Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1506 produtos de "Autofagia"
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ATG7-IN-1
CAS:ATG7-IN-1 is a selective ATG7 inhibitor with an IC50 of 62 nM.Fórmula:C17H19FN6O5S2Pureza:99.85% - >99.99%Cor e Forma:SolidPeso molecular:470.5Maprotiline hydrochloride
CAS:Maprotiline hydrochloride (Psymion) is a tetracyclic antidepressant akin to tricyclics with similar side effects.Fórmula:C20H24ClNPureza:99.68% - 99.84%Cor e Forma:White PowderPeso molecular:313.86Fluvastatin sodium
CAS:Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterolFórmula:C24H25FNNaO4Pureza:98.54% - 99.56%Cor e Forma:Light Yellow Solid PowderPeso molecular:433.45NBDHEX
CAS:NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).Fórmula:C12H15N3O4SPureza:97.38%Cor e Forma:SolidPeso molecular:297.33Quinacrine dihydrochloride
CAS:Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplasticFórmula:C23H30CLN3O·2HClPureza:98.24% - 99.80%Cor e Forma:Yellow Crystals Or PowderPeso molecular:472.88Silmitasertib sodium salt
CAS:Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).Fórmula:C19H11ClN3NaO2Pureza:99.49% - 99.62%Cor e Forma:SolidPeso molecular:371.75BIX 02565
CAS:BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).Fórmula:C26H30N6O2Pureza:97.44% - 99.7%Cor e Forma:SolidPeso molecular:458.56Ref: TM-T5428
25mgA consultar50mgA consultar1mg52,00€2mg74,00€5mg112,00€1mL*10mM (DMSO)138,00€10mg167,00€Ciclopirox
CAS:Ciclopirox is an antifungal that chelates Fe3+ and Al3+, inhibiting enzymes and has antibacterial and anti-inflammatory effects.Fórmula:C12H17NO2Pureza:97.72% - 99.78%Cor e Forma:SolidPeso molecular:207.27Carboplatin
CAS:Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor.
Fórmula:C6H12N2O4PtPureza:98% - 99.72%Cor e Forma:White Crystalline PowderPeso molecular:371.25Irinotecan Hydrochloride
CAS:Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.Fórmula:C33H39ClN4O6Pureza:98% - 99.94%Cor e Forma:Yellow Crystalline PowderPeso molecular:623.14Ref: TM-T0486L
10mg34,00€25mg49,00€50mg65,00€1mL*10mM (DMSO)71,00€100mg89,00€200mg129,00€500mg254,00€Dihydroartemisinin
CAS:Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!Fórmula:C15H24O5Pureza:98% - 99.41%Cor e Forma:White SolidPeso molecular:284.35Imiquimod
CAS:Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.Fórmula:C14H16N4Pureza:99.62% - >99.99%Cor e Forma:White To Off White Crystalline PowderPeso molecular:240.30Lycorine hydrochloride
CAS:Lycorine hydrochloride (Narcissine hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.Fórmula:C16H18ClNO4Pureza:99.45% - 99.49%Cor e Forma:Fine Crystal PowderPeso molecular:323.77Tioconazole
CAS:Tioconazole (Vagistat) is a synthetic imidazole derivative, inhibits cell wall synthesis by inhibiting the biosynthesis of ergosterol or other sterols.Fórmula:C16H13Cl3N2OSPureza:99.57%Cor e Forma:SolidPeso molecular:387.71Lapatinib ditosylate monohydrate
CAS:Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.
Fórmula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPureza:98% - 99.41%Cor e Forma:Colourless To Light-Yellow CrystalPeso molecular:943.47Matrine
CAS:Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.Fórmula:C15H24N2OPureza:99.77% - >99.99%Cor e Forma:SolidPeso molecular:248.36Paclitaxel
CAS:Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer.
Fórmula:C47H51NO14Pureza:98% - 99.92%Cor e Forma:White PowderPeso molecular:853.91Memantine hydrochloride
CAS:Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects.Fórmula:C12H22ClNPureza:99.56% - 99.96%Cor e Forma:Crystalline SolidPeso molecular:215.76Xylitol
CAS:Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group.Fórmula:C5H12O5Pureza:99.89% - 99.96%Cor e Forma:White Solid PowderPeso molecular:152.15Fendiline hydrochloride
CAS:Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel.Fórmula:C23H26ClNPureza:98.76% - 99.75%Cor e Forma:SolidPeso molecular:351.91Pravastatin sodium
CAS:Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.Fórmula:C23H35NaO7Pureza:97.14% - 99.97%Cor e Forma:White Crystalline PowderPeso molecular:446.52Vitamin B3-d4
CAS:Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is a deuterated substitute for Niacin and can be used to track Niacin metabolism in vivo.
Fórmula:C6HD4NO2Pureza:99.86%Cor e Forma:SolidPeso molecular:127.13Raloxifene hydrochloride
CAS:Raloxifene HCl treats postmenopausal osteoporosis, acts as estrogen on bone/cholesterol, and blocks it in breast/uterus.Fórmula:C28H28ClNO4SPureza:98% - 99.97%Cor e Forma:Light Yellow SolidPeso molecular:510.044Berberine chloride
CAS:Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae, and used orally for various fungal and parasitic infections.Fórmula:C20H18ClNO4Pureza:99.47% - 99.93%Cor e Forma:Yellow Crystalline PowderPeso molecular:371.80Linagliptin
CAS:Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.Fórmula:C25H28N8O2Pureza:99.15% - >99.99%Cor e Forma:SolidPeso molecular:472.54Naringin
CAS:Naringin: flavanone glycoside with blood lipid-reducing, antioxidant, anticancer properties, inhibits cytochrome P450.Fórmula:C27H32O14Pureza:99.23%Cor e Forma:Beige Creamish Powder Solid Solid Particulate/PowderPeso molecular:580.53Pepstatin
CAS:Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Fórmula:C34H63N5O9Pureza:96.74% - 99.94%Cor e Forma:SolidPeso molecular:685.89Olanzapine
CAS:Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.Fórmula:C17H20N4SPureza:99.86% - ≥95%Cor e Forma:Yellowish Crystalline PowderPeso molecular:312.43Deferoxamine Mesylate
CAS:Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Fórmula:C26H52N6O11SPureza:94.68% - 99.8%Cor e Forma:SolidPeso molecular:656.79Erythromycin ethylsuccinate
CAS:Erythromycin ethylsuccinate (EES) is a macrolide antibiotic, produced by Streptomyces erythreus.Fórmula:C43H75NO16Pureza:77% - 98%Cor e Forma:White Or Slightly Yellow Crystalline Powder White To Yellowish Crystalline SolidPeso molecular:862.05Nitroxoline
CAS:Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found inFórmula:C9H6N2O3Pureza:97.74% - 99.09%Cor e Forma:SolidPeso molecular:190.16Lovastatin
CAS:Lovastatin (MK-803) is an HMG-CoA reductase inhibitor. Lovastatin lowers cholesterol and is used as a lipid-lowering agent. Cost-effective and quality-assured.Fórmula:C24H36O5Pureza:99.66% - 99.92%Cor e Forma:The Substance Is A White-Yellowish To Yellow Powder Solid PowderPeso molecular:404.54Erlotinib
CAS:Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Fórmula:C22H23N3O4Pureza:98.19% - 99.98%Cor e Forma:White To Off-White PowderPeso molecular:393.44Stavudine
CAS:Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.Fórmula:C10H12N2O4Pureza:99.01% - 99.88%Cor e Forma:White PowderPeso molecular:224.21Piperine
CAS:Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.
Fórmula:C17H19NO3Pureza:98.41% - 98.51%Cor e Forma:SolidPeso molecular:285.34Rhein
CAS:Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.Fórmula:C15H8O6Pureza:99.04% - 99.72%Cor e Forma:Physical Description Yellow Needles (From Methanol) Or Yellow-Brown Powder (Ntp 1992)Peso molecular:284.22Glucosamine hydrochloride
CAS:Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.Fórmula:C6H13NO5·HClPureza:99.77%Cor e Forma:White Solid CrystallinePeso molecular:215.63KAN0438757
CAS:KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.
Fórmula:C21H18FNO7SPureza:99.34%Cor e Forma:SolidPeso molecular:447.43Sodium salicylate
CAS:Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.Fórmula:C7H5NaO3Pureza:99.36% - 99.92%Cor e Forma:White Solid AmorphousPeso molecular:160.11Ancitabine hydrochloride
CAS:Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity.Fórmula:C9H12ClN3O4Pureza:99.02% - 99.37%Cor e Forma:White SolidPeso molecular:261.66Irinotecan hydrochloride trihydrate
CAS:Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.Fórmula:C33H45ClN4O9Pureza:98.22% - >99.99%Cor e Forma:Pale Yellow To Yellow Crystalline PowderPeso molecular:677.18Pemetrexed
CAS:Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).Fórmula:C20H21N5O6Pureza:98.1% - 99.92%Cor e Forma:Similar To White PowderPeso molecular:427.41Oxidopamine hydrochloride
CAS:Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.Fórmula:C8H12ClNO3Pureza:98.34% - 99.85%Cor e Forma:Physical Description Beige Solid (Ntp 1992)Peso molecular:205.64Isoliquiritigenin
CAS:Isoliquiritigenin (ISL) is a natural flavonoid that inhibits influenza virus and aldose reductase. Isoliquiritigenin has antitumor effect. Cost-effective and quality-assured.Fórmula:C15H12O4Pureza:97.61% - 99.44%Cor e Forma:PowderPeso molecular:256.25Ursolic acid
CAS:Ursolic acid (Prunol) is a natural pentacyclic triterpene carboxylic acid. Ursolic acid has anti-tumor and anti-inflammatory effects. Cost-effective and quality-assured.Fórmula:C30H48O3Pureza:99.7% - 99.81%Cor e Forma:Platelets From Alcohol SolidPeso molecular:456.70Carvedilol phosphate hemihydrate
CAS:Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent.Fórmula:C24H26N2O4·5H2O·H3O4PPureza:99.24% - 99.98%Cor e Forma:SolidPeso molecular:513.49Danshensu sodium salt
CAS:Danshensu sodium salt (Sodium Danshensu) is sodium salt of danshensu from the widely used Chinese herb Danshen.Fórmula:C9H9NaO5Pureza:99.52% - 99.94%Cor e Forma:SolidPeso molecular:220.16Bosutinib
CAS:Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.Fórmula:C26H29Cl2N5O3Pureza:98.98% - 99.9%Cor e Forma:Yellowish-Orange Or Pink To Brownish Solid Solid PowderPeso molecular:530.45Baicalin
CAS:Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFórmula:C21H18O11Pureza:90.08% - 99.32%Cor e Forma:Yellow PowderPeso molecular:446.36Ref: TM-T2775
50mg34,00€100mg49,00€200mg49,00€1mL*10mM (DMSO)50,00€500mg55,00€1g80,00€2g102,00€5g152,00€Monacolin J
CAS:Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.Fórmula:C19H28O4Pureza:98.06%Cor e Forma:SolidPeso molecular:320.42Ref: TM-T12092
1mg74,00€5mg152,00€1mL*10mM (DMSO)161,00€10mg222,00€25mg376,00€50mg537,00€100mg777,00€Honokiol
CAS:Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.Fórmula:C18H18O2Pureza:99.65% - 99.94%Cor e Forma:Dark Brown To White Fine Powder With Pleasant Odor Spicy And Slightly Bitter TastePeso molecular:266.33Elexacaftor
CAS:Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.Fórmula:C26H34F3N7O4SPureza:98.87% - 99.87%Cor e Forma:SolidPeso molecular:597.65Ref: TM-T14935
1mg93,00€2mg130,00€5mg230,00€1mL*10mM (DMSO)304,00€10mg371,00€25mg730,00€50mg1.018,00€100mg1.369,00€Ezetimibe
CAS:Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.Fórmula:C24H21F2NO3Pureza:97.28% - 99.77%Cor e Forma:SolidPeso molecular:409.43Ref: TM-T1593
10mg46,00€1mL*10mM (DMSO)52,00€25mg58,00€50mg73,00€100mg93,00€200mg118,00€500mg187,00€1g268,00€Dilmapimod
CAS:Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.Fórmula:C23H19F3N4O3Pureza:97.53%Cor e Forma:SolidPeso molecular:456.42Salicylic acid
CAS:Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.Fórmula:C7H6O3Pureza:98.04% - 98.83%Cor e Forma:White Solid PowderPeso molecular:138.12Dexamethasone
CAS:Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.Fórmula:C22H29FO5Pureza:98% - 99.91%Cor e Forma:Crystals From Ether (Ntp 1992)Peso molecular:392.46Dexamethasone acetate
CAS:Dexamethasone acetate (NSC 39471) is a potent anti-inflammatory steroid, blocks NF-kB, and lacks salt-retention.Fórmula:C24H31FO6Pureza:99.22% - 99.65%Cor e Forma:White Or Almost White Crystalline PowderPeso molecular:434.50Taurine
CAS:Taurine (2-Aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues and is one of the constituents of bile acids. Cost-effective and quality-assured.Fórmula:C2H7NO3SPureza:99.81% - 99.87%Cor e Forma:White Crystalline PowderPeso molecular:125.15Phenformin hydrochloride
CAS:Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.Fórmula:C10H16ClN5Pureza:97.11% - 99.80%Cor e Forma:Lactic AcidosisPeso molecular:241.72Felodipine
CAS:Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.Fórmula:C18H19Cl2NO4Pureza:99.91%Cor e Forma:SolidPeso molecular:384.25Ref: TM-T0145
2mg34,00€5mg50,00€1mL*10mM (DMSO)54,00€10mg67,00€25mg96,00€50mg123,00€100mg168,00€500mg409,00€Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Fórmula:C17H17ClF6N2OPureza:99% - 99.99%Cor e Forma:Off-White To Yellow SolidPeso molecular:414.77Sulfanilamide
CAS:Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.Fórmula:C6H8N2O2SPureza:97.4% - 99.76%Cor e Forma:White To Yellowish Crystalline PowderPeso molecular:172.20Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Fórmula:C23H34O5Pureza:99.12%Cor e Forma:White-Yellowish To Yellow Powder Solid PowderPeso molecular:390.51Autophagy/REV-ERB-IN-1 hydrochloride
Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual inhibitor of autophagy and REV-ERB with anticancer properties. It enhances the efficacy of autophagy blockade and increases cytotoxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) is applicable in melanoma research.Fórmula:C24H32Cl2F2N2Peso molecular:456.19106(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc
(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. This compound serves as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.Fórmula:C31H41N5O6Peso molecular:579.30568RCP168
RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.Fórmula:C365H585N105O95S5Peso molecular:8119.27766Autophagy/REV-ERB-IN-1
Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.Fórmula:C24H30F2N2Peso molecular:384.23771(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate combining an E3 ligase ligand with a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. This compound functions as a Cereblon ligand, recruiting the CRBN protein and serving as a crucial intermediate in the synthesis of complete PROTAC molecules.Fórmula:C29H36N8O6Peso molecular:592.27578(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.
Fórmula:C30H39N5O6Peso molecular:565.29003CXCL8 (54-72)
CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.Fórmula:C107H173N33O30Peso molecular:2400.30261(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is an E3 ligase ligand-linker conjugate (E3LigaseLigand-Linker Conjugates) composed of thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of CRBN protein, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.Fórmula:C33H42N8O7Peso molecular:662.31765(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), consisting of Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit the CRBN protein and serves as a crucial intermediate for synthesizing complete PROTAC molecules.Fórmula:C27H32N8O5Peso molecular:548.24957Antitumor agent-133
Antitumor agent-133 (compound 4d) is a bis-santine derivative that demonstrates activity against Huh1 (IC50 = 17.13 μM) and Huh7 (IC50 = 8.27 μM). It induces autophagy and inhibits tumor growth by modulating the levels of the LC3BII, ATG5, and p62 proteins.Fórmula:C27H24Br2N4O8Peso molecular:689.99609Autophagy Compound Library
A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) andCor e Forma:Odour SolidRef: TM-L3200
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarCCR7 antagonist 1
CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.Fórmula:C13H22N6OSPeso molecular:310.15758CXCR4-IN-3
CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).
PDEδ autophagic degrader 1
PDEδ autophagic degrader 1 (compound 12c) is an autophagosome-tethering compound (ATTEC) and a potent autophagic degrader of PDEδ. This compound effectively reduces PDEδ protein levels through lysosome-mediated autophagy without affecting PDEδ mRNA expression. Additionally, PDEδ autophagic degrader 1 inhibits the growth of KRAS mutant pancreatic cancer cells.Fórmula:C41H42Br2IN7O5Peso molecular:997.06589Deoxy-thalidomide-Pip-C-PIP-boc
CAS:Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.Fórmula:C28H39N5O5Cor e Forma:SolidPeso molecular:525.64Polyphyllin G
CAS:Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.Fórmula:C51H84O22Pureza:98%Cor e Forma:SolidPeso molecular:1049.21ACKR3 agonist 1
ACKR3 agonist 1 (compound 27), exhibiting selective agonistic properties for ACKR3 (EC 50 =69 nM, E max =82%), demonstrates the capability to inhibit platelet aggregation and shows potential in mitigating platelet-mediated thrombosis. This compound is characterized by its metabolic stability and non-cytotoxic nature.Fórmula:C25H30N2OSCor e Forma:SolidPeso molecular:406.58ALA-A2 peptide
ALA-A2, a cancer peptide found in α-lactalbumin, selectively kills cancer cells by inducing autophagy (Autophagy). It possesses cell-penetrating properties, allowing it to enter cells effectively without relying on membrane solubilization effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. This peptide shows promise for research in cancer treatment and autophagy regulation.Fórmula:C67H111N21O19SCor e Forma:SolidPeso molecular:1546.79N6-Isopentenyladenosine
CAS:N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.Fórmula:C15H21N5O4Pureza:97.13% - 99.69%Cor e Forma:SolidPeso molecular:335.36PBA-1105 TFA
PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. This compound selectively binds to the exposed hydrophobic regions of misfolded proteins, promoting their degradation through the autophagy (autophagy) pathway. Additionally, PBA-1105 TFA enhances the autophagic flux of Ub-bound aggregates.Fórmula:C41H49F3N2O8Cor e Forma:SolidPeso molecular:754.832SQA1
CAS:SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Fórmula:C22H26N4O5Cor e Forma:SolidPeso molecular:426.47TRAF6 peptide
CAS:TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.Fórmula:C145H238N34O44Cor e Forma:SolidPeso molecular:3161.64LC3in-C42
LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.Cor e Forma:Odour SolidPBA-1105b
CAS:PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.Fórmula:C47H64N2O10Cor e Forma:SolidPeso molecular:817.02Fumagilin-105
CAS:Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.Fórmula:C46H60N2O9Cor e Forma:SolidPeso molecular:784.98PHTPP-1304
CAS:PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.Fórmula:C51H50F6N4O7Cor e Forma:SolidPeso molecular:944.96Polyphemusin II-Derived Peptide
CAS:T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Fórmula:C90H141N33O18S2Cor e Forma:SolidPeso molecular:2037.42HDAC6-IN-58
HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM for HDAC6 and 7374.5 nM for HDAC1. It enhances tubulin acetylation, exhibits antiproliferative effects, and induces autophagy (autophagy).Cor e Forma:Odour SolidMicrocolin H
CAS:Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].Fórmula:C38H63N5O9Cor e Forma:SolidPeso molecular:733.93Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Cor e Forma:Odour SolidElaiophylin
CAS:Elaiophylin exhibits anti-Plasmodium falciparum and anti-Trypanosoma brucei activity; IC50: 0.36 μM & 0.45 μM, respectively.Fórmula:C54H88O18Pureza:98%Cor e Forma:SolidPeso molecular:1025.27Hoechst 33342 analog trihydrochloride
CAS:Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating theFórmula:C32H38Cl3N7Cor e Forma:SolidPeso molecular:627.05cGMP-HTL
cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.Fórmula:C31H51ClN7O14PSCor e Forma:SolidPeso molecular:844.27Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Fórmula:C39H59N13O8S2Cor e Forma:SolidPeso molecular:902.1Zn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Fórmula:C115H145ClN18O31S2Zn2Cor e Forma:SolidPeso molecular:2505.83Fe-TMPyP
CAS:Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.Fórmula:C44H36Cl5FeN8Cor e Forma:SolidPeso molecular:909.92Erlotinib-13C6
CAS:Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.Fórmula:C22H23N3O4Cor e Forma:SolidPeso molecular:399.397
