CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Foram encontrados 166 produtos para "CCR".
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Maraviroc-D6
CAS:Maraviroc-D6 is the deuterated form of Maraviroc (T6016). Maraviroc ( T6016) (UK-427857) acts as a selective CCR5 antagonist and exhibits inhibitory activity against HIV.Fórmula:C29H41F2N5OPeso molecular:519.7INCB 3284 dimesylate
CAS:INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.Fórmula:C28H39F3N4O10S2Pureza:98%Cor e Forma:SolidPeso molecular:712.76TBK1 degrader-4
TBK1degrader-4 (Compound 30) is a molecular glue degrader targeting TBK1. It effectively inhibits cyst growth, reduces inflammation, and lowers levels of pro-inflammatory factors such as Ccl2, IFNβ, and IL-6. TBK1degrader-4 shows potential for research in autosomal dominant polycystic kidney disease (ADPKD).Cor e Forma:Odour SolidAplaviroc hydrochloride
CAS:Aplaviroc, a potent CCR5 inhibitor, binds selectively, blocking HIV entry and specific monoclonal antibody attachment in vitro.Fórmula:C33H44ClN3O6Cor e Forma:SolidPeso molecular:614.172MLN-3897 TFA
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.Fórmula:C32H32ClF3N2O6Pureza:99.80%Cor e Forma:SolidPeso molecular:633.05CCR4 antagonist 3 hydrochloride
CAS:Orally active CCR4 antagonist 3 hydrochloride with potent selectivity, IC50s: 22/50 nM; has antitumor properties.Fórmula:C24H27Cl2N7O·xHClCor e Forma:SolidCCR6 inhibitor 1
CAS:CCR6 inhibitor 1 selectively blocks CCR6 (0.45 nM in monkeys, 6 nM in humans), aiding in vitro/vivo disease studies.Fórmula:C24H23F3N4O3SPureza:99.89%Cor e Forma:SolidPeso molecular:504.525LT166
LT166 is a fluorescent ligand for CC chemokine receptor 1 (CCR1) with a dissociation constant (KD) of 1.90 μM.Fórmula:C52H55BrFN7O9Peso molecular:1019.32287BMS-753426
CAS:BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .Fórmula:C25H33F3N6O2Cor e Forma:SolidPeso molecular:506.574CCR4 antagonist 3
CAS:Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.Fórmula:C24H27Cl2N7OCor e Forma:SolidPeso molecular:500.423CAP-100
CAP-100 is a monoclonal antibody targeting CCR7. It neutralizes the ligand binding site and signaling of CCR7. This compound effectively inhibits migration, extravasation, homing, and survival in chronic lymphocytic leukemia (CLL) samples induced by CCR7. CAP-100 can mediate potent tumor cell killing through host immune mechanisms and exhibits favorable toxicity profiles in related hematopoietic cell subsets. It is involved in research on antitumor activity and diseases like chronic lymphocytic leukemia (CLL).Cor e Forma:Odour LiquidR707
R707 is a mAb targeting CCR7 that inhibits cell migration and lymph node metastasis by blocking the CCL19/CCL21 axis.Pureza:95%Peso molecular:145.46 kDaZK 756326
CAS:ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.Fórmula:C21H28N2O3Pureza:99.43%Cor e Forma:White SolidPeso molecular:356.46Vercirnon
CAS:Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.Fórmula:C22H21ClN2O4SPureza:99.23%Cor e Forma:SolidPeso molecular:444.9317,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Fórmula:C15H10O4Pureza:99.39% - 99.6%Cor e Forma:White SolidPeso molecular:254.2375AZD-4818
CAS:AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.Fórmula:C27H32Cl2N2O7Pureza:98.61%Cor e Forma:SolidPeso molecular:567.458AZD2098
CAS:AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.Fórmula:C11H9Cl2N3O3SPureza:99.75% - 99.94%Cor e Forma:SolidPeso molecular:334.178CCR2 antagonist 4 hydrochloride
CAS:CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).Fórmula:C21H22Cl2F3N3O2Cor e Forma:SolidPeso molecular:476.319RS102895
CAS:RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.Fórmula:C21H21F3N2O2Pureza:97.64% - 99.80%Cor e Forma:SolidPeso molecular:390.3988Cenicriviroc
CAS:Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.Fórmula:C41H52N4O4SPureza:97.87%Cor e Forma:Yellow SolidPeso molecular:696.941
