Desidrogenase
As desidrogenases são enzimas envolvidas nas reações de oxidação-redução das vias metabólicas, desempenhando um papel central na produção de energia e na respiração celular. Estas enzimas são cruciais para processos como o ciclo do ácido cítrico, a glicólise e a oxidação dos ácidos graxos. Os inibidores de desidrogenases são ferramentas importantes no estudo de doenças metabólicas, câncer e estresse oxidativo. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de desidrogenases para apoiar sua pesquisa em metabolismo, biologia do câncer e bioquímica.
Foram encontrados 300 produtos de "Desidrogenase"
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XEN723
CAS:XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).Fórmula:C21H20FN5O2SPureza:99.5%Cor e Forma:SolidPeso molecular:425.48Ref: TM-T13356
1mg52,00€5mg110,00€10mg170,00€25mg289,00€50mg414,00€100mg583,00€200mg785,00€1mL*10mM (DMSO)132,00€ML390
CAS:ML390 exerts its potent differentiation effect on multiple leukemia models.Fórmula:C21H21F3N2O3Pureza:99.76%Cor e Forma:SolidPeso molecular:406.4LDH-IN-1
CAS:LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).Fórmula:C30H26N4O4S2Pureza:99.6%Cor e Forma:SolidPeso molecular:570.68Ref: TM-T11829
1mg188,00€5mg393,00€10mg588,00€25mg938,00€50mg1.359,00€100mg1.786,00€200mg2.442,00€1mL*10mM (DMSO)494,00€SCD1 inhibitor-4
CAS:SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.Fórmula:C17H16F3N5OPureza:99.71%Cor e Forma:SolidPeso molecular:363.34Ref: TM-T10525
2mg43,00€5mg60,00€10mg99,00€25mg192,00€50mg309,00€100mg444,00€200mg617,00€1mL*10mM (DMSO)71,00€Trilostane
CAS:Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties.Fórmula:C20H27NO3Pureza:99.46% - >99.99%Cor e Forma:Tan CrystalsPeso molecular:329.43RS 61443
CAS:RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)Fórmula:C23H31NO7Pureza:99.37% - 99.96%Cor e Forma:SolidPeso molecular:433.5MF-438
CAS:MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).Fórmula:C19H18F3N5OSPureza:98.98% - 99.50%Cor e Forma:SolidPeso molecular:421.44Ref: TM-T16068
1mg92,00€2mg137,00€5mg203,00€10mg310,00€25mg527,00€50mg755,00€100mg1.044,00€500mg2.088,00€1mL*10mM (DMSO)224,00€PTC299
CAS:PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNAFórmula:C25H20Cl2N2O3Pureza:99.72%Cor e Forma:SolidPeso molecular:467.34Ref: TM-T12574
1mg117,00€5mg243,00€10mg369,00€25mg622,00€50mg885,00€100mg1.206,00€1mL*10mM (DMSO)250,00€DHODH-IN-11
CAS:DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.Fórmula:C15H11N3O2Pureza:98.14%Cor e Forma:SolidPeso molecular:265.27Mutant IDH1 inhibitor
CAS:Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).Fórmula:C25H34N6O3Pureza:98.3%Cor e Forma:SolidPeso molecular:466.58Ref: TM-T16161
1mg39,00€5mg86,00€10mg128,00€25mg210,00€50mg306,00€100mg429,00€200mg597,00€1mL*10mM (DMSO)89,00€IDH-305
CAS:IDH-305: Oral, mutation-specific IDH1 inhibitor, 200x selective for R132 mutants; IC50: 27/28/6.14 nM for R132H/C/WT.Fórmula:C23H22F4N6O2Pureza:99.68%Cor e Forma:SolidPeso molecular:490.45CVT-10216
CAS:CVT-10216 inhibits ALDH2 (IC50: 29 nM) and ALDH-1 (IC50: 1.3 μM), reducing alcohol intake and anxiety in rats.Fórmula:C24H19NO7SPureza:98.76%Cor e Forma:SolidPeso molecular:465.48Mycophenolic acid
CAS:Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.Fórmula:C17H20O6Pureza:98.79% - 99.77%Cor e Forma:SolidPeso molecular:320.34Adrenosterone
CAS:Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.Fórmula:C19H24O3Pureza:98.13% - 98.29%Cor e Forma:SolidPeso molecular:300.39CAY10566
CAS:CAY10566 is a potent SCD1 inhibitor, orally bioavailable, with IC50s: HepG2 cells, 7.9nM; mouse, 4.5nM; human, 26nM.Fórmula:C18H17ClFN5O2Pureza:99.5% - 99.54%Cor e Forma:SolidPeso molecular:389.81Ref: TM-T14878
1mg48,00€5mg131,00€10mg195,00€25mg353,00€50mg505,00€100mg710,00€200mg954,00€1mL*10mM (DMSO)112,00€CBR-5884
CAS:CBR-5884: active PHGDH inhibitor, IC50=33μM, disrupts serine synthesis, selectively targets high-serine cancers.Fórmula:C14H12N2O4S2Pureza:99.97%Cor e Forma:SolidPeso molecular:336.39GSK2837808A
CAS:GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).Fórmula:C31H25F2N5O7SPureza:99.78% - 99.78%Cor e Forma:SolidPeso molecular:649.62Ref: TM-T15435
1mg46,00€5mg105,00€10mg167,00€25mg313,00€50mg432,00€100mg612,00€1mL*10mM (DMSO)150,00€LY 345899
CAS:LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for
Fórmula:C20H21N7O7Pureza:99.7%Cor e Forma:SolidPeso molecular:471.42BAY-2402234
CAS:BAY-2402234: a selective DHODH inhibitor targeting myeloid cancers with low-nanomolar potency.Fórmula:C21H18ClF5N4O4Pureza:98.9%Cor e Forma:SolidPeso molecular:520.84Ref: TM-T14501
1mg170,00€2mg234,00€5mg349,00€10mg537,00€25mg858,00€50mg1.161,00€100mg1.558,00€1mL*10mM (DMSO)401,00€NCT-502
CAS:NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) is a human phosphoglycerate dehydrogenase inhibitor,Fórmula:C18H20F3N5SPureza:99.60%Cor e Forma:SolidPeso molecular:395.45Ref: TM-T16277
2mg37,00€5mg54,00€10mg82,00€25mg150,00€50mg227,00€100mg394,00€500mg883,00€1mL*10mM (DMSO)59,00€Olutasidenib
CAS:Olutasidenib (FT-2102), an IDH1 inhibitor (IC50: 21.2/114 nM), is studied for treating AML/MDS and can cross the blood-brain barrier.Fórmula:C18H15ClN4O2Pureza:98.57%Cor e Forma:SolidPeso molecular:354.79Ref: TM-T16384
1mg62,00€5mg169,00€10mg264,00€25mg487,00€50mg710,00€100mg998,00€200mg1.320,00€1mL*10mM (DMSO)178,00€4-Diethylaminobenzaldehyde
CAS:4-Diethylaminobenzaldehyde: reversible ALDH1 inhibitor (Ki: 4 nM), potent anti-androgen (IC50: 1.71μM).Fórmula:C11H15NOPureza:99.6%Cor e Forma:Brown-Black CrystalsPeso molecular:177.24KPLH1130
CAS:KPLH1130, a PDK inhibitor, boosts glucose tolerance and reduces inflammation in high-fat diet mice.Fórmula:C15H13N3O3Pureza:99.07%Cor e Forma:SolidPeso molecular:283.28Ref: TM-T11765
1mg79,00€5mg205,00€10mg333,00€25mg560,00€50mg797,00€100mg1.071,00€500mg2.187,00€1mL*10mM (DMSO)178,00€2,3-Dihydroxybenzaldehyde
CAS:2,3-Dihydroxybenzaldehyde exhibits activity against NADH dehydrogenase (Km = 35 µM) and can be used in biochemical experiments and drug synthesis.Fórmula:C7H6O3Cor e Forma:SolidPeso molecular:138.12WAY-311610
CAS:WAY-311610 is an HSD11B1 inhibitor targeting 11β-HSD1 enzyme with 0.34 μM IC; used for neuropathic and inflammatory pain research.Fórmula:C16H13F3N4O2Pureza:99.75%Cor e Forma:SolidPeso molecular:350.3PDK-IN-2
PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells.Fórmula:C17H23AsCl2N2O2S2Cor e Forma:SolidPeso molecular:497.33LDHA-IN-3
CAS:LDHA-IN-3 is a potent selenobenzene-based LDHA inhibitor with a 145.2 nM IC50, useful in cancer research.Fórmula:C13H9F3SePureza:99.71%Cor e Forma:SolidPeso molecular:301.17Ref: TM-T39805
1mg52,00€5mg113,00€10mg177,00€25mg371,00€50mg517,00€100mg707,00€200mg973,00€1mL*10mM (DMSO)124,00€MTHFD2-IN-3
MTHFD2-IN-3 (compound 10), a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2), demonstrates significant efficacy in obstructing the activityFórmula:C22H19NO7SCor e Forma:SolidPeso molecular:441.45hDHODH-IN-16
hDHODH-IN-16 (Compound 3t) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 0.11 μM. It demonstrates very low cytotoxicity towards healthy HaCaT cells, with an IC50 value exceeding 200 μM.Fórmula:C18H20N2O2Cor e Forma:SolidPeso molecular:296.36hDHODH-IN-12
hDHODH-IN-12 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an inhibitory concentration (IC50) of 0.421 μM.Fórmula:C22H15F3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:440.37Nedosiran sodium
CAS:Nedosiran sodium, a GalNAc-dsRNA conjugate, is engineered to suppress the synthesis of the hepatic lactate dehydrogenase (LDH) enzyme.
Cor e Forma:SolidKOTX1
CAS:KOTX1 is an orally active and selective inhibitor of ALDH1A3. In a diabetic mouse model, KOTX1 improves glucose tolerance, insulin secretion, and blood glucose levels.Fórmula:C17H16FN3O2Cor e Forma:SolidPeso molecular:313.33WQQ-345
WQQ-345, a BCAT1 inhibitor, exhibits an IC50 of 10.8 mM. In 67R cells, it reduces α-KG levels and upregulates H3K27me3 expression while downregulating the expression of glycolytic enzymes (PFKP and LDHA), leading to impaired glycolytic activity. Additionally, WQQ-345 demonstrates tumor-suppressive activity in a 67R subcutaneous xenograft model.Fórmula:C10H17NO2Cor e Forma:SolidPeso molecular:183.25MTHFD2-IN-4 sodium
MTHFD2-IN-4 sodium, a potent inhibitor of MTHFD2 and a tricyclic coumarin derivative, is applicable in cancer research [1].Fórmula:C26H21F6N2NaO5Cor e Forma:SolidPeso molecular:578.4411β-HSD1 inibitor 17
CAS:11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).Fórmula:C22H20F3N3O2SPureza:99.26% - 99.72%Cor e Forma:SoildPeso molecular:447.47MCI-INI-3
CAS:MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3, with a Ki value of 0.55 μM for ALDH1A3 and 78.2 μM for ALDH1A1. It inhibits retinoic acid biosynthesis and can reduce the viability of glioblastoma cells GSC-83 and GSC-326.Fórmula:C21H15N3O4Cor e Forma:SolidPeso molecular:373.36Octanoyl Coenzyme A (sodium salt)
Octanoyl Coenzyme A (sodium salt) inhibits citrate synthase and glutamate dehydrogenase with an IC50 of 0.4–1.6 mM.Fórmula:C29H49N7NaO17P3SCor e Forma:SolidPeso molecular:915.71DSM1465
DSM1465 (Compound 82) is a potent and selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM. It inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM and demonstrates significant in vivo efficacy in humanized P. falciparum mouse models.Fórmula:C17H12ClF6N5O2Cor e Forma:SolidPeso molecular:467.753IGUANA-1 free base
CAS:IGUANA-1: selective ALDH1 B1 inhibitor, IC50=30 nM, hinders SW480 cell growth with IC50=2.46/0.39 μM in adherent/spheroid forms, for cancer research.Fórmula:C26H24ClN3O2Cor e Forma:SolidPeso molecular:445.94(Rac)-BMS-816336
(Rac)-BMS-816336 is a racemic 11β-HSD1 inhibitor; IC50: 10 nM (human), 68 nM (mouse), metabolically stable.Fórmula:C21H27NO3Pureza:98%Cor e Forma:SolidPeso molecular:341.44Ascochlorin A
CAS:Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitorFórmula:C23H31ClO4Cor e Forma:SolidPeso molecular:406.95PDK-IN-1
CAS:PDK-IN-1, a PDK inhibitor, IC50: 0.03μM (PDK1), 0.1μM (HSP90), reduces tumor mass.Fórmula:C20H16BrN7OCor e Forma:SolidPeso molecular:450.29MTHFD2-IN-4
MTHFD2-IN-4, a tricyclic coumarin derivative, serves as a potent inhibitor of MTHFD2 and has applications in cancer research [1].Fórmula:C26H21F6N2O5Cor e Forma:SolidPeso molecular:555.45D-Lactate dehydrogenase
CAS:D-LDH is an oxidoreductase turning D-lactate into pyruvate, using NAD+/NADP+; prevalent in bacteria and fungi, key for biochemical research.Cor e Forma:SolidOsmanthuside H
CAS:Osmanthuside H is a useful organic compound for research related to life sciences. The catalog number is T125796 and the CAS number is 149155-70-4.Fórmula:C19H28O11Cor e Forma:SolidPeso molecular:432.422DSM705
CAS:DSM705: Pyrrole-based, potent nanomolar Plasmodium DHODH inhibitor with strong antimalarial efficacy; spares mammalian DHODH.Fórmula:C19H19F3N6OCor e Forma:SolidPeso molecular:404.397CM121
CAS:CM121, a reversible ALDH1A2 inhibitor, targets active site with IC50=0.54μM, Kd=1.1μM, using hydrophobic interactions.Fórmula:C24H17FN4O3SCor e Forma:SolidPeso molecular:460.48Necroptosis-IN-3
CAS:Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.Fórmula:C12H17NOSPureza:99.85%Cor e Forma:SoildPeso molecular:223.33DHODH-IN-18
CAS:DHODH-IN-18 is a human DHODH inhibitor ( IC 50 = 0.2 nM).Fórmula:C21H16ClF5N6O4Cor e Forma:SolidPeso molecular:546.84SCD1 inhibitor-3
CAS:SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety.Fórmula:C19H16FN7O2Pureza:99.5%Cor e Forma:SolidPeso molecular:393.37Ref: TM-T38683
1mg92,00€5mg187,00€10mg298,00€25mg507,00€50mg730,00€100mg1.026,00€1mL*10mM (DMSO)205,00€
