Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 959 produtos de "Dano de DNA/Reparo de DNA"
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ITF3756
CAS:<p>ITF3756 is a selective HDAC6 inhibitor.</p>Fórmula:C13H11N5O2SPureza:97.74%Cor e Forma:SolidPeso molecular:301.32ATR-IN-10
CAS:<p>ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).</p>Fórmula:C27H24N4OCor e Forma:SolidPeso molecular:420.51Hepsulfam
CAS:<p>Hepsulfam is an anticancer agent. It also displays excellent antileukemic activity (a median IC50: 0.91 μg/mL in a panel of different tumors).</p>Fórmula:C7H18N2O6S2Cor e Forma:SolidPeso molecular:290.36CM-579
CAS:<p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>Fórmula:C29H40N4O3Pureza:99.23%Cor e Forma:SolidPeso molecular:492.65C-333H
CAS:<p>C-333H is a new PPARalpha/gamma dual agonist.</p>Fórmula:C28H26N2O6Pureza:98%Cor e Forma:SolidPeso molecular:486.52F-14512
CAS:<p>F-14512, a DNA topoisomerase II inhibitor, is used potentially for the treatment of acute myeloid leukemia.</p>Fórmula:C33H47N5O8Cor e Forma:SolidPeso molecular:641.76MHY908
CAS:<p>MHY908, a novel inhibitor of melanogenesis, potently inhibits mushroom tyrosinase activity in a dose-dependent manner.</p>Fórmula:C17H14ClNO3SPureza:98%Cor e Forma:SolidPeso molecular:347.82S26948
CAS:<p>S26948 is a PPARγ agonist.</p>Fórmula:C28H25NO7SPureza:98%Cor e Forma:SolidPeso molecular:519.57Topoisomerase IIα-IN-1
CAS:<p>Topoisomerase IIα-IN-1 (compound 2) is a DNA-binding ligands and a potent inhibitor of TopoIIα, a topoisomerase.</p>Fórmula:C22H20N4O5Cor e Forma:SolidPeso molecular:420.42KRP-297
CAS:<p>KRP297 is a PPAR agonist potentially for the treatment of type 2 diabetes and dyslipidemia.</p>Fórmula:C20H17F3N2O4SCor e Forma:SolidPeso molecular:438.42MPT0G211
CAS:<p>MPT0G211: oral HDAC6 inhibitor with IC50=0.291 nM, 1000x selectivity, neuroprotective, anti-metastatic, crosses blood-brain barrier for Alzheimer's.</p>Fórmula:C17H15N3O2Pureza:98% - 99.88%Cor e Forma:SolidPeso molecular:293.32ST247
CAS:<p>ST247: Potent PPARβ/δ inverse agonist, blocks CCL2 expression and agonist-driven PPARβ/δ transcription, promotes co-repressor interaction.</p>Fórmula:C19H26N2O5S2Cor e Forma:SolidPeso molecular:426.55SW155246
CAS:<p>SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).</p>Fórmula:C16H11ClN2O5SPureza:98.99%Cor e Forma:SolidPeso molecular:378.79DC_501
CAS:<p>DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.</p>Fórmula:C25H23Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:452.38XR 5944
CAS:<p>XR 5944 is an effective DNA binder that stabilizes topoisomerase-dependent cleavage and has shown superior efficacy in a variety of mouse and human tumor models</p>Fórmula:C34H34N8O2Pureza:98.29% - 98.66%Cor e Forma:SolidPeso molecular:586.69Huanglongmycin N
CAS:<p>Huanglongmycin N acts as a DNA topoisomerase I inhibitor, demonstrating an EC50 value of 14 μM.</p>Fórmula:C19H16O5Cor e Forma:SolidPeso molecular:324.33DNA-PK-IN-1
CAS:<p>DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.</p>Fórmula:C23H26N8O2Cor e Forma:SolidPeso molecular:446.5Eicosatetraynoic acid
CAS:<p>ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).</p>Fórmula:C20H24O2Pureza:98%Cor e Forma:SolidPeso molecular:296.4DNA-PK-IN-3
CAS:<p>DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.</p>Fórmula:C19H19N9OCor e Forma:SolidPeso molecular:389.41TFMB-(S)-2-HG
CAS:<p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>Fórmula:C13H11F3O4Pureza:98.07%Cor e Forma:SolidPeso molecular:288.22(S)-Gyramide A
CAS:<p>(S)-Gyramide A is a bacterial DNA gyrase inhibitor that acts by exhibiting antimicrobial activity and inhibiting bacterial cell division.</p>Fórmula:C21H27FN2O3SPureza:98%Cor e Forma:SolidPeso molecular:406.51Topoisomerase II inhibitor 4
CAS:<p>Compound E17, a topoisomerase II inhibitor, halts cell cycle at G2/M, possesses anticancer properties and cytotoxic effects.</p>Fórmula:C25H25N5O4Cor e Forma:SolidPeso molecular:459.55-Aza-4'-thio-2'-deoxycytidine
CAS:<p>5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].</p>Fórmula:C8H12N4O3SCor e Forma:SolidPeso molecular:244.27Lexitropsin
CAS:<p>Lexitropsin is a novel anticancer drug.</p>Fórmula:C20H29N5O4Cor e Forma:SolidPeso molecular:403.48NU-7163
CAS:<p>NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.</p>Fórmula:C18H17NO3Pureza:98%Cor e Forma:SolidPeso molecular:295.33ATR-IN-16
CAS:<p>ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.</p>Fórmula:C19H25N7OCor e Forma:SolidPeso molecular:367.45Piroxantrone
CAS:<p>Piroxantrone (CI942; PD111815) is an anthrapyrazole antibiotic that disrupts DNA replication and repair, with limited cardiotoxicity and antineoplastic range.</p>Fórmula:C21H25N5O4Cor e Forma:SolidPeso molecular:411.45Procarbazine free base
CAS:<p>Procarbazine: chemo drug for Hodgkin's, brain cancer; liver-activated; MAO inhibitor.</p>Fórmula:C12H19N3OPureza:98%Cor e Forma:SolidPeso molecular:221.3MLR24
CAS:<p>MLR24 is a selective modulator of PPARγ that acts by displaying robust anti-diabetic activity.</p>Fórmula:C28H24F3NO6Pureza:98%Cor e Forma:SolidPeso molecular:527.49CAY10744
CAS:<p>CAY10744, a topoisomerase II-α inhibitor (78.9% at 20 μM), blocks cancer cell proliferation with varying IC50s and induces apoptosis in T47D cells.</p>Fórmula:C24H16ClNO2Cor e Forma:SolidPeso molecular:385.84Anticancer agent 75
CAS:<p>Anticancer agent 75: potent, selective, less toxic to kidneys than Doxorubicin by 35x, with antiplasmodial properties.</p>Fórmula:C22H24N2OCor e Forma:SolidPeso molecular:332.44Givinostat hydrochloride monohydrate
CAS:<p>Givinostat hydrochloride monohydrate (ITF2357) is an HDAC inhibitor.</p>Fórmula:C24H27N3O4·HCl·H2OPureza:97.97% - 99.51%Cor e Forma:SolidPeso molecular:475.97ZINC08438472
CAS:<p>ZINC08438472 is a selective peroxisome proliferator-activated receptors-α agonist.</p>Fórmula:C25H25NO8SPureza:98%Cor e Forma:SolidPeso molecular:499.53Topoisomerase I inhibitor 4
CAS:<p>Topoisomerase I inhibitor 4 targets cancer cells like HepG2, A549, MCF-7, HeLa with low IC50, promising for research.</p>Fórmula:C23H19FN4OCor e Forma:SolidPeso molecular:386.42WEHI-150
CAS:<p>WEHI-150, a mitoxantrone analog, cross-links DNA, targets methylated CpG, halts transcription, and avoids guanine N-2 interaction.</p>Fórmula:C22H30N6O4Cor e Forma:SolidPeso molecular:442.51Exatecan mesylate dihydrate
CAS:<p>Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].</p>Fórmula:C25H30FN3O9SPureza:98%Cor e Forma:SolidPeso molecular:567.58ZINC17167211
CAS:<p>ZINC17167211 is a selective peroxisome proliferator-activated receptors-α agonist.</p>Fórmula:C24H17FN2O6SPureza:98%Cor e Forma:SolidPeso molecular:480.46Ceralasertib formate
CAS:<p>Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.</p>Fórmula:C21H26N6O4SCor e Forma:SolidPeso molecular:458.54CAY10514
CAS:<p>CAY10514 is an aromatic analog of 8(S)-HETE. It acts as a dual agonist of PPARα and PPARγ with EC50 values of 0.173 and 0.642 μM, respectively.</p>Fórmula:C20H28O4Cor e Forma:SolidPeso molecular:332.43Ranimustine
CAS:<p>Ranimustine (MCNU) can be used for polycythemia vera and chronic myelogenous leukemia research, which is a nitrosourea alkylating agent [1] [3] [4].</p>Fórmula:C10H18ClN3O7Cor e Forma:SolidPeso molecular:327.72AA-CW236
CAS:<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Fórmula:C17H16ClF3N4O2Cor e Forma:SolidPeso molecular:400.78PPARδ agonist 8
CAS:<p>Pparδ agonist 8 is a potent agonist of Pparδ. Pparδ agonist 8 has potential for the study of nonalcoholic fatty liver disease (NAFLD).</p>Fórmula:C25H29NO5Cor e Forma:SolidPeso molecular:423.5DRF 2519
CAS:<p>DRF 2519 is an activator of PPAR-alpha and PPAR-gamma.</p>Fórmula:C20H18N2O5SCor e Forma:SolidPeso molecular:398.43CLX 0921
CAS:<p>CLX 0921, a PPAR gamma agonist, is used potentially for the treatment of type 2 diabetes.</p>Fórmula:C28H25NO7SPureza:98%Cor e Forma:SolidPeso molecular:519.57ARTD10/PARP10-IN-1
CAS:<p>ARTD10/PARP10-IN-1 is a PARP inhibitor that inhibits ARTD8/PARP14 and has anticancer and antitumour activity for the study of prostate cancer.</p>Fórmula:C12H12N2O4Pureza:99.14%Cor e Forma:SolidPeso molecular:248.23Gartisertib
CAS:<p>Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.</p>Fórmula:C25H29F2N9O3Pureza:99.52%Cor e Forma:SolidPeso molecular:541.55NSC-311068
CAS:<p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>Fórmula:C10H6N4O4SCor e Forma:SolidPeso molecular:278.24Daniquidone
CAS:<p>Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasms</p>Fórmula:C15H11N3OPureza:98.39% - 99.52%Cor e Forma:SolidPeso molecular:249.27ICRF-196
CAS:<p>ICRF-196 is a Topoisomerase II Inhibitor and antineoplastic agent.</p>Fórmula:C12H18N4O4Cor e Forma:SolidPeso molecular:282.3
