Receptor TAM
Os inibidores dos receptores TAM têm como alvo a família de receptores tirosina quinase TAM, que inclui Tyro3, Axl e Mer. Estes receptores estão envolvidos na regulação das respostas imunológicas, na sobrevivência celular e na eliminação de células apoptóticas. A desregulação dos receptores TAM está implicada no câncer, em doenças autoimunes e na inflamação crônica. Na CymitQuimica, oferecemos inibidores dos receptores TAM para apoiar sua pesquisa em imunologia, oncologia e inflamação.
Foram encontrados 32 produtos de "Receptor TAM"
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TAM-IN-2
CAS:<p>TAM-IN-2 is an inhibitor of TAM.</p>Fórmula:C31H27F2N7O3Pureza:98.09% - 99.74%Cor e Forma:SolidPeso molecular:583.59Tilvestamab
CAS:<p>Tilvestamab (BGB149) is a humanized monoclonal antibody targeting AXL with anti-tumor and anti-fibrotic activities, inhibiting Gas6-induced AXL activation.</p>Pureza:>95%Cor e Forma:LiquidEnapotamab vedotin
CAS:<p>Enapotamab vedotin (anti-AXL ADC) targets AXL with MMAE payload, showing potential against AXL-expressing, EGFR-resistant NSCLC.</p>Pureza:95%Cor e Forma:LiquidMecbotamab vedotin
CAS:<p>Mecbotamab vedotin (BA301) is an inhibitory IgG1 antibody that targets human tyrosine kinase receptor AXL and the humanized murine monoclonal BA301 γ1 chain. It can be utilized in the preparation of immunoconjugates for research into cancers expressing the Axl type.</p>Cor e Forma:LiquidUNC 569 hydrochloride
<p>UNC 569 hydrochloride: reversible ATP-competitive Mer inhibitor, IC50 2.9 nM, Ki 4.3 nM, also inhibits Axl/Tyro3; used in leukemia, teratoid tumor studies.</p>Fórmula:C22H30ClFN6Pureza:99.93%Cor e Forma:SolidPeso molecular:432.96UNC2541
CAS:<p>UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.</p>Fórmula:C24H34FN7O2Pureza:98.33%Cor e Forma:SolidPeso molecular:471.572-D08
CAS:<p>2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.</p>Fórmula:C15H10O5Pureza:98.58% - 98.95%Cor e Forma:SolidPeso molecular:270.24Bemcentinib
CAS:<p>Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.</p>Fórmula:C30H34N8Pureza:97% - 99.8%Cor e Forma:SolidPeso molecular:506.64RU-301
CAS:<p>RU-301 is a novel pan-tam inhibitor</p>Fórmula:C21H19F3N4O4SPureza:98.87%Cor e Forma:SolidPeso molecular:480.46UNC569
CAS:<p>UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.</p>Fórmula:C22H29FN6Pureza:98.91% - 99.67%Cor e Forma:SolidPeso molecular:396.5BMS 777607
CAS:<p>BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3. BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.</p>Fórmula:C25H19ClF2N4O4Pureza:98.30% - >99.99%Cor e Forma:SolidPeso molecular:512.89CEP-40783
CAS:<p>CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).</p>Fórmula:C31H26F2N4O6Pureza:99.76% - 99.84%Cor e Forma:SolidPeso molecular:588.56Ningetinib Tosylate
CAS:<p>Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.</p>Fórmula:C38H37FN4O8SPureza:99.93%Cor e Forma:SolidPeso molecular:728.79NPS-1034
CAS:<p>NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.</p>Fórmula:C31H23F2N5O3Pureza:98.48%Cor e Forma:SolidPeso molecular:551.54Gilteritinib
CAS:<p>Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM,</p>Fórmula:C29H44N8O3Pureza:97.75% - 99.90%Cor e Forma:SolidPeso molecular:552.71UNC2881
CAS:<p>UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.</p>Fórmula:C25H33N7O2Pureza:98.97% - 99.85%Cor e Forma:SolidPeso molecular:463.58SGI-7079
CAS:<p>SGI-7079: selective Axl inhibitor; hinders tumor growth dose-dependently; may target EGFR inhibitor resistance.</p>Fórmula:C26H26FN7Pureza:95.51% - 99.26%Cor e Forma:SolidPeso molecular:455.53LDC1267
CAS:<p>LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).</p>Fórmula:C30H26F2N4O5Pureza:99.38% - 99.88%Cor e Forma:SolidPeso molecular:560.55Ningetinib
CAS:<p>Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.</p>Fórmula:C31H29FN4O5Pureza:99.95% - 99.98%Cor e Forma:SolidPeso molecular:556.58ONO-7475
CAS:<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>Fórmula:C32H26N4O6Pureza:98.74%Cor e Forma:SolidPeso molecular:562.57
