK (IC50=40nM), blocks p-c-Jun in mouse optic nerve crush.</p>Fórmula:C18H19F4N7O2Pureza:98.56%Cor e Forma:SolidPeso molecular:441.38SIRT5 inhibitor 1
CAS:<p>SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.</p>Fórmula:C31H39FN6O6S2Pureza:97.8%Cor e Forma:SolidPeso molecular:674.81Cedazuridine
CAS:<p>Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.</p>Fórmula:C9H14F2N2O5Pureza:99.66%Cor e Forma:SolidPeso molecular:268.21AGI-24512
CAS:<p>AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in</p>Fórmula:C24H24N4O2Pureza:98.55%Cor e Forma:SolidPeso molecular:400.47Procainamide
CAS:<p>Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.</p>Fórmula:C13H21N3OPureza:99.92% - 99.92%Cor e Forma:SolidPeso molecular:235.33L82
CAS:<p>L82: A selective, non-competitive DNA Lig1 inhibitor with anti-proliferative effects on breast cancer cells. IC50=12 μM.</p>Fórmula:C11H8ClN5O4Pureza:97.45% - 98.91%Cor e Forma:SolidPeso molecular:309.67BTB09089
CAS:<p>BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production</p>Fórmula:C14H12Cl2N4OS2Pureza:99.78%Cor e Forma:SoildPeso molecular:387.31SIRT6-IN-5
CAS:<p>SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.</p>Fórmula:C19H14N2O6Pureza:98.77%Cor e Forma:SolidPeso molecular:366.32HDAC8-IN-20a
CAS:<p>HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM.</p>Fórmula:C15H15NO4Pureza:98.24% - 99.22%Cor e Forma:SolidPeso molecular:273.28Suksdorfin
CAS:<p>Suksdorfin has hypoglycemic effects and activates PPARγ, which promotes insulin-dependent glucose uptake by adipocytes and can be used to study obesity .</p>Fórmula:C21H24O7Pureza:98.54%Cor e Forma:SolidPeso molecular:388.41Bobcat339 hydrochloride
CAS:<p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>Fórmula:C16H13Cl2N3OPureza:99.22%Cor e Forma:SolidPeso molecular:334.2Alalevonadifloxacin
CAS:<p>Alalevonadifloxacin is a DNA gyrase and DNA topoisomerase inhibitor and a novel antibacterial compound of the quinolone class targeting MRSa.</p>Fórmula:C23H30FN3O8SPureza:99.75% - 99.82%Cor e Forma:SoildPeso molecular:527.56Pegamotecan
CAS:<p>Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell</p>Fórmula:C52H48N6O14Pureza:96.40% - 97.83%Cor e Forma:SolidPeso molecular:980.984Miriplatin hydrate
CAS:Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).Fórmula:C34H70N2O5PtPureza:99.6%Cor e Forma:SolidPeso molecular:782.01BRD6688
CAS:<p>BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes</p>Fórmula:C16H18N4OPureza:97.53%Cor e Forma:SolidPeso molecular:282.34PARP10-IN-2
CAS:<p>PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and</p>Fórmula:C14H10N2O2Pureza:99.27%Cor e Forma:SolidPeso molecular:238.24Tenifatecan
CAS:<p>Tenifatecan (SN2310) is a highly lipophilic preparation of 7-ethyl-10-hydroxycamptothecin (SN) with potential antitumor activity.</p>Fórmula:C55H72N2O9Pureza:99.58% - 99.82%Cor e Forma:SolidPeso molecular:905.17SS-208
CAS:<p>SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.</p>Fórmula:C13H11Cl2N3O4Pureza:99.69%Cor e Forma:SolidPeso molecular:344.15(R)-(-)-Rolipram
CAS:<p>(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.</p>Fórmula:C16H21NO3Pureza:99.54%Cor e Forma:SolidPeso molecular:275.34Givinostat hydrochloride
CAS:<p>Givinostat HCl (ITF2357 HCl) inhibits HDAC1/3 (IC50: 198/157 nM) with anti-inflammatory, anti-angiogenic, and antineoplastic properties.</p>Fórmula:C24H28ClN3O4Pureza:99.39%Cor e Forma:SolidPeso molecular:457.95EB-47
CAS:<p>EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).</p>Fórmula:C24H27N9O6Pureza:99.81%Cor e Forma:SolidPeso molecular:537.53CEP-9722
CAS:<p>CEP-9722 is a PARP-1 and PARP-2 inhibitor with anticancer activity and is used in the study of ovarian cancer.</p>Fórmula:C24H26N4O3Pureza:98.38% - 98.56%Cor e Forma:SolidPeso molecular:418.49ACY-957
CAS:<p>ACY-957: Oral HDAC1/2 inhibitor (IC50: HDAC1=7nM, HDAC2=18nM, HDAC3=1300nM); inactive on HDAC4/5/6/7/8/9.</p>Fórmula:C24H23N5OSPureza:99.79%Cor e Forma:SolidPeso molecular:429.54OUL232
CAS:<p>OUL232 is a potent single ARTs PARP7, PARP10, PARP11, PARP12, PARP14 and PARP15 inhibitor for cancer and tumour research.</p>Fórmula:C10H10N4O2SPureza:99.04%Cor e Forma:SolidPeso molecular:250.28ACY-1083
CAS:<p>ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.</p>Fórmula:C17H18F2N4O2Pureza:99.19% - 99.43%Cor e Forma:SolidPeso molecular:348.35BRD4097
CAS:<p>BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve</p>Fórmula:C16H17N3O2Pureza:99.75%Cor e Forma:SolidPeso molecular:283.33BRD2492
CAS:<p>BRD2492 is an HDAC1 and HDAC2 inhibitor with antiproliferative activity, inhibits HDAC1/2 and induces apoptosis.</p>Fórmula:C20H18N4O2Pureza:99.56%Cor e Forma:SolidPeso molecular:346.38KRP-101
CAS:<p>KRP-101, a PPARɑ agonist, is used potentially for the treatment of diabetes and hyperlipidaemia.</p>Fórmula:C26H26FNO5Cor e Forma:SolidPeso molecular:451.49PPARγ agonist 7
CAS:<p>PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ).</p>Fórmula:C20H30O6Cor e Forma:SolidPeso molecular:366.45K-756
CAS:<p>K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).</p>Fórmula:C24H27N5O3Pureza:99.81%Cor e Forma:SolidPeso molecular:433.5L-783483
CAS:<p>L-783483 is an agonist of PPAR.</p>Fórmula:C22H21ClF3NO4SPureza:98%Cor e Forma:SolidPeso molecular:487.92ATR-IN-21
CAS:<p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>Fórmula:C23H27N7OPureza:98%Cor e Forma:SolidPeso molecular:417.51HDAC8-IN-4
CAS:<p>HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].</p>Fórmula:C17H14N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:342.44Duocarmycin analog-2
CAS:<p>Duocarmycin analog-2 is a potent DNA alkylating agent that exhibits antitumor effects and can be used in the synthesis of immunocouplers.</p>Fórmula:C29H23ClN4O3Cor e Forma:SolidPeso molecular:510.97GNE-8505
CAS:<p>GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).</p>Fórmula:C21H24F3N5OCor e Forma:SolidPeso molecular:419.44CM-579 trihydrochloride (1846570-40-8 free base)
<p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>Fórmula:C29H43Cl3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:602.04LCB-2853
CAS:<p>LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.</p>Fórmula:C21H24ClNO4SPureza:97.15%Cor e Forma:SolidPeso molecular:421.94ARN-21934
CAS:<p>ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.</p>Fórmula:C21H24N6Pureza:99.8%Cor e Forma:SolidPeso molecular:360.46XY-4
CAS:<p>XY-4, a derivative of 1-palmitoyl lysophosphatidic acid (1-palmitoyl LPA094) and an agonist of peroxisome proliferator-activated receptor γ (PPARγ), effectively</p>Fórmula:C19H37F2O6PCor e Forma:SolidPeso molecular:430.46Bocodepsin hydrochloride
CAS:<p>Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration.</p>Fórmula:C26H40ClN5O6S2Pureza:98%Cor e Forma:SolidPeso molecular:618.21TP0480066
CAS:<p>TP0480066 inhibits topoisomerase II, DNA gyrase (IC50=1.1nM), topo IV (IC50=62.89nM), effective against drug-resistant bacteria and N. gonorrhoeae.</p>Fórmula:C18H14FN3O5Cor e Forma:SolidPeso molecular:371.32Topoisomerase IIα-IN-8
CAS:<p>Topoisomerase IIα-IN-8 (compound 15) serves as a modest inhibitor of human DNA topoisomerase IIα (htIIα), exhibiting an inhibitory concentration (IC50) of 462 ± 38.0 μM [1].</p>Fórmula:C15H15FN6OCor e Forma:SolidPeso molecular:314.324ATR-IN-13
CAS:<p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>Fórmula:C24H24FN9OCor e Forma:SolidPeso molecular:473.51GSK-3484862
CAS:<p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>Fórmula:C19H19N5OSPureza:99.87% - 99.963%Cor e Forma:SolidPeso molecular:365.45Peliglitazar
CAS:<p>Peliglitazar is a activator of α/γ peroxisome proliferator-activated receptor.</p>Fórmula:C30H30N2O7Cor e Forma:SolidPeso molecular:530.57SR 2595
CAS:<p>SR2595 is an inverse agonist of nuclear receptor PPARγ with an IC 50 of 30 nM [1].</p>Fórmula:C37H38N2O3Cor e Forma:SolidPeso molecular:558.71BMS-250749
CAS:<p>BMS-250749 is a fluoroglycosylated fluoroindolocarbazole, it has antitumor activity.</p>Fórmula:C26H18F3N3O6Pureza:98%Cor e Forma:SolidPeso molecular:525.43HDAC6-IN-21
CAS:<p>HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histone deacetylase 6 (HDAC6) [1].</p>Fórmula:C14H13F2N5O2Pureza:98%Cor e Forma:SolidPeso molecular:321.28DS-6930
CAS:<p>DS-6930 is an potent and selective PPAR γ Agonists with EC50 of 41 nM.</p>Fórmula:C23H21N3O4Cor e Forma:SolidPeso molecular:403.43CM-675
CAS:<p>CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to</p>Fórmula:C31H32N6O3Pureza:99.82%Cor e Forma:SolidPeso molecular:536.62SIRT6-IN-3
CAS:<p>SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts</p>Fórmula:C21H30Br3ClN6SPureza:98%Cor e Forma:SolidPeso molecular:673.73Makaluvamine A
CAS:<p>Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors.</p>Fórmula:C11H11N3OCor e Forma:SolidPeso molecular:201.22Tankyrase-IN-5
CAS:<p>Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2, with half-maximal inhibitory</p>Fórmula:C17H18N2O2Pureza:98%Cor e Forma:SolidPeso molecular:282.34SU-11752
CAS:<p>SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.</p>Fórmula:C26H27N3O5SCor e Forma:SolidPeso molecular:493.57Pparδ agonist 1
CAS:<p>Pparδ agonist 1 is an agonist of PPAR-δ(EC50 of 5.06 nM).</p>Fórmula:C26H27NO5Pureza:98%Cor e Forma:SolidPeso molecular:433.5U-46619
CAS:<p>U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (</p>Fórmula:C21H34O4Pureza:98%Cor e Forma:SolidPeso molecular:350.49ATR-IN-20
<p>ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.</p>Fórmula:C29H31N5O4SCor e Forma:SolidPeso molecular:545.65CAY10410
CAS:<p>CAY10410 is a PGD2/PGJ2 analog, modified for enhanced PPARγ activity and metabolic stability, non-toxic to SH-SY5Y cells at ≤25μM.</p>Fórmula:C20H30O3Cor e Forma:SolidPeso molecular:318.45LMP744 hydrochloride
CAS:<p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>Fórmula:C24H25ClN2O7Pureza:99.59% - 99.85%Cor e Forma:SolidPeso molecular:488.92AZ 5704
CAS:<p>ATM kinase inhibitor with 0.6 nM IC50, >600-fold selective, enhances irinotecan effects, oral use.</p>Fórmula:C23H23FN6O2Cor e Forma:SolidPeso molecular:434.479A1P9
CAS:<p>9A1P9, a multi-tail ionizable cationic phospholipid, facilitates membrane destabilization and is applicable for CRISPR-Cas9 gene editing in mice [1].</p>Fórmula:C27H58NO4PCor e Forma:SolidPeso molecular:491.73BO 2367
CAS:<p>BO 2367, a topoisomerase inhibitor, is used to suppress the growth of tumor .</p>Fórmula:C21H22ClF2N3O3Cor e Forma:SolidPeso molecular:437.87ATR-IN-22
CAS:<p>ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and</p>Fórmula:C25H31N7OPureza:98%Cor e Forma:SolidPeso molecular:445.56ATR-IN-5
CAS:<p>ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.</p>Fórmula:C27H32F3N9OCor e Forma:SolidPeso molecular:555.6Topoisomerase I inhibitor 9
CAS:<p>Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value</p>Fórmula:C23H15Br2FN2Pureza:98%Cor e Forma:SolidPeso molecular:498.19Topoisomerase inhibitor 2
CAS:<p>Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].</p>Fórmula:C23H23N5O4Pureza:98%Cor e Forma:SolidPeso molecular:433.46
