Ubiquitinação
Os inibidores de ubiquitinação são compostos que interferem no processo de ubiquitinação, onde as proteínas são marcadas com moléculas de ubiquitina para degradação pelo proteassoma. Esses inibidores são críticos para o estudo da renovação de proteínas, transdução de sinais e regulação de vários processos celulares. A ubiquitinação desempenha um papel fundamental em muitas doenças, incluindo câncer, distúrbios neurodegenerativos e disfunções do sistema imunológico. Ao modular a ubiquitinação, esses inibidores podem fornecer insights sobre os mecanismos das doenças e abrir novas vias para intervenções terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de ubiquitinação de alta qualidade para apoiar sua pesquisa em biologia celular, proteômica e descoberta de medicamentos.
Subcategorias de "Ubiquitinação"
Foram encontrados 107 produtos de "Ubiquitinação"
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C527
CAS:<p>C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).</p>Fórmula:C17H8FNO3Pureza:97.22%Cor e Forma:SolidPeso molecular:293.25MF-094
CAS:<p>MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.</p>Fórmula:C30H37N3O4SPureza:99.93%Cor e Forma:SolidPeso molecular:535.7TAS4464 hydrochloride
CAS:<p>TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).</p>Fórmula:C21H24ClFN6O6SPureza:98.61% - 98.96%Cor e Forma:SolidPeso molecular:542.97NSC232003
CAS:<p>NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.</p>Fórmula:C6H7N3O3Pureza:97.72%Cor e Forma:SolidPeso molecular:169.14ML-792
CAS:<p>ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.</p>Fórmula:C21H23BrN6O5SPureza:99.32% - 99.82%Cor e Forma:SolidPeso molecular:551.41WS-383
CAS:<p>WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).</p>Fórmula:C18H21Cl2N9S2Pureza:98.46%Cor e Forma:SolidPeso molecular:498.46HBX 19818
CAS:<p>HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).</p>Fórmula:C25H28ClN3OPureza:97.71%Cor e Forma:SolidPeso molecular:421.96IU1-47
CAS:<p>IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。</p>Fórmula:C19H23ClN2OPureza:98.94%Cor e Forma:SolidPeso molecular:330.85USP8-IN-3
CAS:<p>USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.</p>Fórmula:C18H18F3N5O2SPureza:99.79%Cor e Forma:SolidPeso molecular:425.43E3 ligase Ligand 36
CAS:<p>E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM/BRG1 degrader-1.</p>Fórmula:C25H30N4O5SCor e Forma:SolidPeso molecular:498.6USP8-IN-2
CAS:<p>USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.</p>Fórmula:C19H20ClF3N4OSPureza:99.92%Cor e Forma:SolidPeso molecular:444.9E3 ligase Ligand 41
CAS:<p>E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.</p>Fórmula:C13H12ClF3N2O4Cor e Forma:SolidPeso molecular:352.69dCeMM3
CAS:<p>dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.</p>Fórmula:C14H11ClN4OSPureza:98.48% - 99.41%Cor e Forma:SolidPeso molecular:318.78NSC819701
<p>NSC819701 is a triazole-based inhibitor of p97ATPase. It inhibits the activity of p97ATPase by binding to specific sites on p97.</p>Fórmula:C30H32F2N8O3SCor e Forma:SolidPeso molecular:622.69Post-Translational Modification Compound Library
<p>Contains xnum active small molecules for research related to post-translational modifications (PTMs);</p>Cor e Forma:Odour SolidSkp2 inhibitor 3
<p>Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.</p>Cor e Forma:Odour SolidBIO-2007817
<p>BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. This compound enhances the activity of wild-type Parkin, stimulates Parkin's autoubiquitination, and induces the appearance of mono-ubiquitinated forms of Miro1 (a Parkin substrate) with an EC50 of 0.17 μM.</p>Fórmula:C32H36N6O3Cor e Forma:SolidPeso molecular:552.67Ubiquitination Compound Library
<p>A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；</p>Cor e Forma:Odour SolidOTUB1/USP8-IN-1 HCl
<p>OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemia</p>Fórmula:C22H17Cl2FN2O4Pureza:99.92%Cor e Forma:SolidPeso molecular:463.29OTUB2-IN-1
<p>OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).</p>Fórmula:C19H18N2O6S2Pureza:98.19%Cor e Forma:SolidPeso molecular:434.49
