TLR
Os receptores Toll-like (TLRs) são uma classe de proteínas que desempenham um papel crítico no sistema imunológico inato ao reconhecer padrões moleculares associados a patógenos (PAMPs) e iniciar respostas imunes. Os TLRs estão envolvidos na detecção de uma ampla gama de patógenos, incluindo bactérias, vírus e fungos, e são essenciais para a ativação de vias de sinalização inflamatória. A desregulação da sinalização dos TLRs está associada a doenças inflamatórias crônicas, distúrbios autoimunes e câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de TLR de alta qualidade para apoiar sua pesquisa em imunidade inata, inflamação e doenças infecciosas.
Foram encontrados 66 produtos de "TLR"
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TLR7/8 agonist 3
CAS:<p>TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.</p>Fórmula:C17H23N5OPureza:99.84%Cor e Forma:SolidPeso molecular:313.4CU-CPT17e
CAS:<p>CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).</p>Fórmula:C27H24N2O8Pureza:98.49%Cor e Forma:SolidPeso molecular:504.49BMS-905
CAS:<p>BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.</p>Fórmula:C23H29N3Pureza:99.94%Cor e Forma:SoildPeso molecular:347.5CU-CPT22
CAS:<p>CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).</p>Fórmula:C19H22O7Pureza:98.66% - 99.8%Cor e Forma:SolidPeso molecular:362.37IAXO-102
CAS:<p>IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.</p>Fórmula:C35H71NO5Pureza:98.17%Cor e Forma:SolidPeso molecular:585.94CU-T12-9
CAS:<p>CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).</p>Fórmula:C17H13F3N4O2Pureza:99.84%Cor e Forma:SolidPeso molecular:362.31Pam3CSK4-Biotin
CAS:<p>Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.</p>Fórmula:C103H192N14O17S2Pureza:98%Cor e Forma:SolidPeso molecular:1962.85MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA
<p>MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA is the trifluoroacetate form of MC-Val-Cit-PAB-Amide-TLR7 agonist 4,a HER2-TLR7 and HER2- TLR8 immune agonist complexes.</p>Fórmula:C54H73F3N12O13Pureza:99.67%Cor e Forma:SolidPeso molecular:1155.22CRX 527
CAS:<p>CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.</p>Fórmula:C81H151N2O19PCor e Forma:SolidPeso molecular:1488.04TLR8 agonist 7
CAS:<p>TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.</p>Fórmula:C54H63N9O16Cor e Forma:SolidPeso molecular:1094.13Tomaralimab
CAS:<p>Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).</p>Pureza:100% (SEC-HPLC) - > 95%Cor e Forma:LiquidPeso molecular:145.32 kDaTLR7/8 agonist 12
<p>TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.</p>Fórmula:C29H38N6O3Cor e Forma:SolidPeso molecular:518.65TLR7 agonist 17
CAS:<p>TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].</p>Fórmula:C25H37N7O3Cor e Forma:SolidPeso molecular:483.61TLR8 agonist 8
CAS:<p>TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.</p>Fórmula:C53H63N11O10Cor e Forma:SolidPeso molecular:1014.14Pam2CSK4
CAS:<p>TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.</p>Fórmula:C65H126N10O12SPureza:98%Cor e Forma:SolidPeso molecular:1271.83CU-115
CAS:<p>CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively.</p>Fórmula:C21H11F7INO2Pureza:99.96%Cor e Forma:SolidPeso molecular:569.21Ezeprogind
CAS:<p>Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can Trust</p>Fórmula:C25H44N6Pureza:99.28%Cor e Forma:SolidPeso molecular:428.66MTvkPABC-P5 TFA
<p>MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).</p>Cor e Forma:Odour SolidDesethyl chloroquine diphosphate
CAS:<p>Desethyl chloroquine diphosphate is the active metabolite of Desethylchloroquine, an inhibitor of TLRs with antiplasmodial activity and inhibition of autophagy.</p>Fórmula:C16H28ClN3O8P2Pureza:99.72%Cor e Forma:SolidPeso molecular:487.81Neoseptin-3
CAS:<p>Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.</p>Fórmula:C29H34N2O4Pureza:98%Cor e Forma:SolidPeso molecular:474.59
