Antifúngicos

Aflatoxin Q1, a hydroxy metabolite of Aflatoxin B1, is a major detoxication product formed in human liver.

Bivittoside B is a non-sulfated hexoside analog obtained from Bovine sea cucumber with antifungal activity and potential antitumor activity.

Pectate Lyase, an enzyme secreted by plant pathogens, is essential for pectin degradation and plays a vital role in fungal virulence.

NP213 is a rapidly acting synthetic antimicrobial peptide (AMP).

NK 1971 is a bioactive chemical.

Fludioxonil (CGA 173506), a phenylpyrrole fungicide, inhibits the growth of B. cinerea from strawberry and blackberry crops.

Chamaejasmenin D is a useful organic compound for research related to life sciences and the catalog number is T124064.

Trichostatin C, a natural glycosylated hydroxamate, is a histone deacetylase inhibitor with antifungal properties and can induce cell differentiation.

Monaschromone, a polyketide, hinders B. cinerea, A. solani, M. oryzae, G. saubinettii growth; MICs 6.25-12.5 μM.

Metam-sodium: organic salt, yellow-green, smells of amine/sulfur; used as herbicide, insecticide, fungicide, pesticide.

Antifungalagent 108 (compound 14d) is an original imidazo[1,2-b]pyridazine derivative that exhibits potent antifungal activity against Madurella mycetomatis (MM55 strain) with an IC50 of 0.9 μM. The compound shows an IC50 of 14.3 μM for cell viability in NIH-3T3 mouse fibroblasts.

α-Guaiene, a sesquiterpene identified in P. cablin, showcases its presence within this species.

Quellenin, an anti-saprolegnia compound, is isolated from the deep-sea fungus Aspergillus sp. YK-76 [1].

Amphocil is used to treat patients with invasive fungal infection.

Methyl 2-ethylhexanoate (2-Ethylhexanoic Acid Methyl Ester) is a volatile substance with antifungal activity that can be used to study anthrax.

Voriconazole N-oxide, a key metabolite of voriconazole, results from oxidation by CYP3A4 and CYP2C19.

L-Diguluronic acid, a linear copolymer with two L-guluronic units, forms Alginate, useful in antifungal delivery research.

IKD-8344: a macrocyclic dilactone with anticancer, antimicrobial, anthelmintic effects; IC50 = 0.54 ng/ml on L5178Y cells; enhances polymyxin B efficacy.

Compound 5c (Antifungal agent 64) exhibits potent fungicidal activity against Fusarium oxysporum f.sp.

1-Undecanoyl-rac-glycerol is an antibacterial monoacylglycerol, effective against various bacteria and fungi at 250-1500 mg/L.

Mepronil is a compound of pesticide.

Antifungal agent 81(G22) exhibits excellent antifungal properties, demonstrating an in vitro IC50 value of 0.48 mg/L against Valsa mali.

CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM).

Lipopolysaccharides (LPS) are components of the cell walls of Gram-negative bacteria.

Dermaseptin-S2, an antimicrobial peptide sourced from frog skin, exhibits activity against filamentous fungi [1].

Laccase-IN-1 (compound 4b) is an orally active laccase inhibitor, demonstrating an IC50 of 11.3 μM.

Beta-Amyrin acetate: HMGCR & sEH inhibitor (IC50 3.4 μM), anti-inflammatory, antifungal, antioxidant, anti-hyperlipidemic.

Restricticin is used as a naturally-occurring antifungal agent which contains triene, pyran and glycine ester functionalities.

Canadensolide is an antifungal metabolite of Penicillium canadense .

Chaetoviridin A, an azaphilone isolated from Chaetomium globosum, is characterized as 6H-furo[2,3-h]isochromene-6,8(6aH)-dione with substitutions including a chloro group at position 5, a 3-hydroxy-2-methylbutanoyl group at position 9, a methyl group at position 6a, and a 3-methylpent-1-en-1yl group at position 3. It exhibits antifungal activity against plant pathogenic fungi.

SDH-IN-2: Strong SDH blocker (IC50 0.55 μg/mL), antifungal; EC50 3.82-9.81 μg/mL against plant fungi.

Gamma-Glutamyl Transferase-IN-1 (compound 4de), a β-carboline 1-hydrazide inhibitor, exhibits antifungal and antibacterial properties by targeting

Aspyrone, a polyketide from Aspergillus, has antifungal, antibacterial (20 µg/mL, 100 µg/disc), and nematocidal properties (10-1000 mg/L).

Compound 24f, an antifungal agent also known as 'Antifungal agent 85,' demonstrates potent antibacterial properties, exhibiting minimum inhibitory concentration

Amphotericin B methyl ester: a cholesterol-binding antifungal derivative of Amphotericin B; inhibits HIV-1.

Cytochalasin A, a cell-penetrating fungal toxin, blocks HIV-1 protease (IC50 = 3 μM) and hinders actin and microtubule assembly. It's an antibiotic.

Flutianil is a chemical compound from the group of thiazolidines .

Deoxyfusapyrone, an antifungal α-pyrone, combats C. neoformans and Aspergillus species; ineffective against yeast and B. megaterium.

Ratjadon is an antifungal compound isolated from Sorangium cellulosum.

CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM

Ophiobolin B is a sesterterpene Helminthosporium oryzae metabolite, inhibits proton extrusion from maize coleoptiles.

Kievitone, an isoflavanone from Phaseolus vulgaris, has antifungal and antitumor properties.

Compound Fr13414, with CAS No. 13114-72-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13414 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Iturin A: antifungal compound targeting cell membranes, forms ion pores in yeast/fungi.

Sclerotiorin, from Penicillium, inhibits soybean lipoxygenase-1 (IC50: 4.2 μM) and other proteins, antagonizes endothelin receptors.

(-)-Mycousnine, derived from usnic acid, combats Gram-positive bacteria and fungi, but is ineffective against Gram-negative types.

Efungumab, a monoclonal antibody exhibiting antifungal properties, specifically targets HSP 90 to inhibit a conformational alteration crucial for fungal

Antifungal agent 72 (Compound B8) demonstrates potent activity by inhibiting the efflux pump function and downregulating resistance-associated genes via

Latrunculin B: alkaloid, inhibits actin polymerization, antifungal, antiprotozoal, modulates heart rhythm, studied in glaucoma.

Prumycin dihydrochloride is an agent of antifungal antibiotic.

Antifungal agent 82 (compound G34) demonstrates outstanding in vitro antifungal efficacy against Valsa mali, exhibiting an EC50 value of 0.57 μg/mL, and has

Compound 3a (Antifungal agent 62) exhibits potent fungicidal properties, particularly against Fusarium oxysporum f.sp.

Fonsecin is a useful organic compound for research related to life sciences. The catalog number is T124935 and the CAS number is 3748-39-8.

Triphala: Ayurvedic mix, blocks NF-κB, antifungal, anti-inflammatory, fights fat & cancer.

L-4-Oxalysine hydrochloride has shown antitumor activities, is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China.

Gymnoascolide A is a fungal metabolite found in M. filamentosa that exhibits vasodilatory activity. At a concentration of 1 µM, it can inhibit calcium-induced contractions in isolated rat aortic rings.

deacetylsclerotiorin is a new chloroazaphilones produced by the fungus Bartalinia robillardoides strain LF550.

Dactylfungins A: antifungal from Dactylaria Parvispora, effective against fungi like Candida pseudotropicalis, MIC < 10 µg/ml.

Antifungalagent 117 is a bipyrrole carboxamide derivative with antifungal activity, exhibiting an EC50 value of 11.58 mg/L against Sclerotinia sclerotiorum. This compound induces cell death by increasing cell membrane permeability, causing an imbalance in osmotic pressure between the interior and exterior of the cell. It also promotes oxidative damage to the cell membrane by inducing the accumulation of reactive oxygen species (ROS), leading to the leakage of cellular contents. RNA sequencing analysis has demonstrated that Antifungalagent 117 disrupts cell membrane structure by downregulating catalase genes and upregulating neutral ceramidase genes, accelerating ceramide metabolism and hastening cell death. The compound holds significant potential for application in plant protection and the control of fungal infections.

Y12196, a newly developed succinate dehydrogenase inhibitor (SDHI), demonstrates potent fungicidal effects specifically targeting F. graminearum.

5-epi-Jinkoheremol exhibits more potent fungicidal activity than validamycin.

1-Isomangostin hydrate, a natural product extracted from the Mangosteen vine, exhibits antifungal activity.

AR ligand-30 serves as the target protein ligand for PROTAC Bavdegalutamide, utilized in prostate cancer research.

Malachite Green Carbinol Base (MGOH, MGCB), non-fluorescent MG derivative, changes color under UV, releasing OH- for pH shift.

PF-1163A, a depsipeptide antifungal compound isolated from Penicillium, blocks ergosterol synthesis with an IC50 of 12 ng/ml. This compound specifically inhibits the enzyme ERG25p, a C-4 methyl oxidase in the ergosterol biosynthetic pathway, leading to its antifungal activity. Notably, in Saccharomyces cerevisiae modified to express ERG biosynthesis genes, PF-1163A exhibits an inhibition concentration (MIC value) of 12.5 µg/ml against ERG25p, though strains overexpressing ERG25p show resistance. Additionally, PF-1163A effectively suppresses the growth of Candida albicans (MIC = 8 µg/ml), without affecting other Candida species, Aspergillus fumigatus, or HepG2 cells. Remarkably, it enhances the efficacy of fluconazole against azole-resistant C. albicans strains, showing a significant decrease in MICs (1 and 0.0078 µg/ml alone and in combination, respectively). PF-1163A distinguishes itself from PF-1163B by its more polar nature.

Picoxystrobin, a strobilurin fungicide, halts mitochondrial respiration in plants by blocking electron transfer.

Janthitrem F, a naphthopyran also known as 10-O-acetyljanthitrem E, is a tremorgenic mycotoxin produced by Penicillium janthinellum.

Dermaseptin-S1, an antimicrobial peptide sourced from frog skin, exhibits efficacy against filamentous fungi [1].

MK-5204 is an orally active β-1,3-glucan synthesis inhibitor.

Bassianin, a fungal metabolite identified in Beauveria, demonstrates inhibition of Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocyte ghosts, with inhibition rates of 81%, 58%, and 23%, respectively, at a concentration of 200 µg/ml. Additionally, bassianin exhibits cytotoxic properties against Sf9 and Sf21 insect cells, with 50% cytotoxic concentration (CC50) values of 4.91 µM and 12.12 µM, respectively.

Succinate dehydrogenase-IN-9 (Compound Iik) is an inhibitor of succinate dehydrogenase with an IC50 of 3.6 μM. It demonstrates strong inhibitory activity against various fungi, such as S. sclerotiorum, with an EC50 of 1.14 μg/mL. Additionally, Succinate dehydrogenase-IN-9 enhances nitrate reductase activity, promoting plant growth.

Dermaseptin-S5 is an antimicrobial peptide sourced from frog skin that exhibits activity against filamentous fungi [1].

TPS1-IN-1 (Compound O1) is a potent and broad-spectrum inhibitor of TPS1. It exhibits IC50 values of 14.73 μM for MoTPS1 (Magnaporthe oryzae TPS1) and 59.99 μM for BcTPS1 (Botrytis cinerea TPS1). TPS1-IN-1 exerts its broad-spectrum fungicidal effects by disrupting spore germination, appressorium formation, and turgor pressure accumulation in fungi. With good safety profiles, TPS1-IN-1 has potential as a candidate for novel fungicide development.

2,2-Dibromopropanoic acid, with two bromines, is a propionic acid derivative used as a mold inhibitor and food preservative.

Concanamycin C, a natural macrolide antibiotic, was initially isolated from Streptomyces and identified as an inhibitor of T-cell proliferation in response to concanavalin A (1,2). It exhibits cytotoxicity to fungi, including yeasts, by inhibiting vacuolar-type ATPases (3,4).

Methyl 3-(1H-indol-3-yl)propanoate has antifungal activity and is both an analogue of brassinin and a weaker antidote.

LW3 is an effective broad-spectrum antifungal compound.

1,3,6-Trihydroxy-5-methoxyxanthone is a useful organic compound for research related to life sciences and the catalog number is T124882.

Frequentin, an antibiotic from P. frequentans, combats bacteria and fungi; MICs: 200 µg/ml for B. subtilis, 300 for S. aureus.

CYP51/Hsp90-IN-1 (Compound MM4) is a dual inhibitor of CYP51 and Hsp90. This compound exhibits antifungal activity against Candida albicans and effectively suppresses key fungal virulence factors. CYP51/Hsp90-IN-1 shows potential for research in treating invasive candidiasis.

SDH-IN-7 (compound G28) is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 26 nM against porcine SDH and possesses fungicidal

Calcium gluconate monohydrate is a useful organic compound for research related to life sciences. The catalog number is T35350 and the CAS number is 66905-23-5.

β-Tomatine, a derivative of α-tomatine, is a fungitoxic compound that efficiently inhibits plant defense responses.

Picarbutrazox: potent pesticide/fungicide for corn/soybean against Pythium/Phytophthora.

Compound 9d is a potent, selective, non-toxic antifungal effective against Cryptococcus neoformans (MIC ≤ 0.23 μM).

CCR1/5/8 activator 1 is a cytoplasmic phospholipase A inhibitor with antifungal activity.

2, 3-Dichloro-1, 4-naphthoquinone is an inhibitor of Itch, a HECT domain-E3 ligase. It is also used in pesticide formulations.

Lupinine, (+)- is a bioactive chemical.

(E)-Ajoene, found in A. sativum, fights bacteria (MICs: 10-500 μg/ml), fungi (MICs: 15-50 μg/ml), cancer cells, and protects neurons in ischemia.

PK-10, when combined with Fluconazole, exhibits potent synergistic antifungal activity against multiple Fluconazole-resistant Candida albicans strains.

Cyclo(Arg-Pro) TFA, also known as Cyclo(Pro-Arg) TFA, serves as an inhibitor of chitinase. This compound impedes the cell separation of Saccharomyces cerevisiae without affecting its growth. Additionally, Cyclo(Arg-Pro) TFA inhibits the morphological transition of Candida albicans from a yeast form to a filamentous form.

CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.