Oligossacarídeos

<p>Hyaluronic acid is a polysaccharide containing repeating disaccharide units of 1,3-N-acetyl glucosamine and 1, 4-glucuronic acid.  This tetrasaccharide and other enzymatically produced polymer homologs have been of value in the study of hyaluronic acid metabolism in both healthy and diseased tissues (Hascall, 2019).</p>

Disialylated tetrasaccharide naturally present in human breast milk that has been identified as one of the binding sites of the C fragment of the clostridial tetanus toxin.

4-Methoxyphenyl 4-O-(3,6-di-O-benzyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-3-O-benzyl-2-deoxy -6-(4methoxybenzyl)-2 phthalimid (4) is a carbohydrate compound with the molecular formula C27H32N2O9. It is a white to off white powder that has a molecular weight of 565.5 and an empirical formula of C27H32N2O9.

4-Methoxyphenyl 4-O-(3,6-di-O-benzyl-2-deoxy-4-O-levulinoyl-2-phthalimido-b-D-[1]glucopyranosyl)-3,6,6'-triphosphate (4MP) is a fluorinated monosaccharide that can be synthesized from 4,4'-dimethoxybenzophenone and 2,3,4,5',6'-pentachlorobenzene. This synthetic compound is used to prepare modified polysaccharides. 4MP has been shown to methylate glycoproteins and modify oligosaccharides. It has also been shown to inhibit the growth of Mycobacterium tuberculosis by inhibiting the synthesis of cell wall lipids.

<p>Produced from high maltose syrup by treatment with transglucosidase</p>

Heparin Disaccharide II-A Disodium Salt is a modification of heparin. It is an oligosaccharide with a molecular weight of about 2,000 Daltons. This product can be custom synthesized as per the requirement of the customer. The purity level of this product is very high and it has been shown to have antiviral, anticoagulant, anti-inflammatory, and anticlotting properties.

Sucrose octabenzoate is a practically colorless, odorless, transparent, glass-like material which is compatible with a number of synthetic resins, such as polyvinyl chloride, vinyl chloride-vinyl acetate copolymer, polyvinyl acetate and cellulose acetate. Sucrose octabenzoate improves the hardness and gloss of these products and has also been found to be useful as a component of inks, adhesives, coatings and plastic objects.

<p>Produced from starch; white hygroscopic spray-dried powder; easily digestible</p>

Galactosyllactose attenuated NF-κB inflammatory signaling in human intestinal epithelial cells and in human immature intestine. Thus, galactosyllactoses are strong anti-inflammatory agents in human colostrum and early milk, contributing to innate immune modulation. This product has a 13C heavy-label and so can be used in applications such as metabolic tracing and quantitative mass spectrometry.

<p>N-Glycolylneuraminic acid dimer sodium salt is a synthetic sugar that is a glycosylat of N-glycolylneuraminic acid. It is soluble in water and has a CAS number of 1114-12-3. The product has been modified with methyl groups and is available for custom synthesis. It can be used as an intermediate for the synthesis of oligosaccharides, or it can be modified to form complex carbohydrates. This product has been fluorinated and is high purity, making it ideal for use in Click chemistry applications.</p>

Sodium Tetragalacturonate (α-1,4 sodium tetrgalacturonate) is derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s) and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, and tetra-galacturonate oligosaccharides, restore development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).

<p>Ex algal/bacterial polysaccharides-value in b1-3 glucanase assays &amp; diagnostics</p>

<p>6-Amino-6-deoxy-D-lactosylamine is a modified sugar that is used to synthesize glycosides. It is also used as a reagent for the methylation of saccharides and polysaccharides. This product can be custom synthesized or ordered from our catalog. We offer high purity 6-amino-6-deoxy-D-lactosylamine, which has been chemically modified with fluorine and has a CAS number of 7092-12-3. It is available in different quantities and can be ordered with other custom modifications, such as Click chemistry.</p>

Found in glycoproteins including ovalbumin and human immunoglobulin M

a-Sophorose monohydrate is a water soluble β 1-2’ diglucoside which can be used to induce cellulase production from fungi. The industrial production of cellulase is of importance due to its application in the degradation of lignocellulosic biomass to biofuels. a-Sophorose monohydrate is also a useful chemical building block for carbohydrate synthesis.

Milk oligosaccharide; expressed on human induced pluripotent cells

<p>4-Methoxyphenyl 4-O-[4-O-(3,4,6-tri-O-acetyl-2,4,6-trimethylbenzoyl)-b-D-glucopyranosyl]-3,6-di-O-[α-(1→2)-bromoacetamido]-b-D-glucopyranoside is a complex carbohydrate which belongs to the group of glycosides. It was synthesized by modification of the natural bovine erythrocyte glycoglycerolipid (glycolipid) and monosaccharide (monoglyceride). The synthesis is based on a series of reactions that include methylation and fluorination. This compound has been shown to have high purity and can be made in custom synthesis.</p>

<p>Sucralfate is a drug that is used to treat and prevent injury-related inflammation by forming a protective barrier on the lining of the stomach and duodenum. Sucralfate has been shown to be effective in the treatment of infectious diseases, such as viral or bacterial infections, and also for radiation enteritis and ulcerative colitis. Sucralfate may interfere with the absorption of other drugs, such as acyclic nucleoside phosphonates, which are used to treat HIV/AIDS. This drug has also been shown to have anti-inflammatory properties through inhibition of prostaglandin synthesis. Sucralfate has been shown to have anti-inflammatory properties through inhibition of prostaglandin synthesis.</p>

4-O-(b-D-Galactopyranosyl)-b-D-thioglucopyranose is a custom synthesis carbohydrate. It is an oligosaccharide that consists of a monosaccharide with a b-D-galactopyranosyl group and a b-D-thioglucopyranose group. 4-O-(b-D-Galactopyranosyl)-b-D-thioglucopyranose is a polysaccharide and belongs to the class of carbohydrates, which are saccharides or sugars. Carbohydrates are important in cell walls and are modified by methylation, glycosylation, and click modification. Carbohydrates can be classified as simple or complex carbohydrates. Simple carbohydrates contain one molecule with one type of sugar unit bonded together, while complex carbohydrates have more than one type of sugar unit bonded together.

Detergent used for the solubilization of membrane proteins.  Important for the solubilization is the detergent-to-protein ratio. At low ratios (1:10) the membranes are lysed and large complexes of are formed containing protein, detergent, and membrane lipids. With progressively larger ratios smaller complexes are obtained. Finally, at ratios of 10:1 to 20:1 individual detergent-protein complexes are formed free of membrane lipids. To determine the optimal conditions it is important to vary both the detergent and the protein concentration (EMBL).

<p>This mixture contains some of the penta- and hexasaccharides in human milk.</p>

<p>Key synthetic precursor for the synthesis of lacto-oligosaccharides</p>

Synthetic building block for oligosaccharide synthesis

<p>Produced from high maltose syrup by treatment with transglucosidase</p>

<p>Galactosyllactose attenuated NF-κB inflammatory signaling in human intestinal epithelial cells and in human immature intestine. Thus, galactosyllactoses are strong anti-inflammatory agents in human colostrum and early milk, contributing to innate immune modulation. This product has a 13C heavy-label and so can be used in applications such as metabolic tracing and quantitative mass spectrometry.</p>

A tetra-O-acetyl-6-O-(2,3,4,6-tetra-O-acetyl-a-D-galactopyranosyl)-b-D-thioglucopyranose is a 1,2,3,4 tetraol. It is synthesized by the modification of a disaccharide that has been modified with fluorine and methyl groups on the C1 and C4 positions of the sugar. The complex carbohydrate is a glycosylated sugar that is composed of one monosaccharide and one oligosaccharide. This product is CAS No. 1820574-50-2.

<p>GD3 ganglioside (shown as sodium salt) has a core disaccharide structure (Gal-1,4-Glc) with two sialic acids linked to the non-reducing galactose residue, and ceramide linked to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD3 ganglioside is a minor ganglioside in most normal tissues but plays a crucial role in the development of the brain; its presence is significantly reduced in adults. However, expression of GD3 ganglioside is increased in pathological conditions, such as, cancers and neurodegenerative disorders (Malisan, 2002). GD3 ganglioside was the first cancer-associated ganglioside discovered, that promotes adhesion and invasion of cancers. GD3 ganglioside and GD2 ganglioside are highly expressed in a various malignant cancers and have become potential targets for next-generation cancer therapy (Liu, 2018).</p>

4-Methoxyphenyl 4-O-(2-acetamido-2-deoxy-b-D-galactopyranosyl)-2-acetamido-2-deoxy-b-D-glucopyranoside is a modification of the natural polysaccharide, which is a complex carbohydrate. It is synthesized by our high purity, custom synthesis service and can be modified with methylation, fluorination, or glycosylation. This product has been proven to have high purity and stability in the past.

<p>an important cell surface epitope that acts as the receptor for Shiga-like toxin</p>

Heparin sulfate NS-oligosaccharide NS is a high purity, custom synthesis, sugar-based heparin. Heparin sulfate NS-oligosaccharide NS is designed for use in glycosylation reactions and provides the opportunity to introduce a variety of functional groups including Click modification, fluorination, methylation, and glycosylation. This product contains no animal derived ingredients. Heparin sulfate NS-oligosaccharide NS can be used in a range of applications such as pharmaceuticals, agrochemicals, and food additives.

Core antigen fragment in ABO blood group system

<p>1,4-D-Xylobiose, also called 4-O-(b-D-Xylopyranosyl)-D-xylopyranose, is a beta 1-4 linked disaccharide made of 2 xylose monomers. 1,4-D-Xylobiose is a low-calories sweetener that can be used as an alternative or additive to sucrose. Supplementing a high fat diet with 1,4-D-xylobiose has been shown to prevent and treat obesity in mice.</p>

Tetracose is a complex carbohydrate that is composed of 1,2,3,6-tetra-O-acetyl-4-O-[2,4,6-tri-O-acetyl-3-O-(2 acetamido)-β-D-galactopyranosyl]-β-D-glucopyranose and β--D--galactopyranosyl. Tetracose is a high purity custom synthesis sugar. It has been fluorinated at the 3' position and glycosylated with an acetamide group. Tetracose has also been methylated and modified with a click modification. Tetracose has CAS No.: 145925-75-5

b-D-(2-Acetamido-2-deoxy-D-glucopyranosyl)-2-acetamido-2-deoxy-b-D-thioglucopyranoside is an oligosaccharide that belongs to the carbohydrate class. It is a fluorinated monosaccharide with a high purity and custom synthesis. This compound is methylated and glycosylated, making it a complex carbohydrate with click modification.

<p>GD2 oligosaccharide is the core trisaccharide structure of the ganglioside GD2 (sodium salt) (GalNAcβ1,4Galβ1,4Glc) with its two sialic acids linked α2,3/α2,8 to the central galactose residue (Ledeen, 2009). GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors, including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).</p>

The compound 4-Methoxyphenyl 4-O-(3,6-di-O-benzyl-2-deoxy-4-O-levulinoyl)-2,3,4,6-tetra‑O‑benzyl‑a‑L -fucopyranosyl)-2,3,4,6‑tetra‑O‑benzyl‑a‑L -fucopyranoside is a glycoside of the monosaccharide 2,3,4,6 tetra O benzyl a L fucopyranose. It is prepared by the reaction of methyl 4 methoxyphenol with 2 deoxy 4 levulinoyl 2 phthalimido b D glucopyranoside in the presence of an acid catalyst. The compound has been shown to have anti inflammatory and anti allergic effects.

3-Fucosyllactose (3-FL) is a small and neutral human milk oligosaccharide (HMO) that is metabolized by bacteria in the large intestine. It's a trisaccharide composed of L-fucose, D-galactose and D-glucose and like many other HMOs it offers great interest for the studies of baby milk formula.

<p>GlcA[3S]b(1-3)Galb(1-4)GlcNAcb(1-2)Mana-Ethylazide is an oligosaccharide used in glycosylation and esterification reactions. It is a complex carbohydrate that consists of a methylated mannosamine backbone, with alpha-D-glucose and alpha-D-galactose units attached to the mannosamine. GlcA[3S]b(1-3)Galb(1-4)GlcNAcb(1-2)Mana-Ethylazide has a fluorinated ethyl group at the 3 position of the mannosamine, which can be modified with other reactive groups. The CAS number for this compound is 84726-43-7.</p>

Blood group H type II trisaccharide is a carbohydrate that is modified with a spacer-biotin conjugate. It can be used in the synthesis of oligosaccharides and saccharides. This product has been fluorinated, has high purity, and is custom synthesized to order. The product also has methylation, glycosylation, and click modification.

<p>Leucrose (5-O-a-d-glucopyranosyl-D-fructose) is formed by enzymatic synthesis using Leuconostoc mesenteroides in the presence of sucrose.</p>

<p>Pentasaccharide derived from chitin</p>

<p>Mixed DP 10-15 Na galacturonans (α-1,4 10-15 Na galacturonans) are derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis. They are used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s) and gluconase(s). In recent studies, it has been shown that long oligogalacturonides (degree of polymerization (DP) from 10–15) help to induce plant defense signaling resulting in enhanced defenses to necrotrophic pathogens.</p>

3-O-(a-L-fucopyranosyl)-D-galactopyranose is a glycosidic residue that is part of the β-D-Galactoside. It is an amino acid that is used to form carbohydrates. The chemical formula for 3-O-(a-L-fucopyranosyl)-D-galactopyranose is C 12 H 18 O 11 . The molecular weight of 3-O-(a-L-fucopyranosyl)-D-galactopyranose is 308.

This product is a custom synthesis of an oligosaccharide. It is a complex carbohydrate that has been modified with methylation, glycosylation, and fluorination. It is synthesized from monosaccharides and saccharides. The CAS number for this product is _________________.

<p>Maltotetraose is the shortest chain oligosaccharide that can be classified as a maltodextrin. It’s a component of liquid glucose (a commercial sweetener composed of glucose, maltose, maltotriose and maltotetraose), used in bread-making industry.</p>

Ex algal/bacterial polysaccharides-value in b1-3 glucanase assays & diagnostics

Synthesized by the 4,6-O-benzylidene acetal-controlled method of Crich

<p>6'-Fucosyllactose is a fucosylated form of lactose, which is a complex carbohydrate. It is a custom synthesis and has been synthesized in high purity. 6'-Fucosyllactose has CAS No. 80756-86-1 and can be found as an oligosaccharide or polysaccharide. 6'-Fucosyllactose is a monosaccharide that has been methylated and glycosylated to increase its stability. The saccharides are modified with fluorination to make it more soluble in water and to improve its solubility in organic solvents.</p>

<p>Lewis Y tetrasaccharide-BSA is a synthetic oligosaccharide that contains Lewis Y, a sugar that is naturally found in human blood. It is used in glycoprotein research and can be modified with fluorination, methylation, or click chemistry to suit the needs of the researcher. This product has high purity and can be custom synthesized to meet specific requirements.</p>

1-O-Allyl-D-lactose is a fluorinated carbohydrate with the chemical formula C6H12O5. It is an oligosaccharide that can be synthesized in high purity and custom synthesis. 1-O-Allyl-D-lactose is a modified saccharide that has been fluorinated at the 1 position and methylated at the 2 position. It can be used as a substrate for glycosylation or click chemistry reactions.