Receptor OX
Os receptores de orexina (OX1 e OX2) são GPCRs que se ligam às orexinas, neuropeptídeos envolvidos na regulação da vigília, apetite e homeostase energética. A desregulação da sinalização da orexina está ligada a distúrbios do sono, como a narcolepsia, bem como a condições metabólicas, como a obesidade. Moduladores dos receptores de orexina estão sendo investigados por seu potencial terapêutico no tratamento de distúrbios do sono, ansiedade e dependência. Na CymitQuimica, oferecemos uma gama de moduladores de receptores de orexina de alta qualidade para apoiar sua pesquisa em biologia do sono, metabolismo e neurofarmacologia.
Foram encontrados 54 produtos para "Receptor OX".
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YNT-185
CAS:YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R,Fórmula:C33H37N5O5SPureza:99.67%Cor e Forma:SolidPeso molecular:615.74Seltorexant
CAS:Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.Fórmula:C21H22FN7OPureza:99.79% - >99.99%Cor e Forma:White SolidPeso molecular:407.44Ref: TM-T12877L
1mg34,00€2mg49,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg98,00€25mg144,00€50mg260,00€100mg358,00€500mg822,00€Filorexant
CAS:Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).Fórmula:C24H25FN4O2Pureza:98.88%Cor e Forma:SolidPeso molecular:420.48EMPA
CAS:EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nMFórmula:C23H26N4O4SPureza:99.11%Cor e Forma:SolidPeso molecular:454.54Ref: TM-T11186
1mg49,00€2mg69,00€5mg92,00€1mL*10mM (DMSO)104,00€10mg142,00€25mg250,00€50mg375,00€100mg563,00€200mg795,00€SB-408124
CAS:SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x more selective than OX2.Fórmula:C19H18F2N4OPureza:99.75% - 99.81%Cor e Forma:SolidPeso molecular:356.37Suntinorexton
CAS:Suntinorexton (TAK 861) is an orexin type 2 receptor (OX2R) agonist used in the study of neurologic disorders.Fórmula:C23H28F2N2O4SPureza:99.89%Cor e Forma:White SolidPeso molecular:466.54Ref: TM-T39807
1mg158,00€5mg385,00€1mL*10mM (DMSO)395,00€10mg625,00€25mg954,00€50mg1.288,00€100mg1.738,00€200mg2.332,00€ZL-1101
ZL-1101 is a human monoclonal antibody (mAb) targeting TNFRSF4/OX40/CD134.Cor e Forma:Odour LiquidOrexin A (human, rat, mouse) acetate
Orexin A (human, rat, mouse) acetate (Hypocretin-1 (human, rat, mouse) acetate) is an excitatory neuropeptide with analgesic properties.Fórmula:C154H247N47O46S4Pureza:99.79%Cor e Forma:White SolidPeso molecular:3621.15OXA(17-33)
CAS:Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.Fórmula:C79H125N23O22Pureza:98%Cor e Forma:SolidPeso molecular:1749Orexin B, rat, mouse
CAS:Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.Fórmula:C126H215N45O34SPureza:98%Cor e Forma:SolidPeso molecular:2936.45Xenopus orexin B
CAS:Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].Fórmula:C130H219N45O40S2Cor e Forma:SolidPeso molecular:3116.54[Ala11,D-Leu15]-Orexin B acetate
[Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM).Fórmula:C122H210N44O37SPureza:98.18%Cor e Forma:SolidPeso molecular:2917.31[Ala11,D-Leu15]-Orexin B(human)
CAS:OX2 receptor agonist with 400x selectivity vs OX1. EC50: 0.13 nM (OX2), 52 nM (OX1).Fórmula:C120H206N44O35SPureza:98%Cor e Forma:SolidPeso molecular:2857.28Orexin A (human, rat, mouse) (TFA)
Endogenous orexin receptor agonist with Ki of 20 nM (OX1) and 38 nM (OX2), promotes feeding, may regulate sleep-wake cycle.Fórmula:C154H244N47F3O46S4Pureza:98%Cor e Forma:SolidPeso molecular:3675.12Orexin 2 Receptor Agonist 3
Orexin 2 Receptor Agonist 3 is an orally active and brain-penetrant agonist of the orexin receptor 2 (OX2) with an EC50 value of 2.5 nM. This compound increases wakefulness in both orexin/ataxin-3 NT1 mouse models and healthy Beagle dogs. It is applicable for research related to narcolepsy.Fórmula:C27H29F2N7O3Peso molecular:537.56Orexin B, human
CAS:Orexin B, human agonizes Orexin receptors (OX1 Ki=420 nM, OX2 Ki=36 nM), promotes feeding in rats, and is a neuropeptide.Fórmula:C123H212N44O35SPureza:98%Cor e Forma:SolidPeso molecular:2899.34Orexin A (human, rat, mouse)
CAS:Orexin A, a 33 AA neuropeptide in humans, rats, mice, influences various processes, studied in pancreatic function and as an OX1R antagonist.Fórmula:C152H243N47O44S4Pureza:98%Cor e Forma:SolidPeso molecular:3561.1Orexin B, rat, mouse TFA
Orexin B, rat/mouse TFA, activates OX1-R & OX2-R receptors, influencing food intake, energy, and sleep regulation.Fórmula:C128H216F3N45O36SCor e Forma:SolidPeso molecular:3050.42OXA(17-33) TFA
OXA(17-33) TFA: Potent OX1 agonist, ~23x more selective for OX1 (EC50=8.29nM) than OX2 (187nM).Fórmula:C81H126F3N23O24Cor e Forma:SolidPeso molecular:1863[Ala11,D-Leu15]-Orexin B(human) TFA
"[Ala11,D-Leu15]-Orexin B(human) TFA is an OX2 receptor agonist with 400x selectivity over OX1 (EC50: 0.13 nM vs. 52 nM)."Fórmula:C122H207F3N44O37SPeso molecular:2971.28
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