Receptor TAM
Os inibidores dos receptores TAM têm como alvo a família de receptores tirosina quinase TAM, que inclui Tyro3, Axl e Mer. Estes receptores estão envolvidos na regulação das respostas imunológicas, na sobrevivência celular e na eliminação de células apoptóticas. A desregulação dos receptores TAM está implicada no câncer, em doenças autoimunes e na inflamação crônica. Na CymitQuimica, oferecemos inibidores dos receptores TAM para apoiar sua pesquisa em imunologia, oncologia e inflamação.
Foram encontrados 34 produtos de "Receptor TAM"
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Tilvestamab
CAS:Tilvestamab (BGB149) is a humanized monoclonal antibody targeting AXL with anti-tumor and anti-fibrotic activities, inhibiting Gas6-induced AXL activation.Pureza:>95%Cor e Forma:LiquidTAM-IN-2
CAS:TAM-IN-2 is an inhibitor of TAM.Fórmula:C31H27F2N7O3Pureza:98.09% - 99.74%Cor e Forma:SolidPeso molecular:583.59UNC 569 hydrochloride
UNC 569 hydrochloride: reversible ATP-competitive Mer inhibitor, IC50 2.9 nM, Ki 4.3 nM, also inhibits Axl/Tyro3; used in leukemia, teratoid tumor studies.Fórmula:C22H30ClFN6Pureza:99.93%Cor e Forma:SolidPeso molecular:432.96SGI-7079
CAS:SGI-7079: selective Axl inhibitor; hinders tumor growth dose-dependently; may target EGFR inhibitor resistance.
Fórmula:C26H26FN7Pureza:95.51% - 99.26%Cor e Forma:SolidPeso molecular:455.53LDC1267
CAS:LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).Fórmula:C30H26F2N4O5Pureza:99.38% - 99.88%Cor e Forma:SolidPeso molecular:560.55Ref: TM-T2311
1mg34,00€2mg49,00€5mg73,00€10mg100,00€25mg165,00€50mg235,00€100mg396,00€1mL*10mM (DMSO)88,00€UNC2541
CAS:UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.Fórmula:C24H34FN7O2Pureza:98.33%Cor e Forma:SolidPeso molecular:471.572-D08
CAS:2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.Fórmula:C15H10O5Pureza:98.58% - 98.95%Cor e Forma:SolidPeso molecular:270.24Ref: TM-T7379
2mg39,00€5mg54,00€10mg93,00€25mg170,00€50mg268,00€100mg447,00€200mg650,00€1mL*10mM (DMSO)59,00€Bemcentinib
CAS:Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.Fórmula:C30H34N8Pureza:97% - 99.8%Cor e Forma:SolidPeso molecular:506.64Ref: TM-T6269
1mg40,00€2mg52,00€5mg87,00€10mg144,00€25mg212,00€50mg274,00€100mg465,00€200mg622,00€500mg948,00€1mL*10mM (DMSO)92,00€RU-301
CAS:RU-301 is a novel pan-tam inhibitorFórmula:C21H19F3N4O4SPureza:98.87%Cor e Forma:SolidPeso molecular:480.46Ref: TM-T7425
1mg98,00€5mg222,00€10mg344,00€25mg587,00€50mg803,00€100mg1.063,00€1mL*10mM (DMSO)241,00€UNC569
CAS:UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.Fórmula:C22H29FN6Pureza:98.91% - 99.67%Cor e Forma:SolidPeso molecular:396.5BMS 777607
CAS:BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3. BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.Fórmula:C25H19ClF2N4O4Pureza:98.89% - >99.99%Cor e Forma:SolidPeso molecular:512.89Ref: TM-T2699
1mg35,00€5mg79,00€10mg124,00€25mg217,00€50mg359,00€100mg533,00€500mg1.169,00€1mL*10mM (DMSO)92,00€NPS-1034
CAS:NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.Fórmula:C31H23F2N5O3Pureza:98.48%Cor e Forma:SolidPeso molecular:551.54Ref: TM-T6907
1mg34,00€2mg46,00€5mg66,00€10mg92,00€25mg167,00€50mg245,00€100mg356,00€200mg530,00€1mL*10mM (DMSO)82,00€Gilteritinib
CAS:Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM,Fórmula:C29H44N8O3Pureza:97.75% - 99.90%Cor e Forma:SolidPeso molecular:552.71Ref: TM-T4409
1g1.288,00€1mg38,00€2mg52,00€5mg85,00€10mg114,00€25mg177,00€50mg261,00€100mg411,00€500mg954,00€UNC2881
CAS:UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.Fórmula:C25H33N7O2Pureza:98.97% - 99.85%Cor e Forma:SolidPeso molecular:463.58CEP-40783
CAS:CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).
Fórmula:C31H26F2N4O6Pureza:99.76% - 99.84%Cor e Forma:SolidPeso molecular:588.56Ningetinib Tosylate
CAS:Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Fórmula:C38H37FN4O8SPureza:99.93%Cor e Forma:SolidPeso molecular:728.79DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Fórmula:C41H42FN5O7Pureza:99.75%Cor e Forma:SolidPeso molecular:735.8Dubermatinib
CAS:Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.Fórmula:C24H30ClN7O2SPureza:98.65% - 99.58%Cor e Forma:SolidPeso molecular:516.06Ningetinib
CAS:Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Fórmula:C31H29FN4O5Pureza:99.95% - 99.98%Cor e Forma:SolidPeso molecular:556.58ONO-7475
CAS:ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinaseFórmula:C32H26N4O6Pureza:98.74%Cor e Forma:SolidPeso molecular:562.57
