Lípidos

Impurity Atorvastatin EP Impurity E
Stability Hygroscopic
Applications (3S,5S)-Atorvastatin Sodium Salt (Atorvastatin EP Impurity E) is a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18. 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)

Applications An impurity of Griseofulvin (G787500).
References Oda, T., et al.: Chem. Pharma. Bull., 34, 858 (1986),

Applications A glycidol fatty acid esters in edible oils. An acyl acceptor for the unspecific bifunctional wax ester synthase/acyl-CoA:Diacylglycerol acyltransferase.
References Masukawa, Y. et al.: J. Am. Oil. Chem. Soc., 88, 15 (2011); Kalscheuer, R. et al.: Eur. J. Lipid. Sci. Tech., 105, 578 (2003)

Applications Campestanol can be used as analyte in biological and analytical studies for the determination of 22 natural brassinosteroids in a minute sample of plant tissue by UHPLC-ESI-MS/MS.
References Tarkowska, D., et al.: Anal. Bioanal. Chem., 408, 6799-6812 (2016)

Stability Light Sensitive
Applications cis-7,10,13,16-Docosatetraenoic Acid has been identified as a protein kinase inhibitor, affecting serotonin levels in studies.
References Mirnikjoo, B. et al.: J. Biol. Chem., 276, 10888 (2001);

Stability Light Sensitive
Applications 1,2-Dilinoleoyl-3-palmitoyl-rac-glycerol is a triacylglycerol found in sesame oil.
References Lee, D., et al.: Analytica Chimica Acta, 429, 321 (2001); Jahaniaval, F., et al.: J. AM. Oil Chem. Soc., 77,847 (2000)

Applications Monolaurin has antibacterial, antiviral, and other antimicrobial effects in vitro.
References Li, Q., et al.: Nature, 458, 1034 (2009)

Applications D-erythro-N,N-Dimethylsphingosine is general modulator of protein kinases . D-erythro-N,N-Dimethylsphingosine is implicated in neuropathic pain.
References Igarashi, Y. et al.: Biochemistry, 28, 6796 (1989), Igarashi, Y. et al.: J. Biol. Chem., 265, 5385 (1990); Chemical and Engineering News, 90(4) 8 (2012)

Applications (4bS)-trans-8,8-Trimethyl-4b,5,6,7,8,8a,9,10-octahydro-1-isopropylphenanthren-2-ol is a naturally occurring diterpene that exhibits potent antimicrobial activity.
References Tian, M., et al.: Records of Natural Products, 14, 219 (2020)

Stability Hygroscopic
Applications 3-Methylglutaconic acid is a glutarate which builds up in the urine in 3-methylglutaconic aciduria. 3-methylglutaconic aciduria is a term used to describe five different disorders that impair the functioning of energy-producing centers within cells (mitochondria)
References Walsh, R., et al.: J. Inherit. Metab. Dis., 22, 251 (1999); Gonzalez, I., et al.: Am J Med Genet A., 134, 409 (2005); MacKenzie, J., et al.: Biochim Biophys Acta., 1772, 509 (2007)

Applications 2-Methylenecyclopropaneacetic Acid is an intermediate in the preparation of novel agents for the therapy of non-insulin dependent diabetes mellitus.
References Bell, P., et al.: Bioorg. Med. Chem. Lett., 3, 1007 (1993);

Applications α-Hyodeoxycholic Acid is isolated from pig bile. Antitumor agent.
References Abadie, C., et al.: Biochem. J., 299, 725 (1994), Taniguchi, T., et al.: J. Biol. Chem., 269, 10071 (1994), Davis, R., et al.: J. Lipid Res., 43, 533 (2002),

Applications Dihydrolanosterol, is a derivative of Lanosterol (L174580). It is also one of cytochrome P 450 lanosterol 14α-demethylase (CYP51), which is shown to have an important role in regulating meiosis and reproduction.
References Smiljanic, K., et. al.: Lipids, 48, 1069 (2013); Ma, L., et. al.: Food Chem., 139, 503 (2013);

Applications Polyunsaturaded fatty acid.

Applications 7-Keto Cholesterol is a metabolite of Cholesterol.
References Wang, J., et al.: Biochemistry, 43, 1010 (2004), Lemaire-Ewing, S., et al.: Cell Biol. Toxicol., 21, 97 (2005), Fuda, H., et al.: J. Lipid Res., 48, 1343 ( 2007), Sasaki, H., et al.: Metabolism, 56, 357 (2007),

Applications 3-Hydroxydodecanoic Acid Methyl Ester is a 3-hydroxyl fatty acid Me ester as methionine regulator.
References Akamatsu, Y., et al.: J. Biol. Chem., 245, 709 (1970); Alvarez, L., et al.: Biochem. J., 301, 557 (1994), Varbanova, M., et al.: Plant Cell, 19, 32 (2007), Atsumi, S., et al.: Nature, 451, 86 (2008),

Stability Unstable even at -20°C
Applications Derivative of α-Glucosidase inhibitory phosphatidic acids in wheat germ.
References Liu, L. et al.: Food Chem. 126, 553 (2011)