ROR
Os receptores órfãos relacionados ao ácido retinoico (RORs) são receptores nucleares que regulam vários processos fisiológicos, incluindo ritmo circadiano, resposta imune e metabolismo. Inibidores de RORs são de grande interesse no estudo de doenças autoimunes, distúrbios metabólicos e câncer, pois podem modular a expressão gênica e influenciar as funções celulares. Na CymitQuimica, oferecemos inibidores de RORs para apoiar sua pesquisa em imunologia, endocrinologia e oncologia.
Foram encontrados 45 produtos de "ROR"
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RORγ agonist 2
RORγ agonist2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03 μM for hRORγ. It significantly inhibits tumor growth in an MC38 tumor mouse model with the same genetic background.Cor e Forma:Odour SolidBevurogant
CAS:<p>Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.</p>Fórmula:C26H28N8O3SPureza:99.32%Cor e Forma:SolidPeso molecular:532.62ROR1-IN-2
<p>ROR1-IN-2 (compound 9I) is a potent and selective inhibitor of ROR1. It exhibits antiproliferative activity in various cancer cell lines and significantly inhibits tumor growth in vivo.</p>Fórmula:C30H27N3O4Cor e Forma:SolidPeso molecular:493.20016ROR1 ligand-1
<p>ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.</p>Fórmula:C23H30BrN7Cor e Forma:SolidPeso molecular:484.44TMP-778
CAS:TMP-778 is a selective inverse agonist of RORγt.Fórmula:C31H30N2O4Pureza:99.68%Cor e Forma:SolidPeso molecular:494.58RORγt inverse agonist 33
<p>RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.</p>Fórmula:C27H37NO5SCor e Forma:SolidPeso molecular:487.651RORγ antagonist 1
RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM.Fórmula:C35H60N2O2Pureza:98%Cor e Forma:SolidPeso molecular:540.86RORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent antagonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an inhibitory concentration (Fórmula:C23H15Cl2F3N4O3SPureza:98%Cor e Forma:SolidPeso molecular:555.36XY039
XY039 (compound 13e) is an RORγ inverse agonist with an IC50 value of 0.55 μM. XY039 induces cell apoptosis and exhibits antiproliferative activity both in vivo and in vitro.Fórmula:C23H19F5N2O4S2Peso molecular:546.07064TMP920
CAS:TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.Fórmula:C29H30N2O3Pureza:98%Cor e Forma:SolidPeso molecular:454.56XY018
CAS:<p>XY018 is a ROR-γ antagonist with anti-tumor activity, inhibits ROR-γ activity, and can be used to study drug-resistant prostate cancer.</p>Fórmula:C23H15F7N2O4Pureza:99.95% - 99.96%Cor e Forma:SolidPeso molecular:516.37SR1001
CAS:SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).Fórmula:C15H13F6N3O4S2Pureza:98.93%Cor e Forma:SolidPeso molecular:477.4SR0987
CAS:<p>SR0987 is a RORγt agonist,</p>Fórmula:C16H10ClF6NO2Pureza:99.43%Cor e Forma:SolidPeso molecular:397.7GSK2981278
CAS:GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).Fórmula:C25H35NO5SPureza:99.31% - 99.67%Cor e Forma:SolidPeso molecular:461.61SR1078
CAS:SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.Fórmula:C17H10F9NO2Pureza:99.58%Cor e Forma:SolidPeso molecular:431.25Cintirorgon
CAS:Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.Fórmula:C27H23F6NO6SPureza:99.92%Cor e Forma:SolidPeso molecular:603.53S18-000003
CAS:S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.Fórmula:C26H25F3N2O4SPureza:99.24% - 99.31%Cor e Forma:SolidPeso molecular:518.55T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Fórmula:C17H12F9NO3SPureza:98% - 99.64%Cor e Forma:SolidPeso molecular:481.33Neoruscogenin
CAS:1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.Fórmula:C27H40O4Pureza:99.5% - 99.92%Cor e Forma:SolidPeso molecular:428.60RORγt inverse agonist 13
CAS:RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].Fórmula:C23H17Cl2F3N2O4Pureza:99.04%Cor e Forma:SolidPeso molecular:513.29
