Sinalização JAK/STAT
Os inibidores da sinalização JAK/STAT são compostos que interrompem a via da Janus quinase (JAK) e do transdutor e ativador da transcrição (STAT), que está envolvida na sinalização de citocinas, crescimento celular e resposta imunológica. Esses inibidores são ferramentas importantes para estudar a regulação dessa via e seu papel em diversas doenças, incluindo cânceres, distúrbios imunológicos e condições inflamatórias. Os inibidores de JAK/STAT também estão sendo desenvolvidos como terapias direcionadas para essas doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de sinalização JAK/STAT de alta qualidade para apoiar sua pesquisa em biologia molecular, oncologia e imunologia.
Subcategorias de "Sinalização JAK/STAT"
Foram encontrados 361 produtos de "Sinalização JAK/STAT"
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NVP-BSK805
CAS:NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.Fórmula:C27H28F2N6OPureza:98%Cor e Forma:SolidPeso molecular:490.55TLC1566-0618
CAS:TLC1566-0618 shows antitumor activity and targets stat.Fórmula:C20H15NO3S3Pureza:98%Cor e Forma:SolidPeso molecular:413.53Golotimod TFA
CAS:Golotimod TFA (SCV 07 TFA) is a dipeptide exhibiting immunomodulatory and antibacterial activity, alleviates radiation-induced oral mucositis.Fórmula:C18H20F3N3O7Pureza:98%Cor e Forma:SoildPeso molecular:447.36(3S,4S)-Tofacitinib
CAS:(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.Fórmula:C16H20N6OPureza:98%Cor e Forma:SolidPeso molecular:312.37JAK3-IN-12
CAS:JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.Fórmula:C19H19N5O4SCor e Forma:SolidPeso molecular:413.45K00135
CAS:K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.Fórmula:C18H18N4OPureza:98.16%Cor e Forma:SolidPeso molecular:306.36JAK-IN-11
CAS:JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.Fórmula:C23H22FN5O4SPureza:99.75%Cor e Forma:SolidPeso molecular:483.52CX-6258
CAS:CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.Fórmula:C26H24ClN3O3Pureza:97.46%Cor e Forma:SolidPeso molecular:461.94Ref: TM-T1834
1mg34,00€5mg75,00€10mg101,00€25mg197,00€50mg295,00€100mg447,00€200mg623,00€1mL*10mM (DMSO)77,00€JAK-IN-20
CAS:JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.Fórmula:C28H30FN7O2Cor e Forma:SolidPeso molecular:515.58Niclosamide monohydrate
CAS:Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication.Fórmula:C13H10Cl2N2O5Pureza:98%Cor e Forma:SolidPeso molecular:345.14Peficitinib hydrochloride
CAS:Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).Fórmula:C18H23ClN4O2Cor e Forma:SolidPeso molecular:362.86TK4b
CAS:TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).Fórmula:C21H22N2O2Cor e Forma:SolidPeso molecular:334.41TK4g
CAS:TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) & 15.80 nM (JAK3); promising for lymphoid diseases & leukemia research.Fórmula:C19H19N3O4SCor e Forma:SolidPeso molecular:385.44JAK-2/3-IN-2
CAS:JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).Fórmula:C19H19ClN2OSCor e Forma:SolidPeso molecular:358.89XZH-5
CAS:XZH-5 is an inhibitor of STAT3.Fórmula:C22H25F6N5O4Pureza:98%Cor e Forma:SolidPeso molecular:537.46JAK-IN-14
CAS:JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.Fórmula:C19H15FN4OPureza:98.27%Cor e Forma:SolidPeso molecular:334.35Ref: TM-T9764
1mg81,00€5mg170,00€10mg268,00€25mg555,00€50mg888,00€100mg1.414,00€200mg1.882,00€1mL*10mM (DMSO)178,00€TyK2-IN-2
CAS:TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).Fórmula:C16H18N6OPureza:98%Cor e Forma:SolidPeso molecular:310.35JAK-IN-18
CAS:"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."Fórmula:C27H28F2N6O3Cor e Forma:SolidPeso molecular:522.55Tyk2-IN-5
CAS:Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).Fórmula:C21H19FN8O2Pureza:98%Cor e Forma:SolidPeso molecular:434.43Tyk2-IN-7
CAS:Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).Fórmula:C18H15D3N6O3SPureza:98%Cor e Forma:SolidPeso molecular:401.46
