gsk-3
Os inibidores da GSK-3 são compostos que alvo a Glicogênio Sintase Quinase 3 (GSK-3), uma enzima envolvida em numerosos processos celulares, incluindo o metabolismo do glicogênio, a transcrição genética e a proliferação celular. A GSK-3 está implicada em várias doenças, como diabetes, distúrbios neurodegenerativos e câncer. Os inibidores da GSK-3 são ferramentas importantes para explorar essas vias e desenvolver potenciais terapias. Na CymitQuimica, oferecemos inibidores da GSK-3 para apoiar sua pesquisa em doenças metabólicas, neurobiologia e oncologia.
Foram encontrados 110 produtos de "gsk-3"
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TDZD-8
CAS:TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.Fórmula:C10H10N2O2SPureza:97.13% - 99.61%Cor e Forma:White SolidPeso molecular:222.26Bisindolylmaleimide I
CAS:Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.Fórmula:C25H24N4O2Pureza:97.51% - 98.75%Cor e Forma:Orange SolidPeso molecular:412.48SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Fórmula:C19H12Cl2N2O2Pureza:98.9% - 99.13%Cor e Forma:SolidPeso molecular:371.22Ref: TM-T3077
2mg39,00€5mg52,00€10mg79,00€25mg131,00€50mg197,00€100mg334,00€500mg803,00€1mL*10mM (DMSO)52,00€CP21R7
CAS:CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.Fórmula:C19H15N3O2Pureza:96.14% - 99.16%Cor e Forma:SolidPeso molecular:317.34Ref: TM-T3684
1mg40,00€2mg52,00€5mg88,00€10mg127,00€25mg250,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)81,00€GSK 3 Inhibitor IX
CAS:GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.
Fórmula:C16H10BrN3O2Pureza:98% - 99.72%Cor e Forma:SolidPeso molecular:356.17Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Fórmula:C16H11N3O2Pureza:99.55%Cor e Forma:Dark Red SolidPeso molecular:277.28PF-04802367
CAS:PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.Fórmula:C16H16ClN5O3Pureza:98.76%Cor e Forma:SolidPeso molecular:361.78Ref: TM-T9611
1mg49,00€5mg100,00€10mg152,00€25mg264,00€50mg399,00€100mg532,00€200mg705,00€1mL*10mM (DMSO)111,00€KY19382
CAS:KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.Fórmula:C17H11Cl2N3O2Pureza:98.06%Cor e Forma:SolidPeso molecular:360.19Ref: TM-T9025
1mg94,00€5mg187,00€10mg333,00€25mg560,00€50mg797,00€100mg1.071,00€500mg2.187,00€1mL*10mM (DMSO)230,00€IM-12
CAS:IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.
Fórmula:C22H20FN3O2Pureza:99.42% - >99.99%Cor e Forma:SolidPeso molecular:377.41Tideglusib
CAS:Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.Fórmula:C19H14N2O2SPureza:98.40% - 99.35%Cor e Forma:SolidPeso molecular:334.39Ref: TM-T3067
10mg47,00€25mg77,00€50mg113,00€100mg187,00€200mg283,00€500mg490,00€1mL*10mM (DMSO)50,00€LY2090314
CAS:LY2090314, a potent GSK-3α/β blocker (IC50: 1.5/0.9 nM), could boost platinum chemo. Tested in leukemia and advanced cancers.Fórmula:C28H25FN6O3Pureza:99.21% - 99.91%Cor e Forma:SolidPeso molecular:512.53Ref: TM-T1755
1mg37,00€2mg52,00€5mg95,00€10mg138,00€25mg238,00€50mg389,00€100mg575,00€200mg820,00€1mL*10mM (DMSO)97,00€GS87
CAS:GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.Fórmula:C16H11N5O2SPureza:98.86%Cor e Forma:SolidPeso molecular:337.36Ref: TM-T8605
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)178,00€AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Fórmula:C19H18N4O2Pureza:97.72% - 99.75%Cor e Forma:SolidPeso molecular:334.37Ref: TM-T1741
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg429,00€1mL*10mM (DMSO)63,00€BIO-acetoxime
CAS:BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
Fórmula:C18H12BrN3O3Pureza:97.15%Cor e Forma:SolidPeso molecular:398.21Bikinin
CAS:Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.
Fórmula:C9H9BrN2O3Pureza:99.86% - >99.99%Cor e Forma:SolidPeso molecular:273.08SB 415286
CAS:SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.Fórmula:C16H10ClN3O5Pureza:99.55%Cor e Forma:SolidPeso molecular:359.72GSK-3β inhibitor 10
CAS:GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.Fórmula:C12H12N2O3SPureza:98.06%Cor e Forma:SolidPeso molecular:264.3RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Fórmula:C29H35N7O4Pureza:98% - 99.91%Cor e Forma:SolidPeso molecular:545.63GNF4877
CAS:GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.Fórmula:C25H27FN6O4Pureza:98.68% - 99.40%Cor e Forma:SolidPeso molecular:494.52(E/Z)-GSK-3β inhibitor 1
CAS:(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.Fórmula:C14H10N2OPureza:98.60%Cor e Forma:SolidPeso molecular:222.24Ref: TM-T9178
2mg35,00€5mg56,00€10mg94,00€25mg154,00€50mg222,00€100mg318,00€200mg432,00€1mL*10mM (DMSO)63,00€
