Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 958 produtos de "Dano de DNA/Reparo de DNA"
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Anti-obesity agent 1
<p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>Fórmula:C21H22N2O6Cor e Forma:SolidPeso molecular:398.409Wistin
CAS:<p>Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .</p>Fórmula:C23H24O10Cor e Forma:SolidPeso molecular:460.43Topoisomerases/ribosomes-IN-1
<p>Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).</p>Fórmula:C53H83FN6O15Cor e Forma:SolidPeso molecular:1063.26Monascin
CAS:<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Fórmula:C21H26O5Pureza:98%Cor e Forma:SolidPeso molecular:358.43Nanaomycin A
CAS:<p>Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).</p>Fórmula:C16H14O6Pureza:98%Cor e Forma:SolidPeso molecular:302.28VH 032 amide-PEG1-acid
CAS:<p>VHL ligand for PROTAC R&D; E3 ligase with PEG1 linker and carboxylic acid for target conjugation.</p>Fórmula:C28H38N4O7SCor e Forma:SolidPeso molecular:574.69SMPB Crosslinker
CAS:<p>SMPB crosslinker reacts with sulfhydryl/amino groups, has a longer chain than MBS, and a non-cleavable spacer arm.</p>Fórmula:C18H16N2O6Pureza:98%Cor e Forma:SolidPeso molecular:356.33Amrubicin
CAS:<p>The compound is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II.</p>Fórmula:C25H25NO9Pureza:98%Cor e Forma:SolidPeso molecular:483.47Silatecan
CAS:<p>Silatecan is a useful organic compound for research related to life sciences. The catalog number is T67968 and the CAS number is 220913-32-6.</p>Fórmula:C26H30N2O5SiCor e Forma:SoildPeso molecular:478.61DMT-dG(ib) Phosphoramidite
CAS:<p>DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.</p>Fórmula:C44H54N7O8PPureza:99.21%Cor e Forma:SolidPeso molecular:839.92CHDI 00484077
CAS:<p>CHDI 00484077 is a highly selective, central nervous system (CNS) permeable Class IIa HDAC inhibitor, and can be used to study Huntington's disease.</p>Fórmula:C18H21F3N4O2Pureza:99.26%Cor e Forma:SolidPeso molecular:382.38ARN24139
<p>ARN24139: a topoisomerase II poison; IC50=7.3μM. Inhibits DU145, HeLa, A549 cell growth; IC50s=4.7, 3.8, 3.1μM.</p>Cor e Forma:SolidSJ-106C
<p>SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.</p>Cor e Forma:Odour SolidHDAC-IN-76
HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.Fórmula:C27H26N4O4Cor e Forma:SolidPeso molecular:470.52SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Fórmula:C22H24N2O9SCor e Forma:SolidPeso molecular:492.5Leriglitazone
CAS:<p>Leriglitazone, pioglitazone's metabolite, is a PPARγ agonist (Ki:1.2μM, EC50:680nM), enhancing transcription and stabilizing AF-2.</p>Fórmula:C19H20N2O4SPureza:98%Cor e Forma:SolidPeso molecular:372.44Larsucosterol Ammonium salt
CAS:<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Cor e Forma:SoildPeso molecular:499.75CAY10599
CAS:<p>CAY10599 has a wide range of applications in life science related research.</p>Fórmula:C38H41NO5Cor e Forma:SolidPeso molecular:591.748STAT3/HDAC-IN-2
<p>STAT3/HDAC-IN-2 (compound 18), a dual inhibitor of STAT3 and HDAC, promotes autophagy and apoptosis. This compound features an amphiphilic hydroxamic acid hybrid structure, derived from the natural product isopropanol lactone (IAL), and functions as a nanoscale anticancer agent. It has the ability to self-assemble into nanoparticles in aqueous environments, leading to enhanced tumor tissue accumulation, increased cellular uptake, and improved anticancer efficacy compared to its free state.</p>Fórmula:C28H32N2O7Cor e Forma:SolidPeso molecular:508.56CL2-MMT-SN38
CAS:<p>CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.</p>Fórmula:C102H122N12O24Cor e Forma:SolidPeso molecular:1900.15823-epi-26-Deoxyactein
CAS:<p>23-epi-26-Deoxyactein is a naturally occurring compound exhibiting anti-obesity and anti-cancer properties when administered orally [1] [2] [3].</p>Fórmula:C37H56O10Cor e Forma:SolidPeso molecular:660.83CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Fórmula:C26H26N4O4Pureza:98%Cor e Forma:SolidPeso molecular:458.5117-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Fórmula:C22H32O3Cor e Forma:SolidPeso molecular:344.49515-deoxy-Δ-12,14-Prostaglandin J2
CAS:<p>15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.</p>Fórmula:C20H28O3Pureza:98%Cor e Forma:Neat OilPeso molecular:316.43Top1/2-IN-1
<p>Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.</p>Fórmula:C21H21N3O2Cor e Forma:SolidPeso molecular:347.41Leriglitazone hydrochloride
CAS:<p>Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.</p>Fórmula:C19H21ClN2O4SCor e Forma:SolidPeso molecular:408.90SP4e
<p>SP4e is a PPAR-γ activator.SP4e was effective in decreasing blood glucose, total cholesterol, triglycerides and LDL levels and increasing HDL levels.</p>Fórmula:C22H17ClN2O2S2Pureza:99.79%Cor e Forma:SoildPeso molecular:440.97Topoisomerase IIα-IN-9
CAS:Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C14H14O4SCor e Forma:SolidPeso molecular:278.32NSC 370284
CAS:<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Fórmula:C21H25NO6Pureza:99.74%Cor e Forma:SolidPeso molecular:387.43Saroglitazar Magnesium
CAS:<p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>Fórmula:C50H56MgN2O8S2Pureza:98.1%Cor e Forma:SolidPeso molecular:901.43Elomotecan
CAS:<p>Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II.Cost-effective and quality-assured.</p>Fórmula:C29H32ClN3O4Cor e Forma:SolidPeso molecular:522.04(R)-VX-984
CAS:<p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>Fórmula:C23H21D2N7OPureza:98%Cor e Forma:SolidPeso molecular:415.49Prednimustine
CAS:<p>Prednimustine (Leo 1031; NSC 134087), an ester of Prednisolone and Chlorambucil, is used in leukemia and lymphoma studies.</p>Fórmula:C35H45Cl2NO6Cor e Forma:SolidPeso molecular:646.64GJ071 oxalate
CAS:<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Fórmula:C20H29N3O7SPureza:99.97%Cor e Forma:SolidPeso molecular:455.53Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Fórmula:C34H46N6O6SPureza:99.52%Cor e Forma:SolidPeso molecular:666.83PPAR agonist 6
<p>PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].</p>Cor e Forma:Odour SolidTibesaikosaponin V
CAS:<p>TKV, a triterpene diglycoside from Bupleurum chinense, curbs lipid build-up and fat content in adipocytes without harm and hinders fat cell differentiation.</p>Fórmula:C42H68O15Cor e Forma:SolidPeso molecular:812.98PPARγ/GR modulator 1
<p>PPARγ/GR Modulator 1, an orally active dual agonist for the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Glucocorticoid Receptor (GR), exhibits</p>Fórmula:C14H10FNO4Cor e Forma:SolidPeso molecular:275.23TUG-499
CAS:<p>TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors</p>Fórmula:C16H11Cl2NO2Pureza:99.93%Cor e Forma:SoildPeso molecular:320.17PARP/HDAC-IN-1
<p>PARP/HDAC-IN-1 is a PARP and HDAC inhibitor that inhibits PARP1, PARP2, and HDAC1, and may be used to study pancreatic cancer.</p>Fórmula:C36H32F2N6O3Pureza:95.00%Cor e Forma:SolidPeso molecular:634.67Sibiromycin
CAS:<p>Sibiromycin: natural, potent antitumor PBD that binds DNA's minor groove at guanine NH2.</p>Fórmula:C24H33N3O7Cor e Forma:SolidPeso molecular:475.542Hippeastrine Hydrobromide
CAS:<p>Hippeastrine hydrobromide is a natural alkaloid which demonstrates significant cytotoxicity against a panel of human and murine tumor cell lines.</p>Fórmula:C17H18BrNO5Cor e Forma:SolidPeso molecular:396.237AZD-5099
CAS:<p>AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection.</p>Fórmula:C21H27Cl2N5O6SCor e Forma:SolidPeso molecular:548.44GSK3735967
CAS:<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Fórmula:C25H31N7OSCor e Forma:SolidPeso molecular:477.62Sulotroban
CAS:<p>sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.</p>Fórmula:C16H17NO5SPureza:98.86% - 99.88%Cor e Forma:SolidPeso molecular:335.37Ciprofibrate impurity A
CAS:<p>Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate is a PPARα agonist[1].</p>Fórmula:C12H14O3Cor e Forma:SolidPeso molecular:206.241Antitumor agent-28
CAS:<p>Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.</p>Fórmula:C25H32N6O4SCor e Forma:SolidPeso molecular:512.631-O-Hexadecyl-Rac-Glycerol
CAS:<p>1-O-Hexadecyl-Rac-Glycerol (1-O-Hexadecylglycerol) is a marine derived natural products found in Tritoniella belli.</p>Fórmula:C19H40O3Pureza:99.94%Cor e Forma:SolidPeso molecular:316.52Z26395438
CAS:<p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>Fórmula:C17H15FN2OPureza:99.63%Cor e Forma:SolidPeso molecular:282.31Becatecarin
CAS:<p>Becatecarin, water-soluble and anti-cancer, inhibits topoisomerases I/II and induces DNA cleavage and apoptosis; has myelosuppressive effects; ABCG2 substrate.</p>Fórmula:C33H34Cl2N4O7Cor e Forma:SolidPeso molecular:669.56
