Sinalização JAK/STAT
Os inibidores da sinalização JAK/STAT são compostos que interrompem a via da Janus quinase (JAK) e do transdutor e ativador da transcrição (STAT), que está envolvida na sinalização de citocinas, crescimento celular e resposta imunológica. Esses inibidores são ferramentas importantes para estudar a regulação dessa via e seu papel em diversas doenças, incluindo cânceres, distúrbios imunológicos e condições inflamatórias. Os inibidores de JAK/STAT também estão sendo desenvolvidos como terapias direcionadas para essas doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de sinalização JAK/STAT de alta qualidade para apoiar sua pesquisa em biologia molecular, oncologia e imunologia.
Subcategorias de "Sinalização JAK/STAT"
Foram encontrados 361 produtos de "Sinalização JAK/STAT"
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Gandotinib
CAS:LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Fórmula:C23H25ClFN7OPureza:99.33% - 99.86%Cor e Forma:SolidPeso molecular:469.94Peficitinib
CAS:Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Fórmula:C18H22N4O2Pureza:98.67% - 99.4%Cor e Forma:SolidPeso molecular:326.39Ref: TM-T6933
2mg38,00€5mg63,00€10mg99,00€25mg172,00€50mg268,00€100mg416,00€200mg610,00€1mL*10mM (DMSO)70,00€XL019
CAS:XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.Fórmula:C25H28N6O2Pureza:99.19%Cor e Forma:SolidPeso molecular:444.53Ref: TM-T3072
2mg43,00€5mg63,00€10mg92,00€25mg150,00€50mg215,00€100mg321,00€200mg477,00€1mL*10mM (DMSO)78,00€WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.Fórmula:C16H14Br2ClN3O3Pureza:99.49%Cor e Forma:SolidPeso molecular:491.56Ref: TM-T4657L
2mg34,00€5mg48,00€10mg86,00€25mg138,00€50mg182,00€100mg261,00€200mg371,00€1mL*10mM (DMSO)73,00€SMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Fórmula:C13H13NO3SPureza:99.99%Cor e Forma:SolidPeso molecular:263.31Ref: TM-T3989
1mg34,00€2mg46,00€5mg66,00€10mg93,00€25mg152,00€50mg222,00€100mg334,00€1mL*10mM (DMSO)87,00€ZM39923 hydrochloride
CAS:ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Fórmula:C23H25NO·HClPureza:98.05%Cor e Forma:SolidPeso molecular:367.91Baricitinib phosphate
CAS:Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.Fórmula:C16H20N7O6PSPureza:99.4% - 99.91%Cor e Forma:SolidPeso molecular:469.41Ref: TM-T2360
5mg40,00€10mg52,00€25mg73,00€50mg93,00€100mg105,00€200mg157,00€500mg260,00€1mL*10mM (DMSO)46,00€BP-1-102
CAS:BP-1-102 is an orally active, effective and specific STAT3 inhibitor.Fórmula:C29H27F5N2O6SPureza:99.25% - 99.44%Cor e Forma:SolidPeso molecular:626.59Ref: TM-T3708
1mg37,00€2mg49,00€5mg79,00€10mg113,00€25mg200,00€50mg334,00€100mg495,00€1mL*10mM (DMSO)99,00€Momelotinib HCl
CAS:Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.Fórmula:C23H24Cl2N6O2Cor e Forma:SolidPeso molecular:487.38Tofacitinib Citrate
CAS:Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).Fórmula:C22H28N6O8Pureza:99.19% - 99.75%Cor e Forma:SolidPeso molecular:504.49Pim1/AKK1-IN-1
CAS:Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Fórmula:C20H13N5OPureza:97.03% - 98.69%Cor e Forma:SolidPeso molecular:339.35Ref: TM-T5093
1mg85,00€2mg124,00€5mg173,00€10mg263,00€25mg464,00€50mg672,00€100mg945,00€1mL*10mM (DMSO)192,00€Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Fórmula:C15H18O2Pureza:97.55% - 99.92%Cor e Forma:SolidPeso molecular:230.30Ruxolitinib (S enantiomer)
CAS:Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Fórmula:C17H18N6Pureza:99.37% - 99.79%Cor e Forma:SolidPeso molecular:306.36Pacritinib
CAS:Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Fórmula:C28H32N4O3Pureza:99.25% - 99.49%Cor e Forma:SolidPeso molecular:472.58Gusacitinib HCl
CAS:Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.Fórmula:C24H29ClN8O2Cor e Forma:SolidPeso molecular:497GLPG0634 analog
CAS:GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.Fórmula:C23H18N6O2Pureza:99.52% - >99.99%Cor e Forma:SolidPeso molecular:410.43Ref: TM-T3076
1mg38,00€2mg50,00€5mg84,00€10mg137,00€25mg250,00€50mg442,00€100mg623,00€500mg1.305,00€1mL*10mM (DMSO)93,00€BD750
CAS:BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFórmula:C14H13N3OSPureza:99.02%Cor e Forma:SolidPeso molecular:271.34AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Cor e Forma:SolidPeso molecular:381.43CEP-33779
CAS:CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.Fórmula:C24H26N6O2SPureza:98.24% - ≥95%Cor e Forma:SolidPeso molecular:462.57Ref: TM-T6122
1mg43,00€2mg56,00€5mg93,00€10mg137,00€25mg231,00€50mg356,00€100mg530,00€500mg1.153,00€1mL*10mM (DMSO)92,00€
