Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 958 produtos de "Dano de DNA/Reparo de DNA"
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Palifosfamide
CAS:<p>Palifosfamide lysine (ZIO-201) stable, effective vs. sarcomas in vitro. IC50: 2.25-6.75 μM, except OS222 at 31.5 μM.</p>Fórmula:C4H11Cl2N2O2PPureza:99.72%Cor e Forma:SolidPeso molecular:221.02360A
CAS:<p>360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).</p>Fórmula:C27H23N5O2Pureza:98.68%Cor e Forma:SolidPeso molecular:449.5Lomeguatrib
CAS:<p>Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .</p>Fórmula:C10H8BrN5OSPureza:99.26% - >99.99%Cor e Forma:SolidPeso molecular:326.17Nexturastat A
CAS:<p>Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.</p>Fórmula:C19H23N3O3Pureza:99.40% - 99.57%Cor e Forma:SolidPeso molecular:341.4ETP-45658
CAS:<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Fórmula:C16H17N5O2Pureza:99.14%Cor e Forma:SolidPeso molecular:311.34Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Fórmula:C30H23N5OPureza:97.64% - 99.85%Cor e Forma:SolidPeso molecular:469.54Pimelic diphenylamide 106
CAS:<p>Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC, showing no activity against class II HDACs.</p>Fórmula:C20H25N3O2Pureza:95.25% - 99.28%Cor e Forma:SolidPeso molecular:339.43TMP269
CAS:<p>TMP269: Class IIa HDAC inhibitor; HDAC4 IC50=157 nM, HDAC5 IC50=97 nM, HDAC7 IC50=43 nM, HDAC9 IC50=23 nM.</p>Fórmula:C25H21F3N4O3SPureza:98% - 99.72%Cor e Forma:SolidPeso molecular:514.52Amonafide
CAS:<p>Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.</p>Fórmula:C16H17N3O2Pureza:99.39%Cor e Forma:SolidPeso molecular:283.33A-966492
CAS:<p>A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.</p>Fórmula:C18H17FN4OPureza:98.53% - 99.27%Cor e Forma:SolidPeso molecular:324.356-AZATHYMINE
CAS:<p>6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.</p>Fórmula:C4H5N3O2Pureza:99.47%Cor e Forma:SolidPeso molecular:127.1ACY-775
CAS:<p>ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).</p>Fórmula:C17H19FN4O2Pureza:97.67% - 98.83%Cor e Forma:SolidPeso molecular:330.36Satraplatin
CAS:<p>Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinical</p>Fórmula:C10H22Cl2N2O4PtPureza:98.25%Cor e Forma:SolidPeso molecular:500.28CRT0044876
CAS:<p>CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.</p>Fórmula:C9H6N2O4Pureza:98.27% - 98.98%Cor e Forma:Brown PowderPeso molecular:206.15azd1390
CAS:<p>AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.</p>Fórmula:C27H32FN5O2Pureza:97.41% - 99.72%Cor e Forma:SolidPeso molecular:477.57RGFP966
CAS:<p>RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 μM.</p>Fórmula:C21H19FN4OPureza:99.2% - 99.88%Cor e Forma:SolidPeso molecular:362.4RG2833
CAS:<p>RG2833 (RGFP109) (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.</p>Fórmula:C20H25N3O2Pureza:99% - 99.50%Cor e Forma:SolidPeso molecular:339.433,4-Dicaffeoylquinic acid
CAS:<p>3,4-Dicaffeoylquinic acid (Isochlorogenic acid B) has antioxidant activity.</p>Fórmula:C25H24O12Pureza:96.33% - 98.82%Cor e Forma:SolidPeso molecular:516.45Seclidemstat
CAS:<p>Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.</p>Fórmula:C20H23ClN4O4SPureza:98.28% - 99.76%Cor e Forma:SolidPeso molecular:450.94Veliparib dihydrochloride
CAS:<p>Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.</p>Fórmula:C13H18Cl2N4OPureza:98% - 99.81%Cor e Forma:SolidPeso molecular:317.21Prexasertib dihydrochloride
CAS:<p>Prexasertib dihydrochloride (LY2606368) inhibits CHK1 (Ki: 0.9 nM); IC50: CHK2 8 nM, RSK 9 nM.</p>Fórmula:C18H21Cl2N7O2Pureza:98.46% - 99.82%Cor e Forma:SolidPeso molecular:438.316-Thioguanine
CAS:<p>6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.</p>Fórmula:C5H5N5SPureza:98.34% - >99.99%Cor e Forma:Odorless Or Almost Odorless Pale Yellow Crystalline PowderPeso molecular:167.19SIS17
CAS:<p>SIS17: Potent, selective HDAC11 inhibitor (IC50: 0.83 μM), blocks serine hydroxymethyl transferase 2 demyristoylation, spares other HDACs.</p>Fórmula:C21H38N2OSPureza:98.22%Cor e Forma:SolidPeso molecular:366.6CC-115
CAS:<p>CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).</p>Fórmula:C16H16N8OPureza:86.79% - 99.01%Cor e Forma:SolidPeso molecular:336.35SRT 1460
CAS:<p>SRT 1460 is a SIRT1 activator.</p>Fórmula:C26H29N5O4SPureza:98.25%Cor e Forma:SolidPeso molecular:507.6Venadaparib
CAS:<p>Venadaparib, a PARP inhibitor (IC50: 1.4/1.0 nM for PARP1/2), is orally active, selective, not affecting PARP-5, used in tumor studies.</p>Fórmula:C23H23FN4O2Pureza:99.86%Cor e Forma:SolidPeso molecular:406.45Ochromycinone
CAS:<p>Ochromycinone (STA 21) is a selective STAT3 inhibitor.</p>Fórmula:C19H14O4Pureza:99.21%Cor e Forma:SolidPeso molecular:306.315-Methyl-2'-deoxycytidine
CAS:<p>5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.</p>Fórmula:C10H15N3O4Pureza:99.18% - 99.69%Cor e Forma:SolidPeso molecular:241.245-Fluoro-2'-deoxycytidine
CAS:<p>5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .</p>Fórmula:C9H12FN3O4Pureza:97.91%Cor e Forma:Fine White PowderPeso molecular:245.21Bimolane
CAS:<p>Bimolane is a topoisomerase II inhibitor.</p>Fórmula:C20H32N6O6Pureza:99.13% - 99.29%Cor e Forma:SolidPeso molecular:452.5Amsacrine hydrochloride
CAS:<p>Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.</p>Fórmula:C21H20ClN3O3SPureza:99.05% - 99.92%Cor e Forma:SolidPeso molecular:429.92Levofloxacin
CAS:<p>Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.</p>Fórmula:C18H20FN3O4Pureza:98.14% - 99.80%Cor e Forma:Off-White To Yellow CrystalsPeso molecular:361.37ACY-738
CAS:<p>ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.</p>Fórmula:C14H14N4O2Pureza:98.85% - 99.89%Cor e Forma:SolidPeso molecular:270.29YU238259
CAS:<p>YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.</p>Fórmula:C22H22ClN3O4SPureza:99.28% - 99.56%Cor e Forma:SolidPeso molecular:459.95GeA-69
CAS:<p>GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).</p>Fórmula:C20H16N2OPureza:99.85%Cor e Forma:SolidPeso molecular:300.35Talazoparib
CAS:<p>Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).</p>Fórmula:C19H14F2N6OPureza:97.02% - 99.92%Cor e Forma:SolidPeso molecular:380.35Tunicamycin
CAS:<p>Tunicamycin is a mixture of antibiotics that inhibit N-linked glycosylation by blocking GlcNAc phosphotransferase (GPT).</p>Fórmula:C39H64N4O16Pureza:98.77%Cor e Forma:White Crystalline SolidPeso molecular:844.94 (n=10)LY-294002 hydrochloride
CAS:<p>LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.</p>Fórmula:C19H17NO3·HClPureza:99.95%Cor e Forma:SolidPeso molecular:343.81HDAC8-IN-1
CAS:<p>MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines.</p>Fórmula:C22H19NO3Pureza:97.13% - 99.19%Cor e Forma:SolidPeso molecular:345.39Belinostat
CAS:<p>Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.</p>Fórmula:C15H14N2O4SPureza:99.75% - >99.99%Cor e Forma:SolidPeso molecular:318.35Veliparib
CAS:<p>Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.</p>Fórmula:C13H16N4OPureza:98.66% - 99%Cor e Forma:SolidPeso molecular:244.29SF2523
CAS:<p>SF2523 is a highly selective and potent inhibitor.</p>Fórmula:C19H17NO5SPureza:99.1% - 99.51%Cor e Forma:SolidPeso molecular:371.41SGI-1027
CAS:<p>SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT).</p>Fórmula:C27H23N7OPureza:99.45% - 99.78%Cor e Forma:SolidPeso molecular:461.523-Methoxybenzamide
CAS:<p>3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.</p>Fórmula:C8H9NO2Pureza:98.52%Cor e Forma:SolidPeso molecular:151.16HDAC-IN-7
CAS:<p>HDAC-IN-7 (HBI-8000) (Chidamide impurity) is an impurity of Chidamide.</p>Fórmula:C22H19FN4O2Pureza:97.64% - 98.45%Cor e Forma:SolidPeso molecular:390.41Pirarubicin
CAS:<p>Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.</p>Fórmula:C32H37NO12Pureza:97.80% - 99.15%Cor e Forma:Red Crystalline PowderPeso molecular:627.64Potassium acetate
CAS:<p>Potassium acetate (Diuretic salt) with antibacterial and antifungal properties.</p>Fórmula:C2H3KO2Pureza:≥98%Cor e Forma:Colorless Lustrous Rapidly Deliquescent Crystals Or White Crystal Powder Or Flakes Solid Repidly Deliquescent Crystals Or White Crystal Powder Or FlakesPeso molecular:98.14TAS-103 dihydrochloride
CAS:<p>TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.</p>Fórmula:C20H21Cl2N3O2Pureza:97.78%Cor e Forma:SolidPeso molecular:406.31KU-0060648
CAS:<p>KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.</p>Fórmula:C33H34N4O4SPureza:98.75%Cor e Forma:SolidPeso molecular:582.71Hypericin
CAS:<p>Hypericin (Cyclosan) is a natural anthraquinone compound. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant effects. Cost-effective and quality-assured.</p>Fórmula:C30H16O8Pureza:99.05% - ≥98%Cor e Forma:Red-Coloured Anthraquinone-DerivativePeso molecular:504.44
