Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 958 produtos de "Dano de DNA/Reparo de DNA"
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Tafluposide
CAS:<p>Tafluposide is a DNA topoisomerase inhibitor with anti-tumor activity.</p>Fórmula:C45H35F10O20PCor e Forma:SolidPeso molecular:1116.713DNA gyrase/Topo IV-IN-1
<p>DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of DNA gyrase and topoisomerase IV with antibacterial properties. It exhibits IC50 values of 11 and 17 nM against the DNA gyrase of Escherichia coli and methicillin-resistant Staphylococcus aureus, respectively, and IC50 values of 83 and 21 nM against topoisomerase IV of the same organisms. DNA gyrase/Topo IV-IN-1 is applicable in anti-infective research.</p>Fórmula:C44H59NO8Cor e Forma:SolidPeso molecular:729.941Antitumor agent-28
CAS:<p>Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.</p>Fórmula:C25H32N6O4SCor e Forma:SolidPeso molecular:512.63Wistin
CAS:<p>Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .</p>Fórmula:C23H24O10Cor e Forma:SolidPeso molecular:460.43WAY-323061
CAS:<p>WAY-323061 is a SIRT2 inhibitor.</p>Fórmula:C25H21N5O2SPureza:99.33%Cor e Forma:SolidPeso molecular:455.53Hippeastrine Hydrobromide
CAS:<p>Hippeastrine hydrobromide is a natural alkaloid which demonstrates significant cytotoxicity against a panel of human and murine tumor cell lines.</p>Fórmula:C17H18BrNO5Cor e Forma:SolidPeso molecular:396.237Sulotroban
CAS:<p>sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.</p>Fórmula:C16H17NO5SPureza:98.86% - 99.88%Cor e Forma:SolidPeso molecular:335.37TAS-103
CAS:<p>TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.</p>Fórmula:C20H19N3O2Cor e Forma:SolidPeso molecular:333.38Leriglitazone hydrochloride
CAS:<p>Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.</p>Fórmula:C19H21ClN2O4SCor e Forma:SolidPeso molecular:408.90DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Cor e Forma:Odour SolidCUDA disodium
<p>CUDA disodium is an effective, soluble epoxide hydrolase (sEH) inhibitor, with IC50 values of 11.1 nM for murine sEH and 112 nM for human sEH. It selectively enhances the activity of peroxisome proliferator-activated receptor PPARalpha. CUDA disodium may be valuable for cardiovascular disease research.</p>Cor e Forma:Odour SolidGW 1929 hydrochloride
CAS:<p>Oral PPARγ agonist with pEC50 of 8.05; low affinity for PPARα, PPARδ. Reduces blood glucose, fatty acids, triglycerides in vivo.</p>Fórmula:C30H30ClN3O4Cor e Forma:SolidPeso molecular:532.04PR-104 sodium
CAS:<p>PR-104 sodium: hypoxia-activated, tumor-targeting pre-prodrug; turns into PR-104A for research.</p>Fórmula:C14H19BrN4NaO12PSCor e Forma:SolidPeso molecular:601.25Banoxantrone (D12)
CAS:<p>Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.</p>Fórmula:C22H28N4O6Pureza:98%Cor e Forma:SolidPeso molecular:456.55Gemfibrozil 1-O-β-glucuronide
CAS:<p>Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil , is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.</p>Fórmula:C21H30O9Pureza:98%Cor e Forma:SolidPeso molecular:426.46ARN24139
<p>ARN24139: a topoisomerase II poison; IC50=7.3μM. Inhibits DU145, HeLa, A549 cell growth; IC50s=4.7, 3.8, 3.1μM.</p>Cor e Forma:SolidMethylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Cor e Forma:Odour Solid15-deoxy-Δ-12,14-Prostaglandin J2
CAS:<p>15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.</p>Fórmula:C20H28O3Pureza:98%Cor e Forma:Neat OilPeso molecular:316.43Monascin
CAS:<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Fórmula:C21H26O5Pureza:98%Cor e Forma:SolidPeso molecular:358.43CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Fórmula:C26H26N4O4Pureza:98%Cor e Forma:SolidPeso molecular:458.51DB1255 2TFA
<p>DB1255 2TFA is an ERG/DNA binding inhibitor with an unusual and potent monomer binding pattern at the minor groove site for the study of genetic disorders.</p>Fórmula:C26H20F6N4O4S2Pureza:98.32%Cor e Forma:SolidPeso molecular:630.5825-Hydroxytachysterol3
CAS:<p>25-Hydroxytachysterol3 is a metabolite of Vitamin D3 that inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts while promoting the differentiation of keratinocytes and the expression of antioxidant-related genes. It activates receptors including the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXRα/β), and peroxisome proliferator-activated receptor γ (PPARγ), and enhances the expression of CYP24A1.</p>Fórmula:C27H44O2Cor e Forma:SolidPeso molecular:400.64CL2-MMT-SN38
CAS:<p>CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.</p>Fórmula:C102H122N12O24Cor e Forma:SolidPeso molecular:1900.158(±)9-HEPE
CAS:<p>(±)9-HEPE is produced by non-enzymatic oxidation of EPA.</p>Fórmula:C20H30O3Cor e Forma:SolidPeso molecular:318.457HDAC6-IN-50
<p>HDAC6-IN-50 (Compound 4) is an effective inhibitor of HDAC6 with an IC50 value of 35 nM. It is utilized in the study of Parkinson's disease (PD) and Alzheimer's disease (AD).</p>Cor e Forma:Odour SolidTRF1-TIN2 interaction-IN-1
<p>TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM). By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.</p>Fórmula:C19H18O6SCor e Forma:SolidPeso molecular:374.411-O-Hexadecyl-Rac-Glycerol
CAS:<p>1-O-Hexadecyl-Rac-Glycerol (1-O-Hexadecylglycerol) is a marine derived natural products found in Tritoniella belli.</p>Fórmula:C19H40O3Pureza:99.94%Cor e Forma:SolidPeso molecular:316.52Gimatecan HCl
<p>Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Fórmula:C25H26ClN3O5Pureza:97.04%Cor e Forma:SoildPeso molecular:483.94Multi-target kinase inhibitor 4
<p>Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.</p>Cor e Forma:Odour SolidHippeastrine
CAS:<p>Hippeastrine is an alkaloid that inhibits Top I dose-dependently with a 7.25 μg/mL IC50 and has anticancer properties.</p>Fórmula:C17H17NO5Cor e Forma:SolidPeso molecular:315.32Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Fórmula:C34H46N6O6SPureza:99.52%Cor e Forma:SolidPeso molecular:666.83(±)4(5)-DiHDPA lactone
CAS:<p>(±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET , which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5</p>Fórmula:C22H32O3Cor e Forma:SolidPeso molecular:344.495CP 84364
CAS:<p>CP 84364 is a metabolite of CP-80794.</p>Fórmula:C14H18N2O4Cor e Forma:SolidPeso molecular:278.30AsCas12a Nuclease
<p>AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.</p>HDAC-IN-52
CAS:<p>HDAC-IN-52: Pyridine-based inhibitor for HDAC1/2/3/10 with IC50s 0.189-0.446 μM, used in cancer studies.</p>Fórmula:C24H20N4O2Pureza:99.47%Cor e Forma:SolidPeso molecular:396.4417-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Fórmula:C22H32O3Cor e Forma:SolidPeso molecular:344.49517-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:<p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>Fórmula:C22H30O3Cor e Forma:SolidPeso molecular:342.479Saroglitazar Magnesium
CAS:<p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>Fórmula:C50H56MgN2O8S2Pureza:98.1%Cor e Forma:SolidPeso molecular:901.43Stearolic acid
CAS:<p>Stearolic acid is a useful organic compound for research related to life sciences. The catalog number is T124753 and the CAS number is 506-24-1.</p>Fórmula:C18H32O2Cor e Forma:SolidPeso molecular:280.452Amorfrutin B
CAS:<p>Amorfrutin B is a useful organic compound for research related to life sciences. The catalog number is T124211 and the CAS number is 78916-42-4.</p>Fórmula:C26H32O4Cor e Forma:SolidPeso molecular:408.538STAT3/HDAC-IN-2
<p>STAT3/HDAC-IN-2 (compound 18), a dual inhibitor of STAT3 and HDAC, promotes autophagy and apoptosis. This compound features an amphiphilic hydroxamic acid hybrid structure, derived from the natural product isopropanol lactone (IAL), and functions as a nanoscale anticancer agent. It has the ability to self-assemble into nanoparticles in aqueous environments, leading to enhanced tumor tissue accumulation, increased cellular uptake, and improved anticancer efficacy compared to its free state.</p>Fórmula:C28H32N2O7Cor e Forma:SolidPeso molecular:508.56Larsucosterol Ammonium salt
CAS:<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Cor e Forma:SoildPeso molecular:499.75PDPH Crosslinker
CAS:<p>PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.</p>Fórmula:C8H11N3OS2Cor e Forma:SolidPeso molecular:229.32GJ071 oxalate
CAS:<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Fórmula:C20H29N3O7SPureza:99.97%Cor e Forma:SolidPeso molecular:455.53SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Fórmula:C22H24N2O9SCor e Forma:SolidPeso molecular:492.5HDAC-IN-76
HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.Fórmula:C27H26N4O4Cor e Forma:SolidPeso molecular:470.52(iso)-BRD20322
CAS:<p>(iso)-BRD20322 is an isomer of BRD20322, a novel potent inhibitor of spCas9，disrupts the binding of spCas9 to DNA and reduces non-specific DNA editing events.</p>Fórmula:C27H31N3O2Pureza:99.60% - 99.60%Cor e Forma:SoildPeso molecular:429.55CHDI 00484077
CAS:<p>CHDI 00484077 is a highly selective, central nervous system (CNS) permeable Class IIa HDAC inhibitor, and can be used to study Huntington's disease.</p>Fórmula:C18H21F3N4O2Pureza:99.26%Cor e Forma:SolidPeso molecular:382.38HDAC1/6-IN-2
<p>HDAC1/6-IN-2 (I-c4), a dual inhibitor of HDAC1 and HDAC6, exhibits potent activity with IC50 values of 3.1 nM for HDAC1 and 2.95 nM for HDAC6. This compound demonstrates notable antitumor activity.</p>Fórmula:C22H17FN4O3Cor e Forma:SolidPeso molecular:404.391-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
CAS:<p>Phospholipid with stearic and docosahexaenoic acids used in membrane studies; decreases in ALS mouse model.</p>Fórmula:C48H84NO8PCor e Forma:SolidPeso molecular:834.16
