PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 188 produtos para "PDE".
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PDE10-IN-1
CAS:PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.Fórmula:C21H19N7Pureza:99.65%Cor e Forma:SolidPeso molecular:369.42RS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Fórmula:C19H13N5O4Pureza:98.98%Cor e Forma:White SolidPeso molecular:375.34Ref: TM-T9239
1mg84,00€5mg168,00€1mL*10mM (DMSO)177,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Fórmula:C26H24N4O5Pureza:97.03% - 99.29%Cor e Forma:SolidPeso molecular:472.49Enpp-1-IN-1
CAS:Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)Fórmula:C17H17N3O3SPureza:97.52%Cor e Forma:White SolidPeso molecular:343.4Ref: TM-T7888
1mg126,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg394,00€25mg677,00€50mg954,00€100mg1.288,00€GSK256066 Trifluoroacetate
CAS:GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.Fórmula:C29H27F3N4O7SCor e Forma:SolidPeso molecular:632.61Crisaborole-D4
Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.Fórmula:C14H6D4BNO3Cor e Forma:White SolidPeso molecular:255.07ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Fórmula:C22H19N3O4Pureza:98%Cor e Forma:SolidPeso molecular:389.4Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Fórmula:C40H37N5OPureza:99.4%Cor e Forma:SolidPeso molecular:603.75PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Fórmula:C19H17ClN2O2Pureza:99.55%Cor e Forma:White SolidPeso molecular:340.8K134
CAS:K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.Fórmula:C22H29N3O4Pureza:98%Cor e Forma:SolidPeso molecular:399.48Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C30H39ClN6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:647.25Propentofylline
CAS:Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.Fórmula:C15H22N4O3Pureza:99.76% - 99.86%Cor e Forma:SolidPeso molecular:306.36PAT-048
CAS:PAT-048 is an effective and selective autotaxin inhibitor.Fórmula:C22H18ClF2N3O2SPureza:98%Cor e Forma:SolidPeso molecular:461.91(R)-DNMDP
CAS:(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.Fórmula:C15H20N4O3Cor e Forma:SolidPeso molecular:304.34KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Fórmula:C25H35N7O6SPureza:99.55%Cor e Forma:SolidPeso molecular:561.65Lirimilast
CAS:Lirimilast is a PDE4 inhibitor for respiratory disease research.Fórmula:C17H12Cl2N2O6SPureza:99.68%Cor e Forma:SolidPeso molecular:443.26BAY 73-6691
CAS:BAY 73-6691 is an inhibitor of brain penetrant PDE9A.Fórmula:C15H12ClF3N4OCor e Forma:SolidPeso molecular:356.73Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Fórmula:C15H15ClN4OPureza:99.93%Cor e Forma:SolidPeso molecular:302.76Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C32H40ClF3N6O6S2Pureza:98%Cor e Forma:SolidPeso molecular:761.28GRI918013
CAS:GRI918013 is a compound that competitively inhibits the autocrine motility factor (ATX/NPP2), thereby suppressing tumor cell invasion and metastasis.Fórmula:C17H15Cl2FN2O4SPureza:99.80%Cor e Forma:White SolidPeso molecular:433.28
