TGF-beta/Smad
Os inibidores da via TGF-beta/Smad são compostos que interferem na via de sinalização do TGF-beta (Transforming Growth Factor-beta), mediada por proteínas Smad. Esta via está envolvida na regulação do crescimento celular, diferenciação, apoptose e função das células-tronco. A desregulação da sinalização TGF-beta/Smad está associada ao câncer, fibrose e outras doenças. Os inibidores desta via são ferramentas importantes para estudar estas condições e desenvolver potenciais terapias. Na CymitQuimica, oferecemos inibidores de TGF-beta/Smad para apoiar sua pesquisa em sinalização celular, oncologia e reparação de tecidos.
Foram encontrados 55 produtos de "TGF-beta/Smad"
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Oxymatrine
CAS:Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic.Fórmula:C15H24N2O2Pureza:98.72% - 99.72%Cor e Forma:SolidPeso molecular:264.36Isoviolanthin
CAS:Isoviolanthin, a flavonoid from Dendrobium Officinale, inhibits migration of TGF-β1-treated HCC cells, non-toxic to normal cells, potential HCC therapy.Fórmula:C27H30O14Pureza:99.25% - 99.66%Cor e Forma:SolidPeso molecular:578.52Ponsegromab
CAS:Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.Pureza:100% (SEC-HPLC) - > 95%Cor e Forma:LiquidPeso molecular:146.08 kDaHydrochlorothiazide
CAS:Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能，减少纤维化并具有降压作用。Fórmula:C7H8ClN3O4S2Pureza:99.43% - 99.50%Cor e Forma:Crystals Physical Description Crystals Or White Powder (Ntp 1992)Peso molecular:297.74SLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS:SLLK is a control peptide for LSKL.
Fórmula:C21H41N5O6Pureza:98%Cor e Forma:SolidPeso molecular:459.58Tubastatin
CAS:Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Fórmula:C21H22N2O2Pureza:98.23%Cor e Forma:SolidPeso molecular:334.41Emugrobart
Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidLSKL TFA
CAS:LSKL TFA (H-Leu-Ser-Lys-Leu-NH2 TFA) is a TGF-尾1 antagonist that inhibits TSP-1 binding to LAP and reduces renal interstitial fibrosis and liver fibrosis.Fórmula:C23H43F3N6O7Pureza:99.33%Cor e Forma:SolidPeso molecular:572.62Cirevetmab
CAS:Cirevetmab (ZTS-00521426), a caninized monoclonal antibody targeting Canis lupus familiaris TGFB1, is classified as an immunoglobulin G2-kappa.Cor e Forma:LiquidALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Fórmula:C20H23N7O2SCor e Forma:SolidPeso molecular:425.51Disitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Fórmula:C70H113N17O24S2Pureza:95.11%Cor e Forma:SoildPeso molecular:1640.88Rilogrotug
CAS:Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Cor e Forma:SoildFresolimumab
CAS:Fresolimumab (GC1008) is a human monoclonal antibody targeting active TGFβ1, TGFβ2, TGFβ3, studied for cancer and focal segmental glomerulosclerosis.Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:144.4 kDaP17 Peptide
CAS:P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.Fórmula:C95H139N27O21Cor e Forma:SolidPeso molecular:1995.29Prafnosbart
CAS:Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody targeting ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1), utilized inCor e Forma:LiquidTGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Fórmula:C27H32N6O2Cor e Forma:SolidPeso molecular:472.582Asiaticoside
CAS:Asiaticoside, in Centella asiatica, may treat wounds/burns.Fórmula:C48H78O19Pureza:98% - 99.96%Cor e Forma:PowderPeso molecular:959.12Galunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Fórmula:C22H19N5OPureza:97.09% - 99.98%Cor e Forma:SolidPeso molecular:369.42Ref: TM-T2510
1g657,00€5mg46,00€10mg52,00€25mg84,00€50mg114,00€100mg178,00€200mg269,00€500mg442,00€1mL*10mM (DMSO)52,00€ITD-1
CAS:ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Fórmula:C27H29NO3Pureza:99.89% - >99.99%Cor e Forma:SolidPeso molecular:415.52Kartogenin
CAS:Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Fórmula:C20H15NO3Pureza:96.25% - 97.79%Cor e Forma:SolidPeso molecular:317.34
