IκB/IKK
O complexo IκB/IKK é um regulador chave da via de sinalização NF-κB, que controla a expressão de genes envolvidos em respostas imunes, inflamação e sobrevivência celular. As proteínas IκB inibem a atividade do NF-κB sequestrando-o no citoplasma, enquanto as IKKs fosforilam a IκB, levando à sua degradação e à ativação do NF-κB. A desregulação da via IκB/IKK está associada à inflamação crônica, câncer e doenças autoimunes. Na CymitQuimica, oferecemos uma seleção de moduladores IκB/IKK de alta qualidade para apoiar sua pesquisa em transdução de sinal, inflamação e desenvolvimento terapêutico.
Foram encontrados 56 produtos para "IκB/IKK".
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TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Fórmula:C26H27N5O3Pureza:98.89%Cor e Forma:SolidPeso molecular:457.5243IMD-0560
CAS:IMD-0560 is a novel inhibitor of IκB kinase β.Fórmula:C15H8BrF6NO2Pureza:99.51%Cor e Forma:SolidPeso molecular:428.124BAY-985
CAS:BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Fórmula:C27H30F3N9OPureza:99.62%Cor e Forma:SolidPeso molecular:553.582Ac2-26 ammonium
Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.Fórmula:C141H210N32O44S·xNH3Pureza:95.58%Cor e Forma:SolidPeso molecular:3089.43 (free base)Siegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.Fórmula:C20H28O6Cor e Forma:SolidPeso molecular:364.43PS 1145 dihydrochloride
CAS:IκB kinase (IKK) inhibitorFórmula:C17H13Cl3N4OPureza:98%Cor e Forma:SolidPeso molecular:395.67TBK1/IKKε-IN-6
CAS:TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.Fórmula:C31H36F2N8O4Cor e Forma:SolidPeso molecular:622.678TBK1 PROTAC 3i
CAS:TBK1 PROTAC 3i is a potent PROTAC degrader targeting the serine/threonine kinase TANK-binding kinase-1 (TBK1), composed of a TBK1-targeting ligand, a linker, and a von-Hippel Lindau (VHL) E3 ubiquitin ligase ligand. TBK1 PROTAC 3i exhibits high affinity for TBK1 (Kd = 4.6 nM) and potent degradation activity (DC₅₀ = 15 nM, maximum degradation efficiency of 96%), and can achieve near-complete degradation of TBK1 in mutant K-Ras and wild-type cancer cell lines without significantly affecting cell proliferation.Fórmula:C53H74BrN9O9SPeso molecular:1093.19PROTAC STING degrader-4
PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI).Fórmula:C39H42Cl2N8O9Cor e Forma:SolidPeso molecular:836.24518IKK-IN-3
CAS:IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).Fórmula:C17H17N5SCor e Forma:SolidPeso molecular:323.42Tat-IKIP (46-60)
Tat-IKIP (46-60) is a transmembrane peptide that targets IκB kinase (IKK). It inhibits the activation of IKK and the expression of NF-κB target genes by disrupting the IKKβ/NEMO complex. In mouse models, Tat-IKIP (46-60) significantly alleviates DSS-induced acute inflammation in inflammatory bowel disease (IBD) and reduces zymosan-induced acute arthritis in acute arthritis models (AAM). This compound is applicable in research on inflammatory diseases such as IBD, pancreatitis, and rheumatoid arthritis.LY2409881
CAS:LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.Fórmula:C24H29ClN6OSCor e Forma:SolidPeso molecular:485.05SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Cor e Forma:Odour SolidML 120B dihydrochloride
CAS:ML 120B dihydrochloride is an ATP-competitive IKKβ inhibitor (IC50 60 nM) reducing multiple myeloma cell growth.Fórmula:C19H17Cl3N4O2Cor e Forma:White SolidPeso molecular:439.72IKK 16 hydrochloride
CAS:IKK 16 hydrochloride, a potent IKK1/2 and LRRK2 inhibitor, IC50s: 40-200 nM and 50 nM respectively.Fórmula:C28H30ClN5OSCor e Forma:SolidPeso molecular:520.09BMS-066
CAS:BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor used in NF-κB and inflammatory signaling research.Fórmula:C19H21N7O2Pureza:99.24%Cor e Forma:SolidPeso molecular:379.42GSK8612
CAS:GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .Fórmula:C17H17BrF3N7O2SPureza:99.70% - 99.99%Cor e Forma:SolidPeso molecular:520.327AZD3264
CAS:AZD3264 is a new type IKK2 inhibitor.Fórmula:C21H23N5O4SPureza:98.98% - 99.17%Cor e Forma:SolidPeso molecular:441.503MLN120B
CAS:MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Fórmula:C19H15ClN4O2Pureza:98.92%Cor e Forma:SolidPeso molecular:366.8012-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.Fórmula:C11H10N2OSPureza:99.48%Cor e Forma:SolidPeso molecular:218.275
