Gama-secretase
Os inibidores da gama-secretase são compostos que têm como alvo o complexo enzimático gama-secretase, que está envolvido na clivagem da proteína precursora do amiloide (APP) para produzir peptídeos beta-amiloides. Esses peptídeos podem se agregar para formar placas amiloides, uma característica da doença de Alzheimer. Ao inibir a gama-secretase, esses compostos visam reduzir a produção de beta-amiloide e sua acumulação no cérebro, sendo, portanto, um foco importante na pesquisa sobre a doença de Alzheimer. Na CymitQuimica, oferecemos inibidores da gama-secretase para apoiar sua pesquisa em biologia amiloide, terapia do Alzheimer e doenças neurodegenerativas.
Foram encontrados 59 produtos de "Gama-secretase"
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Rovalpituzumab
CAS:<p>Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.</p>Pureza:> 95%Cor e Forma:LiquidPeso molecular:145.02 kDaDemcizumab
CAS:<p>Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.</p>Pureza:> 95%Cor e Forma:LiquidPeso molecular:145.34 kDaBrontictuzumab
CAS:<p>Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.</p>Pureza:98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Cor e Forma:LiquidCB-103
CAS:<p>CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.</p>Fórmula:C15H18N2OPureza:99.44%Cor e Forma:SolidPeso molecular:242.32γ-Secretase modulator 10
CAS:<p>γ-Secretase modulator 10 is a novel γ-secretase modulator.</p>Fórmula:C25H23F3N4O2Cor e Forma:SolidPeso molecular:468.48PSEN1-IN-1
<p>PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50</p>Fórmula:C20H19ClF3NO3SCor e Forma:SolidPeso molecular:445.88PSEN1-IN-2
<p>PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.</p>Fórmula:C20H18ClFN2O3SCor e Forma:SolidPeso molecular:420.88SAHM1
CAS:<p>Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.</p>Fórmula:C94H162N36O23SPureza:98%Cor e Forma:SolidPeso molecular:2196.58RBPJ Inhibitor-1
CAS:<p>RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell</p>Fórmula:C17H14FN3O2Pureza:99.58%Cor e Forma:SoildPeso molecular:311.31Notch 1 TFA
<p>Notch 1 TFA encodes a member of the NOTCH family of proteins.</p>Fórmula:C64H98N15F3O25S3Pureza:98%Cor e Forma:SolidPeso molecular:1614.815β-Cholanic acid
CAS:<p>5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.</p>Fórmula:C24H40O2Pureza:98.91% - 99.89%Cor e Forma:SoildPeso molecular:360.57CIA-1 (Free base)
CAS:<p>CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.</p>Fórmula:C17H19N3O2SPureza:99%Cor e Forma:SolidPeso molecular:329.42FRM-024
CAS:<p>FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment of</p>Fórmula:C22H22ClN5O2Cor e Forma:SolidPeso molecular:423.9Navicixizumab
CAS:<p>Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.</p>Cor e Forma:LiquidSPL-707
CAS:<p>SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).</p>Fórmula:C27H28FN5O4Pureza:98%Cor e Forma:SolidPeso molecular:505.54BMS-906024
CAS:<p>BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.</p>Fórmula:C26H26F6N4O3Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:556.5Enoticumab
CAS:<p>Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.</p>Pureza:98.2% (SDS-PAGE); 98.9% (SEC-HPLC) - 98.2% (SDS-PAGE); 98.9% (SEC-HPLC)Cor e Forma:LiquidLegumain inhibitor 1
CAS:<p>Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.</p>Fórmula:C23H25N5O4SPureza:98.14%Cor e Forma:SolidPeso molecular:467.54γ-secretase modulator 3
CAS:<p>Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.</p>Fórmula:C24H23FN4OSPureza:98%Cor e Forma:SolidPeso molecular:434.53γ-secretase modulator 1 hydrochloride
CAS:<p>gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].</p>Fórmula:C24H25ClN4OSPureza:98%Cor e Forma:SolidPeso molecular:453
