Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(50 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 963 produtos de "Dano de DNA/Reparo de DNA"
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Exatecan mesylate dihydrate
CAS:<p>Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].</p>Fórmula:C25H30FN3O9SPureza:98%Cor e Forma:SolidPeso molecular:567.58ATR-IN-16
CAS:<p>ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.</p>Fórmula:C19H25N7OCor e Forma:SolidPeso molecular:367.45MPT0G211
CAS:<p>MPT0G211: oral HDAC6 inhibitor with IC50=0.291 nM, 1000x selectivity, neuroprotective, anti-metastatic, crosses blood-brain barrier for Alzheimer's.</p>Fórmula:C17H15N3O2Pureza:98% - 99.88%Cor e Forma:SolidPeso molecular:293.32Saroglitazar
CAS:Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.Fórmula:C25H29NO4SPureza:98.51%Cor e Forma:SolidPeso molecular:439.57Daltroban
CAS:<p>Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist.</p>Fórmula:C16H16ClNO4SPureza:99.74%Cor e Forma:SolidPeso molecular:353.82ARH-049020
CAS:ARH-049020, a peroxisome proliferator-activated receptor (PPAR) agonist, is used potentially for the treatment of insulin resistance and type 2 diabetes.Fórmula:C24H31NO6Pureza:97.19% - 99.82%Cor e Forma:SolidPeso molecular:429.515-Aza-4'-thio-2'-deoxycytidine
CAS:<p>5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].</p>Fórmula:C8H12N4O3SCor e Forma:SolidPeso molecular:244.27Lobeglitazone Sulfate
CAS:Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.Fórmula:C24H26N4O9S2Pureza:99.6%Cor e Forma:SolidPeso molecular:578.61MLR24
CAS:<p>MLR24 is a selective modulator of PPARγ that acts by displaying robust anti-diabetic activity.</p>Fórmula:C28H24F3NO6Pureza:98%Cor e Forma:SolidPeso molecular:527.49XR-5000
CAS:<p>XR-5000 is a DNA topoisomerase I and II inhibitor.</p>Fórmula:C18H19N3OPureza:98%Cor e Forma:SolidPeso molecular:293.36Piroxantrone
CAS:<p>Piroxantrone (CI942; PD111815) is an anthrapyrazole antibiotic that disrupts DNA replication and repair, with limited cardiotoxicity and antineoplastic range.</p>Fórmula:C21H25N5O4Cor e Forma:SolidPeso molecular:411.456-Methyl-5-azacytidine
CAS:<p>6-Methyl-5-azacytidine is a potent DNMT inhibitor.</p>Fórmula:C9H14N4O5Pureza:98%Cor e Forma:SolidPeso molecular:258.23NS-220
CAS:NS-220 selectively activates PPAR-alpha, reducing triglycerides and glucose in KK-Ay mice, also altering lipoproteins.Fórmula:C21H27NO5Pureza:98%Cor e Forma:SolidPeso molecular:373.44BVT.13
CAS:<p>BVT.13 is used as a selective PPAR-gamma activator.</p>Fórmula:C18H11Cl2N3O4Cor e Forma:SolidPeso molecular:404.2CAY10514
CAS:<p>CAY10514 is an aromatic analog of 8(S)-HETE. It acts as a dual agonist of PPARα and PPARγ with EC50 values of 0.173 and 0.642 μM, respectively.</p>Fórmula:C20H28O4Cor e Forma:SolidPeso molecular:332.43Anticancer agent 75
CAS:<p>Anticancer agent 75: potent, selective, less toxic to kidneys than Doxorubicin by 35x, with antiplasmodial properties.</p>Fórmula:C22H24N2OCor e Forma:SolidPeso molecular:332.44L-796449
CAS:<p>L-796449 is an agonist of PPAR-gamma.</p>Fórmula:C28H27ClO4SPureza:98%Cor e Forma:SolidPeso molecular:495.03Ranimustine
CAS:<p>Ranimustine (MCNU) can be used for polycythemia vera and chronic myelogenous leukemia research, which is a nitrosourea alkylating agent [1] [3] [4].</p>Fórmula:C10H18ClN3O7Cor e Forma:SolidPeso molecular:327.72Topoisomerase I inhibitor 4
CAS:<p>Topoisomerase I inhibitor 4 targets cancer cells like HepG2, A549, MCF-7, HeLa with low IC50, promising for research.</p>Fórmula:C23H19FN4OCor e Forma:SolidPeso molecular:386.42WEHI-150
CAS:<p>WEHI-150, a mitoxantrone analog, cross-links DNA, targets methylated CpG, halts transcription, and avoids guanine N-2 interaction.</p>Fórmula:C22H30N6O4Cor e Forma:SolidPeso molecular:442.51RG-12525
CAS:<p>RG-12525（NID 525） is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of</p>Fórmula:C25H21N5O2Pureza:95.49%Cor e Forma:SolidPeso molecular:423.47Ceralasertib formate
CAS:<p>Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.</p>Fórmula:C21H26N6O4SCor e Forma:SolidPeso molecular:458.54GSK-7227
CAS:<p>GSK-7227 is a novel PPARδ partial agonist that upregulates target genes in muscle cells, indicating its potential role in modulating muscle metabolism and energy.</p>Fórmula:C25H22N2O6SPureza:99.17%Cor e Forma:SolidPeso molecular:478.52AA-CW236
CAS:<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Fórmula:C17H16ClF3N4O2Cor e Forma:SolidPeso molecular:400.78NC190 sodium
CAS:NC190 inhibits topoisomerase II, halts FM3A cell growth (IC50: 0.019 μg/ml in 48h), and suppresses DNA synthesis by 90% at 0.1 μg/ml.Fórmula:C23H22N4NaO5Pureza:98%Cor e Forma:SolidPeso molecular:457.442DB-959 (free base)
CAS:<p>DB-959 is a potential agonist of PPAR.</p>Fórmula:C25H27NO5Cor e Forma:SolidPeso molecular:421.49KDT 501 potassium
CAS:<p>KDT 501, a PPAR agonist and G protein-coupled receptor (GPR) 120 agonist, is used potentially for the treatment of type 2 diabetes.</p>Fórmula:C21H34KO5Pureza:98%Cor e Forma:SolidPeso molecular:405.596Mitobronitol
CAS:<p>Mitobronitol, a brominated mannitol analog, is an alkylating anticancer drug that aids in reducing allogeneic bone marrow transplant risks.</p>Fórmula:C6H12Br2O4Cor e Forma:SolidPeso molecular:307.97NC182
CAS:<p>NC182 is a topo II inhibitor that shows selective and potent topo II inhibition on the induction of topo II-dependent DNA fragmentation.</p>Fórmula:C24H24N4O5Pureza:98%Cor e Forma:SolidPeso molecular:448.47PPARδ agonist 8
CAS:<p>Pparδ agonist 8 is a potent agonist of Pparδ. Pparδ agonist 8 has potential for the study of nonalcoholic fatty liver disease (NAFLD).</p>Fórmula:C25H29NO5Cor e Forma:SolidPeso molecular:423.5Chloroquinoxaline sulfonamide
CAS:Chloroquinoxaline sulfonamide (Chloroquinoxaline) is an organic micropollutant with antimicrobial activity.Fórmula:C14H11ClN4O2SPureza:99.79% - 99.89%Cor e Forma:SolidPeso molecular:334.78Bobcat339 hydrochloride
CAS:<p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>Fórmula:C16H13Cl2N3OPureza:99.22%Cor e Forma:SolidPeso molecular:334.2L82
CAS:<p>L82: A selective, non-competitive DNA Lig1 inhibitor with anti-proliferative effects on breast cancer cells. IC50=12 μM.</p>Fórmula:C11H8ClN5O4Pureza:97.45% - 98.91%Cor e Forma:SolidPeso molecular:309.67ACY-957
CAS:<p>ACY-957: Oral HDAC1/2 inhibitor (IC50: HDAC1=7nM, HDAC2=18nM, HDAC3=1300nM); inactive on HDAC4/5/6/7/8/9.</p>Fórmula:C24H23N5OSPureza:99.79%Cor e Forma:SolidPeso molecular:429.54BRD4097
CAS:<p>BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve</p>Fórmula:C16H17N3O2Pureza:99.75%Cor e Forma:SolidPeso molecular:283.33BRD2492
CAS:<p>BRD2492 is an HDAC1 and HDAC2 inhibitor with antiproliferative activity, inhibits HDAC1/2 and induces apoptosis.</p>Fórmula:C20H18N4O2Pureza:99.56%Cor e Forma:SolidPeso molecular:346.38Dehydroepiandrosterone sulfate
CAS:<p>Dehydroepiandrosterone sulfate (PB-005) influences the migration of neurons, arborization of dendrites, and formation of new synapses.</p>Fórmula:C19H28O5SPureza:97.18%Cor e Forma:SolidPeso molecular:368.49SIRT6-IN-5
CAS:<p>SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.</p>Fórmula:C19H14N2O6Pureza:98.77%Cor e Forma:SolidPeso molecular:366.32Pegamotecan
CAS:<p>Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell</p>Fórmula:C52H48N6O14Pureza:96.40% - 97.83%Cor e Forma:SolidPeso molecular:980.984Suksdorfin
CAS:<p>Suksdorfin has hypoglycemic effects and activates PPARγ, which promotes insulin-dependent glucose uptake by adipocytes and can be used to study obesity .</p>Fórmula:C21H24O7Pureza:98.54%Cor e Forma:SolidPeso molecular:388.41BRD6688
CAS:<p>BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes</p>Fórmula:C16H18N4OPureza:97.53%Cor e Forma:SolidPeso molecular:282.34CEP-9722
CAS:<p>CEP-9722 is a PARP-1 and PARP-2 inhibitor with anticancer activity and is used in the study of ovarian cancer.</p>Fórmula:C24H26N4O3Pureza:98.38% - 98.56%Cor e Forma:SolidPeso molecular:418.49Vutiglabridin
CAS:<p>Vutiglabridin (HSG4112), a PON2 modulator, is more stable and aids weight loss than Glabridin. In phase 2 trials for obesity, shows promise for PD therapy.</p>Fórmula:C22H26O4Pureza:98.47% - 99.07%Cor e Forma:SolidPeso molecular:354.44Dazmegrel
CAS:<p>Dazmegrel (UK 38,485) is a thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy.</p>Fórmula:C16H17N3O2Pureza:98.81%Cor e Forma:SolidPeso molecular:283.33EB-47
CAS:<p>EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).</p>Fórmula:C24H27N9O6Pureza:99.81%Cor e Forma:SolidPeso molecular:537.53Linotroban
CAS:<p>Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.</p>Fórmula:C14H15NO5S2Pureza:97.95% - >99.99%Cor e Forma:SolidPeso molecular:341.4Alalevonadifloxacin
CAS:<p>Alalevonadifloxacin is a DNA gyrase and DNA topoisomerase inhibitor and a novel antibacterial compound of the quinolone class targeting MRSa.</p>Fórmula:C23H30FN3O8SPureza:99.75% - 99.82%Cor e Forma:SoildPeso molecular:527.56DN-1289
<p>DN-1289: oral, BBB-penetrating, selectively inhibits DLK (IC50=17nM) & LZK (IC50=40nM), blocks p-c-Jun in mouse optic nerve crush.</p>Fórmula:C18H19F4N7O2Pureza:98.56%Cor e Forma:SolidPeso molecular:441.38ISX-1
CAS:<p>ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.</p>Fórmula:C14H14N4O2SPureza:98.7%Cor e Forma:SolidPeso molecular:302.35SIRT5 inhibitor 1
CAS:SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Fórmula:C31H39FN6O6S2Pureza:97.8%Cor e Forma:SolidPeso molecular:674.81
