Sinalização JAK/STAT
Os inibidores da sinalização JAK/STAT são compostos que interrompem a via da Janus quinase (JAK) e do transdutor e ativador da transcrição (STAT), que está envolvida na sinalização de citocinas, crescimento celular e resposta imunológica. Esses inibidores são ferramentas importantes para estudar a regulação dessa via e seu papel em diversas doenças, incluindo cânceres, distúrbios imunológicos e condições inflamatórias. Os inibidores de JAK/STAT também estão sendo desenvolvidos como terapias direcionadas para essas doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de sinalização JAK/STAT de alta qualidade para apoiar sua pesquisa em biologia molecular, oncologia e imunologia.
Subcategorias de "Sinalização JAK/STAT"
Foram encontrados 363 produtos de "Sinalização JAK/STAT"
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STAT3-IN-14
CAS:STAT3-IN-14 is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 can directly bind to the hinge region of STAT3 .Fórmula:C14H10O5Cor e Forma:SolidPeso molecular:258.23Upadacitinib tartrate
CAS:Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.Fórmula:C21H33F3N6O11Pureza:98%Cor e Forma:SolidPeso molecular:602.521JAK-IN-31
CAS:JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,Fórmula:C21H19N7O2S2Pureza:98%Cor e Forma:SolidPeso molecular:465.55PIM1-IN-1
CAS:PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Fórmula:C25H30N8O2Pureza:98.59%Cor e Forma:SolidPeso molecular:474.56Ref: TM-T12474
10mgA consultar1mL*10mM (DMSO)A consultar1mg117,00€5mg281,00€25mg858,00€50mg1.341,00€100mg2.125,00€JAK-IN-1
CAS:JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.Fórmula:C20H24N6O2Pureza:98%Cor e Forma:SolidPeso molecular:380.44GNE-955
CAS:GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Fórmula:C22H24N8OPureza:98%Cor e Forma:SolidPeso molecular:416.48Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Fórmula:C42H70O12Pureza:98.46% - 99.13%Cor e Forma:SolidPeso molecular:767.00Tubulin/JAK2-IN-1
CAS:Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significantFórmula:C22H20N6O3Cor e Forma:SolidPeso molecular:416.43STAT6-IN-1
CAS:STAT6-IN-1: STAT6 inhibitor, IC50=0.028 µM, targets SH2 domain, for allergy and cancer research.Fórmula:C33H37IN3O7PCor e Forma:SolidPeso molecular:745.54STAT3-IN-20
CAS:STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclearFórmula:C30H27F4N7SPureza:98%Cor e Forma:SolidPeso molecular:593.64Antitumor agent-73
CAS:Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.Fórmula:C50H82BrO4PPureza:98%Cor e Forma:SolidPeso molecular:858.06STAT3-IN-B9
CAS:STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.Fórmula:C20H13NO5SPureza:98.19%Cor e Forma:SolidPeso molecular:379.39Ref: TM-T28865
1mg109,00€2mg154,00€5mg235,00€1mL*10mM (DMSO)255,00€10mg349,00€25mg532,00€50mg745,00€100mg999,00€200mg1.333,00€JAK-IN-5
CAS:JAK-IN-5 is a JAK inhibitor.Fórmula:C27H31FN6OPureza:98.1% - 99.37%Cor e Forma:SolidPeso molecular:474.57Ref: TM-T11710
1mg177,00€5mg370,00€1mL*10mM (DMSO)537,00€10mg552,00€25mg879,00€50mg1.189,00€100mg1.603,00€500mg3.205,00€Brepocitinib
CAS:Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).Fórmula:C18H21F2N7OPureza:99.82%Cor e Forma:SolidPeso molecular:389.4Ref: TM-TQ0010
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg205,00€50mg371,00€100mg595,00€200mg833,00€NMS-P953
CAS:NMS-P953: JAK2 inhibitor, reduces tumor growth in SET-2 model, confirmed in vivo action, good pharmacokinetics and safety.Fórmula:C16H11ClF3N5OCor e Forma:SolidPeso molecular:381.74FM-479
CAS:FM-479, a structural analog of FM-381, lacks inhibition of JAK3/kinases within 100-300 nM, serving as FM-381's negative control.
Fórmula:C25H26N6O2Pureza:98%Cor e Forma:SolidPeso molecular:442.523inS3-54A18
CAS:inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.Fórmula:C23H16ClNO2Pureza:99.68%Cor e Forma:SolidPeso molecular:373.83Ref: TM-T15582
2mg39,00€5mg62,00€1mL*10mM (DMSO)67,00€10mg87,00€25mg152,00€50mg215,00€100mg304,00€200mg427,00€QL-1200186
CAS:QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production followingFórmula:C26H27N7O3Pureza:98%Cor e Forma:SolidPeso molecular:485.54Tyk2-IN-9
CAS:Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.Fórmula:C20H17N9Pureza:98%Cor e Forma:SolidPeso molecular:383.41STAT3 degrader-2
CAS:STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and variousFórmula:C59H62N9O13PPureza:98%Cor e Forma:SolidPeso molecular:1136.15
