Lipoxigenase
As lipoxigenases são uma família de enzimas que catalisam a oxigenação de ácidos graxos poli-insaturados, levando à produção de mediadores lipídicos bioativos, como os leucotrienos e as lipoxinas. Esses mediadores desempenham papéis críticos na inflamação, nas respostas imunes e no câncer. Inibidores de lipoxigenase são utilizados para estudar seu papel em doenças inflamatórias, asma e câncer. Na CymitQuimica, oferecemos uma variedade de inibidores de lipoxigenase para apoiar sua pesquisa em inflamação, oncologia e metabolismo lipídico.
Foram encontrados 134 produtos para "Lipoxigenase".
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3-Hydroxycoumarin
CAS:3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitorsFórmula:C9H6O3Pureza:99.5% - 99.77%Cor e Forma:SolidPeso molecular:162.14ML355
CAS:ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.Fórmula:C21H19N3O4S2Pureza:97.17% - 98.02%Cor e Forma:SolidPeso molecular:441.52Ref: TM-T4347
1mg43,00€5mg92,00€1mL*10mM (DMSO)96,00€10mg152,00€25mg281,00€50mg462,00€100mg708,00€200mg964,00€11-Keto-β-boswellic acid
CAS:11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.Fórmula:C30H46O4Pureza:99.68%Cor e Forma:SolidPeso molecular:470.68Ref: TM-TN1182
1mg57,00€5mg130,00€1mL*10mM (DMSO)133,00€10mg200,00€25mg338,00€50mg497,00€100mg710,00€Terameprocol
CAS:Terameprocol (EM-1421), a synthetic NDGA derivative, shows potent anti-HIV, antiangiogenic, and anticancer properties.Fórmula:C22H30O4Pureza:99.38%Cor e Forma:SolidPeso molecular:358.47Wedelolactone
CAS:Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.Fórmula:C16H10O7Pureza:98.07% - 99.87%Cor e Forma:SolidPeso molecular:314.25Ref: TM-T3384
1mg34,00€1mL*10mM (DMSO)50,00€5mg71,00€10mg109,00€25mg175,00€50mg314,00€100mg414,00€500mg954,00€CAY10698
CAS:CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 μM).Fórmula:C17H17N3O4S2Pureza:98.97%Cor e Forma:SolidPeso molecular:391.46Ref: TM-T8950
2mg38,00€5mg52,00€1mL*10mM (DMSO)62,00€10mg88,00€25mg161,00€50mg243,00€100mg355,00€200mg502,00€U-73122
CAS:U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.Fórmula:C29H40N2O3Pureza:97.50% - 98.66%Cor e Forma:White SolidPeso molecular:464.64a-Boswellic Acid
CAS:Produto ControladoApplications The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
References Safayhi, H. et al.: J. Pharmacol. Exp. Therap., 261, 1143 (1992); Siemoneit, U., et al.: Eur. J. Pharmacol., 606, 246 (2009); Cao, H. et al.: Pharamacol. Res., 61, 519 (2010);Fórmula:C30H48O3Cor e Forma:NeatPeso molecular:456.7Oxyberberin
CAS:Produto ControladoApplications Oxyberberin is a naturally occurring isoquinoline alkaloid shown to inhibit lipoxygenase and provide antioxidant activity.
References Misík V. et al.: Planta. Med., 61, 372 (1995)Fórmula:C20H17NO5Cor e Forma:NeatPeso molecular:351.35Golocdacimab
CAS:Golocdacimab (anti-LOX-1 mAb) targets LOX-1, with potential applications for type 2 diabetes complications and preventing HAE attacks.Pureza:95%Cor e Forma:LiquidPeso molecular:~150 kDa1-Stearoyl-2-Oleoyl-3-Linoleoyl-rac-glycerol
CAS:1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol is a triacylglycerol consisting of stearic acid, oleic acid, and linoleic acid esterified at the sn-1, sn-2, and sn-3 positions, respectively. This compound is present in peanut and soybean oils as well as in ostrich and emu oils. Additionally, it serves as a substrate for soybean lipoxygenase in cell-free assays.Fórmula:C57H104O6Cor e Forma:SolidPeso molecular:885.434-(2-Methylpropyl)benzenemethanol
CAS:Produto ControladoFórmula:C11H16OCor e Forma:NeatPeso molecular:164.24RG 6866
CAS:RG 6866 is a inhibitor of 5-lipoxygenase.Fórmula:C16H17NO3Pureza:98%Cor e Forma:SolidPeso molecular:271.31Cgp 8065
CAS:Cgp 8065 is a filaricidal compound, a dithiocarbamate-derivative of amoscanate.Fórmula:C16H15N3O4S2Cor e Forma:SolidPeso molecular:377.44SB 210661
CAS:SB 210661 is a potent and selective 5-lipoxygenase inhibitor.Fórmula:C16H14F2N2O4Pureza:98%Cor e Forma:SolidPeso molecular:336.29Enazadrem
CAS:Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.Fórmula:C18H25N3OPureza:98%Cor e Forma:SolidPeso molecular:299.412-TEDC
CAS:2-TEDC: Potent LOX inhibitor, blocks 5-LOX, 12-LOX, 15-LOX (IC50: 0.09, 0.013, 0.5 μM); aids atherosclerosis research.Fórmula:C16H13NO4SPureza:99.97%Cor e Forma:SolidPeso molecular:315.34tHGA
CAS:tHGA is a potent inhibitor of lipoxygenase.Fórmula:C18H24O4Pureza:98%Cor e Forma:SolidPeso molecular:304.38E 3040
CAS:E 3040 is an oral dual inhibitor of 5-lipoxygenase and thromboxane synthase with anti-inflammatory activity.Fórmula:C16H17N3OSCor e Forma:White SolidPeso molecular:299.39Nafazatrom
CAS:Nafazatrom: pyrazolinone lipoxygenase inhibitor, anticancer & antithrombotic, boosts PGI2, reduces arrhythmias.Fórmula:C16H16N2O2Cor e Forma:SolidPeso molecular:268.31
