GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Foram encontrados 265 produtos para "GluR".
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Basimglurant
CAS:Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).Fórmula:C18H13ClFN3Pureza:98.35%Cor e Forma:SolidPeso molecular:325.77Ref: TM-T12717
1mg71,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg222,00€25mg358,00€50mg532,00€100mg665,00€200mg898,00€Decoglurant
CAS:Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.Fórmula:C21H11F6N5Pureza:99.77%Cor e Forma:SolidPeso molecular:447.34Ref: TM-T15090
1mg52,00€5mg111,00€1mL*10mM (DMSO)152,00€10mg164,00€25mg294,00€50mg411,00€100mg572,00€200mg772,00€γ-DGG acetate
CAS:gamma-DGG acetate(6729-55-1 free base) (γ-D-Glutamylglycine) is a competitive blocker of AMPA receptor.Fórmula:C9H16N2O7Pureza:99.92%Cor e Forma:SolidPeso molecular:264.23DHPG
CAS:DHPG is a potent Group I mGluR agonist; doesn't affect Group II/III; linked to phospholipase D.Fórmula:C8H10ClNO4Pureza:99.55% - 99.59%Cor e Forma:SolidPeso molecular:219.622AZD-8529 mesylate
CAS:AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM).Fórmula:C25H28F3N5O6SPureza:99.19%Cor e Forma:SolidPeso molecular:583.58VU0483605
CAS:VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.Fórmula:C20H10Cl3N3O3Pureza:99.61%Cor e Forma:SolidPeso molecular:446.67Ref: TM-T21747
2mg39,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg92,00€25mg173,00€50mg269,00€100mg404,00€200mg532,00€Piracetam
CAS:Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.Fórmula:C6H10N2O2Pureza:97.16% - 99.98%Cor e Forma:SolidPeso molecular:142.1558(R)-ADX-47273
CAS:(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).Fórmula:C20H17F2N3O2Pureza:99.87%Cor e Forma:SolidPeso molecular:369.36VU0650786
CAS:VU0650786: selective mGlu3 NAM, CNS-penetrant, IC50 392 nM, shows antidepressant/anxiolytic effects in rodents.Fórmula:C18H15ClFN5O2Pureza:99.09%Cor e Forma:SolidPeso molecular:387.8Ref: TM-T13318
1mg90,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg313,00€25mg530,00€50mg757,00€100mg1.044,00€(R)-3,4-DCPG HCl
(R)-3,4-DCPG HCl is a potent and selective mGlu8a receptor agonist that activates metabotropic glutamate receptors on primary afferent terminals in the neonatalFórmula:C10H10ClNO6Pureza:99.74% - 99.83%Cor e Forma:SolidPeso molecular:275.64ML353
ML353 activates TREK-1/2, binds mGlu5 SAM (Ki=18.2 nM), surpasses 5mpep, may address SAM activity/blocking.Fórmula:C19H15FN2OPureza:99.98% - 99.98%Cor e Forma:SolidPeso molecular:306.33Ref: TM-T67917
5mg50,00€1mL*10mM (DMSO)50,00€10mg74,00€25mg114,00€50mg156,00€100mg219,00€200mg298,00€KM02894
CAS:KM02894 inhibits glutamate release, potentially reducing cancer-induced bone pain in tumor studies.Fórmula:C7H9N3OS2Pureza:99.98%Cor e Forma:SolidPeso molecular:215.296Org-26576
CAS:Org-26576 is a positive allosteric modulator of the AMPA receptor.Fórmula:C11H12N2O2Pureza:99.67%Cor e Forma:White SolidPeso molecular:204.23NBQX disodium
CAS:NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity.Fórmula:C12H6N4Na2O6SPureza:97.32% - 97.60%Cor e Forma:Brown SolidPeso molecular:380.2415LY339434 HCl
LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA)Fórmula:C18H20ClNO4Pureza:97.10% - 97.19%Cor e Forma:SoildPeso molecular:349.81mGluR1 activator-1
mGluR1activator-1 is a stable vitamin K analog and mGluR1 activator capable of crossing the blood-brain barrier. It strongly activates transcription through steroid and xenobiotic receptors and retinoic acid receptors, effectively inducing neurogenesis in neural progenitor cells in mice. mGluR1activator-1 is applicable in studying neurodegenerative diseases, such as Alzheimer's.Cor e Forma:Odour SolidMMPIP hydrochloride
CAS:MMPIP hydrochloride is a selective antagonist of allosteric mGluR7.Fórmula:C19H16ClN3O3Pureza:99.88%Cor e Forma:Yellow SolidPeso molecular:369.8Ref: TM-T23008L
1mg56,00€5mg119,00€1mL*10mM (DMSO)133,00€10mg192,00€25mg394,00€50mg585,00€100mg833,00€200mg1.134,00€GYKI-47261 dihydrochloride
CAS:GYKI-47261 dihydrochloride is an AMPA receptor antagonist and CYP2E1 inducer, demonstrating broad-spectrum anticonvulsant and neuroprotective activities.Fórmula:C18H17Cl3N4Pureza:98.32% - 99.14%Cor e Forma:White SolidPeso molecular:395.71(S,S)-BMS-984923
CAS:(S,S)-BMS-984923 is a weak mGluR5 modulator with EC50 >1μM; less active than its potent counterpart.Fórmula:C22H15ClN2O2Cor e Forma:SolidPeso molecular:374.82MGS0028
CAS:MGS0028 is a selective agonist of metabotropic glutamate 2/3 receptor, it could reverse abnormal behaviors in mice induced by isolation rearing.Fórmula:C8H8FNO5Cor e Forma:SolidPeso molecular:217.15
