PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 166 produtos de "PDE"
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Deltarasin
CAS:<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Fórmula:C40H37N5OPureza:99.4%Cor e Forma:SolidPeso molecular:603.75K134
CAS:<p>K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.</p>Fórmula:C22H29N3O4Pureza:98%Cor e Forma:SolidPeso molecular:399.48PAT-048
CAS:<p>PAT-048 is an effective and selective autotaxin inhibitor.</p>Fórmula:C22H18ClF2N3O2SPureza:98%Cor e Forma:SolidPeso molecular:461.91Propentofylline
CAS:<p>Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.</p>Fórmula:C15H22N4O3Pureza:99.76% - 99.86%Cor e Forma:Off-White SolidPeso molecular:306.36Deltasonamide 2
CAS:<p>Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Fórmula:C30H39ClN6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:647.25Deltasonamide 2 (TFA)
CAS:<p>Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Fórmula:C32H40ClF3N6O6S2Pureza:98%Cor e Forma:SolidPeso molecular:761.28PDE9-IN-1
CAS:<p>PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).</p>Fórmula:C17H23FN6O2Pureza:99.86%Cor e Forma:SolidPeso molecular:362.4Tilivapram
CAS:<p>Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.</p>Fórmula:C16H15Cl2N3O4Pureza:99.87%Cor e Forma:SolidPeso molecular:384.21AN3199
CAS:<p>AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.</p>Fórmula:C17H18BNO5Pureza:99.45%Cor e Forma:SolidPeso molecular:327.14Imazodan hydrochloride
CAS:<p>Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.</p>Fórmula:C13H13ClN4OPureza:98.97%Cor e Forma:SolidPeso molecular:276.72BAY 73-6691
CAS:<p>BAY 73-6691 is an inhibitor of brain penetrant PDE9A.</p>Fórmula:C15H12ClF3N4OCor e Forma:SolidPeso molecular:356.73Lirimilast
CAS:<p>Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.</p>Fórmula:C17H12Cl2N2O6SPureza:98%Cor e Forma:SolidPeso molecular:443.26WAY127093B racemate
CAS:<p>WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.</p>Fórmula:C23H28N4O4Pureza:99.67%Cor e Forma:SolidPeso molecular:424.49PDE7-IN-2
CAS:<p>PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.</p>Fórmula:C14H11ClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:322.77(R)-DNMDP
CAS:<p>(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.</p>Fórmula:C15H20N4O3Cor e Forma:SolidPeso molecular:304.34Autotaxin-IN-1
CAS:<p>Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.</p>Fórmula:C21H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:405.45Senazodan hydrochloride
CAS:<p>Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.</p>Fórmula:C15H15ClN4OPureza:99.93%Cor e Forma:SolidPeso molecular:302.76KD-027
CAS:<p>KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.</p>Fórmula:C25H35N7O6SPureza:99.55%Cor e Forma:SolidPeso molecular:561.65ATX inhibitor 5
CAS:<p>ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.</p>Fórmula:C22H18ClF3N6OPureza:98.77%Cor e Forma:SolidPeso molecular:474.87PF-04822163
CAS:<p>PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.</p>Fórmula:C19H17ClN2O2Pureza:99.55%Cor e Forma:SolidPeso molecular:340.8
