Sinalização JAK/STAT
Os inibidores da sinalização JAK/STAT são compostos que interrompem a via da Janus quinase (JAK) e do transdutor e ativador da transcrição (STAT), que está envolvida na sinalização de citocinas, crescimento celular e resposta imunológica. Esses inibidores são ferramentas importantes para estudar a regulação dessa via e seu papel em diversas doenças, incluindo cânceres, distúrbios imunológicos e condições inflamatórias. Os inibidores de JAK/STAT também estão sendo desenvolvidos como terapias direcionadas para essas doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de sinalização JAK/STAT de alta qualidade para apoiar sua pesquisa em biologia molecular, oncologia e imunologia.
Subcategorias de "Sinalização JAK/STAT"
Foram encontrados 361 produtos de "Sinalização JAK/STAT"
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Protosappanin A
CAS:Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Fórmula:C15H12O5Pureza:99.42% - 99.82%Cor e Forma:SolidPeso molecular:272.25Ref: TM-TJS1779
1mg88,00€5mg195,00€10mg318,00€25mg523,00€50mg743,00€100mg999,00€1mL*10mM (DMSO)178,00€Cerdulatinib
CAS:Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.Fórmula:C20H27N7O3SPureza:98.74% - 99.49%Cor e Forma:SolidPeso molecular:445.54Ref: TM-T2487
1mg42,00€2mg52,00€5mg74,00€10mg101,00€25mg175,00€50mg268,00€100mg409,00€200mg573,00€500mg888,00€1mL*10mM (DMSO)81,00€AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Fórmula:C17H14N2O3Pureza:98.6% - 99.85%Cor e Forma:Yellow SolidPeso molecular:294.3SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Fórmula:C15H8Cl2FN3OPureza:99.56%Cor e Forma:SolidPeso molecular:336.15Ref: TM-T8719
1mg43,00€5mg87,00€10mg133,00€25mg227,00€50mg344,00€100mg429,00€200mg597,00€1mL*10mM (DMSO)94,00€NT157
CAS:NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.Fórmula:C16H14BrNO5SPureza:99.64%Cor e Forma:SolidPeso molecular:412.26Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Fórmula:C27H36N6O3SPureza:97.31% - 99.96%Cor e Forma:SolidPeso molecular:524.68Ref: TM-T1995
1g592,00€5mg50,00€10mg65,00€50mg107,00€100mg127,00€200mg205,00€500mg447,00€1mL*10mM (DMSO)54,00€Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Fórmula:C15H18O2Pureza:97.55% - 99.92%Cor e Forma:SolidPeso molecular:230.30Thymidylate Kinase Inhibitor, YMU1
CAS:YMU1 inhibits hTMPK, stabilizes its LID region, and blocks the catalytic/ATP-binding site.Fórmula:C17H22N4O4SPureza:98.06%Cor e Forma:SolidPeso molecular:378.45HODHBt
CAS:HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.Fórmula:C7H5N3O2Pureza:99.45% - 99.95%Cor e Forma:Off-White To Yellow SolidPeso molecular:163.13Cucurbitacin I
CAS:Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.Fórmula:C30H42O7Pureza:96.69% - 99.8%Cor e Forma:SolidPeso molecular:514.65Quercetagetin
CAS:Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.Fórmula:C15H10O8Pureza:99.65% - 99.91%Cor e Forma:SolidPeso molecular:318.24Ref: TM-T8114
1mg94,00€5mg192,00€10mg286,00€25mg482,00€50mg695,00€100mg945,00€500mg1.882,00€1mL*10mM (DMSO)202,00€HJ-PI01
CAS:HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.Fórmula:C14H11NO2Pureza:98.92%Cor e Forma:SolidPeso molecular:225.24Ref: TM-T9583
1mg34,00€5mg75,00€10mg110,00€25mg245,00€50mg363,00€100mg515,00€200mg700,00€1mL*10mM (DMSO)73,00€Ruxolitinib phosphate
CAS:Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.Fórmula:C17H21N6O4PPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:404.36Ref: TM-T3043
1g583,00€5mg49,00€10mg62,00€25mg78,00€50mg92,00€100mg138,00€200mg215,00€500mg395,00€1mL*10mM (DMSO)56,00€Pacritinib hydrochloride
CAS:Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.Fórmula:C28H32N4O3·xClHCor e Forma:SolidNapabucasin
CAS:Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.Fórmula:C14H8O4Pureza:98.43% - 99.85%Cor e Forma:SolidPeso molecular:240.21AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.
Fórmula:C21H21N3O2SPureza:97.24% - 99.83%Cor e Forma:SolidPeso molecular:379.48Peficitinib
CAS:Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Fórmula:C18H22N4O2Pureza:98.67% - 99.4%Cor e Forma:SolidPeso molecular:326.39Ref: TM-T6933
2mg38,00€5mg63,00€10mg99,00€25mg172,00€50mg268,00€100mg416,00€200mg610,00€1mL*10mM (DMSO)70,00€Abrocitinib
CAS:Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Fórmula:C14H21N5O2SPureza:99.09% - 99.91%Cor e Forma:SolidPeso molecular:323.41TP-3654
CAS:TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Fórmula:C22H25F3N4OPureza:99.8% - 99.95%Cor e Forma:SolidPeso molecular:418.46Delgocitinib EtOH
CAS:Delgocitinib (LEO-124249/JTE052) is a selective JAK inhibitor used for reducing skin inflammation and treating chronic dermatitis.Fórmula:C18H24N6O2Cor e Forma:SolidPeso molecular:356.43
