Sinalização JAK/STAT
Os inibidores da sinalização JAK/STAT são compostos que interrompem a via da Janus quinase (JAK) e do transdutor e ativador da transcrição (STAT), que está envolvida na sinalização de citocinas, crescimento celular e resposta imunológica. Esses inibidores são ferramentas importantes para estudar a regulação dessa via e seu papel em diversas doenças, incluindo cânceres, distúrbios imunológicos e condições inflamatórias. Os inibidores de JAK/STAT também estão sendo desenvolvidos como terapias direcionadas para essas doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de sinalização JAK/STAT de alta qualidade para apoiar sua pesquisa em biologia molecular, oncologia e imunologia.
Subcategorias de "Sinalização JAK/STAT"
Foram encontrados 362 produtos de "Sinalização JAK/STAT"
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Lorpucitinib
CAS:Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.Fórmula:C22H28N6O2Pureza:99.72%Cor e Forma:SolidPeso molecular:408.5JAK3i
CAS:JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.Fórmula:C18H15FN4O3Pureza:98.61% - 99.81%Cor e Forma:SolidPeso molecular:354.34Jaspamycin
CAS:Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.Fórmula:C12H12N4O5Cor e Forma:SolidPeso molecular:292.25PIM-1 Inhibitor 2
CAS:PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Fórmula:C17H11ClN4OPureza:98.81%Cor e Forma:SolidPeso molecular:322.75SD-1029
CAS:SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.Fórmula:C25H32Br2Cl2N2O3Cor e Forma:SolidPeso molecular:639.25JAK-STAT-IN-1
CAS:JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Fórmula:C21H21N5O2Pureza:99.59%Cor e Forma:SolidPeso molecular:375.42STS-E412
CAS:STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.Fórmula:C15H15ClN4O2Pureza:99.01%Cor e Forma:SolidPeso molecular:318.76JAK1-IN-8
CAS:JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Fórmula:C22H23FN4O3SPureza:98.4%Cor e Forma:SolidPeso molecular:442.51Izencitinib
CAS:Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Fórmula:C22H26N8Pureza:99.82%Cor e Forma:SolidPeso molecular:402.50Ref: TM-T35898
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg281,00€25mg567,00€50mg888,00€100mg1.431,00€200mg1.963,00€NT219
CAS:NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Fórmula:C16H14BrNO5SPureza:98.06% - 99.72%Cor e Forma:SolidPeso molecular:412.26Butyzamide
CAS:Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.Fórmula:C29H32Cl2N2O5SPureza:99.39% - 99.83%Cor e Forma:SoildPeso molecular:591.55Ref: TM-T67894
1mg149,00€5mg253,00€1mL*10mM (DMSO)329,00€10mg371,00€25mg573,00€50mg862,00€100mg1.305,00€200mg1.755,00€PM-43I
CAS:PM-43I is a potent inhibitor of both STAT5- and STAT6-dependent allergic airway disease in mice.Fórmula:C38H50F2N3O10PCor e Forma:SolidPeso molecular:777.79PIM-IN-2
CAS:PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Fórmula:C19H22N4O2Pureza:98%Cor e Forma:SolidPeso molecular:338.4Lepzacitinib
CAS:Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.Fórmula:C18H21N5O3Pureza:99.85%Cor e Forma:SolidPeso molecular:355.39Ref: TM-T78207
1mg50,00€5mg104,00€1mL*10mM (DMSO)114,00€10mg167,00€25mg340,00€50mg505,00€100mg712,00€200mg1.009,00€JAK2-IN-4
CAS:JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.Fórmula:C23H27N5O4SPureza:98%Cor e Forma:SolidPeso molecular:469.56JAK-IN-31
CAS:JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,Fórmula:C21H19N7O2S2Pureza:98%Cor e Forma:SolidPeso molecular:465.55TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Fórmula:C27H25F3N4O4Pureza:99.39% - ≥98%Cor e Forma:SolidPeso molecular:526.51JAK-IN-24
CAS:JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.Fórmula:C20H25N5O2Cor e Forma:SolidPeso molecular:367.44Upadacitinib tartrate
CAS:Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.Fórmula:C21H33F3N6O11Pureza:98%Cor e Forma:SolidPeso molecular:602.521JAK-IN-26
CAS:JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency inFórmula:C22H24N6O3Pureza:98%Cor e Forma:SolidPeso molecular:420.46
