Microbiologia/Virologia
Os inibidores de microbiologia e virologia são compostos que têm como alvo microrganismos, incluindo bactérias, vírus e fungos, interrompendo seu crescimento, replicação ou sobrevivência. Esses inibidores são essenciais para estudar a patogênese microbiana, entender os mecanismos de resistência e desenvolver novas terapias antimicrobianas e antivirais. Os inibidores nessa categoria são usados para combater doenças infecciosas, explorar a ecologia microbiana e investigar as interações hospedeiro-patógeno. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para microbiologia e virologia para apoiar sua pesquisa em doenças infecciosas, microbiologia e virologia.
Subcategorias de "Microbiologia/Virologia"
- Antibacteriano(2.949 produtos)
- Antibiótico(918 produtos)
- Antifecção(23 produtos)
- DHFR(32 produtos)
- Síntese de DNA/RNA(706 produtos)
- HBV(176 produtos)
- HIV Protease(447 produtos)
- HSV(91 produtos)
- Integrase(2 produtos)
- Ribossomo(13 produtos)
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Foram encontrados 5832 produtos de "Microbiologia/Virologia"
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GHP-88309
CAS:<p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>Fórmula:C16H11FN2OCor e Forma:SolidPeso molecular:266.27Arterolane maleate
CAS:<p>Arterolane, an adenosine triphosphatase inhibitor, is used potentially for the treatment of malaria.</p>Fórmula:C26H40N2O8Pureza:98%Cor e Forma:SolidPeso molecular:508.612cis-RdRP-IN-5
<p>Cis-RdRP-IN-5 is an effective inhibitor of the influenza virus RNA-dependent RNA polymerase (RdRP), employed in influenza virus research.</p>Fórmula:C23H21N3O5Cor e Forma:SolidPeso molecular:419.43ZIKV-IN-4
<p>ZIKV-IN-4 is a low cytotoxic, acid-stable anti-ZIKV agent with an EC50 value of 3.49 μM. ZIKV-IN-4 exhibited potent inhibition of ZIKV NS5 MTase.</p>Fórmula:C33H37NO4Cor e Forma:SolidPeso molecular:511.65Chitin synthase inhibitor 9
<p>CHS inhibitor 9: a broad-spectrum antifungal for studying fungal infections.</p>Fórmula:C24H25N3O6Cor e Forma:SolidPeso molecular:451.47Antifungal agent 17
<p>Antifungal agent 17 showed good antifungal activity against B. cinerea (EC50: 2.86 μg/mL).</p>Fórmula:C18H16Br2O2Cor e Forma:SolidPeso molecular:424.13Cap-dependent endonuclease-IN-5
CAS:<p>Cap-dependent endonuclease-IN-5 inhibits CEN and fights influenza with low toxicity and good in vivo properties.</p>Fórmula:C27H21F2N3O4S2Cor e Forma:SolidPeso molecular:553.60MRL-494
<p>MRL-494, a small-molecule BamA inhibitor, resists efflux and outer membrane permeability, with antibacterial properties.</p>Fórmula:C26H35FN16O2Pureza:98%Cor e Forma:SolidPeso molecular:622.66Antibacterial agent 82
<p>Antibacterial agent 82 (compound 7p) is an antibacterial agent [1].</p>Fórmula:C22H18N2O2Cor e Forma:SolidPeso molecular:342.39G247
<p>G247 inhibits MsbA by keeping NBDs apart, blocking ATPase activity.</p>Fórmula:C24H19Cl2FO3Cor e Forma:SolidPeso molecular:445.31FPI-1465
CAS:<p>FPI-1465: Dual serine-β-lactamase & PBP inhibitor; IC50 PBP2=1.0 μg/mL; Kd CTX-M-15=0.011μM, OXA-48=5.3μM.</p>Fórmula:C11H18N4O7SCor e Forma:SolidPeso molecular:350.35Antibacterial agent 262
CAS:<p>Antibacterialagent 262 (compound A23) is a potent antibacterial agent that inhibits the activity of Xanthomonas oryzae pv oryzae. It also disrupts the integrity of bacterial cell membranes by preventing the formation of biofilms of Xanthomonas oryzae pv oryzae.</p>Fórmula:C17H18F2N6O4S3Cor e Forma:SolidPeso molecular:504.554Pyriftalid
CAS:<p>Pyriftalid is a novel insecticide known for its potent inhibitory activity against a variety of pests. It is widely utilized in agriculture to effectively manage crop pests, thereby enhancing both the yield and quality of crops. Additionally, research is exploring the use of Pyriftalid in boosting plant resistance to pests and diseases.</p>Fórmula:C15H14N2O4SCor e Forma:SolidPeso molecular:318.35MurA-IN-6
CAS:<p>MurA-IN-6 (Compound L16) is a selective MurA inhibitor with an IC50 of 26.63 μM. It exhibits antibacterial activity by inhibiting the function of MurA, a key protein essential for bacterial cell wall synthesis.</p>Fórmula:C22H17N3O3SCor e Forma:SolidPeso molecular:403.454Ambelline
CAS:<p>Ambelline has antitumor activity.</p>Fórmula:C18H21NO5Pureza:98%Cor e Forma:SolidPeso molecular:331.36SARS 3CLpro-IN-1
CAS:<p>SARS 3CLpro-IN-1: stereospecific SARS 3CL protease inhibitor, octahydroisochromene class, IC50 = 95 μM.</p>Fórmula:C22H38N4O2Cor e Forma:SolidPeso molecular:390.56Chitinase-IN-5
<p>Chitinase-IN-5 (8i) blocks OfChi-h (IC50: 0.051 μM), has insecticidal qualities, useful for eco-friendly pest control.</p>Fórmula:C20H21ClFN7Cor e Forma:SolidPeso molecular:413.88Antibacterial agent 278
CAS:<p>Antibacterialagent 278 (compound B1) is an antimicrobial agent that exhibits potent inhibitory activity against Gram-positive bacteria.</p>Fórmula:C24H17ClF2N4O3Cor e Forma:SolidPeso molecular:482.87GS-9822
CAS:<p>GS-9822 is a new LEDGIN inhibitor targeting LEDGF/p75 to alter HIV integration, showing a block-and-lock effect in cells.</p>Fórmula:C36H39ClN4O4SCor e Forma:SolidPeso molecular:659.24NS2B/NS3-IN-3
CAS:<p>NS2B/NS3-IN-3 (Compd 66) is an inhibitor of Flavivirus NS2B-NS3 protease [1] .</p>Fórmula:C19H21N3O2Cor e Forma:SolidPeso molecular:323.39Tuberculosis inhibitor 5
<p>Compound 11i: potent, non-toxic anti-tuberculosis biphenyl analogue.</p>Fórmula:C25H18N2O2SCor e Forma:SolidPeso molecular:410.495-Iminodaunorubicin hydrochloride
CAS:<p>5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.</p>Fórmula:C27H31ClN2O9Cor e Forma:SolidPeso molecular:563.00Triazophos
CAS:<p>Triazophos is a non-systemic pesticide that acts as an acetylcholinesterase (AChE) inhibitor, forming a covalent and irreversible bond with the acetylcholine binding site. This action blocks the hydrolysis of acetylcholine, leading to increased excitability. It is effective against a wide range of soil insects and mites, including aphids, thrips, midges, beetles, lepidopteran larvae, mole crickets, and red spiders. Triazophos is suitable for use on various crops such as ornamental plants, cotton, rice, corn, soybeans, oil palm, olives, and coffee.</p>Fórmula:C12H16N3O3PSCor e Forma:SolidPeso molecular:313.31SHEN26
CAS:<p>SHEN26 (ATY014) is a potent, orally active RdRp inhibitor with an IC50 of 1.36 μM for SARS-CoV-2. As a 5'-cyclohexanecarboxylate derivative of GS-441524, SHEN26 inhibits viral nucleic acid synthesis, achieving antiviral effects. SHEN26 can be used for COVID-19 research [1] [2].</p>Fórmula:C19H23N5O5Cor e Forma:SolidPeso molecular:401.42PKZ18
CAS:<p>PKZ18 is an antibiotic that inhibits bacterial growth with a MIC value of 32-64 μg/mL against most Gram-positive bacteria. It suppresses the in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria, directly reducing T-box transcription readthrough of associated genes. It prevents codon-anticodon pairing necessary for tRNA binding and is less likely to induce resistance.</p>Fórmula:C22H26N2O3SCor e Forma:SolidPeso molecular:398.518GR 122222X
CAS:<p>GR 122222X is an inhibitor of topoisomerase II.</p>Fórmula:C26H35N5O11SPureza:98%Cor e Forma:SolidPeso molecular:625.65RAD51-IN-7
CAS:<p>RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)</p>Fórmula:C25H31N5O4S2Cor e Forma:SolidPeso molecular:529.67Tenellin
CAS:<p>Tenellin is a fungal metabolite that inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in erythrocytes. Tenellin is cytotoxic to Sf9 and Sf21 insect cells.</p>Fórmula:C21H23NO5Cor e Forma:SolidPeso molecular:369.41Anthelvencin A
CAS:<p>Anthelvencin A is a pyrrolylamide metabolite with moderate antibacterial and anthelmintic activity.</p>Fórmula:C19H25N9O3Cor e Forma:SolidPeso molecular:427.46TREX1-IN-4
CAS:<p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>Fórmula:C24H19ClN6O4Cor e Forma:SolidPeso molecular:490.898Antifungal agent 39
CAS:<p>Antifungal agent 39 (Compound 9h) is a broad-spectrum antifungal agent.</p>Fórmula:C23H22ClN3O5Cor e Forma:SolidPeso molecular:455.89SPB07935
CAS:<p>SPB07935 inhibits plasmepsin II in the malaria-causing parasite Plasmodium falciparum and serves as an antimalarial agent. It affects the life cycle of P. falciparum, hindering the growth of the parasite's FcB1 and 3D7 strains, with IC50 values of 8 μM and 4.7 μM, respectively.</p>Fórmula:C22H15N5O4S2Cor e Forma:SolidPeso molecular:477.516HPH-15
CAS:<p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>Fórmula:C19H31N3S4Cor e Forma:SolidPeso molecular:429.73VV261
CAS:<p>VV261 is an orally active inhibitor of the Influenza Virus. It exhibits activity against the Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) and the Lymphocytic Choriomeningitis Virus (LCMV), with EC50 values of 0.89 and 0.15, respectively.</p>Fórmula:C28H34FN3O11Cor e Forma:SolidPeso molecular:607.58Antifungal agent 43
<p>Antifungal agent 43 inhibits biofilms with low toxicity to human cancer cells.</p>Fórmula:C24H26N4Se2Cor e Forma:SolidPeso molecular:528.41TREX1-IN-3
CAS:<p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>Fórmula:C24H19ClN6O4Cor e Forma:SolidPeso molecular:490.898Arohynapene B
CAS:<p>Arohynapene B is an anticoccidial compound that inhibits the growth of Eimeria parasites.</p>Fórmula:C18H22O3Cor e Forma:SolidPeso molecular:286.366Diclosulam
CAS:<p>Diclosulam (XDE 564) is an herbicide with a Ki value of less than 32 nM. It exhibits a MIC of 6.25 and 12.5 μM, and a MIC50 of 1.40 and 3.01 μM against the CBS10913 and CBS12373 strains, respectively.</p>Fórmula:C13H10Cl2FN5O3SCor e Forma:SolidPeso molecular:406.22Ac-Atovaquone
CAS:<p>Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.</p>Fórmula:C24H21ClO4Cor e Forma:SolidPeso molecular:408.87Antibacterial agent 266
CAS:<p>Antibacterialagent 266 (Compound C5) is an inhibitor of plant pathogenic bacteria that disrupts the integrity of bacterial cell membranes. It exhibits an EC50 of 24.1 μg/mL against Xanthomonasoryzaepvoryzae (Xoo) and 39.0 μg/mL against X. axonopodispvcitri (Xac). Antibacterialagent 266 is valuable for research in plant pathology and the development of agricultural antibacterial agents.</p>Fórmula:C13H11N3OCor e Forma:SolidPeso molecular:225.246Aurachin C
CAS:<p>Aurachin C is a quinoline alkaloid belonging to the isoprenoid class, known for its antimalarial, antifungal, and antibacterial properties. It acts as a selective terminal oxidase inhibitor.</p>Fórmula:C25H33NO2Cor e Forma:SolidPeso molecular:379.535Antibacterial agent 88
<p>Antibacterial agent 88 is an effective antibacterial agent against B. subtilis (MIC: 4 μg/ml) with MIC values of ≤0.0156 μg/mL for MRSA, MRSE and S. aureus.</p>Fórmula:C31H44N2O6SCor e Forma:SolidPeso molecular:572.76NDM-1 inhibitor-7
CAS:<p>NDM-1 inhibitor-7 (Compound A8) is an NDM-1 inhibitor with an IC50 of 10.284 μM. It restores the ability of meropenem (MEM) to penetrate the cell wall of Gram-negative bacteria and effectively reinstates MEM's antibacterial activity against NDM-1 positive Escherichia coli. Moreover, NDM-1 inhibitor-7 demonstrates significant efficacy in both Galleria mellonella and murine peritonitis infection models.</p>Fórmula:C9H10N2OS2Cor e Forma:SolidPeso molecular:226.319T-2513 hydrochloride
CAS:<p>T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.</p>Fórmula:C25H28ClN3O5Cor e Forma:SolidPeso molecular:485.96KWR095
CAS:<p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>Fórmula:C33H31ClF3N9O4Cor e Forma:SolidPeso molecular:710.105DC-159a
CAS:<p>DC-159a, an 8-methoxy fluoroquinolone, possesses broad-spectrum antibacterial activity, with a particular efficacy against Gram-positive pathogens. The MIC90 values for DC-159a are 0.5 μg/mL against Streptococcus anginosus group, 4 μg/mL against Clostridium difficile, and 2 μg/mL against Bacteroides fragilis.</p>Fórmula:C21H23F2N3O40·5H2OCor e Forma:SolidPeso molecular:428.4295Anticaries agent-1
CAS:<p>Anticaries agent-1 (Compound 21b) is utilized as an anticaries agent. It effectively inhibits biofilm formation with an IC50 of 77 μM and restricts the growth of S. mutans.</p>Fórmula:C15H12O4Cor e Forma:SolidPeso molecular:256.253SLU-10906
CAS:<p>SLU-10906 (Compound 63) is an orally active inhibitor of Cryptosporidium. It demonstrates activity against the parasite in cell-based infection models with an EC50 of 0.19 μM and exhibits no cytotoxicity. SLU-10906 is a promising candidate for research in cryptosporidiosis.</p>Fórmula:C22H21BFN5O2Cor e Forma:SolidPeso molecular:417.244NEU-1017
CAS:<p>NEU-1017 serves as a broad-spectrum antiparasitic compound, effectively inhibiting T. brucei, L. major, and P. falciparum with EC50 values of 210 nM, 240 nM, and 3 nM, respectively.</p>Fórmula:C33H31ClFN5O3SCor e Forma:SolidPeso molecular:632.147GRL-190-21
CAS:<p>GRL-190-21 (compound 5e), an inhibitor of SARS-Cov-2-Mpro, shows potent antiviral activity, with a K_i of 0.04 nM and an EC_50 of 0.26 μM in VeroE6 cells. It significantly reduces the infectivity, replication, and cytopathic effect of SARS-CoV-2 without notable toxicity [1].</p>Fórmula:C24H34F3N5O4Cor e Forma:SolidPeso molecular:513.55Arterolane
CAS:<p>Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1 nM.</p>Fórmula:C22H36N2O4Cor e Forma:SolidPeso molecular:392.53Rubropunctatin
CAS:<p>Rubropunctatin is a monascus pigment with very potent cancer cell proliferation inhibitory effects.</p>Fórmula:C21H23NO4Cor e Forma:SolidPeso molecular:353.41Antifungal agent 125
CAS:<p>Antifungalagent 125 (compound 4H) is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 3.59 μg/mL and exhibits fungicidal activity against Alternaria alternata.</p>Fórmula:C13H10BrNO4SCor e Forma:SolidPeso molecular:356.192CDA-IN-2
CAS:<p>CDA-IN-2 (Compound VS#2-3) is an inhibitor of chitin deacetylase (CDA) that exhibits antifungal properties. At a concentration of 100 μM, it inhibits P. xanthii's CDAPxCDA1 by 83.7% and PxCDA2 by 74.5%. CDA-IN-2 is applicable in research on agricultural fungal diseases, including resistance to powdery mildew and gray mold.</p>Fórmula:C17H16N2O7Cor e Forma:SolidPeso molecular:360.318Antibacterial agent 62
<p>Novel anti-TB agent 62 is a redox compound with bactericidal activity against active and dormant bacteria.</p>Fórmula:C24H33BrN2O2Cor e Forma:SolidPeso molecular:461.44HSV-TK substrate
CAS:<p>HSV-TK substrate is a substrate for HSV-TK with antitumor activity. It induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells.</p>Fórmula:C11H15N5O4Pureza:98%Cor e Forma:SolidPeso molecular:281.27Anti-MRSA agent 27
CAS:<p>Anti-MRSA agent 27 (compound 4a) is a potent antimicrobial agent against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 0.0975 μmol/L. It effectively disrupts MRSA biofilms and inhibits the production of hemolysins.</p>Fórmula:C15H10F3N3OSCor e Forma:SolidPeso molecular:337.32BRL-42715
CAS:<p>BRL-42715 is an effective inhibitor of bacterial beta-lactamases.</p>Fórmula:C10H7N4NaO3SPureza:98%Cor e Forma:SolidPeso molecular:286.24L-2'-Fd4C
CAS:<p>L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].</p>Fórmula:C9H10FN3O3Cor e Forma:SolidPeso molecular:227.193-Deazaguanosine
CAS:<p>3-Deazaguanosine (C3Guo) exhibits potent antiviral activity against SARS-CoV-2 with an EC50 of 1.14 μM and a CC50 greater than 200 μM in Vero E6 cells. It has the potential to prevent COVID-19.</p>Fórmula:C11H14N4O5Cor e Forma:SolidPeso molecular:282.25Glutamate-5-kinase-IN-2
<p>Glutamate-5-kinase-IN-2 (compound 54) is a potent G5K inhibitor with 4.2 μM MIC, potential in anti-TB research.</p>Fórmula:C17H10ClFN2Cor e Forma:SolidPeso molecular:296.73Meclocycline
CAS:<p>Meclocycline: a tetracycline antibiotic, inhibits LDH, reduces cell toxicity from mutant huntingtin, doesn't change protein levels in PC12 cells.</p>Fórmula:C22H21ClN2O8Cor e Forma:SolidPeso molecular:476.86SARS-CoV-2 nsp14-IN-2
<p>SARS-CoV-2 nsp14-IN-2: Strong Nsp14 methyltransferase inhibitor (IC50: 0.09 μM), potential for COVID-19 research.</p>Fórmula:C21H21N5O5SCor e Forma:SolidPeso molecular:455.491,5-Dideoxy-1,5-imino-D-mannitol
CAS:<p>1,5-Dideoxy-1,5-imino-D-mannitol is an antibiotic with antibacterial properties.</p>Fórmula:C6H13NO4Cor e Forma:SolidPeso molecular:163.172Furametpyr
CAS:<p>Furametpyr is a kind of low toxicity pesticides used to control plant diseases caused by various pathogenic microorganisms.</p>Fórmula:C17H20ClN3O2Pureza:98%Cor e Forma:SolidPeso molecular:333.81CB 30900
CAS:<p>CB30900 is a novel and effective thymidylate synthase inhibitor.</p>Fórmula:C31H32FN5O9Cor e Forma:SolidPeso molecular:637.61LN-439A
CAS:<p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>Fórmula:C24H26FN3O4Cor e Forma:SolidPeso molecular:439.48DENV-IN-6
CAS:<p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>Fórmula:C23H26ClFN4OSCor e Forma:SolidPeso molecular:461Elongation factor P-IN-2
<p>Elongation factor P-IN-2, a β-lysine derivative, is a potent EFP inhibitor reducing E. coli growth.</p>Fórmula:C16H35N3O2Cor e Forma:SolidPeso molecular:301.47NDM-1 inhibitor-5
CAS:<p>NDM-1 Inhibitor-5 (compound 57) exhibits strong inhibition of NDM-1, characterized by a K i of 2.5 μM. Additionally, it demonstrates synergistic antibacterial effects when combined with meropenem [1].</p>Fórmula:C24H23NO4Cor e Forma:SolidPeso molecular:389.44ZK-806450
CAS:<p>ZK-806450 is a compound with antiviral properties. It exhibits high binding potential to the allosteric site of the SARS-CoV-2 3CL protease and is capable of specific and stable interaction with the GAG site of the dengue virus envelope protein.</p>Fórmula:C31H31N5OCor e Forma:SolidPeso molecular:489.611WRN inhibitor 7
CAS:<p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>Fórmula:C27H23N3O6Cor e Forma:SolidPeso molecular:485.49WQ3810 TFA
<p>WQ3810 TFA is an orally available fluoroquinolone with antimicrobial activity against Mycobacterium tuberculosis and inhibits the DNA rotamase activity of</p>Fórmula:C24H23F6N5O5Pureza:99.52%Cor e Forma:SoildPeso molecular:575.46Antibiofilm agent-14
CAS:<p>Antibiofilm agent-14 (compound 11) functions as an antibiofilm agent. It exhibits antifungal activity against C.albicans SC5314, with a minimum inhibitory concentration (MIC) of 50 μM.</p>Fórmula:C26H30ClN3OCor e Forma:SolidPeso molecular:435.989SARS-CoV-2-IN-8
<p>SARS-CoV-2-IN-8 is a major protease inhibitor of SARS-CoV-2 (IC50: 0.75 μM).</p>Fórmula:C35H38N6O3Cor e Forma:SolidPeso molecular:590.71Palmitanilide
CAS:<p>Palmitanilide (Palmitic acid anilide) is an antimicrobial agent effective against Gram-positive bacteria. It can electrostatically bind to components of the cell wall of Gram-positive bacteria (such as Bacillus cereus), altering the membrane structure and affecting normal cellular functions. Palmitanilide shows potential for research into infections caused by Gram-positive bacteria.</p>Fórmula:C22H37NOCor e Forma:SolidPeso molecular:331.5352'-(2-Nitrobenzyl)-ATP
CAS:<p>2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.</p>Fórmula:C17H21N6O15P3Cor e Forma:SolidPeso molecular:642.30CDA-IN-4
CAS:<p>CDA-IN-4 (compound VS-24) is an inhibitor of chitin deacetylase (CDA). At a concentration of 100 μg/mL, CDA-IN-4 provides a protective effect of 61.2% against rice blast disease.</p>Fórmula:C10H9BrN4O2SCor e Forma:SolidPeso molecular:329.17Antiviral agent 15
<p>Compound 15f, a Clofazimine derivative, inhibits rabies (EC50: 1.45 μM) and SARS-CoV-2 (EC50: 14.6 μM).</p>Fórmula:C27H24FN5OCor e Forma:SolidPeso molecular:453.51OUN58101
CAS:<p>OUN58101, also MDK-8101/BI-D, is an RSV L-protein inhibitor with no formal name, first reported in patent WO 2005042530.</p>Fórmula:C32H36N6O6Cor e Forma:SolidPeso molecular:600.66Nikkomycin Z
CAS:<p>Nikkomycin Z (Nikkomycin Z from Streptomyces tendae) is a competitive chitin synthase inhibitor.It inhibitor of the growth of filamentous fungi, insects,</p>Fórmula:C20H25N5O10Pureza:98%Cor e Forma:SolidPeso molecular:495.44Ladirubicin
CAS:<p>Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.</p>Fórmula:C29H31NO11SCor e Forma:SolidPeso molecular:601.62N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide
<p>N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is a Ole1p desaturase inhibitor as well as antifungal agent [1].</p>Fórmula:C11H9FN4OCor e Forma:SolidPeso molecular:232.21Neuraminidase-IN-4
<p>Neuraminidase-IN-4 inhibits neuraminidase (EC50: 1.59 μM) and has strong anti-H5N1 activity.</p>Fórmula:C21H20N2O6SCor e Forma:SolidPeso molecular:428.46Cyclophilin inhibitor 1
CAS:<p>Cyclophilin inhibitor 1: orally available, Kd 5 nM, potent against HCV, EC50 for HCV 2a is 98 nM.</p>Fórmula:C31H39N5O7Pureza:98%Cor e Forma:SolidPeso molecular:593.67XR8-69
<p>XR8-69 is a SARS-CoV-2 PLpro inhibitor. XR8-69 has a low micromolar antiviral effect in SARS-CoV-2 infected human cells.</p>Fórmula:C26H30N4O2SCor e Forma:SolidPeso molecular:462.61HBV-IN-18
<p>HBV-IN-18 (Compound 3) is an HBV capsid assembly modulator (CpAM) (EC50: 2790 nM).</p>Fórmula:C17H15F6N5O2Cor e Forma:SolidPeso molecular:435.32HCV-IN-7
CAS:<p>HCV-IN-7: potent oral HCV NS5A inhibitor, pan-genotypic, IC50s 3-47 pM, good pharmacokinetics, favorable liver uptake.</p>Fórmula:C40H48N8O6SPureza:98%Cor e Forma:SolidPeso molecular:768.92PLP_Snyder530
<p>PLP_Snyder530, a potent PL pro inhibitor, halts SARS-CoV-2 by triggering protease conformation changes.</p>Fórmula:C24H24N2O2Cor e Forma:SolidPeso molecular:372.467-APRA
CAS:<p>7-APRA is a semisynthetic intermediate of the cephalosporin class of antibiotics. It exhibits antibacterial activity and is primarily used in the synthesis of other cephalosporin antibiotics, such as Cefaclor and Cefprozil.</p>Fórmula:C10H12N2O3SPeso molecular:240.28Enantiomer of Sofosbuvir
<p>Inactive enantiomer of Sofosbuvir, used for chronic hepatitis C; lacks reported biological activity.</p>Fórmula:C22H29FN3O9PPureza:98%Cor e Forma:SolidPeso molecular:529.45NS2B/NS3-IN-4
CAS:<p>Compound 34e inhibits DENV2/ZIKV proteases; IC50: 0.69 µM (DENV2), 1.04 µM (ZIKV).</p>Fórmula:C15H11NO4Cor e Forma:SolidPeso molecular:269.25DNDI-8219
CAS:<p>DNDI-8219 is an antitubercular agent. It has potent antileishmanial effects.</p>Fórmula:C13H10F3N3O5Cor e Forma:SolidPeso molecular:345.23Ciluprevir
CAS:<p>Ciluprevir is a selective HCV NS3 protease inhibitor, effective against non-genotype-1 HCV; less potent for genotypes 2/3.</p>Fórmula:C40H50N6O8SPureza:98%Cor e Forma:SolidPeso molecular:774.93HIV-1 inhibitor-13
<p>HIV-1 inhibitor-13: oral NNRTI, IC50=0.14μM for HIV-1 RT, effective on resistant strains (EC50=2.85-18nM).</p>Fórmula:C30H32N6O3Cor e Forma:SolidPeso molecular:524.61Isopyrazam
CAS:<p>Isopyrazam, a plant protection product, exhibits potent antifungal activity. When applied to crops, it effectively inhibits the growth of various plant pathogenic fungi, significantly enhancing both the yield and quality of the crops. This compound demonstrates exceptional disease resistance capabilities in agricultural applications.</p>Fórmula:C20H23F2N3OCor e Forma:SolidPeso molecular:359.41Griseofulvic Acid
CAS:<p>Griseofulvic Acid ((±)-Griseofulvic acid) is a metabolite of the antifungal agent Griseofulvin. It induces protein aggregation and tubulin polymerization in cell-free assays.</p>Fórmula:C16H15ClO6Peso molecular:338.74Antifungal agent 19
<p>Antifungal agent 19 shows the potent antifungal activity ( EC 50 = 0.72 μM).</p>Fórmula:C19H18F4O2Cor e Forma:SolidPeso molecular:354.34PqsR-IN-2
<p>PqsR-IN-2, potent PqsR inhibitor, curbs Pseudomonas aeruginosa communication, reduces pyocyanin, with low toxicity.</p>Fórmula:C18H20ClN3OSCor e Forma:SolidPeso molecular:361.89Cap-dependent endonuclease-IN-17
CAS:<p>CEN inhibitor IN-17 targets influenza A/H3N2; IC50: 1.29 μM. From patent CN112898346A, DSC701.</p>Fórmula:C24H20F2N3O7PSCor e Forma:SolidPeso molecular:563.47Xeruborbactam
CAS:<p>QPX7728 is an of ultra-broad-spectrum boronic acid beta-lactamase.</p>Fórmula:C10H8BFO4Pureza:98%Cor e Forma:SolidPeso molecular:221.98Antitubercular agent-23
<p>Antitubercular agent-23 combats Candida albicans (MIC: 1.1 μg/ml) and M. tuberculosis (MIC: 1 μg/ml).</p>Fórmula:C20H22FN5O8SCor e Forma:SolidPeso molecular:511.48L-threo-β-Hydroxyaspartic acid
CAS:<p>L-threo-β-Hydroxyaspartic acid is an amino acid antibiotic with activity against Bacillus subtilis, Xanthomonas oryzae, Mycobacterium phlei, and Botrytis cinerea.</p>Fórmula:C4H7NO5Cor e Forma:SolidPeso molecular:149.102CRS-3123
CAS:<p>CRS-3123, a methionyl-tRNA synthetase inhibitor, is used potentially for the treatment of enteric infections.</p>Fórmula:C19H19Br2N3O2SPureza:98%Cor e Forma:SolidPeso molecular:513.25Lapyrium chloride
CAS:<p>Lapyrium chloride (Emcol E 607) is a broad-spectrum antibacterial agent that serves as a preservative and disinfectant.</p>Fórmula:C21H35ClN2O3Peso molecular:398.97JPL
CAS:<p>JPL is an InhA-cofactor-ligand 3FNG inhibitor and is used for the study of tuberculosis [1].</p>Fórmula:C19H20Cl2O2Cor e Forma:SolidPeso molecular:351.27InhA-IN-7
CAS:<p>InhA-IN-7 (Compound 11), a derivative of Triclocan, shows inhibitory activity against enoyl-acyl carrier protein reductase (InhA) with an IC50 of 96 nM. It effectively inhibits the proliferation of both wildtype and mutant strains of Mycobacterium tuberculosis, exhibiting minimum inhibitory concentrations (MICs) ranging from 19 to 75 μM [1].</p>Fórmula:C17H18Cl2O2Cor e Forma:SolidPeso molecular:325.23SARS-CoV-2-IN-22
CAS:<p>SARS-CoV-2-IN-22 is a SARS-CoV-2 pseudovirus inhibitor (IC50: 16.96 μM).</p>Fórmula:C27H24N2O3SCor e Forma:SolidPeso molecular:456.56Uridine 3',5'-diphosphate
CAS:<p>Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].</p>Fórmula:C9H14N2O12P2Cor e Forma:SolidPeso molecular:404.16Antiviral agent 67
CAS:<p>Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.</p>Fórmula:C19H19N3OCor e Forma:SolidPeso molecular:305.374Desthiazolylmethyl ritonavir
CAS:<p>Desthiazolylmethyl ritonavir is an alkaline-catalyzed degradation product of the HIV protease inhibitor Ritonavir.</p>Fórmula:C33H43N5O4SCor e Forma:SolidPeso molecular:605.7914,5'-Dimethylangelicin-NHS
<p>NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.</p>Fórmula:C21H19NO7SCor e Forma:SolidPeso molecular:429.44BMIM-TFSI
CAS:<p>BMIM-TFSI (compound8) is an HIV-1 integrase inhibitor that effectively suppresses both the 3'-processing (3'-P) and strand transfer (ST) steps of the integration process. It is applicable in HIV-1 research.</p>Fórmula:C10H15F6N3O4S2Cor e Forma:SolidPeso molecular:419.364Deprodone
CAS:<p>Deprodone is an active compound that inhibits key processes such as bacterial cell wall synthesis by interacting with hydrolase and transferase proteins of methicillin-resistant Staphylococcus aureus (MRSA). It is applied in the research of MRSA infections, inflammatory skin diseases, intestinal disorders, and fatty acid metabolism disorders.</p>Fórmula:C21H28O4Cor e Forma:SolidPeso molecular:344.44BPR3P0128
CAS:<p>BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor, is effective orally and can inhibit various SARS-CoV-2 variants. It exhibits EC 50 values of 0.62 µM for SARS-CoV-2 and 0.14 µM for HCoV-229E, demonstrating potent anti-pancoronavirus activity at submicromolar concentrations. Additionally, BPR3P0128 displays synergistic antiviral effects when used in combination with Remdesivir [1].</p>Fórmula:C22H18BrN3O2Cor e Forma:SolidPeso molecular:436.30MsbA-IN-4
<p>MsbA-IN-4 (Compound 32) is a highly selective and potent inhibitor of MsbA (IC50: 3 nM).MsbA-IN-4 inhibits Escherichia coli (MIC: 12 μM).</p>Fórmula:C23H18Cl2FN5OCor e Forma:SolidPeso molecular:470.33Antibacterial agent 81
CAS:<p>Antibacterial agent 81 blocks DNA transcription, targets S. aureus (MIC 12.5μM) & M. smegmatis (MIC 7.8μM). Used in infection research.</p>Fórmula:C33H28N2O8Cor e Forma:SolidPeso molecular:580.58TCMDC-125431
<p>TCMDC-125431 is a novel inhibitor of Plasmodium calcium kinetics with minimal inhibition of haemoglobin crystals.</p>Fórmula:C25H27N3O2SCor e Forma:SolidPeso molecular:433.57Antimicrobial agent-38
CAS:<p>Antimicrobial agent-38 (compound 10) effectively inhibits methicillin-resistant Staphylococcus aureus (S. aureus) strain ATCC 700699 and non-resistant strain ATCC 29213, with minimum inhibitory concentrations (MIC) of 32 mg/L and 64 mg/L, respectively.</p>Fórmula:C14H11N3O4SCor e Forma:SolidPeso molecular:317.32Antibacterial agent 99
CAS:<p>Compound 7b (Antibacterial agent 99) is an effective agent with antibacterial, antifungal properties and no haemolytic activity.</p>Fórmula:C27H27BrN2Cor e Forma:SolidPeso molecular:459.42SARS-CoV-2 nsp3-IN-1
<p>Compound 15c selectively inhibits SARS-CoV-2 nsp3 Mac1 with IC50 of 6.1 μM.</p>Fórmula:C17H15N5O2Cor e Forma:SolidPeso molecular:321.33MPro N3
CAS:<p>Mpro inhibitor blocks MHV-A29, HCoV-229E, FOPV (IC50: 2.7–8.8 μM), and SARS-CoV-2 (IC50: 16.8 μM) in plaque assays.</p>Fórmula:C35H48N6O8Cor e Forma:SolidPeso molecular:680.79Saussureamine C
CAS:<p>Saussureamine C is an inhibitor of H274Y and N294S mutants.</p>Fórmula:C19H26N2O5Cor e Forma:SolidPeso molecular:362.42Deleobuvir
CAS:<p>Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.</p>Fórmula:C34H33BrN6O3Cor e Forma:SolidPeso molecular:653.57XR8-89
CAS:<p>XR8-89, a potent PLpro inhibitor (IC50=0.1μM), blocks SARS-CoV-2 replication; useful for research.</p>Fórmula:C29H36N4O2SCor e Forma:SolidPeso molecular:504.69ZLM-66
<p>ZLM-66: Doravirine analog, HIV-1 NNRTI inhibitor, IC50: 41nM, EC50: HIV-1 13nM, cIAP1 0.32nM; useful in AIDS research.</p>Cor e Forma:SolidCM-728
CAS:<p>CM-728 is an oxazanonaphthoquinone that exhibits cytotoxic and antibacterial properties. It acts as a human peroxidase-1 inhibitor and serves as a source of oxidative stress affecting mitochondrial function.</p>Fórmula:C22H14N2O5Cor e Forma:SolidPeso molecular:386.357Massarilactone H
CAS:<p>Massarilactone H, a polyketide, is a neuraminidase inhibitor, with an IC 50 of 8.18 µM .</p>Fórmula:C11H12O5Cor e Forma:SolidPeso molecular:224.21Antifungal agent 127
CAS:<p>Antifungalagent 127 (Compound 6c) is an antifungal agent with potent inhibitory activity against Botrytis cinerea and Rhizoctonia solani.</p>Fórmula:C13H12ClN3OCor e Forma:SolidPeso molecular:261.707HIV-1 inhibitor-41
<p>HIV-1 inhibitor-41 (B23): Oral non-nucleoside reverse transcriptase blocker, EC50 of 50 nM (E138K), 20.8 nM (WT), low hERG/CYP impact, non-toxic.</p>Fórmula:C16H15F2N3OSCor e Forma:SolidPeso molecular:335.37Emtricitabine triphosphate
CAS:<p>Emtricitabine triphosphate is an active metabolite of Emtricitabine, a drug for HIV/HBV that inhibits reverse transcriptase.</p>Fórmula:C8H13FN3O12P3SCor e Forma:SolidPeso molecular:487.19NITD-688
CAS:<p>NITD-688 is a pan-serotype inhibitor targeting the dengue virus NS4B protein, effective through oral administration.</p>Fórmula:C25H32N4O3S2Cor e Forma:SolidPeso molecular:500.68NBTIs-IN-5
CAS:<p>NBTIs-IN-5 inhibits Mycobacterium abscessus DNA with IC50 1.5μM, halts growth at MIC90 0.4μM.</p>Fórmula:C24H25F3N4O2Cor e Forma:SolidPeso molecular:458.48ZK-316
CAS:<p>ZK-316 is a potent and broad-spectrum NNRTI inhibitor with an EC50 range of 0.99 to 75.1 nM. It is applicable for HIV research.</p>Fórmula:C27H22D6N6O3S2Cor e Forma:SolidPeso molecular:554.72SARS-CoV-2 Mpro-IN-25
CAS:<p>SARS-CoV-2 Mpro-IN-25 (Compound 3a) is a protease inhibitor for SARS-CoV-2, exhibiting an IC50 value of 0.26 μM. It demonstrates antiviral activity and is useful for research in the field of pneumonia.</p>Fórmula:C13H10FNO4Cor e Forma:SolidPeso molecular:263.22CDK9-IN-34
CAS:<p>CDK9-IN-34 (Compound 1b) is an inhibitor of CDK9 with an IC50 of 0.25 μM. It exhibits cytotoxicity against cancer cell lines HCT116, MCF7, and K652, with IC50 values of 1.43 μM, 3.01 μM, and 50.27 μM, respectively. Additionally, CDK9-IN-34 demonstrates antiviral activity against coronavirus 229E with an IC50 of 145.92 μM.</p>Fórmula:C18H20N4Cor e Forma:SolidPeso molecular:292.38FtsZ-IN-13
CAS:<p>FtsZ-IN-13 (Compound C11) functions as an inhibitor of the temperature-sensitive mutant Z (FtsZ), exhibiting IC50 values of 47.97 μM for FtsZSa and 34 μM for FtsZPa. It demonstrates notable antibacterial activity against Staphylococcus aureus (with a minimum inhibitory concentration of 2 μg/mL), cystic fibrosis Staphylococcus aureus clinical isolates, and methicillin-resistant Staphylococcus aureus (MRSA). FtsZ-IN-13 is applicable in research on antibiotic resistance.</p>Fórmula:C18H14N2O4S2Cor e Forma:SolidPeso molecular:386.445FGI-106
CAS:<p>FGI-106 combats Ebola, Rift Valley, Dengue Fever, HCV, and HIV-1; EC50s range from 100-900 nM.</p>Fórmula:C28H38N6Pureza:98%Cor e Forma:SolidPeso molecular:458.64LpxH-IN-2
CAS:<p>LpxH-IN-2 (compound 014), a potent inhibitor of LpxH, exhibits antibacterial activity against E. coli.</p>Fórmula:C27H33ClF2N6O4SCor e Forma:SolidPeso molecular:611.10SARS-CoV-2-IN-23
<p>SARS-CoV-2-IN-23 (compound GRL-0617) is an inhibitor of SARS-COV-2 papain-like protease (PLpro) (IC 50 = 2.3 μM) [1].</p>Fórmula:C21H22N2OCor e Forma:SolidPeso molecular:318.41Antimalarial agent 9
<p>Antimalarial 9, a quinoline-imidazole derivative, effectively targets CQ-susceptible (IC50-0.14 μM) and MDR strains (IC50-0.41 μM) with low toxicity.</p>Fórmula:C28H32BrN3O2Cor e Forma:SolidPeso molecular:522.48HIV-IN-3
<p>HIV-IN-3 (Compound 22a) is a potent inhibitor of HIV (IC50: 1.5 μM). HIV-IN-3 has potential for the study of HIV-related diseases.</p>Fórmula:C21H32ClN7O3Cor e Forma:SolidPeso molecular:465.98N6-Benzoyl-2'-deoxyadenosine monohydrate
CAS:<p>N6-Benzoyl-2'-deoxyadenosine monohydrate is a nucleoside analogue that helps diagnose bacterial infections by binding to double-stranded DNA and altering its structure, which can subsequently be detected using electrophoresis.</p>Fórmula:C17H19N5O5Cor e Forma:SolidPeso molecular:373.363RSV-IN-7
CAS:<p>RSV-IN-7 (example 253) is a RSV inhibitor ( EC 50 : < 0.4 μΜ) .</p>Fórmula:C27H22F3N7O3Cor e Forma:SolidPeso molecular:549.50RdRP-IN-4
<p>RdRP-IN-4, an oral arylbenzohydrazide, inhibits influenza A/B by targeting PB1 of RdRP, with EC50s of 53 nM (H1N1) and 20 nM (Flu B), and aids infected mice.</p>Fórmula:C17H17Br2N3O2Cor e Forma:SolidPeso molecular:455.14Antibacterial agent 80
<p>Antibacterial agent 80 (compound 20) has antibacterial activity [1].</p>Fórmula:C14H21N3S2Cor e Forma:SolidPeso molecular:295.47Flutimide
CAS:<p>Flutimide: Endonuclease inhibitor, IC50 = 3μM, for research on acute respiratory diseases like influenza.</p>Fórmula:C12H18N2O3Cor e Forma:SolidPeso molecular:238.28RdRP-IN-5
CAS:<p>RdRP-IN-5 (compound 20), a potent inhibitor of the influenza virus RNA-dependent RNA polymerase (RdRP), has potential application in influenza research [1].</p>Fórmula:C23H21N3O5Pureza:98%Cor e Forma:SolidPeso molecular:419.43Cetefloxacin
CAS:<p>Cetefloxacin (E 4868) is a broad-spectrum antibacterial antibiotic with a minimum inhibitory concentration (MIC) ranging from 0.007 to 8 µg/ml. In mice, cetefloxacin demonstrates favorable pharmacokinetic properties and provides protection against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.</p>Fórmula:C20H16F3N3O3Peso molecular:403.35Polθ-IN-8
CAS:<p>Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.</p>Fórmula:C22H22ClN7O3SCor e Forma:SolidPeso molecular:499.97Purine phosphoribosyltransferase-IN-1
<p>Compound (S,R)-48 inhibits Pf, Pv, & Tbr PRT with Ki of 50, 20, 2 nM.</p>Fórmula:C11H15N5Na4O10P2Cor e Forma:SolidPeso molecular:531.17EBOV-IN-10
CAS:<p>EBOV-IN-10 is an orally active inhibitor of the Ebola virus (EBOV) with an EC50 value of 0.19 μM.</p>Fórmula:C22H22N2O2SCor e Forma:SolidPeso molecular:378.49ACHN-975
CAS:<p>ACHN-975: potent LpxC inhibitor with subnanomolar activity; targets many gram-negative bacteria; MIC ≤1 μg/mL.</p>Fórmula:C20H23N3O4Pureza:98%Cor e Forma:SolidPeso molecular:369.41HIV-1 inhibitor-18
<p>HIV-1 inhibitor-18 blocks HIV-1 capsid, effective on NL4-3 strain (EC50: 5.14 μM), slightly toxic (MT-4CC50>9.51).</p>Fórmula:C27H31N3O6SCor e Forma:SolidPeso molecular:525.62Colistin adjuvant-2
<p>Colistin adjuvant-2 is a compound that acts as a potentiation agent for colistin, effectively enhancing its activity against Gram-negative bacteria [1].</p>Fórmula:C14H7Cl2F3N2OCor e Forma:SolidPeso molecular:347.12Elongation factor P-IN-1
<p>EFP-IN-1: potent β-lysine derivative, inhibits EFP, slows E. coli growth.</p>Fórmula:C14H31N3O2Cor e Forma:SolidPeso molecular:273.41Polθ-IN-7
CAS:<p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>Fórmula:C28H35F3N6O2Cor e Forma:SolidPeso molecular:544.612MLEB-22043
<p>MLEB-22043 is a synthetic siderophore-monocyclic β-lactam conjugate which enters bacteria through TonB-dependent transport proteins utilizing its siderophore component, subsequently exerting antibacterial activity via its β-lactam portion. This compound acts as a broad-spectrum antibiotic, exhibiting significant inhibitory activity against pathogens such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.</p>Fórmula:C25H25N9O11S2Cor e Forma:SolidPeso molecular:691.65Antibacterial agent 174
CAS:<p>Compound 174 (Compound 5g), an antibacterial agent, exhibits potent anti-infective properties in vivo along with appreciable pharmacokinetic profiles. This highly active substance demonstrates favorable biofilm removal capabilities, low hemolysis, and acceptable mammalian cell toxicity [1].</p>Fórmula:C25H30FN2NaO5Cor e Forma:SolidPeso molecular:480.5HIV-1 protease-IN-6
<p>HIV-1 protease-IN-6 (17d) strongly inhibits HIV-1 protease (IC50: 21 pM, Ki: 4.7 pM) and effectively targets DRV-resistant mutants.</p>Fórmula:C27H31FN2O6SCor e Forma:SolidPeso molecular:530.61SID 26681509 quarterhydrate
<p>SID 26681509 is a selective inhibitor of cathepsin L (IC50: 56 nM) and blocks Plasmodium falciparum (IC50: 15.4 μM) and Leishmania major (IC50: 12.5 μM).</p>Fórmula:C27H35N5O6SCor e Forma:SolidPeso molecular:544.16HCV NS5B polymerase-IN-2
CAS:<p>HCVNS5B polymerase-IN-2 (Compound 298) is an inhibitor of the Ns5b polymerase. It holds potential for research into the treatment of hepatitis C virus (HCV) infections.</p>Fórmula:C26H24N2O4Cor e Forma:SolidPeso molecular:428.48Cephalosporin C
CAS:<p>Cephalosporin C exhibits relatively weak resistance to Gram-positive and Gram-negative bacteria. It is stable against penicillinase, but can be decomposed by cephalosporinase. When hydrolyzed to remove its side chain, it yields 7-amino-cefenoic acid (7-ACA), which is an essential raw material for the production of semisynthetic cephalosporins.</p>Fórmula:C16H21N3O8SCor e Forma:SolidPeso molecular:415.418BRD-K98645985
CAS:<p>BRD-K98645985: BAF inhibitor, binds ARID1A, reverses HIV-1 latency, EC50 ~2.37μM, alters nucleosome placement.</p>Fórmula:C33H43N5O4Pureza:98%Cor e Forma:SolidPeso molecular:573.73Anti-MRSA agent 3
CAS:<p>Anti-MRSA agent 3 targets MRSA with 0.098 μg/ml MIC, low toxicity, binds DNA, and disrupts cell walls/membranes.</p>Fórmula:C29H18BrN3O2Cor e Forma:SolidPeso molecular:520.386(S)-ZG197
<p>(S)-ZG197 is a compound that acts as a highly selective activator of the Staphylococcus aureus Caseinolytic Protease P (Sa ClpP), demonstrating efficacy at a</p>Fórmula:C28H35F3N4O3Cor e Forma:SolidPeso molecular:532.6Antibiotic U 44590
CAS:<p>5,6-Dihydro-5-azathymidine exhibits activity against both Gram-positive and Gram-negative bacteria, as well as DNA viruses.</p>Fórmula:C9H15N3O5Cor e Forma:SolidPeso molecular:245.23SARS-CoV-2-IN-6
<p>SARS-CoV-2-IN-6 is an inhibitor of SARS-CoV-2 3CLpro with the IC 50 value of 73 nM.</p>Fórmula:C17H13ClN2O2Cor e Forma:SolidPeso molecular:312.75ZINC000104379474
<p>ZINC000104379474 is a compound that targets SARS-CoV-2 endoribonuclease.</p>Fórmula:C27H33N3O10Cor e Forma:SolidPeso molecular:559.57Methyl 3-oxodecanoate
CAS:<p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>Fórmula:C11H20O3Cor e Forma:SolidPeso molecular:200.275MT0703
CAS:<p>MT0703 is a cephalosporin antibiotic featuring an aminothiazolylglycyl moiety with a 1,5-dihydroxy-4-pyridinone-2-carbonyl group, displaying potent activity against Pseudomonas species.</p>Fórmula:C26H25N7O9S3Cor e Forma:SolidPeso molecular:675.71Antibacterial agent 172
CAS:<p>Antibacterial Agent 172 (Compound 6a), a <i>Clostridioides difficile (Cd) SpoVD inhibitor with an IC50 value of 89 nM, effectively inhibits the sporulation of Clostridioides difficile. It is useful for research on bacterial infections [1].</p>Fórmula:C21H21N9O5S2Cor e Forma:SolidPeso molecular:543.58LY 215890
CAS:<p>LY 215890 is a compound that exhibits potent Gram-negative and Gram-positive antibacterial activity.</p>Fórmula:C13H12ClN5O5SPureza:98%Cor e Forma:SolidPeso molecular:385.78MraY-IN-3
<p>MraY-IN-3 (12a) is a potent inhibitor of the bacterial translocase MraY (IC50: 140 μM). 46 μg/ml).</p>Fórmula:C35H45N3O5Cor e Forma:SolidPeso molecular:587.75SARS-CoV-2-IN-24
<p>SARS-CoV-2-IN-24 blocks PLpro, altering its shape and stopping virus replication—useful for SARS-CoV-2 research.</p>Fórmula:C27H30N4O5Cor e Forma:SolidPeso molecular:490.55Antifungal agent 25
<p>Antifungal agent 25: broad-spectrum, stable in vivo, effective against Candida albicans, including fluconazole-resistant strains.</p>Cor e Forma:SolidUrease-IN-1
<p>Urease -IN-1 is a urease inhibitor (IC50: 2.21±0.45 μM).</p>Fórmula:C17H12BrFN4O2SCor e Forma:SolidPeso molecular:435.27AB25583
CAS:<p>AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.</p>Fórmula:C22H17ClN4O3SCor e Forma:SolidPeso molecular:452.91MMV03
CAS:<p>MMV03 is an antimalarial compound effective against Plasmodium falciparum, with an EC50 of 0.6 μM.</p>Fórmula:C19H14N4OSCor e Forma:SolidPeso molecular:346.406A25822B
CAS:<p>A25822B is an antifungal agent.</p>Fórmula:C28H45NOPureza:98%Cor e Forma:SolidPeso molecular:411.66RECTAS-2.0
CAS:<p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G>A mutation, intended for research in Fabry disease.</p>Fórmula:C18H17ClN4O4Cor e Forma:SolidPeso molecular:388.805C-467929
CAS:<p>C-467929 is an inhibitor of the Nsp15 endoribonuclease, exhibiting an IC50 value of 8 μM. This compound binds to the SARS-CoVNsp15 protein and is applicable for infection research.</p>Fórmula:C29H20N4O10Cor e Forma:SolidPeso molecular:584.49PF-07957472
CAS:<p>PF-07957472 (Compound 4) is an orally effective inhibitor of the SARS-CoV-2 papain-like protease (PLpro). In NHBE cells infected with SARS-CoV-2, it demonstrated cytopathic effects with an EC50 of 13.9 nM. Additionally, PF-07957472 exhibited antiviral activity in a mouse-adapted COVID-19 infection model.</p>Fórmula:C29H32N6OCor e Forma:SolidPeso molecular:480.60Anti-Influenza agent 3
<p>Compound 11h: Potent, low-toxicity anti-influenza, inhibits M2 ion channels. EC50: 3.29μM (H3N2), 2.45μM (H1N1).</p>Fórmula:C16H22ClNOSCor e Forma:SolidPeso molecular:311.87WM382
CAS:<p>WM382, a potent dual PMIX/X inhibitor, has IC50s of 1.4 nM/0.03 nM and effective against various malaria stages.</p>Fórmula:C29H36N4O4Cor e Forma:SolidPeso molecular:504.62β-Glucuronidase-IN-3
CAS:<p>β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric inhibitor targeting β-glucuronidase. It exhibits potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) with an IC50 of 12.9 nM. The compound exerts its inhibitory effect through reversible covalent modification of cysteine residues (Cys28, Cys443, and Cys197) on EcGUS. It is applicable in research on gut microbiota-related diseases, particularly in reducing the toxic side effects of Irinotecan and non-steroidal anti-inflammatory drugs (NSAIDs).</p>Fórmula:C10H7N3OSeCor e Forma:SolidPeso molecular:264.14ZG297
CAS:<p>ZG297 is an agonist of Staphylococcus aureus ClpP (SaClpP) with an EC50 of 0.26 μM. It degrades SaFtsZ and inhibits bacterial cell division, exhibiting antistaphylococcal activity by inhibiting S. aureus 8325-4 and MRSA strains, with a MIC range of 0.063-256 μg/mL. In mouse models, ZG297 demonstrates anti-infective properties.</p>Fórmula:C31H35F3N4O3Cor e Forma:SolidPeso molecular:568.63NFC nitro probe 1
CAS:<p>NFC nitro probe 1 (compound 18) is a chemical probe designed for the detection of Mtb, exhibiting high potency against both R-Mtb and NR-Mtb.</p>Fórmula:C19H19NO6Cor e Forma:SolidPeso molecular:357.357Pneumolysin-IN-1
CAS:<p>Pneumolysin-IN-1 (compound PB-3), characterized as a targeted small molecule inhibitor of Pneumolysin (PLY) with an IC50 value of 3.1 µM, acts as a pore-blocking agent and an anti-virulence factor. This compound is useful for researching infections caused by Streptococcus pneumoniae [1].</p>Fórmula:C23H16Cl2N2O4Cor e Forma:SolidPeso molecular:455.29NBD-14189
CAS:<p>NBD-14189: Potent HIV-1 entry blocker, binds gp120, IC50: 89 nM, strong antiviral (EC50 <200 nM).</p>Fórmula:C18H16F4N4O2SCor e Forma:SolidPeso molecular:428.40Antimalarial agent 48
CAS:<p>Antimalarial agent 48 (Compound 15a) is a triazine compound with antimalarial activity, showing effectiveness against Plasmodium falciparum K1 and Plasmodium falciparum FCR3 with IC50 values of 280 and 290 nM, respectively. It holds promise for research in the field of anti-infective treatments.</p>Fórmula:C19H14F3N11Cor e Forma:SolidPeso molecular:453.383SARS-CoV-2-IN-97
CAS:<p>SARS-CoV-2-IN-97 (Compound CO-01) is an inhibitor of the SARS-CoV-2Nsp15 endoribonuclease, exhibiting an IC50 of 53.5 μM. It demonstrates low cytotoxicity in A549-AT cells with an IC50 value of 134 μM.</p>Fórmula:C11H3Br2N3OCor e Forma:SolidPeso molecular:352.97HIV-1 inhibitor-61
CAS:<p>HIV-1 Inhibitor-61 (2c) serves as a potent inhibitor of HIV-1 reverse transcriptase, exhibiting an EC50 value of 0.07 nM in NL4-3 wt MT-4 cells [1].</p>Fórmula:C24H24F2N2O2SCor e Forma:SolidPeso molecular:442.52Fabimycin
CAS:<p>Fabimycin, a FabI inhibitor, combats drug-resistant gram-negative bacterial infections effectively.</p>Fórmula:C23H25ClN4O3Cor e Forma:SolidPeso molecular:440.92ABT-072
CAS:<p>ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.</p>Fórmula:C24H27N3O5SPureza:98%Cor e Forma:SolidPeso molecular:469.55Carbodine
CAS:<p>Carbodine is an antiviral targeting CTP synthetase, effective against influenza A0/PR-8/34 and A2/Aichi/2/68.</p>Fórmula:C10H15N3O4Pureza:98%Cor e Forma:SolidPeso molecular:241.24SARS-CoV-IN-6
CAS:<p>SARS-CoV-IN-6 (Compound 17) acts as an inhibitor of SARS-CoV-1 and SARS-CoV-2 RdRp, demonstrating an IC50 value of 7.8 μM against SARS-CoV-2 RdRp. This compound reduces the cytopathic effects of single-round infectious particles (SRIP) infected with SARS-CoV-1 and SARS-CoV-2 replicons and inhibits the expression of SARS-CoVN proteins. The EC50 values for SRIP based on SARS-CoV-1 and SARS-CoV-2 replicons are 0.12 µM and 1.47 µM, respectively.</p>Fórmula:C25H29N5O3Cor e Forma:SolidPeso molecular:447.53Colistin adjuvant-1
<p>Colistin adjuvant-1, inhibits NF-κB (IC50: 0.209 μM), boosts mucin against gram-negative bacteria.</p>Fórmula:C16H7F9N2OCor e Forma:SolidPeso molecular:414.23HBV-IN-12
CAS:<p>HBV-IN-12: strong HBsAg & HBV DNA inhibitor; EC50 0.001-0.05 μM & 0.001-0.02 μM respectively. (WO2021204252A1)</p>Fórmula:C23H27NO8Cor e Forma:SolidPeso molecular:445.46Anticancer agent 36
<p>Compound 11: Sulfonylurea derivative, antimicrobial, anticancer; MIC 0.039-0.156 mg/mL; A549 IC50: 19.7 μg/mL, PC3 IC50: 11.9 μg/mL.</p>Fórmula:C21H17N3O3S2Cor e Forma:SolidPeso molecular:423.51
