Microbiologia/Virologia

<p>NagZ-IN-1 (Compound 11h) is a β-N-acetylglucosaminidase inhibitor with a Ki of 3.3 μM. It is applicable in antibacterial research, especially for studies related to Pseudomonas aeruginosa infections.</p>

<p>Luteoskyrin is a hepatotoxic and hepatocarcinogenic bisdihydroanthraquinone produced by Penicillium islandicum Sopp.</p>

<p>T-2513 inhibits topoisomerase I by covalently bonding to its DNA complex, blocking DNA replication and causing cell death.</p>

<p>Tomaymycin, an antitumor antibiotic, exhibits antimicrobial activity against Gram-positive bacteria [1] [2].</p>

<p>Antifungalagent 257 (Compound 7e) is a broad-spectrum antifungal agent with an EC50 value of 4.15 μM against F. graminearum.</p>

<p>Amino acids 427-441 of FliC epitope from S. serotype a recognized by CD4+ T cells in C57BL/6 mice; common to various Salmonella, in FliC's C-terminus.</p>

<p>Piampicillin Hydrochloride is a Hydrochloride form of an oral active ampicillin new spray with antimicrobial activity.</p>

<p>PF-04064900 is a prodrug of sulopenem penem antibiotic.</p>

<p>Ro 19-9638 is the N-oxide of Ro 15-0216.</p>

<p>Dehydrozingerone, a natural versatile compound, is known for diverse biochemical effects.</p>

<p>4-Acetylbutyric acid is a ketone acid widely used in biochemical experiments and drug synthesis research.</p>

<p>Carbazomycin D, from Streptomyces, fights fungi T. asteroides and T. mentagrophytes, M. tuberculosis, and is cytotoxic to various cells.</p>

HP-101 is the first dual substrate inhibitor of HPPK to demonstrate cellular permeability.

<p>Beludavimab, a monoclonal antibody, targets SARS-CoV-2 spike protein with an EC50 of 14.9 ng/mL and Kd 0.21 nM.</p>

<p>Isariin is a cyclodepsipeptide isolated from the fungus Isaria felina.</p>

<p>CSP1: potent ComD1 receptor agonist, IC50 of 10.3 nM, important in S. pneumoniae transformation, and has antibacterial properties.</p>

<p>SARS-CoV-2-IN-81 (compound 12e) is an effective AAK1 inhibitor with an IC50 value of 9.38 nM. It demonstrates antiviral activity against SARS-CoV-2 by reducing AAK1-induced phosphorylation of threonine 156 on AP2M1 and disrupting the direct interaction between AP2M1 and ACE2, ultimately inhibiting SARS-CoV-2 infection.</p>

SARS-CoV-2-IN-70 (compound 6) is an effective inhibitor of SARS-CoV-2, with an IC50 value of 3.2 μM.

<p>Gramicidin A (TFA) is a peptide component of Gramicidin, an antibiotic mixture originally isolated from B. brevis. It is a highly hydrophobic channel-forming ion carrier that creates monovalent cation-permeable channels in artificial membranes. Additionally, Gramicidin A (TFA) induces the degradation of hypoxia-inducible factor 1α (HIF-1α).</p>

<p>Antifungalagent 96 (Compound WZ-2) is an antifungal agent with excellent blood-brain barrier permeability and brain penetration. It inhibits the growth of C. neoformans H99 and C. albicans 0304103, with MIC values of 0.016 and 32 μg/mL, respectively.</p>

<p>OP-145 is a derivative of the antimicrobial peptide LL-37, known for its antibacterial properties against multiple MRSA strains. This compound is applicable in studies on chronic suppurative otitis media.</p>

<p>AB023a is an antibiotic with antifungal properties.</p>

<p>MPD2 is a PROTAC compound based on a Cereblon-binding ligand that degrades the main protease MPro of SARS-CoV-2. In 293T cells, it effectively reduces MPro protein levels with a DC50 of 296 nM and shows time-dependent activity. MPD2 exhibits strong antiviral properties against various SARS-CoV-2 strains and has increased potency against Nirmatrelvir-resistant variants. It holds potential for researching SARS-CoV-2 diseases.</p>

<p>SARS-CoV-2-IN-83 (compound C6E) exhibits excellent activity against the SARS-CoV-2 spike protein.</p>

<p>PLpro-IN-2 (Compound 16) is an inhibitor of the SARS-CoV-2 papain-like protease (PLpro), with an IC50 value of 0.25 μM.</p>

Antibacterialagent 182 (compound 8c) is an antibacterial agent that exhibits activity against various Gram-positive bacteria, particularly displaying efficacy against vancomycin-resistant Enterococcus faecium (MIC ≤0.125 μg/mL). At sub-MIC levels, Antibacterialagent 182 can inhibit biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa.

β-Lactamase-IN-9 (compound 2) is an inhibitor of β-lactamase, capable of restoring the sensitivity of pathogens to β-lactam antibiotics.

<p>KN-17, a modified derivative based on the cecropin B structure, effectively disrupts bacterial growth and induces the migration of human bone marrow stromal cells (hBMSCs). This compound significantly stimulates angiogenesis both in vitro and in vivo.</p>

<p>SARS-CoV-2-IN-49 acts as an irreversible covalent inhibitor targeting the main protease of SARS-CoV-2 [1].</p>

<p>Dactylocyclines B: novel tetracycline from Dactylosporangium, fights tetracycline-resistant microbes.</p>

Niddamycin is a new macrolide antibiotic.

<p>Leucinostatin B is a peptide antibiotic from Paecilomyces lilacinus A-267.</p>

<p>Maximin 15, an antimicrobial peptide originating from toad brain, exhibits activity against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis, with</p>

<p>N-3-oxo-pentanoyl-L-Homoserine lactone is a quorum sensing inhibitor for E. coli at 230 nM and activates V. fischeri luminescence at 20-200 nM.</p>

<p>KU13 is an inhibitor of non-tuberculous mycobacteria (NTM), demonstrating minimum inhibitory concentrations (MIC) of 0.032-8 μg/mL against Mycobacterium and 2 μg/mL against E. coli. It is applicable in research focused on anti-infective treatments.</p>

<p>N-Methyl-1,3-benzoxazol-2-amine, with CAS No. 19776-98-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. N-Methyl-1,3-benzoxazol-2-amine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>UNC9512 is a potent antagonist of the methyl-lysine reader protein 53BP1, which can be utilized to investigate the function of 53BP1 in DNA repair, gene editing</p>

Albothricin is a streptothricin antibiotic.

<p>Antimalarial agent 33 (compound 5g) exhibits antiplasmodial activity targeting both erythrocytic and hepatic stages of Plasmodium, with an effective</p>

<p>Genkwanol C is a useful organic compound for research related to life sciences and the catalog number is T125772.</p>

<p>Albofungin is a xanthone isolated from A. tumemacerans.</p>

<p>Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting</p>

<p>Kni 102 is a biochemical.</p>

<p>Antcin-B exhibits a high-affinity inhibition of 3CLPro, which is potentially significant in SARS-CoV-2 research [1].</p>

<p>Aurein 2.4, an antibiotic antimicrobial peptide, exhibits activity against Gram-positive bacteria [1] [2].</p>

<p>JNJ-8003 is a potent inhibitor of RSV Polymerase, effectively impeding the early stages of RNA transcription and replication by inhibiting nucleotide</p>

<p>VRC01LS is a humanized monoclonal antibody inhibitor that targets the CD4 binding site of the HIV-1 envelope glycoprotein (Env). By blocking the interaction between HIV-1 and the host cell's CD4 receptor, VRC01LS inhibits viral entry. It holds potential for research in HIV-1 infection.</p>

<p>Antimalarial agent 27 (compound 11a) potently inhibits P.</p>

<p>SARS-CoV-2-IN-48 (compound 19) is an inhibitor of SARS-CoV-2, exhibiting an IC50 of 2.7 μM against the Omicron BA.1 variant and demonstrating antiviral</p>

<p>Amphotericin B methyl ester: a cholesterol-binding antifungal derivative of Amphotericin B; inhibits HIV-1.</p>

<p>T4 RNA ligase is an enzyme that facilitates the ligation of single-stranded DNA.</p>

<p>FtsZ-IN-6: strong FtsZ polymerization promoter, GTPase inhibitor, kills bacteria, low resistance and toxicity.</p>

<p>SARS-CoV-2 Mpro-IN-8 (compound 6b) is an antiviral agent effective against SARS-CoV-2 [1].</p>

<p>ZINC61142882 is a SARS-CoV-2 Nsp14 N7-Methyltransferase inhibitor with an IC50 value of 6 μM [1].</p>

<p>RdRP-IN-7, a RNA-dependent RNA polymerase (RdRp) inhibitor, demonstrates efficacy against SARS-CoV-2 infection with an inhibitory concentration (IC50) of 8.2 μM</p>

<p>Melaleuca alternifolia essential oil, derived from the leaves of Melaleuca alternifolia, exhibits bactericidal and anti-inflammatory properties.</p>

<p>ddGTP trisodium, a ddNTP, inhibits or serves as a substrate for DNA polymerase α, halting DNA chain elongation.</p>

<p>Atanine is a useful organic compound for research related to life sciences. The catalog number is T124320 and the CAS number is 7282-19-1.</p>

<p>Mtb-IN-11 (Compound 1e) is an inhibitor of Mycobacterium tuberculosis salicylate synthase (MbtI) with an IC50 of 11.2 μM. It exhibits strong in vitro antitubercular activity, with an MIC99 of 32 μM against Mycobacterium bovis BCG. Mtb-IN-11 is applicable for tuberculosis research.</p>

<p>SARS-CoV-2 3CLpro-IN-18 (Compound 3C) is a covalent inhibitor of SARS-CoV-2 3CLpro with an IC50 of 0.478 μM.</p>

<p>Ro 25-0534 is an antipseudomonal dual-action drug with antimicrobial activity.</p>

<p>Antimicrobial agent-12 serves as a powerful antibacterial compound that also exhibits inhibitory activity against SARS-CoV-2 [1].</p>

<p>Antibacterial agent 139 fights Gram-positive bacteria, including MRSA, VISA, and LRSE, by depolarizing cell membranes.</p>

<p>SARS-CoV-2-IN-60 (compound 5a) is a specific, irreversible inhibitor of SARS-CoV-2 nsp16-nsp10 methyltransferase, competing with S-adenosylmethionine (SAM) and</p>

<p>Defensin HNP-3 human, a cytotoxic antibiotic peptide referred to as "defensin," exhibits inhibitory effects on Staphylococcus aureus, Pseudomonas aeruginosa,</p>

<p>Antiparasitic Agent-17 (compound 5u), an orally active antiparasitic, demonstrates inhibition against both Chloroquine-sensitive (Pf3D7) and Chloroquine-</p>

<p>Clovibactin, a novel antibiotic, effectively eradicates drug-resistant bacterial pathogens and demonstrates no discernible resistance.</p>

<p>SARS-CoV-2-IN-55 (compound 65) is an inhibitor of SARS-CoV-2 exhibiting low cytotoxicity, characterized by an IC50 of 0.3 μM, effectuated through direct</p>

<p>Antitrypanosomal agent 12, a C20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with GI50 values of 0.</p>

<p>SARS-CoV-2-IN-56 (Compound 63) is a SARS-CoV-2 inhibitor with antiviral activity, demonstrating inhibition of the virus in Vero E6 cells with an IC50 of 0.7 μM</p>

<p>LF11 displays antimicrobial activity.</p>

<p>LFF 571 is an inhibitor of protein-synthesizing GTPase (Elongation Factor).</p>

Ashimycin B is a streptomycin analogue that exhibits broad-spectrum antibacterial activity.

<p>PfSUB1-IN-1 (compound 4c) is an inhibitor of Plasmodium falciparum subtilisin-like serine protease 1 (PfSUB1), exhibiting potent activity with an IC50 value of 15 nM. PfSUB1 is a key target in antimalarial research. PfSUB1-IN-1 demonstrates a 13-fold greater inhibitory effect on the growth of transgenic Plasmodium falciparum strains (expressing lower levels of PfSUB1 compared to the wild-type) than on wild-type parasite strains.</p>

<p>Antibacterialagent 233 (Compound 7c) demonstrates inhibitory activity against Helicobacter pylori, with a minimum inhibitory concentration (MIC) ranging from 0.4 to 1.6 μg/mL. It inhibits jack bean urease with an IC50 of 0.27 μg/mL, alters the permeability of the H. pylori cell membrane, and leads to the leakage of cellular contents. Antibacterialagent 233 shows metabolic stability in both whole blood and artificial gastric fluid. Additionally, it exhibits antitumor activity against U2OS in mice.</p>

Retro-indolicidin, a synthetic analog of the cathelicidin-derived antimicrobial peptide-amide indolicidin, comprises a reversed 13-amino acid sequence isolated

<p>Caprazene is a precursor molecule of semi-synthetic antibacterial antibiotics and an anti-mycobacterial compound used for tuberculosis and Mycobacterium avium complex infection research. It can be isolated from the acid-treated caprazamycin (CPZ) A-G mixture.</p>

Ianthelliformisamine C TFA, an antibiotic enhancer, is used to against resistant Gram-negative bacteria.

Salivaricin B is a broad-spectrum bacteriocin produced by Lactobacillus M7, capable of inhibiting the growth of Listeria monocytogenes, Bacillus cereus, Brochothrix thermosphacta, Enterococcus faecalis, and various Lactobacilli.

<p>Lincosamine is a lincosamide antibiotic produced by Streptomyces lincolnensis.</p>

<p>L 640876 is a semisynthetic antibiotic.</p>

Altromycin C is a new pluramycin-like antibiotic.

<p>DS-8587 is a DNA topoisomerase inhibitor, effective against drug-resistant A. baumannii and F. necrophorum in mice; efflux pump inhibitors don't alter its MIC.</p>

<p>Cefuzonam sodium: second-gen cephalosporin, effective against Staph aureus where third-gen fails.</p>

<p>Lantic acid is a bioactive chemical.</p>

<p>SARS-CoV-2 Mpro-IN-43 (Compound 1) is an inhibitor of the coronavirus main protease (Mpro) with an IC50 of 72 μM. It exerts its antiviral effects by interacting non-covalently with the key residues at the Mpro active site. This compound exhibits moderate to low cytotoxicity with CC50 values of 13.24, 41.02, and 42.26 µM in HaCaT, HEK293T, and HepG2 cells, respectively. SARS-CoV-2 Mpro-IN-43 is applicable for SARS-CoV-2 research.</p>

<p>N-Methyltaurine is a useful organic compound for research related to life sciences. The catalog number is T126442 and the CAS number is 107-68-6.</p>

<p>SPR741 acetate, a polymyxin B derivative, enhances antibiotics against gram-negative bacteria by disrupting their outer membrane.</p>

<p>Anhydrotetracycline (hydrochloride) is a potent competitive inhibitor of broad-spectrum tetracycline destructase enzymes.</p>

<p>Antileishmanial agent-33 (4e) is a hybrid compound of grandisin and machilin G, demonstrating moderate activity against promastigotes with an IC50 of 38.1 μM. In studies of cutaneous leishmaniasis (CL), Antileishmanial agent-33 (4e) has shown potential as an antileishmanial agent.</p>

<p>Kijimicin is a polyether antibiotic and human immunodeficiency virus inhibitor in acutely and chronically infected cells.</p>

<p>BU-2313 A is a new antibiotic complex. It also active against anaerobes.</p>

FR-901235, from Paecilomyces carneus, normalizes suppressed lymphocyte growth.

<p>Tetrahydrorhombifoline, a quinolizidine alkaloid found in the aerial parts of Genista vuralii A.</p>

Clindamycin palmitate hydrochloride (Clindamycin palmitate HCl) is the hydrochloride salt of clindamycin and palmitate, a lincosamide antibiotic.

<p>SARS-CoV-2-IN-29 disodium is an antiviral diphosphate benzene with IC50 of 1.5-1.6 μM and disrupts membranes at 3.0 μM EC50.</p>

<p>BRD1401 is a small molecule that targets the outer membrane protein OprH. It disrupts the interaction between OprH and LPS and can increase membrane fluidity.</p>

<p>Valclavam is a biochemical.</p>

<p>RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .</p>

<p>Althiomycin is an antibiotic.</p>

Teicoplanin sodium: a lipoglycopeptide antibiotic with activity against HIV, SARS-CoV1/2, and MRSA.

<p>Destruxin B2, found in M. anisopliae, has antiviral, insecticidal properties, inhibits HBsAg (IC50=1.3 μM), and is toxic to Sf9 cells (ECIS50=92 μM).</p>

<p>Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.</p>

<p>HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.</p>

<p>Agent 37 from patent WO2015063714A1 is a potent antimicrobial for bacterial infection research.</p>

<p>PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor that disrupts the interaction between PEX5 and TbPEX14 with an</p>

<p>Agent 47 boosts Ceftazidime's efficacy, lowering its MIC as a potent adjunct antibacterial.</p>

<p>Detoxin C1 is a selective blasticidin S antagonist.</p>