Sinalização JAK/STAT
Os inibidores da sinalização JAK/STAT são compostos que interrompem a via da Janus quinase (JAK) e do transdutor e ativador da transcrição (STAT), que está envolvida na sinalização de citocinas, crescimento celular e resposta imunológica. Esses inibidores são ferramentas importantes para estudar a regulação dessa via e seu papel em diversas doenças, incluindo cânceres, distúrbios imunológicos e condições inflamatórias. Os inibidores de JAK/STAT também estão sendo desenvolvidos como terapias direcionadas para essas doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de sinalização JAK/STAT de alta qualidade para apoiar sua pesquisa em biologia molecular, oncologia e imunologia.
Subcategorias de "Sinalização JAK/STAT"
Foram encontrados 361 produtos de "Sinalização JAK/STAT"
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AZD-1480
CAS:AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in solid tumors, PPV, PMF, ET trials.Fórmula:C14H14ClFN8Pureza:98.25% - 99.47%Cor e Forma:SolidPeso molecular:348.77SH5-07
CAS:SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).Fórmula:C29H28F5N3O5SPureza:95.54%Cor e Forma:SolidPeso molecular:625.61WDR5-0103 hydrochloride[890190-22-4(free base)]
WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:Fórmula:C21H26ClN3O4Pureza:99.66%Cor e Forma:SolidPeso molecular:419.9Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Fórmula:C27H36N6O3SPureza:97.31% - 99.96%Cor e Forma:SolidPeso molecular:524.68Ref: TM-T1995
1g592,00€5mg50,00€10mg65,00€50mg107,00€100mg127,00€200mg205,00€500mg447,00€1mL*10mM (DMSO)54,00€Tofacitinib Citrate
CAS:Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Fórmula:C22H28N6O8Pureza:99.19% - 99.75%Cor e Forma:SolidPeso molecular:504.49Oclacitinib
CAS:Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000Fórmula:C15H23N5O2SPureza:98% - 98.45%Cor e Forma:White To Off-White SolidPeso molecular:337.44(Z)-SMI-4a
CAS:(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.Fórmula:C11H6F3NO2SPureza:97.66% - 99.93%Cor e Forma:SolidPeso molecular:273.23Ruxolitinib (S enantiomer)
CAS:Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Fórmula:C17H18N6Pureza:99.37% - 99.79%Cor e Forma:SolidPeso molecular:306.36HJ-PI01
CAS:HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Fórmula:C14H11NO2Pureza:98.92%Cor e Forma:SolidPeso molecular:225.24Ref: TM-T9583
1mg34,00€5mg75,00€10mg110,00€25mg245,00€50mg363,00€100mg515,00€200mg700,00€1mL*10mM (DMSO)73,00€SAR-20347
CAS:SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).Fórmula:C21H18ClFN4O4Pureza:98.99% - 99.77%Cor e Forma:SolidPeso molecular:444.84Ref: TM-T4210
1mg34,00€5mg75,00€10mg110,00€25mg215,00€50mg334,00€100mg557,00€200mg775,00€1mL*10mM (DMSO)84,00€Cerdulatinib
CAS:Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Fórmula:C20H27N7O3SPureza:98.74% - 99.49%Cor e Forma:SolidPeso molecular:445.54Ref: TM-T2487
1mg42,00€2mg52,00€5mg74,00€10mg101,00€25mg175,00€50mg268,00€100mg409,00€200mg573,00€500mg888,00€1mL*10mM (DMSO)81,00€AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Cor e Forma:SolidPeso molecular:381.43Oclacitinib maleate
CAS:Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with no effect on 38 non-JAK kinases.Fórmula:C15H23N5O2S·C4H4O4Pureza:99.17% - 99.92%Cor e Forma:SolidPeso molecular:453.51Ref: TM-T6914
1mg37,00€2mg52,00€5mg74,00€10mg94,00€25mg166,00€50mg258,00€100mg432,00€1mL*10mM (DMSO)81,00€Fosifidancitinib
CAS:Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.Fórmula:C21H21FN5O7PPureza:99.54%Cor e Forma:SolidPeso molecular:505.39Ref: TM-T38624
1mg93,00€2mg117,00€5mg177,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.099,00€Solcitinib
CAS:Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.
Fórmula:C22H23N5O2Pureza:99.61% - 99.82%Cor e Forma:SolidPeso molecular:389.45Golotimod
CAS:Golotimod (SCV 07) is an antimicrobial active dipeptide with immunomodulatory activity for the study of recurrent genital herpes simplex virus 2 infections.Fórmula:C16H19N3O5Pureza:99.88% - 99.98%Cor e Forma:SolidPeso molecular:333.34Cerdulatinib hydrochloride
CAS:Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.Fórmula:C20H28ClN7O3SPureza:99.85%Cor e Forma:SolidPeso molecular:482CX-6258 hydrochloride
CAS:CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).Fórmula:C26H24ClN3O3·HClPureza:96.03% - 98.60%Cor e Forma:SolidPeso molecular:498.4Ref: TM-T6148
1mg40,00€5mg84,00€10mg120,00€25mg222,00€50mg356,00€100mg537,00€200mg762,00€1mL*10mM (DMSO)93,00€Osunprotafib
CAS:Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors.Cost-effective and quality-assured.Fórmula:C17H24FN3O4SPureza:97.11% - 99.91%Cor e Forma:SolidPeso molecular:385.45
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