Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(50 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 962 produtos de "Dano de DNA/Reparo de DNA"
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Suksdorfin
CAS:<p>Suksdorfin has hypoglycemic effects and activates PPARγ, which promotes insulin-dependent glucose uptake by adipocytes and can be used to study obesity .</p>Fórmula:C21H24O7Pureza:98.54%Cor e Forma:SolidPeso molecular:388.41Bobcat339 hydrochloride
CAS:<p>Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.</p>Fórmula:C16H13Cl2N3OPureza:99.22%Cor e Forma:SolidPeso molecular:334.2Alalevonadifloxacin
CAS:<p>Alalevonadifloxacin is a DNA gyrase and DNA topoisomerase inhibitor and a novel antibacterial compound of the quinolone class targeting MRSa.</p>Fórmula:C23H30FN3O8SPureza:99.75% - 99.82%Cor e Forma:SoildPeso molecular:527.56Pegamotecan
CAS:<p>Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell</p>Fórmula:C52H48N6O14Pureza:96.40% - 97.83%Cor e Forma:SolidPeso molecular:980.984Miriplatin hydrate
CAS:Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).Fórmula:C34H70N2O5PtPureza:99.6%Cor e Forma:SolidPeso molecular:782.01BRD6688
CAS:<p>BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes</p>Fórmula:C16H18N4OPureza:97.53%Cor e Forma:SolidPeso molecular:282.34Tenifatecan
CAS:<p>Tenifatecan (SN2310) is a highly lipophilic preparation of 7-ethyl-10-hydroxycamptothecin (SN) with potential antitumor activity.</p>Fórmula:C55H72N2O9Pureza:99.58% - 99.82%Cor e Forma:SolidPeso molecular:905.17SS-208
CAS:<p>SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.</p>Fórmula:C13H11Cl2N3O4Pureza:99.69%Cor e Forma:SolidPeso molecular:344.15(R)-(-)-Rolipram
CAS:(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.Fórmula:C16H21NO3Pureza:99.54%Cor e Forma:SolidPeso molecular:275.34Givinostat hydrochloride
CAS:<p>Givinostat HCl (ITF2357 HCl) inhibits HDAC1/3 (IC50: 198/157 nM) with anti-inflammatory, anti-angiogenic, and antineoplastic properties.</p>Fórmula:C24H28ClN3O4Pureza:99.39%Cor e Forma:SolidPeso molecular:457.95EB-47
CAS:<p>EB-47 imitates NAD+, spans nicotinamide to adenosine sites, inhibits PARP-1 (IC50: 45 nM) and is less effective on ARTD5 (IC50: 410 nM).</p>Fórmula:C24H27N9O6Pureza:99.81%Cor e Forma:SolidPeso molecular:537.53CEP-9722
CAS:<p>CEP-9722 is a PARP-1 and PARP-2 inhibitor with anticancer activity and is used in the study of ovarian cancer.</p>Fórmula:C24H26N4O3Pureza:98.38% - 98.56%Cor e Forma:SolidPeso molecular:418.49ACY-957
CAS:<p>ACY-957: Oral HDAC1/2 inhibitor (IC50: HDAC1=7nM, HDAC2=18nM, HDAC3=1300nM); inactive on HDAC4/5/6/7/8/9.</p>Fórmula:C24H23N5OSPureza:99.79%Cor e Forma:SolidPeso molecular:429.54ACY-1083
CAS:<p>ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.</p>Fórmula:C17H18F2N4O2Pureza:99.19% - 99.43%Cor e Forma:SolidPeso molecular:348.35Ac-Exatecan
CAS:<p>Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.</p>Fórmula:C26H24FN3O5Pureza:97.09%Cor e Forma:SolidPeso molecular:477.48GNE-8505
CAS:<p>GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).</p>Fórmula:C21H24F3N5OCor e Forma:SolidPeso molecular:419.44PPARγ agonist 7
CAS:<p>PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ).</p>Fórmula:C20H30O6Cor e Forma:SolidPeso molecular:366.45SIRT-IN-1
CAS:<p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>Fórmula:C19H27N5O2SPureza:99.29%Cor e Forma:SolidPeso molecular:389.52Epigenetic factor-IN-1
CAS:<p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>Fórmula:C32H34FN5O6S2Pureza:98%Cor e Forma:SolidPeso molecular:667.77Duocarmycin analog-2
CAS:<p>Duocarmycin analog-2 is a potent DNA alkylating agent that exhibits antitumor effects and can be used in the synthesis of immunocouplers.</p>Fórmula:C29H23ClN4O3Cor e Forma:SolidPeso molecular:510.97Prostaglandin B3
CAS:<p>Prostaglandin B3 (PGB3) is a secondary alcohol belonging to the prostaglandin B class, characterized by its relatively low affinity for human PPARγ, exhibiting a K_i value greater than 1 mM, in contrast to PGB1 and PGB2, which have K_i values of 26.28 ± 8.7 μM and 77 ± 37.7 μM, respectively [1].</p>Fórmula:C20H28O4Cor e Forma:SolidPeso molecular:332.43PR-104A
CAS:<p>PR-104A is a hypoxia-targeted anticancer agent.</p>Fórmula:C14H19BrN4O9SCor e Forma:SolidPeso molecular:499.29TP0480066
CAS:<p>TP0480066 inhibits topoisomerase II, DNA gyrase (IC50=1.1nM), topo IV (IC50=62.89nM), effective against drug-resistant bacteria and N. gonorrhoeae.</p>Fórmula:C18H14FN3O5Cor e Forma:SolidPeso molecular:371.32KRP-101
CAS:<p>KRP-101, a PPARɑ agonist, is used potentially for the treatment of diabetes and hyperlipidaemia.</p>Fórmula:C26H26FNO5Cor e Forma:SolidPeso molecular:451.49ARN-21934
CAS:<p>ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.</p>Fórmula:C21H24N6Pureza:99.8%Cor e Forma:SolidPeso molecular:360.46Peliglitazar
CAS:<p>Peliglitazar is a activator of α/γ peroxisome proliferator-activated receptor.</p>Fórmula:C30H30N2O7Cor e Forma:SolidPeso molecular:530.57DNA-PK-IN-10
CAS:<p>DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].</p>Fórmula:C25H28N6O2Pureza:98%Cor e Forma:SolidPeso molecular:444.53ATR-IN-13
CAS:<p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>Fórmula:C24H24FN9OCor e Forma:SolidPeso molecular:473.51L-783483
CAS:<p>L-783483 is an agonist of PPAR.</p>Fórmula:C22H21ClF3NO4SPureza:98%Cor e Forma:SolidPeso molecular:487.92SR 2595
CAS:<p>SR2595 is an inverse agonist of nuclear receptor PPARγ with an IC 50 of 30 nM [1].</p>Fórmula:C37H38N2O3Cor e Forma:SolidPeso molecular:558.71LCB-2853
CAS:<p>LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.</p>Fórmula:C21H24ClNO4SPureza:97.15%Cor e Forma:SolidPeso molecular:421.94GSK-3484862
CAS:<p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>Fórmula:C19H19N5OSPureza:99.87% - 99.963%Cor e Forma:SolidPeso molecular:365.45CAY10410
CAS:<p>CAY10410 is a PGD2/PGJ2 analog, modified for enhanced PPARγ activity and metabolic stability, non-toxic to SH-SY5Y cells at ≤25μM.</p>Fórmula:C20H30O3Cor e Forma:SolidPeso molecular:318.45XY-4
CAS:<p>XY-4, a derivative of 1-palmitoyl lysophosphatidic acid (1-palmitoyl LPA094) and an agonist of peroxisome proliferator-activated receptor γ (PPARγ), effectively</p>Fórmula:C19H37F2O6PCor e Forma:SolidPeso molecular:430.46K-756
CAS:<p>K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity of TNKS1 (IC50 = 31 nM) and TNKS2 (IC50 = 36 nM).</p>Fórmula:C24H27N5O3Pureza:99.81%Cor e Forma:SolidPeso molecular:433.5DS-6930
CAS:<p>DS-6930 is an potent and selective PPAR γ Agonists with EC50 of 41 nM.</p>Fórmula:C23H21N3O4Cor e Forma:SolidPeso molecular:403.43Makaluvamine A
CAS:<p>Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors.</p>Fórmula:C11H11N3OCor e Forma:SolidPeso molecular:201.22Sirtuin modulator 1
CAS:Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Fórmula:C31H32ClN5O2S2Pureza:99.63%Cor e Forma:SolidPeso molecular:606.2BO 2367
CAS:<p>BO 2367, a topoisomerase inhibitor, is used to suppress the growth of tumor .</p>Fórmula:C21H22ClF2N3O3Cor e Forma:SolidPeso molecular:437.87AZD4619
CAS:<p>AZD4619 is a potent, selective and reversible orally bioavailable agonist of PPARα receptor.</p>Fórmula:C25H26O8S2Cor e Forma:SolidPeso molecular:518.6ZL-2201
CAS:<p>ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.</p>Fórmula:C20H25N9O5SPureza:98%Cor e Forma:SolidPeso molecular:503.54Sipoglitazar
CAS:<p>Sipoglitazar, a PPARγ agonist, is used potentially for the treatment of diabetes.</p>Fórmula:C25H25N3O4SPureza:98%Cor e Forma:SolidPeso molecular:463.55SU-11752
CAS:<p>SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.</p>Fórmula:C26H27N3O5SCor e Forma:SolidPeso molecular:493.57ATR-IN-21
CAS:<p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>Fórmula:C23H27N7OPureza:98%Cor e Forma:SolidPeso molecular:417.51AZ 5704
CAS:<p>ATM kinase inhibitor with 0.6 nM IC50, >600-fold selective, enhances irinotecan effects, oral use.</p>Fórmula:C23H23FN6O2Cor e Forma:SolidPeso molecular:434.479-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS:<p>9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential</p>Fórmula:C22H18ClFN2O4Pureza:98%Cor e Forma:SolidPeso molecular:428.84ATR-IN-20
<p>ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.</p>Fórmula:C29H31N5O4SCor e Forma:SolidPeso molecular:545.659A1P9
CAS:<p>9A1P9, a multi-tail ionizable cationic phospholipid, facilitates membrane destabilization and is applicable for CRISPR-Cas9 gene editing in mice [1].</p>Fórmula:C27H58NO4PCor e Forma:SolidPeso molecular:491.73LMP744 hydrochloride
CAS:<p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>Fórmula:C24H25ClN2O7Pureza:99.59% - 99.85%Cor e Forma:SolidPeso molecular:488.92Pparδ agonist 1
CAS:<p>Pparδ agonist 1 is an agonist of PPAR-δ(EC50 of 5.06 nM).</p>Fórmula:C26H27NO5Pureza:98%Cor e Forma:SolidPeso molecular:433.5
