Reagentes Sintéticos

<p>Applications Furyl Hydroxymethyl Ketone is a reagent in the preparation of 3-iodocoumarins. Also used in the preparation of quinoxalines generally used in dyes and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reddy, M. et al.: J. Org. Chem., 78, 5878 (2013); Cho, C. et al.: J. Mol. Catal. A. Chem., 276, 205 (2007);<br></p>

<p>Applications (R)-(+)-α-Methylbenzylamine (cas# 3886-69-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Carmofur is a derivative of fluorouracil (F596002) an is an antineoplastic agent showing antitumor activity against several cells including L1210 leukemia and L5178Y lymphoma cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoshi, A., et al.: J. Pharmacobio-dynam., 3, 478 (1980);<br></p>

<p>Stability Hygroscopic<br>Applications Calcium Dobesilate (cas# 117552-78-0) is a useful research chemical. A vasoprotective.<br>References Caproiu, R., et al.: Revistade Chimie, 39, 528 (1988); Huang, Z., et al.: From Faming Zhuanli Shenqing (2007), CN 101081823 A 20071205<br></p>

<p>Applications VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.<br>References Loo, T. et al.: Biochem. Pharm., 86, 612 (2013); McPhail, G.. et al.: Drugs. Future., 37, 717 (2012);<br></p>

<p>Applications A potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cβ.<br>References Rose, W.C. et al.: Cancer Res., 61, 7507 (2001); Tabernero, J. et al.: J. Clin. Oncol., 23, 2521 (2005); Pellicano, F. et al.: Blood, 114, 4186 (2009);<br></p>

<p>Applications A piperazine derivative and a selective antagonist at D3 receptors that influences the expression of cocaine-induced conditioned place preference (CPP).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Byrska, B. et al.: Zagadnien Nauk Sadowych 81, 101 (2010); Cervo, L. et al.: Pharmacol Biochem Be 82, 727 (2005)<br></p>

<p>Applications L-threo-Phenylserine is a valuable chiral synthon.<br></p>

<p>Stability Hygroscopic<br>Applications (R)-Phenylephrine Hydrochloride is an α-Adrenergic agonist. Mydriatic; decongestant.<br>References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 86, 284 (1946); Gaglia, C.A., et al.: Anal. Profiles Drug Subs., 3, 483 (1974);<br></p>

<p>Applications β-Methylphenethylamine is a positional isomer of Amphetamine (HCl: A634240), and as a result, has been classified as a doping agent by the World-Anti Doping Agency.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cho?bi?ski, P., et al.: Anal. Bioanal. Chem., No vol. given, 1 (2014); Cohen, P., et al.: New Engl. J. Med., 370, 1277 (2014); Pawar, R., et al.: J. Pharm. Biomed. Anal., 88, 457 (2014); Vaclavik, L., et al.: Anal. Chim. Acta, 810, 45 (2014)<br></p>

<p>Stability Freezer at -20°C<br>Applications A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.<br>References HonorÈ, T., et al.: Science, 241, 701 (1988), Gill, et al.: Brain Res., 580, 35 (1992), Pook, et al.: Br. J. Pharmacol., 108, 179 (1993)<br></p>

<p>Applications Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100µM.(±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneSelective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.<br>References Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications Cerivastatin is a competitive inhibitor of HMG-CoA reductase.<br>References Ness, C.G., et al.: Arch. Biochem. Biophys., 325, 242 (1996), Steinke, W., et al.: Japan. Pharmacol. Ther., 24, Suppl. 9, S1217 (1996),<br></p>

<p>Applications A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial.<br>References English, A.R., et al.: Antimicrob. Agents Chemother., 14, 414 (1978), Stromberg, B.V., Surg. Gynecol. Obstet., 162, 575 (1986), Mehtar, S., et al.: J. Antimicrob. Chemother., 17, 389 (1986), Campoli-Richards, D.M., et al.: Drugs, 33, 577 (1987),<br></p>

<p>Applications An aromatase inhibitor. Also blocks adrenal steroidogenesis.<br>References Santen, R.J. and Misbin, R.I.: Pharmacotherapy, 1, 95 (1981), Havlin, K.A. and Trump, D.L.: Cancer Threat. Res., 39, 83 (1988)<br></p>

<p>Applications Synthetic analog of Vasopressin with antidiuretic activity and decreased pressor effects. Improves hemostatsis by increasing plasma levels of von Willebrand factor, factor VIII and tissue plasminogen activator. Antidiuretic; hemostatic.<br>References Mannucci, P.M., et al.: Blood, 90 2515 (1997), Kaufmann, J. E., et al.: Haemostasis, 1, 682 (2003),<br></p>

<p>Stability Hygroscopic and Moisture Sensitive<br>Applications Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009);<br></p>

<p>Applications Dibutyltin(IV) Oxide is used in studies pertaining to discovering novel antitumor agents. Antifungal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boualam, M. et al.: App. Organometal. Chem., 6, 197 (1992); Hadi, S. et al.: Ori. J. Chem., 26, 775 (2010); Hadi, S. et al.: Modern. App. Sci., 3, 12 (2009);<br></p>

<p>Applications MEK 162 is a MEK1/2 inhibitor allowing it to be a effective anti-cancer medication.<br>References Kopetz,S., et al.: N. Engl., 381, 1632-1643<br></p>

<p>Applications Tropolone is found in many natural compounds. It is an inhibitor of grape polyphenol oxidase (PPO).<br>References Nunez-Delicado, E., et al.: J. Agric. Food Chem., 53, 6087 (2005); Okumura, S., et al.: Food Sci Technol Res., 17, 251 (2011);<br></p>

<p>Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.<br>References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),<br></p>

<p>Applications Fmoc-L-2-nitrophenylalanine<br></p>

<p>Applications [Bis(diphenylphosphino)ethane]dichloronickel is a coordination complex with potential antitumor activity. It is also used as a fast and efficient hydrogen production catalyst.<br>References Mirabelli, C.K., et al.: J. Med. Chem., 30, 2181 (1987); Gan, L., et al.: J. Am. Chem. Soc., 137, 1109 (2015)<br></p>

<p>Applications Ammonium Persulfate is used as a reagent in the low temperature synthesis of carbon-encapsulated spherical Fe7S8 nanocrystals as high-performance anode for lithium-ion batteries.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, B., et al.: Mater. Chem. Phys., 151, 60 (2015)<br></p>

<p>Applications N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.<br>References Zheng, C. et al.: Bioorg. Med. Chem. Lett., 22, 39 (2012); Miki, K. et al.: Bull. Chem. Soc. Jap., 85, 1277 (2012);<br></p>

<p>Stability -200C<br>Applications A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase.<br>References Kawasaki, H., et al.: J. Biol. Chem., 272, 18518 (1997), Ward, S.G., et al.: Biochem. Soc. Trans., 245, 304S (1997), Clerk, A., et al.: FEBS Lett., 426, 93 (1998),<br></p>

<p>Applications L-Leucic Acid is a reagent in the synthesis of cryptophycins based macrocyclic depsipeptides which are used as tubulin inhibitors.<br>References Kumar, A., et al.: Eur. J. Med. Chem., 93, 55 (2015)<br></p>

<p>Applications (-)-Dihydroquinine, is a dihydro derivative of Quinine (Q694000), having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties.<br>References Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 12, 547 (1983); Kremsner, P.G., et al.: J. Infect. Dis., 169, 467 (1994);<br></p>

<p>Stability Hygroscopic<br>Applications Bifunctional DOTA conjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and therapeutic radiopharmaceuticals.<br>References Lewis, M., et al.: Bioconjug. Chem., 9, 72 (1998), Chappell, L., et al.: Bioorg. Med. Chem., 7, 2313 (1999), Prantner, A., et al.: Mol. Imaging, 2, 333 (2003), Allen, M., et al.: Chem. Biol., 11, 301 (2004), Weiner, R., et al.: BioDrugs, 19, 145 (2005), Breeman, W., et al.: Radionuclide Peptide Cancer Therapy, 119 (2006),<br></p>

<p>Applications Pilsicainide is a Class IC drug, which induce the ST segment elevationin study with patients with Brugada syndrome.<br>References Fujiki, A., et al.: J. Cardiovasc. Electrophysiol., 10, 214 (1999); Ikeda, T., et al.: J. Cardiovasc. Electrophysiol., 17, 602 (2006);<br></p>

<p>Applications Ulipristal acetate is a selective progesterone receptor modulator. Ulipristal acetate is used during pregnancy.<br>References Gronemeijer, H., et al.: J. Steroid Biochem., 40, 271 (1991), Spitz, I., et al.: Contraception, 48, 403 (1993), Conneely, O., et al.: Steroids, 68, 771 (2003), Chwalisz, K., et al.: Endocr. Rev., 26, 423 (2005),<br></p>

<p>Applications Cyclohexanepropanoic Acid is a small lead compound that possess potential antifungal properties and effective against candida albicans and sacchromyces cerevisiae.<br>References Pilehvar-Soltanahmadi, Y., et al.: Novelty in Biomedicine, 2, 47 (2014)<br></p>

<p>Applications The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B.<br>References Rindi, G., et al.: Biochem. J., 80, 214 (1961), Wolfgang, M., et al.: J. Biol. Chem., 281, 37265 (2006), Navarro, D., et al.: Metab. Brain Dis., 23, 115 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Methanesulfonic acid is a strong acid and is an important intermediate in the cycling process of sulfur in the environment. Methanesulfonic acid is an oxidation product of Dimethyl sulfide (T348000), and is also used as a sole source of carbon and energy for some gram-negative methylotropic bacteria.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References de Marco, P., et al.: J. Bacteriol., 181, 2244 (1999); Kolaitis, L., et al.: Env. Sci. Tech., 23, 236 (1989); Saltzman, E., et al.: Geophys. Res. Lett., 12, 437 (1985)<br></p>

<p>Applications Used to protect alcohols during organic synthesis.<br>References Shen, H., et al.: J. Med. Chem., 53, 2666 (2010), Qiang, L., et al.: Bioorg. Med. Chem. Lett., 20, 836 (2010),<br></p>

<p>Applications Palladium(II) Acetylacetonate is an active anticancer agent. Exhibits growth inhibitory effect more than cisplatin in several cancer cells and treatment with Palladium(II) Acetylacetonate inhibits H460 cells. Palladium(II) Acetylacetonate is a catalyst for various organic transformations.<br>References Wang, Y., et al.: J. Med. Chem., 56, 9601 (2013); Fang, W., et al.: Small, 8, 3816 (2012); Yao, H., et al.: ACS Catalysis, 7, 5456 (2017)<br></p>

<p>Applications The S-enantiomer of Lansoprazole; a gastric proton pump inhibitor. An antiulcerative.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000), Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001), Barradell, L.B., et al.: Drugs, 44, 225 (1992), Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002), Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006),<br></p>

<p>Applications Tetrabutylammonium Bromide is used in the synthesis of polymer solar cells. Also used in the synthesis of single component green-light emitting electrochemical cells.<br>References Yun, H. et al.: Chem. A Eur. J., 19, 13242 (2013); Sun, M. et al.: J. Disp. Tech., 9, 476 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications (-)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid is a chiral NMR solvating agent used for determining the enantiomeric purity and absolute configuration of β-amino acids. It is also used as a solvating agent in the chiral NMR discrimination of pyrrolidines.<br>References Wenzel, T.J., et al.: Tetrahedron-Assymetr., 20, 2052 (2009); Lovely, A.E., et al.: Chirality, 20, 370 (2008); Li, R., et al.: Fenxi Ceshi Xuebao, 26, 305 (2007); Lovely, A.E., et al.: Tetrahedron-Assymetr., 17, 2642 (2006)<br></p>

<p>Applications GBT 440 is a potent allosteric effector of sickle cell hemoglobin (Hb) that increases the affinity of Hb for oxygen and inhibits its polymerization when subjected to hypoxic conditions.<br>References Metcalf, B., et al.: ACS Med. Chem., 8, 321-326 (2017); Li, Q., et al.: Proc. Natl. Acad. Sci. U.S.A., 114, E689-E696 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>

<p>Impurity Flucytosine EP Impurity A<br>Applications 5-Fluoro Uracil is is an DNA/RNA synthesis inhibitor. It is used as a potent antitumor agent since it interrupts nucleotide synthetic by inhibiting thymidylate synthase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Longley, D., et al.: Nat. Rev. Cancer, 3, 330 (2003); Bollag, W., et al.: Eur. J. Cancer, 16, 427 (1980); Pinedo, H., et al.: J. Clin. Oncol., 6, 1653 (1988); Ishikawa, T., et al.: Biochem. Pharmacol., 55, 1091 (1998); Schuller, J., et al.: Cancer Chemother. Pharmacol., 45, 291 (2000);<br></p>

<p>Applications (-)-Perillyl Alcohol is a monoterpene that induces apoptosis in colon tumor cells. Also, it is used in preparation of terpene-vanilloid conjugates as anti-inflammatory agents.<br>References Young, Sherri C., et al.: U.S. Pat. Appl. Publ., (2020);<br></p>

<p>Applications ABT 199 is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.<br>References Davids, M. &amp; Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);<br></p>

<p>Applications Lead(II) Nitrate, is toxic, an oxidising agent, and is categorized as probably carcinogenic to humans . It is shown to inhibit bacterial oxidation of ferrous iron in sulfate-rich systems. Other Lead(II) Nitrate applications include use as a heat stabilizer in nylon and polyesters, as a coating for photothermographic paper, and in rodenticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hongmei, w., et al.: J Hazard. Mat., 244, 718 (2013); Greenwoos, N. N., et al.: 388 (1997); Pauley, J. L., et al.: J. Amer. Chem. Soci., 76 (16), 4220 (1954);<br></p>

<p>Applications 3-Mercaptopropionic Acid (cas# 107-96-0) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Antilipemic.<br>References Fuccella, L.M., et al.: Clin. Pharmacol. Ther., 28, 790 (1980), Lovisolo, P.P., et al.: Pharmacol. Res. Commun., 13, 151 (1981), Aktories, K., et al.: Arzneim.-Forsch., 33, 1525 (1983), Boatman, P., et al.: J. Med. Chem., 51, 7653 (2008), Rigazio, S., et al.: Am. J. Physiol., 295, E413 (2008),<br></p>

<p>Applications A primary Prostaglandin; easily crystallized from purified biological extracts. Vasodilator (peripheral).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anggard, S., et al.: J. Biol. Chem., 239, 4097 (1964), Wooster, D.L., et al.: J. Am. Med. Assoc., 245, 1846 (1981), Linet, O.I., et al.: N. Engl. J. Med., 334, 873 (1996),<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of sesame lignans (sesamin, sesamolin). Inhibits colonic cancer cell growth by inducing cell cycle arrest and apoptosis. Possible relationship between exposure and reduced risk of breast cancer.<br>References Ayella, A. et al.: Nut. Res., 30, 762 (2010); Pianjing, P. et al.: J. Agric. Food Chem., 59, 212 (2011); Buck, K. et al.: Am. J. Clinic. Nut., 92, 141 (2010);<br></p>

<p>Applications An enantiomer of Atracurium Besylate (A794500). A neuromuscular blocking agent. It could be used in liver transplant patient with safety.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hughes, R., et al.: Br. J. Anaesth., 53, 31 (1981), Basta, S.J., et al.: Anesth. Analog., 61, 723 (1982), Neill, E.A., et al.: Xenobiotica, 12, 203 (1982), Bangsbo, J., et al.: J. Physiol., 422, 539 (1990),<br></p>

<p>Applications rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.<br>References Igarashi, J., et al.: J. Biol. Chem., 275, 32363 (2000), Bandhuvula, P., et al.: J. Biol. Chem., 280, 33697 (2005),<br></p>

<p>Applications A MEK inhibitor with antitumor activity.<br>References Lee, W., et al.: Bioorg. Med. Chem. Lett., 15, 3573 (2005), Normanno, N., et al.: J. Cell. Physiology, 207, 420 (2006), Narlawar, R., et al.: J. Med. Chem., 49, 7588 (2006),<br></p>

<p>Applications Angiotensin-converting enzyme (ACE) inhibitor. Hydrolyzed in vivo to the active diacid metabolite.<br>References Qizumi, K., et al.: Jpn. J. Pharmacol., 48, 349 (1988), Arita, M., et al.: Clin. Exp. Pharmacol. Physiol., 21, 195 (1994), Tokunaga, S., et al.: Drug Invest., 7, 161 (1994)<br></p>

<p>Applications 4,4'-Bis(bromomethyl)-1,1'-biphenyl (cas# 20248-86-6) is a useful research chemical.<br></p>

<p>Applications A synthetic, quaternary ammonium anticholinergic. Antispasmodic; preanesthetic medicant.<br>References Kaltiala, E., et al.: J. Pharm. Pharmacol., 26, 352 (1974), Kongsrud, F., et al.: Acta Anaesthesiol. Scand., 26, 620 (1982),<br></p>

<p>Applications A MEK inhibitor with antitumor activity.<br>References Lee, W., et al.: Bioorg. Med. Chem. Lett., 15, 3573 (2005), Normanno, N., et al.: J. Cell. Physiology, 207, 420 (2006), Narlawar, R., et al.: J. Med. Chem., 49, 7588 (2006),<br></p>

<p>Applications L-838417 is an anxiolytic agent and a selective GABAA receptor partial agonist that selectively binds to α1, α2, α3 and α5 subunits (1,2). It also exhibits antinociceptive and anti-inflammatory properties.<br>References (1) Knabl, J., et al.: Nature. 451, 330 (2008) (2) Johnston, G.A.R., et al.: Curr. Pharm. Design, 11, 1867 (2005)<br></p>

<p>Applications Used in the synthesis of (4S,5S)-(-)-isocytoxazone.<br>References Kakeya, H., et al.: J. Antibiot., 51, 1126 (1998), Carter, P., et al.: Bioorg. Med. Chem. Lett., 13, 1237 (2003),<br></p>

<p>Applications Antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kent, J., et al.: Lancet, 355, 911 (2000), Pacher, P., et al.: Curr. Med. Chem., 8, 89 (2001), Titier, K., et al.: Ther. Drug Monit., 25, 581 (2003), Eap, C., et al.: Ther. Drug Monit., 26, 152 (2004),<br></p>

<p>Applications It is an α2 receptor agonist. It is a drug used to treat glaucoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Katz, L.J., et al.: Am. J. Ophthalmol., 127, 20 (1999), Cantor, L. B., Expert Opin. Pharmacother., 1, 815 (2000),<br></p>

<p>Applications IHydroxylamine, is a useful reactant used that is mainly used as a reducing agent in organic reactions.<br></p>

<p>Applications (R)-1-[(SP)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine is a Josiphos ligand.<br>References MacQueen, P., et al.: Chemistry - A European Journal, 21, 11006 (2015);<br></p>

<p>Stability Temperature Sensitive<br>Applications An alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stahl, et al.: Chem. Res. Toxicol., 5, 106 (1992), Kokkinakis, D.M., et al.: Clin. Cancer Res., 5(11), 3676 (1999), Hickman, M.J., et al.: Proc. Natl. Acad. Sci. USA, 96(19), 10764 (1999),<br></p>

<p>Stability Light Sensitive<br>Applications Thiacetic Acid is a commonly used reagent in organic synthesis for the introduction of thiol groups in molecules.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chapman, J.H. et al.: J. Chem. Soc., 579 (1950); Hoque, A., et al.: Bioorg. Med. Chem. Lett., 22, 6770 (2012)<br></p>

<p>Applications Icilin is a potent agonist of the TRPM8 and ENaCδ ion channels.<br>References Noncovich, A., et al.: Bioorganic Med. Chem. Lett., 27, 3931-38 (2017);<br></p>

<p>Stability Light Sensitive<br>Applications Stereomeric with Cinchonidine (C441925). Antimalarial.<br>References Litchfield, J., et al.: J. Pharm. Exp. Ther., 96, 99 (1949), Trager, W., et al.: Science, 193, 673 (1976), Panisko, D., et al.: Drugs, 39, 160 (1990), Karle, J., et al.: Antimicrob. Agents Chemother., 36, 1538 (1992),<br></p>

<p>Applications Citraconic anhydride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive<br>Applications An unsaturated aldehyde used in the manufacture of polymers and synthetic resin. Cancer studies revealed consumption and release of this volatile organic compound in human small cell lung cancer line, a potential cancer biomarker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponring, A. et al.: Cancer Biomarkers, 7, 153 (2010); Ligor, M. et al.; Clin. Chem. Lab. Med., 47, 550 92009);<br></p>