ERK
ERK é uma proteína chave na via de sinalização MAPK (Mitogen-Activated Protein Kinase), que está envolvida na transmissão de sinais dos receptores de superfície celular para o DNA no núcleo da célula. ERK desempenha um papel crucial na regulação de vários processos celulares, incluindo proliferação, diferenciação e sobrevivência. A desregulação da sinalização ERK está associada ao desenvolvimento de câncer e outras doenças, tornando-a um alvo importante para intervenções terapêuticas. Na CymitQuimica, oferecemos uma seleção de inibidores e moduladores de ERK de alta qualidade para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 202 produtos de "ERK"
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Methylthiouracil
CAS:Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Fórmula:C5H6N2OSPureza:99.89% - >99.99%Cor e Forma:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Peso molecular:142.18MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Fórmula:C33H39N7O2Pureza:97.3% - 99.07%Cor e Forma:SolidPeso molecular:565.71CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Fórmula:C22H21F3N6O2Pureza:99.42%Cor e Forma:SolidPeso molecular:458.44Urolithin B
CAS:Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFórmula:C13H8O3Pureza:99.45%Cor e Forma:SolidPeso molecular:212.2Lidocaine hydrochloride
CAS:<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Fórmula:C14H23ClN2OPureza:99.81% - 99.92%Cor e Forma:White Crystal PowderPeso molecular:270.798MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Fórmula:C21H18N4O2Pureza:99.58%Cor e Forma:SolidPeso molecular:358.39Lidocaine
CAS:<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Fórmula:C14H22N2OPureza:99.95% - >99.99%Cor e Forma:Needles From Benzene Or Alcohol SolidPeso molecular:234.34(E/Z)-BCI
CAS:<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Fórmula:C22H23NOPureza:99.94%Cor e Forma:SolidPeso molecular:317.42Honokiol
CAS:Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.Fórmula:C18H18O2Pureza:99.65% - 99.94%Cor e Forma:Dark Brown To White Fine Powder With Pleasant Odor Spicy And Slightly Bitter TastePeso molecular:266.33Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Fórmula:C17H17ClF6N2OPureza:99% - 99.99%Cor e Forma:Off-White To Yellow SolidPeso molecular:414.77Mefloquine
CAS:<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Fórmula:C17H16F6N2OPureza:99.89%Cor e Forma:SolidPeso molecular:378.31ERK5-IN-6
CAS:<p>ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.</p>Fórmula:C23H21N3Pureza:98.59%Cor e Forma:SoildPeso molecular:339.43LUT014
CAS:<p>LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.</p>Fórmula:C27H19F3N8OPureza:99.03%Cor e Forma:SolidPeso molecular:528.49ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Fórmula:C19H16ClN3OPureza:99.89%Cor e Forma:SoildPeso molecular:337.8AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Fórmula:C32H40N8O5SPureza:98.96%Cor e Forma:SolidPeso molecular:648.78Lidocaine Hydrochloride hydrate
CAS:<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Fórmula:C14H22N2O·HCl·H2OPureza:99.95%Cor e Forma:SolidPeso molecular:288.824-P-PDOT
CAS:<p>4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.</p>Fórmula:C19H21NOPureza:99.91%Cor e Forma:SolidPeso molecular:279.38PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Fórmula:C54H69N11O6SPureza:98%Cor e Forma:SolidPeso molecular:1000.26GSK143
CAS:GSK143: Oral SYK inhibitor, pIC50=7.5, curbs pErk, anti-inflammatory, hinders immune cells in mice.Fórmula:C17H22N6O2Cor e Forma:SolidPeso molecular:342.403Edaxeterkib
CAS:Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.Fórmula:C26H27N7O2Cor e Forma:SolidPeso molecular:469.549HDAC6-IN-61
HDAC6-IN-61 (Compound 4e) is an HDAC6 inhibitor with an IC50 of 73 nM, demonstrating greater selectivity compared to other HDAC isomers. It also acts as an activator of GPR40. HDAC6-IN-61 can increase the acetylation of tubulin and phosphorylation levels of ERK. This compound is relevant for studying neuroinflammation, including Alzheimer's disease.Cor e Forma:Odour SolidEmodic acid
CAS:Emodic acid is a useful organic compound for research related to life sciences. The catalog number is T124807 and the CAS number is 478-45-5.Fórmula:C15H8O7Cor e Forma:SolidPeso molecular:300.222PROTAC MEK1 Degrader-1
CAS:PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Fórmula:C53H66FIN8O11S2Pureza:98%Cor e Forma:SolidPeso molecular:1201.17ERK1/2 inhibitor 3
CAS:ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.Fórmula:C28H31ClFN5O6SCor e Forma:SolidPeso molecular:620.09SOS1-IN-18
<p>SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.</p>Fórmula:C26H29F3N4O2Cor e Forma:SolidPeso molecular:486.534′-Demethylnobiletin
CAS:<p>4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and</p>Fórmula:C20H20O8Cor e Forma:SolidPeso molecular:388.37TRV055
CAS:TRV055: Gq-biased AT1R ligand, stimulates Gq signaling, aids Gq-biased agonist development.Fórmula:C42H57N9O9Peso molecular:831.972Firazorexton
CAS:Firazorexton is a potent orexin type 2 receptor (OX2R) agonist.Fórmula:C22H25F3N2O4SCor e Forma:SolidPeso molecular:470.51Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Cor e Forma:Odour SolidMAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Cor e Forma:Odour SolidAnti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Fórmula:C19H30O3Cor e Forma:SolidPeso molecular:306.44KRAS G12C inhibitor 69
<p>KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.</p>Fórmula:C29H29ClF3N5O3Cor e Forma:SolidPeso molecular:588.02PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Fórmula:C18H16F3IN2O2Pureza:99.66%Cor e Forma:SolidPeso molecular:476.23MHJ-627
<p>MHJ-627, a potent inhibitor of ERK5 (MAPK7) with an IC50 value of 0.91 μM, enhances the mRNA expression of tumor suppressors and anti-metastatic genes, leading</p>Fórmula:C34H45BrN2O3Pureza:98%Cor e Forma:SolidPeso molecular:609.64Astragaloside
CAS:Astragaloside, one of the main active ingredients in Astragalus membranaceus.Fórmula:C28H32O17Pureza:99.9%Cor e Forma:Odour SolidPeso molecular:640.54MK2-IN-5
CAS:<p>MK2-IN-5, a pseudosubstrate of Mk2 with an inhibition constant (K_i) of 8 μM, selectively targets the protein interaction domain of the MAPK pathway and</p>Fórmula:C61H113N21O16Pureza:98%Cor e Forma:SolidPeso molecular:1396.68Laxiflorin B-4
<p>Laxiflorin B-4, a derivative of Laxiflorin B, demonstrates increased affinity for ERK1/2 and enhanced tumor-suppressive effects [1].</p>Pureza:98%Cor e Forma:Odour SolidPROTAC HPK1 Degrader-5
PROTACHPK1 Degrader-5 is a potent, orally active HPK1 PROTAC degrader with a DC50 of 5.0 nM and a Dmax of at least 99%. It significantly inhibits HPK1 by degrading it, reducing SLP76 phosphorylation, and enhancing ERK pathway activation, which in turn stimulates the release of IL-2 and IFN-γ. This compound effectively counteracts immune suppression induced by PGE2, NECA, or TGF-β. Alone, PROTACHPK1 Degrader-5 is capable of suppressing tumor growth in MC38 syngeneic mouse models. It is used in research for immunotherapy applications in cancers such as colorectal cancer.Cor e Forma:Odour SolidEndothelin-1 (1-31) (Human) TFA
Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from the chymase-mediated selective hydrolysis of big ET-1 [1].Fórmula:C164H237F3N38O49S5Pureza:98%Cor e Forma:SolidPeso molecular:3742.18SCH772984 HCl
SCH772984 HCl selectively inhibits ERK1/2, acts like type I/II kinase inhibitors, and is potent at 4/1 nM IC50s in certain mutated tumor cells.Fórmula:C33H34ClN9O2Pureza:98%Cor e Forma:SolidPeso molecular:624.14STE-MEK1(13)
CAS:<p>STE-MEK1(13), a cell-permeable ERK1/2 inhibitor with IC50 values ranging from 13 to 30 μM, impedes the phosphorylation of ERK1/2, as demonstrated in studies [1</p>Fórmula:C86H153N19O17SPureza:98%Cor e Forma:SolidPeso molecular:1757.32LC-SF-14
LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.Fórmula:C44H50Cl3N13O5SCor e Forma:SolidPeso molecular:977.28442Rineterkib hydrochloride
CAS:Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.Fórmula:C26H28BrClF3N5O2Cor e Forma:SolidPeso molecular:614.89ROCK-IN-5
CAS:<p>ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.</p>Fórmula:C16H11ClFN3OSPureza:99.72% - 99.83%Cor e Forma:SolidPeso molecular:347.79VSLRGDTRG acetate
<p>VSLRGDTRG acetate is a synthetic peptide of the RGD motif from cadherin17 (CDH17), capable of binding to α2β1 integrin and activating its signaling pathways. It facilitates the high-affinity conformational change of β1 integrin via the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby promoting tumor proliferation and metastasis. VSLRGDTRG acetate is applicable in research on cancers expressing CDH17, such as colon and pancreatic cancers.</p>Cor e Forma:Odour SolidAnti-inflammatory agent 35
CAS:Anti-inflammatory agent 35 is a potent anti-inflammatory agent.Fórmula:C27H29NO8Pureza:99.98%Cor e Forma:SoildPeso molecular:495.52Olomoucine
CAS:<p>Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.</p>Fórmula:C15H18N6OPureza:99.77%Cor e Forma:White Crystalline PowderPeso molecular:298.34Fulipiftide
CAS:<p>Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.</p>Fórmula:C144H227N41O47Cor e Forma:SolidPeso molecular:3284.59A-674563 HCl (552325-73-2(free base))
CAS:<p>A-674563: Oral Akt inhibitor (Ki: 11 nM for Akt1), also targets PKA/Cdk2, with 10-1800x selectivity over other kinases.</p>Fórmula:C22H23ClN4OPureza:≥98%Cor e Forma:SolidPeso molecular:394.9CHPG hydrochloride
CHPG hydrochloride is a selective agonist of mGluR5.Fórmula:C8H9Cl2NO3Pureza:99.57%Cor e Forma:SoildPeso molecular:238.07VSLRGDTRG
CAS:VSLRGDTRG is a synthetic peptide derived from the RGD motif in cadherin17 (CDH17) that binds to the α2β1 integrin, activating its signaling pathways. By promoting high-affinity conformational changes in β1 integrins through the RGD motif, VSLRGDTRG enhances cell adhesion and the phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. This peptide is useful for research on cancers expressing CDH17, such as colorectal and pancreatic cancer.Fórmula:C38H69N15O14Cor e Forma:SolidPeso molecular:960.047TAT-DEF-Elk-1
CAS:TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.Fórmula:C155H259N57O40Pureza:98%Cor e Forma:SolidPeso molecular:3561.136BTX6654
BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.Fórmula:C50H57F4N9O5Cor e Forma:SolidPeso molecular:940.04Pamoic acid disodium
CAS:Pamoic acid disodium is a GPR35 agonist.Fórmula:C23H16NaO6Pureza:99.73%Cor e Forma:Yellow PowderPeso molecular:411.36ERK2 Protein, Human, Recombinant (GST)
ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.Cor e Forma:Lyophilized PowderPeso molecular:67 kDa (predicted); 67 kDa (reducing conditions)EM127
CAS:EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.Fórmula:C14H18ClN3O3Pureza:97.55%Cor e Forma:SolidPeso molecular:311.76SBI-810 hydrochloride
CAS:SBI-810 hydrochloride is a β-arrestin-2 (βarr2)-biased allosteric modulator of NTSR1 (neurotensin receptor 1), exerting analgesic effects.Fórmula:C27H35ClN4O2Pureza:99.42%Peso molecular:483.05EPHB2 Protein, Cynomolgus, Recombinant (His)
EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression.Cor e Forma:Lyophilized PowderPeso molecular:59.09 kDa (predicted). Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.ERK2 Protein, Mouse, Recombinant (His & GST)
ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.Cor e Forma:Lyophilized PowderPeso molecular:69.1 kDa (predicted); 60 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)
EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag.Cor e Forma:Lyophilized PowderPeso molecular:75.2 kDa (predicted); 65 kDa (reducing conditions)EphB2 Protein, Mouse, Recombinant (hFc)
EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Cor e Forma:Lyophilized PowderPeso molecular:84.6 kDa (predicted); 96.6 kDa (reducing conditions)EphB2 Protein, Mouse, Recombinant (His)
EphB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:59.3 kDa (predicted); 65 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (His)
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:59.2 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)EphB2 Protein, Human, Recombinant (His & hFc)
<p>EphB2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:86 kDa (predicted); 90-100 kDa (reducing condition, due to glycosylation)ERα degrader-2
CAS:ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast cancFórmula:C29H27F3N2O2Pureza:99.71%Cor e Forma:SolidPeso molecular:492.53TRPM4 inhibitor 8
CAS:<p>TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.</p>Fórmula:C11H17BrN2Pureza:97%Cor e Forma:SolidPeso molecular:257.17PERK-IN-2
CAS:PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).Fórmula:C23H18F3N5OPureza:98%Cor e Forma:SolidPeso molecular:437.42N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Fórmula:C11H15NOPureza:99.46% - 99.84%Cor e Forma:SolidPeso molecular:177.24Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Fórmula:C16H16F3N5Pureza:99.97%Cor e Forma:SolidPeso molecular:335.33Corynoxeine
CAS:Corynoxeine inhibits ERK1/2, curbs VSMC growth induced by PDGF-BB, and may prevent vascular diseases and restenosis post-angioplasty.Fórmula:C22H26N2O4Pureza:98.61% - 99.94%Cor e Forma:SolidPeso molecular:382.45Periplocin
CAS:<p>Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.</p>Fórmula:C36H56O13Pureza:99.66% - 99.74%Cor e Forma:SolidPeso molecular:696.82Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Fórmula:C42H72O14Pureza:99.42% - 99.65%Cor e Forma:SolidPeso molecular:801.01DCLK1-IN-1
CAS:<p>DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.</p>Fórmula:C26H28F3N7O2Pureza:98.55% - 99.28%Cor e Forma:SolidPeso molecular:527.54Theliatinib
CAS:<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>Fórmula:C25H26N6O2Pureza:99.67%Cor e Forma:SolidPeso molecular:442.51SCH772984
CAS:<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C33H33N9O2Pureza:97.565% - 98.75%Cor e Forma:SolidPeso molecular:587.67VX-11e
CAS:VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Fórmula:C24H20Cl2FN5O2Pureza:98.92% - ≥98%Cor e Forma:SolidPeso molecular:500.35magnolin
CAS:<p>Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.</p>Fórmula:C23H28O7Pureza:98% - 99.77%Cor e Forma:SolidPeso molecular:416.46Ulixertinib
CAS:<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Fórmula:C21H22Cl2N4O2Pureza:99.31% - 99.95%Cor e Forma:SolidPeso molecular:433.33AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Fórmula:C16H17FIN3O4Pureza:98.72%Cor e Forma:SolidPeso molecular:461.23Peramivir Trihydrate
CAS:<p>Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are</p>Fórmula:C15H28N4O4·3H2OPureza:99.52% - ≥95%Cor e Forma:SolidPeso molecular:382.45TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Fórmula:C10H14O2Pureza:99.17% - 99.53%Cor e Forma:White Solid PowderPeso molecular:166.22Pachymic acid
CAS:Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.Fórmula:C33H52O5Pureza:99.43% - >99.99%Cor e Forma:White PowderPeso molecular:528.76SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Fórmula:C26H37N5O2Pureza:99.36%Cor e Forma:SolidPeso molecular:451.6RU-301
CAS:RU-301 is a novel pan-tam inhibitorFórmula:C21H19F3N4O4SPureza:98.87%Cor e Forma:SolidPeso molecular:480.46Triptonide
CAS:<p>Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.</p>Fórmula:C20H22O6Pureza:99.11% - 99.64%Cor e Forma:White Crystalline PowderPeso molecular:358.39Piperlongumine
CAS:Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.Fórmula:C17H19NO5Pureza:97.03% - 99.90%Cor e Forma:SolidPeso molecular:317.34DEL-22379
CAS:DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.Fórmula:C26H28N4O3Pureza:99.3% - 99.53%Cor e Forma:SolidPeso molecular:444.53Aurothiomalate sodium
CAS:<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Fórmula:C4H3AuNa2O4SPureza:99.66%Cor e Forma:SoildPeso molecular:390.07BAY885
CAS:<p>BAY885 is a new ERK5 inhibitor.</p>Fórmula:C25H28F3N7O2Pureza:99.83%Cor e Forma:SolidPeso molecular:515.53XMD8-92
CAS:XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).Fórmula:C26H30N6O3Pureza:98.21%Cor e Forma:SolidPeso molecular:474.55Epieriocalyxin A
CAS:<p>Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.</p>Fórmula:C20H24O5Pureza:97.00%Cor e Forma:SolidPeso molecular:344.46-OAU
CAS:6-OAU is a GPR84 agonist, activates it in HEK293 cells with a 105 nM EC50.Fórmula:C12H21N3O2Pureza:98.14% - 99.01%Cor e Forma:SolidPeso molecular:239.31Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Fórmula:C30H52O4Pureza:99.85% - 99.90%Cor e Forma:SolidPeso molecular:476.73Temuterkib
CAS:<p>LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.</p>Fórmula:C22H27N7O2SPureza:99.57% - >99.99%Cor e Forma:SolidPeso molecular:453.56Avicularin
CAS:Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.Fórmula:C20H18O11Pureza:97.02% - 99.94%Cor e Forma:White PowderPeso molecular:434.35Astragaloside IV
CAS:Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.Fórmula:C41H68O14Pureza:99% - 99.84%Cor e Forma:Hydroscopic Brown Or Yellow PowderPeso molecular:784.97Nitidine chloride
CAS:1.Fórmula:C21H18ClNO4Pureza:96.59% - 99.55%Cor e Forma:SolidPeso molecular:383.82ERK5-IN-1
CAS:ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).Fórmula:C25H29N7O2Pureza:97.70%Cor e Forma:SolidPeso molecular:459.54ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Fórmula:C40H48F3N7O4Pureza:99.71%Cor e Forma:SolidPeso molecular:747.85UNC569
CAS:UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.Fórmula:C22H29FN6Pureza:98.91% - 99.67%Cor e Forma:SolidPeso molecular:396.5
