Células - tronco e Derivados
Os inibidores de células-tronco são compostos que visam especificamente as vias de sinalização e proteínas envolvidas na manutenção, diferenciação e proliferação de células-tronco. Esses inibidores são cruciais para compreender a biologia das células-tronco e para desenvolver estratégias para manipular células-tronco para fins terapêuticos, como medicina regenerativa e tratamento do câncer. Ao controlar o destino das células-tronco, esses inibidores podem ajudar a orientar a diferenciação das células-tronco em tipos celulares específicos ou prevenir o crescimento celular indesejado. Na CymitQuimica, oferecemos uma seleção de inibidores de células-tronco de alta qualidade para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e medicina regenerativa.
Subcategorias de "Células - tronco e Derivados"
- Gama-secretase(59 produtos)
- Hedgehog/Smoothened(44 produtos)
- Via Hippo(6 produtos)
- JAK(245 produtos)
- Porcupine(9 produtos)
- ROCK(70 produtos)
- STAT(98 produtos)
- Células - tronco(486 produtos)
- TGF-beta/Smad(58 produtos)
- Wnt/beta-catenina(66 produtos)
Exibir 2 mais subcategorias
Foram encontrados 695 produtos de "Células - tronco e Derivados"
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SRI-011381
CAS:<p>SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.</p>Fórmula:C20H31N3OPureza:98.64%Cor e Forma:SolidPeso molecular:329.48Hydroxyfasudil
CAS:<p>Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).</p>Fórmula:C14H17N3O3SPureza:98.13%Cor e Forma:SolidPeso molecular:307.37ML116
CAS:<p>ML116 is a potent and selective STAT3 inhibitor.</p>Fórmula:C18H19N3SPureza:99.49%Cor e Forma:SolidPeso molecular:309.43BMS-911543
CAS:<p>BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.</p>Fórmula:C23H28N8OPureza:97.69% - 99.98%Cor e Forma:SolidPeso molecular:432.52NVP-BSK805 trihydrochloride
CAS:<p>NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.</p>Fórmula:C27H31Cl3F2N6OCor e Forma:SolidPeso molecular:599.93PF-5274857
CAS:<p>PF-5274857: selective hedgehog pathway inhibitor (IC50: 5.8 nM, Ki: 4.6 nM), treats brain tumors, crosses blood-brain barrier, orally stable.</p>Fórmula:C20H25ClN4O3SPureza:98.53%Cor e Forma:SolidPeso molecular:436.96BP-1-102
CAS:<p>BP-1-102 is an orally active, effective and specific STAT3 inhibitor.</p>Fórmula:C29H27F5N2O6SPureza:99.25% - 99.44%Cor e Forma:SolidPeso molecular:626.59Fosifidancitinib
CAS:<p>Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.</p>Fórmula:C21H21FN5O7PPureza:99.54%Cor e Forma:SolidPeso molecular:505.39Momelotinib HCl
CAS:<p>Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.</p>Fórmula:C23H24Cl2N6O2Cor e Forma:SolidPeso molecular:487.38FM-381
CAS:<p>FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.</p>Fórmula:C24H24N6O2Pureza:98.44%Cor e Forma:SolidPeso molecular:428.49AS1517499
CAS:<p>AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM). High-Quality, Low-Cost!</p>Fórmula:C20H20ClN5O2Pureza:98.27% - 98.7%Cor e Forma:SolidPeso molecular:397.86TG101209
CAS:<p>TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.</p>Fórmula:C26H35N7O2SPureza:99% - >99.99%Cor e Forma:SolidPeso molecular:509.67exo-IWR-1
CAS:<p>exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin</p>Fórmula:C25H19N3O3Pureza:97.41%Cor e Forma:SolidPeso molecular:409.44Cerdulatinib
CAS:<p>Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.</p>Fórmula:C20H27N7O3SPureza:98.74% - 99.49%Cor e Forma:SolidPeso molecular:445.54Hydroxyfasudil Hydrochloride
CAS:<p>Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).</p>Fórmula:C14H18ClN3O3SPureza:98.05%Cor e Forma:SolidPeso molecular:343.83Solcitinib
CAS:<p>Solcitinib (GLPG-0778), a JAK1 inhibitor, may treat psoriasis, ulcerative colitis, and lupus.</p>Fórmula:C22H23N5O2Pureza:99.61% - 99.82%Cor e Forma:SolidPeso molecular:389.45Ritlecitinib
CAS:<p>Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.</p>Fórmula:C15H19N5OPureza:98.82% - 99.92%Cor e Forma:SolidPeso molecular:285.34SH5-07
CAS:<p>SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).</p>Fórmula:C29H28F5N3O5SPureza:95.54%Cor e Forma:SolidPeso molecular:625.61Upadacitinib
CAS:<p>Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.</p>Fórmula:C17H19F3N6OPureza:98.96% - 99.94%Cor e Forma:SolidPeso molecular:380.37GSK429286A
CAS:<p>GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).</p>Fórmula:C21H16F4N4O2Pureza:97.68% - 98.49%Cor e Forma:SolidPeso molecular:432.37Pyridone 6
CAS:<p>Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).</p>Fórmula:C18H16FN3OPureza:97.1% - 98.74%Cor e Forma:SolidPeso molecular:309.34YO-01027
CAS:<p>YO-01027 (DBZ) is a potent γ-secretase inhibitor.</p>Fórmula:C26H23F2N3O3Pureza:97.21% - 99.58%Cor e Forma:SolidPeso molecular:463.48GNF4877
CAS:<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Fórmula:C25H27FN6O4Pureza:98.68% - 99.40%Cor e Forma:SolidPeso molecular:494.52WHI-P97
CAS:<p>WHI-P97 is a rationally designed potent inhibitor of JAK-3.</p>Fórmula:C16H13Br2N3O3Pureza:99.93%Cor e Forma:SolidPeso molecular:455.1Belumosudil
CAS:<p>Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).</p>Fórmula:C26H24N6O2Pureza:97.64% - 98.59%Cor e Forma:SolidPeso molecular:452.51SR-3677
CAS:<p>SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).</p>Fórmula:C22H24N4O4Pureza:98.46%Cor e Forma:SolidPeso molecular:408.45(E/Z)-GSK-3β inhibitor 1
CAS:<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Fórmula:C14H10N2OPureza:98.60%Cor e Forma:SolidPeso molecular:222.24Netarsudil mesylate
CAS:<p>Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.</p>Fórmula:C30H35N3O9S2Pureza:99.7%Cor e Forma:SolidPeso molecular:645.74TED-347
CAS:<p>TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.</p>Fórmula:C15H11ClF3NOPureza:99.9%Cor e Forma:SolidPeso molecular:313.7SD-208
CAS:<p>SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.</p>Fórmula:C17H10ClFN6Pureza:98.72% - 99.65%Cor e Forma:SolidPeso molecular:352.75IWR-1
CAS:<p>IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).</p>Fórmula:C25H19N3O3Pureza:99.19% - 99.82%Cor e Forma:SolidPeso molecular:409.44Fz7-21
CAS:<p>Fz7-21, a peptide antagonist of FZD7, inhibits Wnt/β-catenin signaling (IC50=50-100nM) in cells with WNT3A.</p>Fórmula:C83H114N18O23S2Pureza:99.8%Cor e Forma:SolidPeso molecular:1796.03BD750
CAS:<p>BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in</p>Fórmula:C14H13N3OSPureza:99.02%Cor e Forma:SolidPeso molecular:271.34RO495
CAS:<p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>Fórmula:C17H14Cl2N6OPureza:97.94%Cor e Forma:SolidPeso molecular:389.24Wnt pathway activator 1
CAS:<p>Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.</p>Fórmula:C18H16O4Pureza:99.93%Cor e Forma:SolidPeso molecular:296.32PF-4800567
CAS:<p>PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.</p>Fórmula:C17H18ClN5O2Pureza:99.76%Cor e Forma:SolidPeso molecular:359.81IWP L6
CAS:<p>IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).</p>Fórmula:C25H20N4O2S2Pureza:99.51% - >99.99%Cor e Forma:SolidPeso molecular:472.58FH535
CAS:<p>FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.</p>Fórmula:C13H10Cl2N2O4SPureza:98.25% - 99.5%Cor e Forma:SolidPeso molecular:361.2Pacritinib hydrochloride
CAS:<p>Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.</p>Fórmula:C28H32N4O3·xClHCor e Forma:Solid2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:<p>2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.</p>Fórmula:C16H13Cl2N3O2Pureza:98.77%Cor e Forma:SolidPeso molecular:350.2Ruxolitinib
CAS:<p>Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.</p>Fórmula:C17H18N6Pureza:99.4% - >99.99%Cor e Forma:SolidPeso molecular:306.36Stafia-1
CAS:<p>Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.</p>Fórmula:C24H27O10PPureza:98.08%Cor e Forma:SolidPeso molecular:506.44(E)-SIS3
CAS:<p>(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!</p>Fórmula:C28H27N3O3·HClPureza:95.64% - 98%Cor e Forma:SolidPeso molecular:489.99MSAB
CAS:<p>MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.</p>Fórmula:C15H15NO4SPureza:99.76%Cor e Forma:SolidPeso molecular:305.35Ritlecitinib tosylate
CAS:<p>Ritlecitinib (PF-06651600) is a potent, selective JAK3 inhibitor with proven in vivo efficacy, low clearance, and has undergone clinical trials.</p>Fórmula:C22H27N5O4SCor e Forma:SolidPeso molecular:457.549WAY-262611
CAS:<p>WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.</p>Fórmula:C20H22N4Pureza:98.09% - 99.09%Cor e Forma:SolidPeso molecular:318.42Cardiogenol C
CAS:<p>Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.</p>Fórmula:C13H16N4O2Pureza:98.46%Cor e Forma:SolidPeso molecular:260.29PF-04802367
CAS:<p>PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.</p>Fórmula:C16H16ClN5O3Pureza:98.76%Cor e Forma:SolidPeso molecular:361.78Y-27632 dihydrochloride
CAS:<p>View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.</p>Fórmula:C14H21N3O·2HClPureza:97.96% - 99.98%Cor e Forma:SolidPeso molecular:320.26S3I-201
CAS:<p>S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.</p>Fórmula:C16H15NO7SPureza:97.83%Cor e Forma:SolidPeso molecular:365.36
