AMPK
Os inibidores de AMPK são compostos que inibem a Quinase Ativada por AMP (AMPK), uma enzima que desempenha um papel crucial na homeostase energética celular. A AMPK é ativada em resposta a baixos níveis de energia nas células e ajuda a regular processos como a captação de glicose, a oxidação de ácidos graxos e a biogênese mitocondrial. Inibir a AMPK é importante para estudar seu papel em doenças metabólicas, câncer e envelhecimento. Na CymitQuimica, oferecemos uma gama de inibidores de AMPK para apoiar sua pesquisa em metabolismo, oncologia e doenças relacionadas ao envelhecimento.
Foram encontrados 161 produtos para "AMPK".
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6-Azuridine
CAS:6-Azauridine is a purine analog with antitumor effects, inhibiting DNA synthesis and inducing apoptosis in lymphatic cancers.Fórmula:C8H11N3O6Pureza:99.02%Cor e Forma:SolidPeso molecular:245.19Teneligliptin hydrobromide hydrate
CAS:Teneligliptin hydrobromide hydrate: potent, long-lasting DPP-4 inhibitor with ~1 nM IC50.Fórmula:C22H33BrN6O2SCor e Forma:SolidPeso molecular:525.51Metformin-D6 hydrochloride
CAS:Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.Fórmula:C4H12ClN5Pureza:98.1%Cor e Forma:SolidPeso molecular:171.66Ginkgolide C
CAS:Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.Fórmula:C20H24O11Pureza:99.71% - 99.98%Cor e Forma:White PowderPeso molecular:440.40Platycodin D
CAS:Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA.Fórmula:C57H92O28Pureza:99.2% - 99.65%Cor e Forma:White SolidPeso molecular:1225.32IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFórmula:C22H23N5O8Pureza:97.73%Cor e Forma:SolidPeso molecular:485.45Ref: TM-T9010
1mg38,00€5mg92,00€1mL*10mM (DMSO)124,00€10mg128,00€25mg215,00€50mg304,00€100mg411,00€200mg570,00€O-304
CAS:O-304 is a pan-activator of AMP-activated protein kinase (AMPK).Fórmula:C16H11Cl2N3O2SPureza:99.84% - ≥98%Cor e Forma:White SolidPeso molecular:380.25Ref: TM-T7362
1mg63,00€2mg92,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg205,00€25mg409,00€50mg605,00€100mg860,00€500mg1.728,00€Vaccarin
CAS:Vaccarin, a key flavonoid glycoside in Vaccariae semen, undergoes methylation, hydroxylation, glycosylation, and deglycosylation.Fórmula:C32H38O19Pureza:99.16% - 99.97%Cor e Forma:SolidPeso molecular:726.63Demethyleneberberine
CAS:Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria eitherFórmula:C19H18NO4Pureza:98.08% - 99.18%Cor e Forma:SolidPeso molecular:324.35GSK621
CAS:GSK621 is a specific and potent AMPK activator.Fórmula:C26H20ClN3O5Pureza:97.02% - 97.05%Cor e Forma:SolidPeso molecular:489.91Metformin
CAS:Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability.Fórmula:C4H11N5Pureza:99.77% - >99.99%Cor e Forma:SolidPeso molecular:129.16Ref: TM-T8526
1mL*10mM (DMSO)33,00€10mg44,00€25mg66,00€50mg93,00€100mg102,00€500mg250,00€2500mg414,00€DASA-58
CAS:DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.Fórmula:C19H23N3O6S2Pureza:96.96% - 99.28%Cor e Forma:SolidPeso molecular:453.53Trilobatin
CAS:Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentiallyFórmula:C21H24O10Pureza:97.16%Cor e Forma:SolidPeso molecular:436.41Ref: TM-T2S0731
1mg50,00€5mg99,00€1mL*10mM (DMSO)109,00€10mg141,00€25mg260,00€50mg385,00€100mg557,00€200mg790,00€ARN-3236
CAS:ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nMFórmula:C19H16N2O2SPureza:98.89% - 99.7%Cor e Forma:SolidPeso molecular:336.41Ref: TM-T5993
1mg57,00€5mg92,00€1mL*10mM (DMSO)142,00€10mg152,00€25mg250,00€50mg334,00€100mg512,00€200mg737,00€STO-609
CAS:STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.Fórmula:C19H10N2O3Pureza:97.14% - 99.35%Cor e Forma:SolidPeso molecular:314.29Ref: TM-T3546
1mg39,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg120,00€25mg250,00€50mg400,00€100mg620,00€200mg873,00€WH-4-025
CAS:WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.Fórmula:C39H38F3N7O5Pureza:99.41%Cor e Forma:White SolidPeso molecular:741.76Ref: TM-T9219
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg130,00€25mg250,00€50mg396,00€100mg585,00€AMAROGENTIN
CAS:Amarogentin, extracted from Swertia/Gentiana roots, aids liver cancer prevention/treatment by affecting cell cycle and apoptosis.Fórmula:C29H30O13Pureza:99.98% - ≥95%Cor e Forma:SolidPeso molecular:586.54Ref: TM-T5497
2mg37,00€5mg54,00€1mL*10mM (DMSO)71,00€10mg84,00€25mg152,00€50mg205,00€100mg289,00€200mg439,00€EB-3D
CAS:EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity.Fórmula:C30H36Br2N4O2Pureza:99.48%Cor e Forma:SolidPeso molecular:644.4Ref: TM-T7955
1mg87,00€2mg114,00€5mg177,00€10mg260,00€1mL*10mM (DMSO)263,00€25mg447,00€50mg620,00€100mg875,00€200mg1.161,00€AMPK activator 2
CAS:AMPK activator 2, a chloroformin derivative, may boost cancer treatment by enhancing AMPK and inhibiting mTOR pathways, and cancer cell growth.Fórmula:C13H18F3N5Pureza:99.86%Cor e Forma:SolidPeso molecular:301.31BC1618
CAS:BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling.Fórmula:C24H24F3NO2Pureza:99.95%Cor e Forma:SolidPeso molecular:415.45Pyraclostrobin
CAS:Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.Fórmula:C19H18ClN3O4Pureza:99.89% - 99.96%Cor e Forma:Yellow SolidPeso molecular:387.82Buformin
CAS:Buformin, a biguanide oral antidiabetic, inhibits liver glucose production and improves insulin sensitivity.Fórmula:C6H15N5Cor e Forma:SolidPeso molecular:157.22WZ4003
CAS:WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.Fórmula:C25H29ClN6O3Pureza:99.65% - >99.99%Cor e Forma:SolidPeso molecular:496.99Ref: TM-T6291
5mg48,00€1mL*10mM (DMSO)50,00€10mg73,00€25mg111,00€50mg166,00€100mg241,00€200mg358,00€500mg590,00€MK-3903
CAS:MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).Fórmula:C27H19ClN2O3Pureza:98.63% - 99.75%Cor e Forma:SolidPeso molecular:454.9Ref: TM-T5187
1mg34,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg114,00€25mg178,00€50mg334,00€100mg557,00€200mg790,00€IMT1
CAS:IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.Fórmula:C21H21NO4Pureza:98.07% - 98.14%Cor e Forma:SolidPeso molecular:351.4Ref: TM-T8841
1mg77,00€5mg166,00€1mL*10mM (DMSO)178,00€10mg285,00€25mg533,00€50mg763,00€100mg1.054,00€Kahweol
CAS:Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaBFórmula:C20H26O3Pureza:99.26% - 99.86%Cor e Forma:Off-White To Yellow SolidPeso molecular:314.42Dorsomorphin dihydrochloride
CAS:Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity onFórmula:C24H25N5O·2HClPureza:97.74% - 99.89%Cor e Forma:SolidPeso molecular:472.41Ref: TM-T6146
2mg34,00€5mg49,00€1mL*10mM (DMSO)54,00€10mg66,00€25mg128,00€50mg222,00€100mg401,00€500mg888,00€COH-SR4
CAS:COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation.Fórmula:C13H8Cl4N2OPureza:98.96%Cor e Forma:SolidPeso molecular:350.03Marein
CAS:Marein prevents PC12 cell damage by protecting mitochondria and activating AMPK, potentially countering diabetic encephalopathy.Fórmula:C21H22O11Pureza:99.12% - 99.84%Cor e Forma:SolidPeso molecular:450.39Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Fórmula:C9H6O4Pureza:97.47% - 99.95%Cor e Forma:SolidPeso molecular:178.14Dorsomorphin
CAS:Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.Fórmula:C24H25N5OPureza:98% - 99.06%Cor e Forma:SolidPeso molecular:399.49Bempedoic acid
CAS:Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C.Fórmula:C19H36O5Pureza:99.85% - 99.94%Cor e Forma:White SolidPeso molecular:344.49Ref: TM-T3625
2mg34,00€5mg50,00€1mL*10mM (DMSO)52,00€10mg70,00€25mg118,00€50mg207,00€100mg333,00€500mg797,00€Teneligliptin hydrobromide
CAS:Teneligliptin hydrobromide: potent, novel DPP-4 inhibitor; inhibits human/rat plasma DPP-4 with ~1 nM IC50.Fórmula:C22H30N6OSBrHPureza:97.83% - 99.92%Cor e Forma:SolidPeso molecular:628.86Flurbiprofen Axetil
CAS:Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.Fórmula:C19H19FO4Pureza:97.58% - 98%Cor e Forma:SolidPeso molecular:330.35STF-118804
CAS:STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.Fórmula:C25H23N3O4SPureza:99.96%Cor e Forma:SolidPeso molecular:461.53SBI-0206965
CAS:SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.Fórmula:C21H21BrN4O5Pureza:99.13%Cor e Forma:SolidPeso molecular:489.32Gomisin J
CAS:Gomisin J is a natural product and have vasodilatory activity.Fórmula:C22H28O6Pureza:99.59% - 99.60%Cor e Forma:SolidPeso molecular:388.45Ref: TM-T3904
1mg44,00€2mg62,00€1mL*10mM (DMSO)92,00€5mg113,00€10mg178,00€25mg313,00€50mg465,00€100mg662,00€GSK-690693
CAS:GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.Fórmula:C21H27N7O3Pureza:98.07% - 99.77%Cor e Forma:SolidPeso molecular:425.48RSVA405
CAS:RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitorFórmula:C17H20N4O2Pureza:99.30%Cor e Forma:SolidPeso molecular:312.37MOTS-c(Human) Acetate(1627580-64-6 free)
MOTS-c(Human) Acetate is a mitochondrial-derived peptide.Fórmula:C103H156N28O24S2Pureza:99.93%Cor e Forma:White SolidPeso molecular:2234.64Nepodin
CAS:Nepodin exhibits antimalarial, anti-inflammatory, and antidiabetic effects by inhibiting COX and activating AMPK to stimulate GLUT4.Fórmula:C13H12O3Pureza:97.9% - 99.12%Cor e Forma:SolidPeso molecular:216.23Ref: TM-TN1100
1mg54,00€2mg80,00€1mL*10mM (DMSO)114,00€5mg120,00€10mg192,00€25mg324,00€50mg480,00€100mg683,00€PKC-iota inhibitor 1
CAS:PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι ; IC50 : 0.34 μM)Fórmula:C21H22N6OPureza:98.82%Cor e Forma:SolidPeso molecular:374.44Ref: TM-T8764
1mg107,00€2mg152,00€5mg219,00€1mL*10mM (DMSO)226,00€10mg349,00€25mg583,00€50mg833,00€100mg1.134,00€500mg2.268,00€MRT67307 HCl (1190378-57-4(free base))
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).Fórmula:C26H37ClN6O2Pureza:98.19%Cor e Forma:SolidPeso molecular:501.07ON123300
CAS:ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Fórmula:C24H27N7OPureza:99.53% - 99.7%Cor e Forma:SolidPeso molecular:429.52Metformin glycinate
CAS:Metformin glycinate activates AMPK, enhances insulin sensitivity, and reduces glucose absorption for better glycemic control.Fórmula:C6H16N6O2Cor e Forma:SolidPeso molecular:204.23[6]-Gingerol
CAS:[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for tumors.Fórmula:C17H26O4Pureza:98% - 99.95%Cor e Forma:White SolidPeso molecular:294.39Ref: TM-T3405
1mL*10mM (DMSO)38,00€5mg39,00€10mg52,00€1ml*10 (DMSO)67,00€25mg84,00€50mg111,00€20mg116,00€100mg163,00€200mg233,00€4g1.350,00€Palmitelaidic Acid
CAS:Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.Fórmula:C16H30O2Pureza:99.76%Cor e Forma:SolidPeso molecular:254.41YKL-06-061
CAS:YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.Fórmula:C30H37N7O2Pureza:99.79% - 99.99%Cor e Forma:SolidPeso molecular:527.66Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Fórmula:C10H7N3O4SPureza:98.89% - 99.28%Cor e Forma:SolidPeso molecular:265.25Kudinoside D
CAS:Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.Fórmula:C47H72O17Pureza:99.66% - 99.92%Cor e Forma:SolidPeso molecular:909.06Ref: TM-TN1836
1mg119,00€5mg269,00€1mL*10mM (DMSO)324,00€10mg374,00€25mg577,00€50mg783,00€100mg1.054,00€200mg1.423,00€
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