JNK
As JNKs (c-Jun N-terminal kinases) são um subgrupo da família MAPK que respondem a estímulos de estresse, como citocinas, radiação ultravioleta e choque térmico, e estão envolvidas no controle da apoptose, inflamação e respostas imunológicas. A sinalização JNK é crucial para a regulação das respostas celulares ao estresse e tem sido implicada em várias doenças, incluindo distúrbios neurodegenerativos, câncer e condições inflamatórias. Na CymitQuimica, oferecemos uma variedade de moduladores da via JNK para apoiar sua pesquisa em sinalização de estresse, apoptose e patologia de doenças.
Foram encontrados 97 produtos de "JNK"
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Mefloquine hydrochloride
CAS:<p>Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.</p>Fórmula:C17H17ClF6N2OPureza:99% - 99.74%Cor e Forma:Off-White To Yellow SolidPeso molecular:414.77Tanzisertib
CAS:<p>Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.</p>Fórmula:C21H23F3N6O2Pureza:98.66% - 99.28%Cor e Forma:SolidPeso molecular:448.44SU3327
CAS:<p>SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).</p>Fórmula:C5H3N5O2S3Pureza:98.39%Cor e Forma:SolidPeso molecular:261.3NBDHEX
CAS:<p>NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).</p>Fórmula:C12H15N3O4SPureza:97.38%Cor e Forma:SolidPeso molecular:297.33JNK-IN-13
CAS:<p>JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.</p>Fórmula:C13H7ClN4SPureza:98.74%Cor e Forma:SolidPeso molecular:286.74Metacetamol
CAS:<p>Metacetamol, a non-toxic acetaminophen derivative, is an OTC analgesic/antipyretic and synthesis intermediate.</p>Fórmula:C8H9NO2Pureza:99.76% - 99.90%Cor e Forma:Physical Description Light Gray Solid (Ntp 1992)Peso molecular:151.16Mefloquine
CAS:<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Fórmula:C17H16F6N2OPureza:99.89%Cor e Forma:SolidPeso molecular:378.31Chloramphenicol
CAS:<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>Fórmula:C11H12Cl2N2O5Pureza:99.6% - 99.84%Cor e Forma:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidPeso molecular:323.13Urolithin B
CAS:<p>Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical</p>Fórmula:C13H8O3Pureza:99.45%Cor e Forma:SolidPeso molecular:212.2Fasudil
CAS:<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Fórmula:C14H17N3O2SPureza:99.79% - 99.84%Cor e Forma:SolidPeso molecular:291.37JNK-1-IN-3
CAS:<p>JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.</p>Fórmula:C19H17FN4O3Pureza:97.551%Cor e Forma:SolidPeso molecular:368.36OVA-E1 peptide TFA
CAS:<p>OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.</p>Fórmula:C49H77F3N10O16Pureza:98%Cor e Forma:SolidPeso molecular:1119.19SP 600125, negative control
CAS:<p>SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125.</p>Fórmula:C15H10N2OPureza:≥98%Cor e Forma:SolidPeso molecular:234.25JNK-IN-18
<p>JNK-IN-18 (compound 23b) is a potent inhibitor of JNK1, boasting an IC50 of 2 nM. It demonstrates superior efficacy when compared to its IC50 values of 125 nM for JNK2 and 98 nM for BRAF(V600E).</p>Cor e Forma:Odour SolidMAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Cor e Forma:Odour SolidD-JBD19
CAS:<p>D-JBD19 is a non-permeable peptide with neuroprotective effects.</p>Fórmula:C99H164N32O28Pureza:98%Cor e Forma:SolidPeso molecular:2250.597Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Cor e Forma:Odour SolidJNK-IN-12
<p>JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor with an IC50 value of 66.3 nM, comprising a mitochondrial-specific cell-penetrating peptide</p>Fórmula:C56H82N16O7Pureza:98%Cor e Forma:SolidPeso molecular:1091.35MAP4K4-IN-6
<p>MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).</p>Cor e Forma:Odour SolidCC-401
CAS:<p>CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).</p>Fórmula:C22H24N6OPureza:98%Cor e Forma:SolidPeso molecular:388.47n-Butyl α-D-fructofuranoside
CAS:<p>N-Butyl α-D-fructofuranoside, extracted from the root barks of Ulmus davidiana var.</p>Fórmula:C10H20O6Pureza:98%Cor e Forma:SolidPeso molecular:236.26BRAFV600E/JNK-IN-1
<p>BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3, and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM, and 0.009 μM, respectively. It also inhibits the phosphorylation of MEK1/2 and ERK1/2. Additionally, BRAFV600E/JNK-IN-1 suppresses tumor cell proliferation, NO release, and PGE2 production, exhibiting both antitumor and anti-inflammatory activities.</p>Cor e Forma:Odour SolidL-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Fórmula:C164H286N66O40Pureza:98%Cor e Forma:SolidPeso molecular:3822.44JNK2-IN-1
<p>JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α and</p>Fórmula:C30H26N4O5Pureza:98%Cor e Forma:SolidPeso molecular:522.55JNK3 inhibitor-8
<p>JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.</p>Fórmula:C32H30FN7O3Cor e Forma:SolidPeso molecular:579.62JNK-1-IN-2
<p>"JNK-1-IN-2 (Compound c6) is a potent inhibitor of JNK-1 with an IC50 of 33.5 nM, and also exhibits inhibitory effects on JNK-2 and JNK-3 with IC50 values of</p>Fórmula:C16H20BrN5OPureza:98%Cor e Forma:SolidPeso molecular:378.27AS601245.2TFA (345987-15-7 free base)
CAS:AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3,Fórmula:C24H18F6N6O4SPureza:98%Cor e Forma:SoildPeso molecular:600.50JNK-IN-14
<p>JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.</p>Fórmula:C27H31N5O4SPureza:98%Cor e Forma:SolidPeso molecular:521.63JNK3 inhibitor-7
<p>Potent, oral JNK3 inhibitor-7 crosses blood-brain barrier, IC50: 53 nM (JNK3), offers neuroprotection, potential in AD research.</p>Fórmula:C32H31N7O3Cor e Forma:SolidPeso molecular:561.63IQ-1S
CAS:<p>IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.</p>Fórmula:C15H8N3NaOCor e Forma:SolidPeso molecular:269.23Vacquinol-1
CAS:<p>Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.</p>Fórmula:C21H21ClN2OPureza:98.67%Cor e Forma:SolidPeso molecular:352.86JIP-1(153-163)
CAS:<p>Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.</p>Fórmula:C61H104N20O14Pureza:98%Cor e Forma:SolidPeso molecular:1341.6OVA-E1 peptide
CAS:<p>OVA-E1 peptide, as SIINFEKL variant, triggers similar p38/JNK activation in mutant and normal thymocytes.</p>Fórmula:C47H76N10O14Cor e Forma:SolidPeso molecular:1005.181PROTAC JNK1-targeted-1
<p>PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]</p>Fórmula:C35H32BrN9O6Cor e Forma:SolidPeso molecular:754.589Ezatiostat
CAS:<p>Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.</p>Fórmula:C27H35N3O6SPureza:97.95%Cor e Forma:SolidPeso molecular:529.65JNK1 Protein, Human, Recombinant (GST)
<p>Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family.</p>Cor e Forma:Lyophilized PowderPeso molecular:75 kDa (predicted); 65 kDa (reducing conditions)WHI-P258
CAS:<p>WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.</p>Fórmula:C16H15N3O2Pureza:99.66% - 99.92%Cor e Forma:SolidPeso molecular:281.31IMM-H007
CAS:<p>IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression</p>Fórmula:C22H23N5O8Pureza:97.73%Cor e Forma:SolidPeso molecular:485.45AS601245
CAS:<p>AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.</p>Fórmula:C20H16N6SPureza:98% - 99.02%Cor e Forma:SolidPeso molecular:372.45JNK Inhibitor VIII
CAS:<p>JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,</p>Fórmula:C18H20N4O4Pureza:98.93%Cor e Forma:SolidPeso molecular:356.38Taurochenodeoxycholic Acid
CAS:<p>Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.</p>Fórmula:C26H45NO6SPureza:99.53% - 99.86%Cor e Forma:SolidPeso molecular:499.7DB07268
CAS:<p>DB07268 is a potent and selective JNK1 inhibitor.</p>Fórmula:C17H15N5O2Pureza:98.2% - 98.91%Cor e Forma:SolidPeso molecular:321.33SP600125
CAS:<p>SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive</p>Fórmula:C14H8N2OPureza:97.63% - 99.82%Cor e Forma:SolidPeso molecular:220.23BI-78D3
CAS:<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Fórmula:C13H9N5O5S2Pureza:97.89% - >99.99%Cor e Forma:SolidPeso molecular:379.37Anisomycin
CAS:<p>Anisomycin (NSC-76712), an antibiotic from Streptomyces, blocks protein/DNA synthesis by targeting peptidyl transferase/80S ribosomes.</p>Fórmula:C14H19NO4Pureza:98.33% - 99.81%Cor e Forma:White Crystalline SolidPeso molecular:265.3Loureirin B
CAS:<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Fórmula:C18H20O5Pureza:99.33% - 99.86%Cor e Forma:SolidPeso molecular:316.35TOMATIDINE HYDROCHLORIDE
CAS:<p>Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.</p>Fórmula:C27H46ClNO2Pureza:99.75% - ≥95%Cor e Forma:SolidPeso molecular:452.11Actein
CAS:<p>Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.</p>Fórmula:C37H56O11Pureza:≥98%Cor e Forma:Brown PowderPeso molecular:676.83Polyphyllin I
CAS:<p>Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,</p>Fórmula:C44H70O16Pureza:98% - 99.5%Cor e Forma:SolidPeso molecular:855.02Ro 31-8220 Mesylate
CAS:<p>Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.</p>Fórmula:C25H23N5O2S·CH4O3SPureza:98.79% - 99.02%Cor e Forma:SolidPeso molecular:553.65
