Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 958 produtos de "Dano de DNA/Reparo de DNA"
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Colibactin 742
CAS:<p>Colibactin 742, a stable derivative of colibactin, efficiently induces DNA interstrand cross-links, activates the Fanconi Anemia DNA repair pathway, and leads</p>Fórmula:C37H42N8O5S2Cor e Forma:SolidPeso molecular:742.91BML-278
CAS:<p>BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and</p>Fórmula:C24H25NO4Pureza:99.53%Cor e Forma:SolidPeso molecular:391.46SCR7
CAS:<p>SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).</p>Fórmula:C18H14N4OSPureza:98%Cor e Forma:SolidPeso molecular:334.4(±)9-HEPE
CAS:<p>(±)9-HEPE is produced by non-enzymatic oxidation of EPA.</p>Fórmula:C20H30O3Cor e Forma:SolidPeso molecular:318.457Tibesaikosaponin V
CAS:<p>TKV, a triterpene diglycoside from Bupleurum chinense, curbs lipid build-up and fat content in adipocytes without harm and hinders fat cell differentiation.</p>Fórmula:C42H68O15Cor e Forma:SolidPeso molecular:812.98Melphalan
CAS:<p>Melphalan is an alkylating agent. It has been used in combination with the HDAC inhibitor as a drug for the treatment of multiple myeloma (MM) cell lines and as a chemotherapy agent for breast cancer cell lines.</p>Fórmula:C13H18Cl2N2O2Peso molecular:305.21Leriglitazone hydrochloride
CAS:<p>Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.</p>Fórmula:C19H21ClN2O4SCor e Forma:SolidPeso molecular:408.90MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Cor e Forma:Odour SolidPhosphoramide mustard
CAS:<p>Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.</p>Fórmula:C4H11Cl2N2O2PPureza:93.00%Cor e Forma:SolidPeso molecular:221.02GSK3735967
CAS:<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Fórmula:C25H31N7OSCor e Forma:SolidPeso molecular:477.62BRD7586
CAS:<p>BRD7586 is a cell-permeable small molecule inhibitor of SpCas9 that enhances SpCas9 specificity.</p>Fórmula:C17H14ClN3O3S2Pureza:97.70% - 99.03%Cor e Forma:SolidPeso molecular:407.89VK-1727
<p>VK-1727 inhibits EBNA1 DNA binding, reducing proliferation of EBV-positive cells while sparing EBV-negative cells, useful for multiple sclerosis research.</p>Fórmula:C29H25NO4Pureza:98.074%Cor e Forma:SolidPeso molecular:451.512'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:<p>2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.</p>Fórmula:C9H13ClFN3O4Pureza:99.69%Cor e Forma:SolidPeso molecular:281.67(4-NH2)-Exatecan
CAS:<p>(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).</p>Fórmula:C23H21N3O4Pureza:99.89%Cor e Forma:SolidPeso molecular:403.43O6BTG-octylglucoside
CAS:O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Fórmula:C24H34BrN5O7SPureza:98%Cor e Forma:SolidPeso molecular:616.53Banoxantrone dihydrochloride
CAS:<p>Banoxantrone dihydrochloride (AQ4N dihydrochloride) is a novel hypoxic cytotoxin that selectively kills hypoxic cells through an iNOS-dependent mechanism.</p>Fórmula:C22H30Cl2N4O6Pureza:99.88%Cor e Forma:SolidPeso molecular:517.45'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
CAS:<p>5'-O-DMT-dU, a dUTPase inhibitor (Ki > 1 mM) for E. coli, is used in DNA synthesis.</p>Fórmula:C30H30N2O7Cor e Forma:SolidPeso molecular:530.57Heptaplatin
CAS:<p>Heptaplatin, an anticancer platinum compound, counters many cancers, including cisplatin-resistant types, with a 17% response rate and tolerable toxicity.</p>Fórmula:C11H20N2O6PtCor e Forma:White Crystalline PowderPeso molecular:471.36HDAC-IN-4
CAS:<p>HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.</p>Fórmula:C20H21N3O2Cor e Forma:SolidPeso molecular:335.4SIRT5 inhibitor 3
CAS:<p>SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .</p>Fórmula:C22H12FN3O4Pureza:98%Cor e Forma:SolidPeso molecular:401.35Methyl methanesulfonate (Standard)
CAS:<p>Methyl methanesulfonate (Standard) is a standard material used in the analysis of methyl methanesulfonate, typically referenced in its research and analysis.</p>Fórmula:C2H6O3SCor e Forma:SolidPeso molecular:110.13Balaglitazone
CAS:<p>Balaglitazone is a PPARγ agonist that regulates blood glucose and is used in studies of heart failure and myocardial infarction.</p>Fórmula:C20H17N3O4SPureza:99.74%Cor e Forma:SolidPeso molecular:395.43CP-868388 free base
CAS:<p>CP-868388 free base (CP-868388) is a PPARα agonist with hypolipidemic and anti-inflammatory activity and is used in the study of dyslipidemia.</p>Fórmula:C26H33NO5Pureza:99.84%Cor e Forma:SolidPeso molecular:439.54(R)-(+)-Bay-K-8644
CAS:<p>(R)-(+)-Bay-K-8644, a Ca2+ channel agonist, is a dihydropyridine agonist that induces central respiratory depression and inhibits platelet activation in cats.</p>Fórmula:C16H15F3N2O4Pureza:96.51% - 96.51%Cor e Forma:SolidPeso molecular:356.3Gepotidacin
CAS:<p>Gepotidacin is a triazaacenaphthylene antibacterial inhibiting bacterial type II topoisomerase with lower resistance potential than fluoroquinolones.</p>Fórmula:C24H28N6O3Pureza:99.88%Cor e Forma:SolidPeso molecular:448.52AMA-37
CAS:<p>AMA-37 is a selective, reversible, and ATP-competitive DNA-PK inhibitor.</p>Fórmula:C17H17NO3Pureza:98%Cor e Forma:SolidPeso molecular:283.32Daun02
CAS:<p>Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.</p>Fórmula:C41H44N2O20Pureza:98%Cor e Forma:SolidPeso molecular:884.79Gancaonin L
CAS:<p>Gancaonin L is a natural product that can be used as a reference standard. The CAS number of Gancaonin L is 129145-50-2.</p>Fórmula:C20H18O6Cor e Forma:SolidPeso molecular:354.3589-Hydroxyellipticin free base
CAS:<p>9-hydroxyellipticine is a potent cytotoxic and antitumor agent. 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine.</p>Fórmula:C17H14N2OCor e Forma:SolidPeso molecular:262.31Phosphoramide mustard cyclohexanamine
CAS:<p>Phosphoramide mustard cyclohexanamine is active metabolite of cyclophosphamide, an alkylating agent that cross-links DNA strands,causes cell death, antitumor.</p>Fórmula:C10H24Cl2N3O2PPureza:95%Cor e Forma:SolidPeso molecular:320.2RPR121056
CAS:<p>RPR121056 is a Irinotecan metabolite, which is generated by CYP3A4. Irinotecan is an antineoplastic agent that inhibits topoisomerase type I.</p>Fórmula:C33H38N4O8Pureza:98%Cor e Forma:SolidPeso molecular:618.68Gatifloxacin mesylate
CAS:<p>Gatifloxacin mesylate, a 4th-gen fluoroquinolone antibiotic, inhibits DNA gyrase and topoisomerase IV.</p>Fórmula:C20H26FN3O7SPureza:98%Cor e Forma:SolidPeso molecular:471.5Gatifloxacin sesquihydrate
CAS:<p>Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia.</p>Fórmula:C19H24FN3O5Cor e Forma:SolidPeso molecular:393.41Telomerase-IN-3
CAS:<p>Telomerase-IN-3 is an inhibitor of telomerase.</p>Fórmula:C19H16ClN5O3Pureza:98%Cor e Forma:SolidPeso molecular:397.82Epitalon
CAS:<p>Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in the pineal gland.</p>Fórmula:C14H22N4O9Pureza:98%Cor e Forma:SolidPeso molecular:390.35(R)-GSK-3685032
CAS:<p>(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.</p>Fórmula:C22H24N6OSCor e Forma:SolidPeso molecular:420.54Ciprofloxacin hydrochloride monohydrate
CAS:<p>Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) is a fluoroquinolone antibiotic with potent antibacterial activity.</p>Fórmula:C17H21ClFN3O4Pureza:99.23% - 99.85%Cor e Forma:White Or Yellowish Crystalline PowderPeso molecular:385.82PTGR2-IN-1
CAS:<p>PTGR2-IN-1 is a potent inhibito of PTGR2r. PTGR2-IN-1 increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells.</p>Fórmula:C19H22N2O2Pureza:99.13%Cor e Forma:SolidPeso molecular:310.39YK-3-237
CAS:<p>YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative</p>Fórmula:C19H21BO7Pureza:99.47%Cor e Forma:SolidPeso molecular:372.18Pentamidine dihydrochloride
CAS:<p>Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (</p>Fórmula:C19H26Cl2N4O2Pureza:99.80%Cor e Forma:SolidPeso molecular:413.34Pixantrone dimaleate
CAS:<p>Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.</p>Fórmula:C25H27N5O10Pureza:98.70% - 99.11%Cor e Forma:SolidPeso molecular:557.21Silver sulfadiazine
CAS:<p>Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.</p>Fórmula:C10H9AgN4O2SPureza:99.04% - 99.58%Cor e Forma:SolidPeso molecular:357.14BYK204165
CAS:<p>BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)</p>Fórmula:C15H12N2O2Pureza:99.61%Cor e Forma:SolidPeso molecular:252.27AK-7
CAS:<p>AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.</p>Fórmula:C19H21BrN2O3SPureza:98.43% - 99.34%Cor e Forma:SolidPeso molecular:437.35Voxtalisib
CAS:<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Fórmula:C13H14N6OPureza:98.21% - 99.69%Cor e Forma:SolidPeso molecular:270.29Remetinostat
CAS:<p>Remetinostat (SHP-141), a hydroxamic acid-based inhibitor of histone deacetylase enzymes, is currently being developed for the treatment of cutaneous T-cell</p>Fórmula:C16H21NO6Pureza:98.67%Cor e Forma:SolidPeso molecular:323.34Pixantrone hydrochloride
CAS:<p>Pixantrone hydrochloride is a topoisomerase II inhibitor and DNA intercalator with anti-tumor properties.</p>Fórmula:C17H20ClN5O2Cor e Forma:SolidPeso molecular:361.83PJ34
CAS:<p>PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.</p>Fórmula:C17H17N3O2Pureza:95.05% - 99.85%Cor e Forma:SolidPeso molecular:295.34Resminostat hydrochloride
CAS:<p>Resminostat hydrochloride (RAS2410 hydrochloride) is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent</p>Fórmula:C16H20ClN3O4SPureza:97.63% - 99.68%Cor e Forma:SolidPeso molecular:385.86L67
CAS:<p>L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).</p>Fórmula:C16H14Br2N4O4Pureza:98.34% - 99.56%Cor e Forma:SolidPeso molecular:486.11
