NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 445 produtos de "NF-κB"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
14-Deoxy-11,12-didehydroandrographolide
CAS:<p>14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.</p>Fórmula:C20H28O4Pureza:99.13% - 99.93%Cor e Forma:SolidPeso molecular:332.43Rucaparib Phosphate
CAS:<p>Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.</p>Fórmula:C19H18FN3O·H3PO4Pureza:99.37%Cor e Forma:SolidPeso molecular:421.36Damascenone
CAS:<p>Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.</p>Fórmula:C13H18OPureza:98.03%Cor e Forma:Colorless LiquidPeso molecular:190.28IQ-1S free acid
CAS:<p>IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.</p>Fórmula:C15H9N3OPureza:97.92% - 99.05%Cor e Forma:SolidPeso molecular:247.2520(S)-Ginsenoside Rg3
CAS:<p>20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.</p>Fórmula:C42H72O13Pureza:98.11% - 99.93%Cor e Forma:SolidPeso molecular:785.012,4-Diamino-6-hydroxypyrimidine
CAS:<p>2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis</p>Fórmula:C4H6N4OPureza:99.82%Cor e Forma:White Solid CrystalsPeso molecular:126.12Andrographolide
CAS:<p>Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential</p>Fórmula:C20H30O5Pureza:99.39% - 99.97%Cor e Forma:PowderPeso molecular:350.458-Deoxygartanin
CAS:<p>8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it has</p>Fórmula:C23H24O5Pureza:99.04% - 99.88%Cor e Forma:SolidPeso molecular:380.43TAK-243
CAS:<p>TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM).</p>Fórmula:C19H20F3N5O5S2Pureza:98.09% - 98.93%Cor e Forma:SolidPeso molecular:519.52Caffeic Acid Phenethyl Ester
CAS:<p>CAPE, in propolis, blocks NF-kappa B, suppresses p70S6K/Akt pathways, and inhibits PDGF, aiding in cancer protection and immune modulation.</p>Fórmula:C17H16O4Pureza:99.18% - 99.35%Cor e Forma:Less Transparent Liquid Colorless Transparent LiquidPeso molecular:284.31Betulinic acid
CAS:<p>Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.</p>Fórmula:C30H48O3Pureza:99.12% - 99.7%Cor e Forma:White Crystalline PowderPeso molecular:456.7Indacaterol
CAS:<p>Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.</p>Fórmula:C24H28N2O3Pureza:99.96%Cor e Forma:SolidPeso molecular:392.49Rucaparib monocamsylate
CAS:<p>Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor. Rucaparib Camsylate also displays binding affinity to eight other PARP domains.</p>Fórmula:C29H34FN3O5SPureza:99.82%Cor e Forma:SolidPeso molecular:555.66Tryptanthrin
CAS:<p>Tryptanthrin is a natural DNA gyrase inhibitor.</p>Fórmula:C15H8N2O2Pureza:99.64% - 99.94%Cor e Forma:SolidPeso molecular:248.24Sauchinone
CAS:<p>Sauchinone: Treats infections, prevents liver fibrosis, reduces oxidative stress, and protects skin and vascular cells.</p>Fórmula:C20H20O6Pureza:>99.99%Cor e Forma:SolidPeso molecular:356.37GSK547
CAS:<p>GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.</p>Fórmula:C20H18F2N6OPureza:99.17%Cor e Forma:SolidPeso molecular:396.39Sanggenon C
CAS:<p>Sanggenon C inhibits NF-κB activity, the expression of inducible nitric oxide synthase, tumor necrosis factor-α-stimulated cell adhesion and the expression of vascular cell adhesion molecule-1 in RAW264.7 cells. Cost-effective and quality-assured.</p>Fórmula:C40H36O12Pureza:97.76% - 99.76%Cor e Forma:SolidPeso molecular:708.71HOMOPLANTAGININ
CAS:<p>Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows</p>Fórmula:C22H22O11Pureza:97.63% - 99.66%Cor e Forma:SolidPeso molecular:462.4SC75741
CAS:<p>SC75741 is a potent P65 inhibitor with IC50 of 200 nM</p>Fórmula:C29H23N7O2S2Pureza:99.44% - 99.54%Cor e Forma:SolidPeso molecular:565.67Sulforaphene
CAS:<p>Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.</p>Fórmula:C6H9NOS2Pureza:97.55% - 99.19%Cor e Forma:Slightly Yellowish LiquidPeso molecular:175.27Ginsenoside Rg5
CAS:<p>Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.</p>Fórmula:C42H70O12Pureza:98% - 99.65%Cor e Forma:SolidPeso molecular:767WAY-169916
CAS:<p>WAY-169916 inhibits ER by blocking NF-kB activity, lacks estrogenic effects.</p>Fórmula:C17H13F3N2O2Pureza:98.63% - 98.64%Cor e Forma:SolidPeso molecular:334.29Astilbin
CAS:<p>Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.</p>Fórmula:C21H22O11Pureza:97% - 99.86%Cor e Forma:White PowderPeso molecular:450.39Praeruptorin A
CAS:<p>Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin</p>Fórmula:C21H22O7Pureza:99.63% - 99.65%Cor e Forma:SolidPeso molecular:386.4Tenuigenin
CAS:<p>Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.</p>Fórmula:C30H45ClO6Pureza:98.9% - 99.53%Cor e Forma:SolidPeso molecular:537.13Tectochrysin
CAS:<p>Tectochrysin: antioxidant, hinders ABCG2 transport, induces apoptosis in NSC-LC by blocking STAT3 and activating DR3/Fas.</p>Fórmula:C16H12O4Pureza:99.26%Cor e Forma:SolidPeso molecular:268.26INH14
CAS:<p>INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).</p>Fórmula:C15H16N2OPureza:95.41%Cor e Forma:SolidPeso molecular:240.3Picroside II
CAS:<p>Picroside II (Vanilloyl catalpol) is the main active ingredient in iridoid glycosides.</p>Fórmula:C23H28O13Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:512.46Phorbol 12-myristate 13-acetate
CAS:<p>Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.</p>Fórmula:C36H56O8Pureza:98.55% - >99.99%Cor e Forma:White To Off-White SolidPeso molecular:616.83Handelin
CAS:<p>Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.</p>Fórmula:C32H40O8Pureza:99.02% - 99.345%Cor e Forma:SolidPeso molecular:552.66Sciadopitysin
CAS:<p>Sciadopitysin may thwart diabetic bone disease, boost mitochondria, protect osteoblasts, and hinder Aβ aggregation/neurotoxicity.</p>Fórmula:C33H24O10Pureza:98.14% - 99.17%Cor e Forma:SolidPeso molecular:580.54HS-1371
CAS:<p>HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.</p>Fórmula:C24H24N4OPureza:98%Cor e Forma:SolidPeso molecular:384.47Okanin
CAS:<p>Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.</p>Fórmula:C15H12O6Pureza:95.19% - 99.4%Cor e Forma:SolidPeso molecular:288.25Schisantherin A
CAS:<p>Schisantherin A, a lignan from Schisandra fruit, is used as an antitussive, tonic, and sedative.</p>Fórmula:C30H32O9Pureza:98% - 99.989Cor e Forma:SolidPeso molecular:536.57Necrostatin 2 racemate
CAS:<p>Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.</p>Fórmula:C13H12ClN3O2Pureza:98% - 99.5%Cor e Forma:SolidPeso molecular:277.71Esculentoside H
CAS:<p>Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.</p>Fórmula:C48H76O21Pureza:98.04% - 99.3%Cor e Forma:SolidPeso molecular:989.1Isoliquiritin apioside
CAS:<p>Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.</p>Fórmula:C26H30O13Pureza:98.84% - 99.27%Cor e Forma:SolidPeso molecular:550.51Ginsenoside Re
CAS:<p>Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.</p>Fórmula:C48H82O18Pureza:99.12% - >99.99%Cor e Forma:White PowderPeso molecular:947.15Suberosin
CAS:<p>Suberosin: anti-inflammatory, anticoagulant, deters Aedes aegypti bites, potential mosquito larvicide.</p>Fórmula:C15H16O3Pureza:97.08% - 99.26%Cor e Forma:SolidPeso molecular:244.29NDMC101
CAS:<p>NDMC101 suppresses dipeptidyl peptidase-IV, NFATc1, and NF-κB in human T cells, modulating immunity.</p>Fórmula:C13H9ClFNO2Pureza:99.89%Cor e Forma:SolidPeso molecular:265.67IRAK4-IN-1
CAS:<p>IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.</p>Fórmula:C19H23N5OPureza:98.18% - 99.85%Cor e Forma:SolidPeso molecular:337.42BMS-345541 hydrochloride
CAS:<p>BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).</p>Fórmula:C14H18ClN5Pureza:99.13%Cor e Forma:SolidPeso molecular:291.78IKK 16
CAS:<p>IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.</p>Fórmula:C28H29N5OSPureza:98.76% - 99.61%Cor e Forma:SolidPeso molecular:483.63GSK2983559 active metabolite
CAS:<p>GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.</p>Fórmula:C21H22N4O4S2Pureza:97.07% - 99.57%Cor e Forma:SolidPeso molecular:458.55NF-κΒ activator 2
CAS:<p>NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM.</p>Fórmula:C16H11FN2O3Pureza:98.12%Cor e Forma:SolidPeso molecular:298.27Eurycomalactone
CAS:<p>Eurycomalactone, from Eurycoma longifolia, inhibits NF-κB (IC50 0.5 μM), stops protein synthesis and cyclin D1, spares IκBα and IKK.</p>Fórmula:C19H24O6Pureza:99.48% - 99.87%Cor e Forma:SolidPeso molecular:348.39JSH-23
CAS:<p>JSH-23 is an NF-κB inhibitor that inhibits NF-κB transcriptional activity without affecting IκB degradation. JSH-23 is an antioxidant. Cost effective and quality assured.</p>Fórmula:C16H20N2Pureza:98.03% - 99.67%Cor e Forma:SolidPeso molecular:240.34GS143
CAS:<p>GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.</p>Fórmula:C28H19FN2O4Pureza:97.67%Cor e Forma:SolidPeso molecular:466.46Isodeoxyelephantopin
CAS:<p>Isodeoxyelephantopin can inhibit the growth of various tumor cells.</p>Fórmula:C19H20O6Pureza:99.88%Cor e Forma:SolidPeso molecular:344.36IKKγ NBD Inhibitory Peptide acetate
<p>IKKγ NBD Inhibitory Peptide acetate is a NEMO-binding domain peptide (NBD peptide) acetate corresponding to the NEMO amino-terminal alpha-helical region.</p>Pureza:99.15%Cor e Forma:SolidPeso molecular:N/A
