DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 456 produtos de "DNA Metiltransferase"
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BAY-598 R-isomer
CAS:BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.Fórmula:C22H20Cl2F2N6O3Cor e Forma:SolidPeso molecular:525.34CPI-905
CAS:CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.Fórmula:C18H20N2O5Cor e Forma:SolidPeso molecular:344.36DNMT3A-IN-1
CAS:DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).Fórmula:C30H38N6O4Cor e Forma:SolidPeso molecular:546.66CM-579
CAS:CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.Fórmula:C29H40N4O3Pureza:99.23%Cor e Forma:SolidPeso molecular:492.65Ref: TM-T10840L
1mg52,00€5mg90,00€10mg131,00€25mg207,00€50mg303,00€100mg447,00€1mL*10mM (DMSO)117,00€NSC-311068
CAS:NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.Fórmula:C10H6N4O4SCor e Forma:SolidPeso molecular:278.24EZH2-IN-11
CAS:EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.Fórmula:C28H36ClN3O5SCor e Forma:SolidPeso molecular:562.12EZH2-IN-9
CAS:EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.Fórmula:C28H32ClF2N3O5SCor e Forma:SolidPeso molecular:596.09AA-CW236
CAS:AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).Fórmula:C17H16ClF3N4O2Cor e Forma:SolidPeso molecular:400.78NSD3-IN-1
CAS:NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.Fórmula:C13H13N5OSCor e Forma:SolidPeso molecular:287.34BI-9321
CAS:BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.Fórmula:C22H21FN4Pureza:98%Cor e Forma:SolidPeso molecular:360.43UNC0379 TFA
CAS:UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.Fórmula:C25H36F3N5O4Cor e Forma:SolidPeso molecular:527.589DDO-2093 dihydrochloride
DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.Fórmula:C29H39Cl3FN9O3Cor e Forma:SolidPeso molecular:687.04PRMT5-IN-10
CAS:PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.Fórmula:C13H17N5O4Cor e Forma:SolidPeso molecular:307.31EZH2-IN-7
CAS:EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.Fórmula:C31H37D2N5O3SCor e Forma:SolidPeso molecular:563.755-Aza-4'-thio-2'-deoxycytidine
CAS:5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].Fórmula:C8H12N4O3SCor e Forma:SolidPeso molecular:244.27G9a-IN-2
CAS:G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).Fórmula:C30H42N4O4Cor e Forma:SolidPeso molecular:522.68Lobelane Hydrochloride
CAS:Lobelane Hydrochloride is a vesicular monoamine transporter-2 (VMAT2) inhibitor.Fórmula:C22H30ClNCor e Forma:SolidPeso molecular:343.93Fagaronine chloride
CAS:Fagaronine chloride is a potent inhibitor of Topoisomerases I.Fórmula:C21H20ClNO4Cor e Forma:SolidPeso molecular:385.84DC_501
CAS:DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.Fórmula:C25H23Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:452.38Prospasmine
CAS:Prospasmine is an anticholinergic.Fórmula:C17H28ClNO2Pureza:98%Cor e Forma:SolidPeso molecular:313.87
