TLR
Os receptores Toll-like (TLRs) são uma classe de proteínas que desempenham um papel crítico no sistema imunológico inato ao reconhecer padrões moleculares associados a patógenos (PAMPs) e iniciar respostas imunes. Os TLRs estão envolvidos na detecção de uma ampla gama de patógenos, incluindo bactérias, vírus e fungos, e são essenciais para a ativação de vias de sinalização inflamatória. A desregulação da sinalização dos TLRs está associada a doenças inflamatórias crônicas, distúrbios autoimunes e câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de TLR de alta qualidade para apoiar sua pesquisa em imunidade inata, inflamação e doenças infecciosas.
Foram encontrados 74 produtos de "TLR"
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CU-CPT17e
CAS:CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).Fórmula:C27H24N2O8Pureza:98.49%Cor e Forma:SolidPeso molecular:504.49IAXO-102
CAS:IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.Fórmula:C35H71NO5Pureza:98.17%Cor e Forma:SolidPeso molecular:585.94CU-T12-9
CAS:CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Fórmula:C17H13F3N4O2Pureza:99.84%Cor e Forma:SolidPeso molecular:362.31Ref: TM-T15017
1mg50,00€5mg105,00€10mg160,00€25mg268,00€50mg409,00€100mg583,00€1mL*10mM (DMSO)117,00€TLR7/8 agonist 3
CAS:TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
Fórmula:C17H23N5OPureza:99.84%Cor e Forma:SolidPeso molecular:313.4BMS-905
CAS:BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.Fórmula:C23H29N3Pureza:99.94%Cor e Forma:SoildPeso molecular:347.5CU-CPT22
CAS:CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).Fórmula:C19H22O7Pureza:98.66% - 99.80%Cor e Forma:SolidPeso molecular:362.37Ref: TM-T15020
1mg52,00€2mg70,00€5mg99,00€10mg168,00€25mg313,00€50mg469,00€100mg682,00€200mg938,00€1mL*10mM (DMSO)114,00€(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 serves as the E3 ubiquitin ligase ligand and linker for PROTAC(R)-NX-2127, utilized in cancer research.Fórmula:C29H33N5O4Cor e Forma:SolidPeso molecular:515.6PVP-037.2
CAS:PVP-037.2 is a TLR7/8 agonist that acts as an adjuvant to enhance vaccine-induced TH1 immune responses and boost the production of antigen-specific antibodies IgG1 and IgG2c.Fórmula:C23H20F3N5OCor e Forma:SoildPeso molecular:439.43RKH
PKH is a TLR4 antagonist, and it is a new tripeptide derived from Akkermansia muciniphila. PKH reduces inflammation-related cell activation and the overproduction of pro-inflammatory factors induced by sepsis.Fórmula:C18H33N9O4Peso molecular:439.26555TLR7 agonist 17
CAS:TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].Fórmula:C25H37N7O3Cor e Forma:SolidPeso molecular:483.61Tilsotolimod sodium
CAS:Tilsotolimod sodium, a synthetic Toll-like receptor 9 (TLR9) agonist, has shown antitumor activity in preclinical models.Fórmula:C223H262N74Na22O115P22S22Cor e Forma:SolidPeso molecular:7711.51Pam3CSK4-Biotin
CAS:Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.Fórmula:C103H192N14O17S2Pureza:98%Cor e Forma:SolidPeso molecular:1962.85L07-2
CAS:L07-2 (Compound 6) is an active scaffold that includes a TLR7/8 agonist. It is suitable for the synthesis of immune-stimulating antibody conjugates (ISACs) used in cancer research.Fórmula:C56H83N15O14Cor e Forma:SolidPeso molecular:1190.35Pam2CSK4
CAS:TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.Fórmula:C65H126N10O12SPureza:98%Cor e Forma:SolidPeso molecular:1271.83MTvkPABC-P5 TFA
MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).Cor e Forma:Odour SolidTLR8 agonist 8
CAS:TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.Fórmula:C53H63N11O10Cor e Forma:SolidPeso molecular:1014.14CRX 527
CAS:CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.Fórmula:C81H151N2O19PCor e Forma:SolidPeso molecular:1488.04Ezeprogind
CAS:Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can TrustFórmula:C25H44N6Pureza:99.28%Cor e Forma:SolidPeso molecular:428.66TLR7/8 agonist 12
TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.
Fórmula:C29H38N6O3Cor e Forma:SolidPeso molecular:518.65TLR8 agonist 7
CAS:TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.Fórmula:C54H63N9O16Cor e Forma:SolidPeso molecular:1094.13
