Caseína quinase

As caseína quinases são uma família de proteínas quinases serina/treonina que regulam vários processos celulares, incluindo a reparação do DNA, os ritmos circadianos e a transdução de sinais. Essas quinases estão envolvidas na fosforilação de numerosas proteínas e estão implicadas em doenças como o câncer, distúrbios neurodegenerativos e síndromes metabólicas. Na CymitQuimica, oferecemos uma seleção de inibidores de caseína quinase para apoiar sua pesquisa em transdução de sinais, regulação do ciclo celular e desenvolvimento terapêutico.

Foram encontrados 151 produtos para "Caseína quinase".

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Silmitasertib sodium salt
CAS:
- 1309357-15-0
Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
Fórmula:C₁₉H₁₁ClN₃NaO₂
Pureza:99.49% - 99.95%
Cor e Forma:Solid
Peso molecular:371.752
Ref: TM-T15024
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NMS-P715
CAS:
- 1202055-32-0
NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
Fórmula:C₃₅H₃₉F₃N₈O₃
Pureza:99.84%
Cor e Forma:Solid
Peso molecular:676.7312
Ref: TM-T12237
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Ellagic acid
CAS:
- 476-66-4
Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor. Ellagic acid is an antioxidant. Cost-effective and quality-assured.
Fórmula:C₁₄H₆O₈
Pureza:97.05% - 99.75%
Cor e Forma:Brown Solid
Peso molecular:302.1926
Ref: TM-T0465
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A-3 hydrochloride
CAS:
- 78957-85-4
A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.
Fórmula:C₁₂H₁₄Cl₂N₂O₂S
Pureza:99.32%
Cor e Forma:Solid
Peso molecular:321.22
Ref: TM-T14069
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Emodin
CAS:
- 518-82-1
Emodin (Frangula emodin) is a selective 11β-HSD1 inhibitor,IC50 of 186 and 86 nM against 11β-HSD1 in humans and mice. High-Quality, Low-Cost!
Fórmula:C₁₅H₁₀O₅
Pureza:98.37% - 99.53%
Cor e Forma:Solid
Peso molecular:270.24
Ref: TM-T2869
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Casein Kinase Substrates 3
CAS:
- 154444-97-0
Casein Kinase Substrates 3 is a substrate of casein kinase.
Fórmula:C₈₅H₁₃₉N₂₇O₃₅S
Pureza:98%
Cor e Forma:Solid
Peso molecular:2131.24
Ref: TM-TP1509
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CK1δ/CK1ε liagnd-1
CK1δ/CK1ε ligand-1 is a ligand of CK1δ/CK1ε and can serve as a target protein ligand for the synthesis of the CK1 PROTAC degrader AH078.
Fórmula:C₂₁H₂₀F₂N₆
Cor e Forma:Solid
Peso molecular:394.42
Ref: TM-T205094
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QXG-6442
QXG-6442 is a molecular glue degrader targeting CK1α, demonstrating a degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. In the MOLM-14 cell line, QXG-6442 induces antiproliferative effects.
Fórmula:C₂₁H₁₇N₅O₄
Cor e Forma:Solid
Peso molecular:403.39
Ref: TM-T205020
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CZP-IN-1
CZP-IN-1 (compound SH-1) is an inhibitor targeting the pathogen Trypanosoma cruzi protease (CZP) without affecting cathepsin L (IC50=28 nM). This compound is applicable in Chagas disease research.
Fórmula:C₂₀H₂₆N₄O₄S
Cor e Forma:Solid
Peso molecular:418.51
Ref: TM-T205551
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AH078
AH078 (compound 37) is a selective PROTAC degrader targeting CK1δ and CK1ε with low selectivity for CK1α. AH078 consists of a PROTAC linker (black part) Monomethyl octanoate, a target protein ligand (red part) CK1δ/CK1ε ligand-1, and an E3 ligase ligand (blue part) E3 Ligase Ligand 58. The E3 ligase ligand combined with the linker forms the conjugate E3 Ligase Ligand-linker Conjugate 163.
Fórmula:C₅₁H₆₀F₂N₁₀O₅S
Cor e Forma:Solid
Peso molecular:963.15
Ref: TM-T205491
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CK1-IN-4
CK1-IN-4 (Compound 59) is an inhibitor of casein kinase CK1δ with an IC50 of 2.74 μM. It exhibits neuroprotective activity in SH-SY5Y cells treated with Ethacrynic acid.
Cor e Forma:Odour Solid
Ref: TM-T89036
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Casein kinase 1δ-IN-15
CAS:
- 2765264-27-3
Casein kinase 1δ-IN-15, an inhibitor for casein kinase 1 (CK1δ), exhibits an IC50 of 0.045 μM [1].
Fórmula:C₁₉H₁₇FN₆O
Cor e Forma:Solid
Peso molecular:364.38
Ref: TM-T86006
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MU1742
MU1742 is a probe for CK1δ and CK1ε protein kinases [1] .
Fórmula:C₂₂H₂₂F₂N₆
Cor e Forma:Solid
Peso molecular:408.45
Ref: TM-T74661
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Casein kinase 1δ-IN-9
CAS:
- 854355-54-7
Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.
Fórmula:C₁₅H₁₂ClN₃
Pureza:99.93%
Cor e Forma:White Solid
Peso molecular:269.729
Ref: TM-T64376
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Casein Kinase II Receptor Peptide
CAS:
- 198481-81-1
Casein Kinase II Receptor Peptide: a substrate for measuring enzyme activity; K m = 500 µM.
Fórmula:C₄₆H₇₅N₁₅O₂₃
Peso molecular:1206.17
Ref: TM-T76383
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WAY-297174
CAS:
- 442571-27-9
WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.
Fórmula:C₁₁H₁₂N₂O₂S₂
Pureza:99.53%
Cor e Forma:Solid
Peso molecular:268.355
Ref: TM-T60067
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Casein
CAS:
- 9000-71-9
Casein is a milk protein with multiple roles involved in novel drug delivery systems.
Pureza:95%
Cor e Forma:Solid
Ref: TM-T83969
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WAY-353591
CAS:
- 454427-09-9
WAY-353591 is a casein kinase 1d (CK1d) inhibitor IC₅₀ of 131 μM. WAY-353591 can be used in pathological studies of neurodegenerative diseases.
Fórmula:C₁₆H₁₂FN₃S
Pureza:99.98%
Cor e Forma:White Solid
Peso molecular:297.35
Ref: TM-T212832
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Casein kinase 1δ-IN-14
CAS:
- 793722-88-0
Casein kinase 1δ-IN-14 (WAY-637081) can be used to study atherosclerosis-related cardiovascular disease.
Fórmula:C₁₇H₁₁ClN₄O₂
Pureza:99.66%
Cor e Forma:Solid
Peso molecular:338.748
Ref: TM-T77648
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Casein Kinase 2 Substrate Peptide
CAS:
- 132176-35-3
CK2 Substrate Peptide, C-terminus linked to EDANS, used for CK2 activity assays.
Fórmula:C₄₅H₇₃N₁₉O₂₄
Cor e Forma:Solid
Peso molecular:1264.17
Ref: TM-T76411