NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 390 produtos de "NF-κB"
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Esculentoside H
CAS:Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.Fórmula:C48H76O21Pureza:98.04% - 99.3%Cor e Forma:SolidPeso molecular:989.1Isoliquiritin apioside
CAS:Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.Fórmula:C26H30O13Pureza:98.84% - 99.27%Cor e Forma:SolidPeso molecular:550.51Ginsenoside Re
CAS:Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Fórmula:C48H82O18Pureza:99.12% - >99.99%Cor e Forma:White PowderPeso molecular:947.15Ref: TM-T2872
2mg34,00€5mg48,00€10mg63,00€25mg92,00€50mg138,00€100mg197,00€200mg290,00€1mL*10mM (DMSO)65,00€Suberosin
CAS:Suberosin: anti-inflammatory, anticoagulant, deters Aedes aegypti bites, potential mosquito larvicide.Fórmula:C15H16O3Pureza:97.08% - 99.26%Cor e Forma:SolidPeso molecular:244.29Ref: TM-T5795
2mg37,00€5mg54,00€10mg93,00€25mg167,00€50mg241,00€100mg359,00€200mg525,00€1mL*10mM (DMSO)56,00€NDMC101
CAS:NDMC101 suppresses dipeptidyl peptidase-IV, NFATc1, and NF-κB in human T cells, modulating immunity.Fórmula:C13H9ClFNO2Pureza:99.89%Cor e Forma:SolidPeso molecular:265.67BMS-345541 hydrochloride
CAS:BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Fórmula:C14H18ClN5Pureza:99.13%Cor e Forma:SolidPeso molecular:291.78Ref: TM-T8542
1mg38,00€2mg50,00€5mg82,00€10mg119,00€25mg212,00€50mg356,00€100mg533,00€1mL*10mM (DMSO)52,00€NF-κΒ activator 2
CAS:NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM.Fórmula:C16H11FN2O3Pureza:98.12%Cor e Forma:SolidPeso molecular:298.27Ref: TM-T39924
1mg94,00€2mg136,00€5mg226,00€10mg335,00€25mg538,00€50mg730,00€100mg938,00€1mL*10mM (DMSO)249,00€Eurycomalactone
CAS:Eurycomalactone, from Eurycoma longifolia, inhibits NF-κB (IC50 0.5 μM), stops protein synthesis and cyclin D1, spares IκBα and IKK.Fórmula:C19H24O6Pureza:99.48% - 99.87%Cor e Forma:SolidPeso molecular:348.39JSH-23
CAS:JSH-23 is an NF-κB inhibitor that inhibits NF-κB transcriptional activity without affecting IκB degradation. JSH-23 is an antioxidant. Cost effective and quality assured.Fórmula:C16H20N2Pureza:98.03% - 99.67%Cor e Forma:SolidPeso molecular:240.34Ref: TM-T1930
1mg40,00€2mg54,00€5mg88,00€10mg113,00€25mg177,00€50mg268,00€100mg408,00€1mL*10mM (DMSO)87,00€GS143
CAS:GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Fórmula:C28H19FN2O4Pureza:97.67%Cor e Forma:SolidPeso molecular:466.46Ref: TM-T25465
2mg35,00€5mg55,00€10mg87,00€25mg161,00€50mg245,00€100mg358,00€200mg520,00€1mL*10mM (DMSO)57,00€Isodeoxyelephantopin
CAS:Isodeoxyelephantopin can inhibit the growth of various tumor cells.Fórmula:C19H20O6Pureza:99.88%Cor e Forma:SolidPeso molecular:344.36IKKγ NBD Inhibitory Peptide acetate
IKKγ NBD Inhibitory Peptide acetate is a NEMO-binding domain peptide (NBD peptide) acetate corresponding to the NEMO amino-terminal alpha-helical region.
Pureza:99.15%Cor e Forma:SolidPeso molecular:N/ARef: TM-TP1615L
1mg131,00€2mg173,00€5mg255,00€10mg374,00€25mg625,00€50mg890,00€100mg1.206,00€500mg2.422,00€Vamorolone
CAS:Vamorolone (VBP15) is a steroid-like drug that treats muscular dystrophy with fewer side effects and inhibits NF-κB.Fórmula:C22H28O4Pureza:99.54%Cor e Forma:SolidPeso molecular:356.46Ref: TM-T17217
1mg34,00€2mg49,00€5mg74,00€10mg105,00€25mg178,00€50mg281,00€100mg421,00€200mg605,00€1mL*10mM (DMSO)82,00€Robinin
CAS:Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Fórmula:C33H40O19Pureza:98.78% - 99.13%Cor e Forma:SolidPeso molecular:740.66Polygalasaponin F
CAS:Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.Fórmula:C53H86O23Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:1091.24Embelin
CAS:Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).Fórmula:C17H26O4Pureza:97.07% - 99.88%Cor e Forma:SolidPeso molecular:294.39Triptolide
CAS:Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation.Fórmula:C20H24O6Pureza:97.19% - 99.97%Cor e Forma:White To Off-White SolidPeso molecular:360.40Ref: TM-T2179
1mg39,00€2mg52,00€5mg95,00€10mg123,00€25mg225,00€50mg315,00€100mg444,00€1mL*10mM (DMSO)75,00€Barlerin
CAS:Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and protective effect on oxygen-glucose deprivation-induced injuryFórmula:C19H28O12Pureza:99.83% - ≥95%Cor e Forma:SolidPeso molecular:448.42Ref: TM-T5S1632
1mg38,00€2mg50,00€5mg80,00€10mg109,00€25mg231,00€50mg335,00€100mg505,00€1mL*10mM (DMSO)87,00€TBK1/IKKε-IN-5
CAS:TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).Fórmula:C28H31N7O3Pureza:98.77%Cor e Forma:SolidPeso molecular:513.59Ref: TM-T7951
1mg88,00€5mg182,00€10mg269,00€25mg429,00€50mg587,00€100mg837,00€200mg1.125,00€1mL*10mM (DMSO)224,00€Mollugin
CAS:Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.Fórmula:C17H16O4Pureza:99.87% - ≥95%Cor e Forma:SolidPeso molecular:284.31Tyrosol
CAS:Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present mostFórmula:C8H10O2Pureza:99.24% - 99.86%Cor e Forma:SolidPeso molecular:138.16PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Fórmula:C22H26N4O3Pureza:98.82%Cor e Forma:SolidPeso molecular:394.47SM-7368
CAS:The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.Fórmula:C10H5ClN4O5SPureza:99.64%Cor e Forma:SolidPeso molecular:328.69Ref: TM-T22115
5mg44,00€10mg71,00€25mg128,00€50mg178,00€100mg268,00€200mg389,00€1mL*10mM (DMSO)52,00€IRAK-1-4 Inhibitor I
CAS:IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1.
Fórmula:C20H21N5O4Pureza:98% - 99.89%Cor e Forma:SolidPeso molecular:395.41Tomatidine
CAS:Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.
Fórmula:C27H45NO2Pureza:99.94% - 99.98%Cor e Forma:SolidPeso molecular:415.6511-Keto-β-boswellic acid
CAS:11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.Fórmula:C30H46O4Pureza:99.68%Cor e Forma:SolidPeso molecular:470.68Ref: TM-TN1182
1mg57,00€5mg130,00€10mg200,00€25mg338,00€50mg497,00€100mg710,00€1mL*10mM (DMSO)133,00€Maslinic acid
CAS:Maslinic acid (Crategolic acid) is a DNA polymerase B inhibitor.Fórmula:C30H48O4Pureza:98.1% - 99.98%Cor e Forma:SolidPeso molecular:472.70Malachite green oxalate
CAS:Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.Fórmula:C23H25N2·C2HO4C2H2O4Cor e Forma:Dark Green Crystals With A Metallic LusterPeso molecular:463.51Sarsasapogenin
CAS:Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin.Fórmula:C27H44O3Pureza:90% - 99.73%Cor e Forma:White Or Off-Withe PowderPeso molecular:416.64Obtusifolin
CAS:Obtusifolin is an antioxidant that combats diabetes, bone-resorption, diabetic retinopathy, pain, and cognitive decline.Fórmula:C16H12O5Pureza:99.78% - 99.99%Cor e Forma:SolidPeso molecular:284.26Ref: TM-T4S0969
1mg66,00€5mg177,00€10mg264,00€25mg447,00€50mg623,00€100mg883,00€1mL*10mM (DMSO)177,00€Neferine
CAS:Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.Fórmula:C38H44N2O6Pureza:98.81% - 99.65%Cor e Forma:SolidPeso molecular:624.77Gossypin
CAS:Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.Fórmula:C21H20O13Pureza:97.57% - 98.97%Cor e Forma:SolidPeso molecular:480.38Aconine
CAS:1. Aconine (Jesaconine) is the febrifuge. 2. Aconine possesses gastric anaesthetic props.Fórmula:C25H41NO9Pureza:99.61% - 99.93%Cor e Forma:SolidPeso molecular:499.59Madecassic acid
CAS:Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.Fórmula:C30H48O6Pureza:98.80% - 99.69%Cor e Forma:SolidPeso molecular:504.70Delanzomib
CAS:Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.Fórmula:C21H28BN3O5Pureza:95.52% - 99.46%Cor e Forma:SolidPeso molecular:413.28Ref: TM-T6027
1mg46,00€5mg96,00€10mg140,00€25mg274,00€50mg439,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)95,00€Deoxyelephantopin
CAS:Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Fórmula:C19H20O6Pureza:99.6% - 99.71%Cor e Forma:SolidPeso molecular:344.36Aristolochic acid A
CAS:Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort family of plants.Fórmula:C17H11NO7Pureza:99.85% - 99.97%Cor e Forma:Yellow PowderPeso molecular:341.27Indole-3-carbinol
CAS:Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinaseFórmula:C9H9NOPureza:98.59% - >99.99%Cor e Forma:SolidPeso molecular:147.17GSK-872
CAS:GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.
Fórmula:C19H17N3O2S2Pureza:99.87% - 99.94%Cor e Forma:SolidPeso molecular:383.49MnTBAP chloride
CAS:MnTBAP chloride: SOD mimetic, peroxynitrite scavenger, halves SOD-E. coli growth time, anti-inflammatory, may aid CKD research.Fórmula:C48H25ClMnN4O8Cor e Forma:SolidPeso molecular:876.133'-Sialyllactose sodium
CAS:3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis and can be used to study inflammation.Fórmula:C23H38NNaO19Pureza:>99.99%Cor e Forma:SolidPeso molecular:655.53(S)-(+)-Ibuprofen
CAS:(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).Fórmula:C13H18O2Pureza:99.51% - 99.86%Cor e Forma:Colourless Crystalline SolidPeso molecular:206.281,3-Dibenzyl-5-fluorouracil
CAS:1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor that suppresses the formation of osteoclasts, functioning by downregulating the signaling pathways of nuclear factor κB ligand receptor activator (Receptor activator of NF-κB ligand, RANKL) and macrophage colony-stimulating factor (M-CSF). This compound is used in the research of metabolic bone diseases.Fórmula:C18H15FN2O2Cor e Forma:SolidPeso molecular:310.32Boserolimab
CAS:Boserolimab, Humanized anti-CD27 agonistic mAb, blocks CD70 binding to CD27, used for lung cancer research.Pureza:95% - 95%Cor e Forma:LiquidGatralimab
CAS:Gatralimab (anti-CD52 mAb) shows successful lymphocyte depletion & repopulation in Phase 1, supporting its study for relapsing MS.Pureza:95%Cor e Forma:LiquidPeso molecular:~150 kDaTamtuvetmab
CAS:Tamtuvetmab (AT-005), a caninised version of blontuvetmab targeting CD52, enhances progression-free survival (PFS) and demonstrates in vivo efficacy forCor e Forma:LiquidKamebakaurin
CAS:Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.Fórmula:C20H30O5Pureza:98.05%Cor e Forma:SolidPeso molecular:350.45E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Fórmula:C21H30O6Pureza:99.52%Cor e Forma:SolidPeso molecular:378.46MHY884
CAS:MHY884 inhibits tyrosinase and UVB-triggered NF-κB activation by reducing oxidative stress.Fórmula:C15H14ClNO3SPureza:98%Cor e Forma:SolidPeso molecular:323.79
